{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:22:32Z","timestamp":1790749352248,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Shandong Province","award":["2006GGB14630"],"award-info":[{"award-number":["2006GGB14630"]}]},{"name":"Shandong Province","award":["2011YD18081"],"award-info":[{"award-number":["2011YD18081"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.neuropharm.2014.07.020","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T15:51:17Z","timestamp":1407513077000},"page":"389-396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"special_numbering":"C","title":["Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats"],"prefix":"10.1016","volume":"86","author":[{"given":"Qingqing","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunyao","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziling","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Jing","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2014.07.020_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in\u00a0vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Method Enzymol."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neuroscience.2011.07.046","article-title":"Rosiglitazone decreases peroxisome proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: new evidences on neuroprotection in a progressive Parkinson's disease model","volume":"194","author":"Carta","year":"2011","journal-title":"Neurosci."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1753-4887.1998.tb01691.x","article-title":"Lycopene: chemistry, biology, and implications for human health and disease","volume":"56","author":"Clinton","year":"1998","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neurobiolaging.2005.08.021","article-title":"Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation","volume":"26","author":"Craft","year":"2005","journal-title":"Neurobiol. Aging"},{"issue":"8","key":"10.1016\/j.neuropharm.2014.07.020_bib5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.5483\/BMBRep.2009.42.8.475","article-title":"Insulin resistance and Alzheimer's disease","volume":"42","author":"De la Monte","year":"2009","journal-title":"BMB Rep."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib6","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/0003-9861(89)90467-0","article-title":"Lycopene as the most efficient biological carotenoid singlet oxygen quencher","volume":"274","author":"Di Mascio","year":"1989","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A\u00a0new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbrc.2008.12.071","article-title":"Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model","volume":"379","author":"Escribano","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.neuropharm.2014.07.020_bib9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11064-012-0952-5","article-title":"Lycopene inhibits ischemia\/reperfusion-induced neuronal apoptosis in gerbil hippocampal tissue","volume":"38","author":"Fujita","year":"2013","journal-title":"Neurochem Res."},{"issue":"5","key":"10.1016\/j.neuropharm.2014.07.020_bib10","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1037\/0735-7044.119.5.1389","article-title":"Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity","volume":"119","author":"Gordon","year":"2005","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/01635580701328339","article-title":"Lycopene and lutein inhibit proliferation in rat prostate carcinoma cells","volume":"58","author":"Gunasekera","year":"2007","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.neuropharm.2014.07.020_bib12","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuropharm.2011.01.033","article-title":"Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes","volume":"60","author":"Gupta","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2014.07.020_bib13","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/jn\/104.5.580","article-title":"Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rats","volume":"104","author":"Hafemen","year":"1974","journal-title":"J.\u00a0Nutr."},{"issue":"3","key":"10.1016\/j.neuropharm.2014.07.020_bib14","first-page":"351","article-title":"A\u00a0potent antioxidant, lycopene, affords neuroprotection against microglia activation and focal cerebral ischemia in rats","volume":"18","author":"Hsiao","year":"2004","journal-title":"Vivo"},{"issue":"12","key":"10.1016\/j.neuropharm.2014.07.020_bib15","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1158\/1940-6207.CAPR-13-0178","article-title":"Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice","volume":"6","author":"Ip","year":"2013","journal-title":"Cancer Prev. Res. Canprevres"},{"key":"10.1016\/j.neuropharm.2014.07.020_bib16","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1755-5949.2012.00341.x","article-title":"PPAR\u03b3 agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus","volume":"18","author":"Jiang","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3, 4-bromobenzenoxide as the hepatotoxic intermediate","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacol."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib18","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s11064-011-0469-3","article-title":"Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson's disease","volume":"36","author":"Kaur","year":"2011","journal-title":"Neurochem Res."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib19","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1177\/153537020222701002","article-title":"Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health","volume":"227","author":"Khachik","year":"2002","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.neuropharm.2014.07.020_bib20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.lfs.2008.05.013","article-title":"Lycopene attenuates diabetes-associated cognitive decline in rats","volume":"83","author":"Kuhad","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib21","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cell.2005.11.026","article-title":"The many faces of PPARgamma","volume":"123","author":"Lehrke","year":"2005","journal-title":"Cell."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib22","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib54","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejphar.2011.04.045","article-title":"Effect of pioglitazone on altered expression of A\u03b2 metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance","volume":"664","author":"Luo","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jns.2007.08.011","article-title":"Peripheral and central neurologic complications in type 2 diabetes mellitus: no association in individual patients","volume":"264","author":"Manschot","year":"2008","journal-title":"J.\u00a0Neurol. Sci."