{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:39:03Z","timestamp":1789429143831,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31271186"],"award-info":[{"award-number":["31271186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.neuropharm.2014.09.031","type":"journal-article","created":{"date-parts":[[2014,10,12]],"date-time":"2014-10-12T10:05:55Z","timestamp":1413108355000},"page":"290-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Ht31 peptide inhibited inflammatory pain by blocking NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice"],"prefix":"10.1016","volume":"89","author":[{"given":"Wen-Tao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Qiang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-Wei","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2014.09.031_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0079-6123(07)00006-4","article-title":"Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase","volume":"169","author":"Abel","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0304-3940(93)90275-P","article-title":"Enhancement of the N-methyl-D-aspartate response in spinal dorsal horn neurons by cAMP-dependent protein kinase","volume":"161","author":"Cerne","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0896-6273(00)00013-1","article-title":"Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex","volume":"27","author":"Colledge","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neuropharm.2013.09.024","article-title":"Activation of alpha2 adrenoceptors inhibited NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice with inflammatory pain","volume":"77","author":"Fan","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1523\/JNEUROSCI.23-01-00131.2003","article-title":"KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons","volume":"23","author":"Guillaud","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib6","doi-asserted-by":"crossref","first-page":"4674","DOI":"10.1523\/JNEUROSCI.5365-06.2007","article-title":"Differential regulation of AMPA receptor trafficking by neurabin-targeted synaptic protein phosphatase-1 in synaptic transmission and long-term depression in hippocampus","volume":"27","author":"Hu","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib7","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1126\/science.1127233","article-title":"Synaptic amplifier of inflammatory pain in the spinal dorsal horn","volume":"312","author":"Ikeda","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib8","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.pain.2008.02.022","article-title":"A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1","volume":"138","author":"Jeske","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib9","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/nn.2613","article-title":"A\u00a0calcineurin\/AKAP complex is required for NMDA receptor-dependent long-term depression","volume":"13","author":"Jurado","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib10","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.pain.2011.01.016","article-title":"Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn","volume":"152","author":"Kopach","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrn2153","article-title":"NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders","volume":"8","author":"Lau","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib12","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1523\/JNEUROSCI.1890-04.2004","article-title":"Subunit-specific regulation of NMDA receptor endocytosis","volume":"24","author":"Lavezzari","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib13","doi-asserted-by":"crossref","first-page":"18338","DOI":"10.1073\/pnas.0604560103","article-title":"Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin","volume":"103","author":"Liu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib14","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/j.1532-2149.2014.00455.x","article-title":"Fyn kinase-regulated NMDA receptor- and AMPA receptor-dependent pain sensitization in spinal dorsal horn of mice","volume":"18","author":"Liu","year":"2014","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib15","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1038\/sj.emboj.7601884","article-title":"Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP","volume":"26","author":"Lu","year":"2007","journal-title":"Embo J."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainres.2008.01.012","article-title":"Role of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat","volume":"1200","author":"Lu","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib17","doi-asserted-by":"crossref","first-page":"7462","DOI":"10.1523\/JNEUROSCI.17-19-07462.1997","article-title":"Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase","volume":"17","author":"Malmberg","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cellsig.2012.11.001","article-title":"Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation","volume":"25","author":"Mizuno","year":"2013","journal-title":"Cell. Signal"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib19","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nn1506","article-title":"Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses","volume":"8","author":"Morishita","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib20","doi-asserted-by":"crossref","first-page":"16679","DOI":"10.1073\/pnas.1000589107","article-title":"NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the \u03b32 subunit","volume":"107","author":"Muir","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/embor.2009.58","article-title":"Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1","volume":"10","author":"Nadella","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib22","doi-asserted-by":"crossref","first-page":"10278","DOI":"10.1523\/JNEUROSCI.1602-07.2007","article-title":"Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memory","volume":"27","author":"Nie","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nn.3636","article-title":"LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity","volume":"17","author":"Parisiadou","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib24","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1523\/JNEUROSCI.4514-08.2009","article-title":"Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons","volume":"29","author":"Park","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib25","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0896-6273(93)90197-Y","article-title":"Calcium-induced