},{"issue":"7","key":"10.1016\/j.neuropharm.2014.07.020_bib55","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.neuropharm.2014.07.020_bib26","first-page":"295","article-title":"Sugar substitutes in the diabetic diet","volume":"15","author":"Mehnert","year":"1976","journal-title":"Int. Z Vitam. Ernahrungsforsch Beih"},{"key":"10.1016\/j.neuropharm.2014.07.020_bib27","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.neuropharm.2010.01.018","article-title":"Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3_ and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation","volume":"58","author":"Nemoto","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2014.07.020_bib28","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s10495-005-1393-2","article-title":"Lycopene induces apoptosis in immprtalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad","volume":"10","author":"Palozza","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.neuropharm.2014.07.020_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jnutbio.2010.02.003","article-title":"Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-\u03baB nuclear binding and increase in PPAR\u03b3 expression","volume":"22","author":"Palozza","year":"2011","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib30","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1097\/00005072-199909000-00011","article-title":"Distribution of active synthase kinase-3 beta (GSK-3beta) in brains staged for the Alzheimer disease neurofibrillary changes","volume":"58","author":"Pei","year":"1999","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00005072-199701000-00007","article-title":"Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain","volume":"56","author":"Pei","year":"1997","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"issue":"3","key":"10.1016\/j.neuropharm.2014.07.020_bib33","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.neulet.2011.10.048","article-title":"Protective effects of lycopene against amyloid beta-induced neurotoxicity in cultured rat cortical neurons","volume":"505","author":"Qu","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/1028415021000033767","article-title":"Role of oxidative stress and antioxidants in neurogenerative diseases","volume":"5","author":"Rao","year":"2002","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib35","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/(SICI)1097-4695(19990615)39:4<536::AID-NEU7>3.0.CO;2-J","article-title":"Phosphatidylinositol 3-kinasemediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I","volume":"39","author":"Ryu","year":"1999","journal-title":"J.\u00a0Neurobiol."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib36","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1080\/01635581.2014.894092","article-title":"Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2\/HO-1 and Akt\/mTOR pathways","volume":"66","author":"Sahin","year":"2014","journal-title":"Nutr. Cancer"},{"issue":"5","key":"10.1016\/j.neuropharm.2014.07.020_bib37","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neuint.2010.07.005","article-title":"Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system","volume":"57","author":"Sandhir","year":"2010","journal-title":"Neurochem. Int."},{"issue":"5","key":"10.1016\/j.neuropharm.2014.07.020_bib38","doi-asserted-by":"crossref","first-page":"e19652","DOI":"10.1371\/journal.pone.0019652","article-title":"Lycopene inhibits NF-kB-Mediated IL-8 expression and changes Redox and PPAR\u03b3 signalling in Cigarette Smoke\u2013Stimulated macrophages","volume":"6","author":"Simone","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuropharm.2014.07.020_bib41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.lfs.2005.04.044","article-title":"Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats","volume":"78","author":"Siqueira","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/JAD-2005-7107","article-title":"Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease is this type 3 diabetes?","volume":"7","author":"Steen","year":"2005","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib43","doi-asserted-by":"crossref","first-page":"7380","DOI":"10.1523\/JNEUROSCI.22-17-07380.2002","article-title":"Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways","volume":"22","author":"Stein","year":"2002","journal-title":"J.\u00a0Neurosci."},{"issue":"11","key":"10.1016\/j.neuropharm.2014.07.020_bib45","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/hipo.20470","article-title":"Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats","volume":"18","author":"Stranahan","year":"2008","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuropharm.2014.07.020_bib46","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/mnfr.200700272","article-title":"Lycopene inhibits growth human colon cancer cells via suppression of the AKT signaling pathway","volume":"52","author":"Tang","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib48","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejphar.2006.08.036","article-title":"The direct antioxidative and anti-inflammatory effects of peroxisome proliferator-activated receptors ligands are associated with the inhibition of angiotensin converting enzyme expression in streptozotocin-induced diabetic rat aorta","volume":"549","author":"Toba","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib49","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1042\/bj0990667","article-title":"Mechanism of lipid peroxide formation in animals","volume":"99","author":"Wills","year":"1965","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib50","first-page":"337","article-title":"The estimation of red cell superoxide dismutase activity","volume":"85","author":"Winterbourn","year":"1975","journal-title":"J.\u00a0Lab. Clin. Med."},{"key":"10.1016\/j.neuropharm.2014.07.020_bib51","first-page":"125","article-title":"Determine acetylcholine of whole blood by alkalinity hydroxylammonium and galactose chromatometry","volume":"13","author":"Yang","year":"1995","journal-title":"J.\u00a0Clin. Analy"},{"issue":"3","key":"10.1016\/j.neuropharm.2014.07.020_bib53","doi-asserted-by":"crossref","first-page":"e59313","DOI":"10.1371\/journal.pone.0059313","article-title":"Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistant rats","volume":"8","author":"Yin","year":"2013","journal-title":"PLoS ONE"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814002822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814002822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T16:50:04Z","timestamp":1637686204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390814002822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":47,"alternative-id":["S0028390814002822"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.07.020","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}