actin depolymerization reduces NMDA channel activity","volume":"10","author":"Rosenmund","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib26","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1476-5381.2008.00093.x","article-title":"The role of PKA and PKCepsilon pathways in prostaglandin E2-mediated hypernociception","volume":"156","author":"Sachs","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib27","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1523\/JNEUROSCI.0233-08.2008","article-title":"Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons","volume":"28","author":"Schnizler","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib28","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1126\/science.288.5472.1796","article-title":"Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport","volume":"288","author":"Setou","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib29","doi-asserted-by":"crossref","first-page":"16962","DOI":"10.1074\/jbc.M409693200","article-title":"Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression","volume":"280","author":"Snyder","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib30","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuropharm.2013.01.015","article-title":"Inhibition of protein tyrosine phosphatases in spinal dorsal horn attenuated inflammatory pain by repressing Src signaling","volume":"70","author":"Suo","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/sj.gt.3302376","article-title":"Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat","volume":"12","author":"Tan","year":"2005","journal-title":"Gene Ther."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib32","doi-asserted-by":"crossref","first-page":"12557","DOI":"10.1073\/pnas.0805922105","article-title":"Loss of AKAP150 perturbs distinct neuronal processes in mice","volume":"105","author":"Tunquist","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib33","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1074\/jbc.272.8.4747","article-title":"Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility","volume":"272","author":"Vijayaraghavan","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib34","doi-asserted-by":"crossref","first-page":"8253","DOI":"10.1523\/JNEUROSCI.2555-04.2004","article-title":"Cycling of NMDA receptors during trafficking in neurons before synapse formation","volume":"24","author":"Washbourne","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib35","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1113\/jphysiol.2013.267310","article-title":"Activity-dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones","volume":"592","author":"Wild","year":"2014","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib36","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nrm1527","article-title":"AKAP signalling complexes: focal points in space and time","volume":"5","author":"Wong","year":"2004","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib37","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.1523\/JNEUROSCI.1678-05.2005","article-title":"Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation","volume":"25","author":"Wu","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib38","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/385439a0","article-title":"Competitive binding of alpha-actinin and calmodulin to the NMDA receptor","volume":"385","author":"Wyszynski","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1471-4159.2010.07088.x","article-title":"cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain","volume":"116","author":"Yang","year":"2011","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib40","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.pain.2009.04.005","article-title":"Peripheral inflammation increased the synaptic expression of NMDA receptors in spinal dorsal horn","volume":"144","author":"Yang","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib41","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1523\/JNEUROSCI.1187-05.2005","article-title":"Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism","volume":"25","author":"Yuen","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib42","doi-asserted-by":"crossref","first-page":"29420","DOI":"10.1074\/jbc.M504499200","article-title":"Microtubule regulation of N-methyl-D-aspartate receptor channels in neurons","volume":"280","author":"Yuen","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib43","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1523\/JNEUROSCI.5857-09.2010","article-title":"Opioid-induced long-term potentiation in the spinal cord is a presynaptic event","volume":"30","author":"Zhou","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.09.031_bib44","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neuron.2004.11.011","article-title":"Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses","volume":"44","author":"Zhou","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1756-6606-2-4","article-title":"Plasticity of NMDA receptor NR2B subunit in memory and chronic pain","volume":"2","author":"Zhuo","year":"2009","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neuropharm.2014.09.031_bib46","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.bbrc.2009.10.166","article-title":"Cofilin phosphorylation is involved in nitric oxide\/cGMP-mediated nociception","volume":"390","author":"Zulauf","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814003670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814003670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T23:33:38Z","timestamp":1565912018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390814003670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":46,"alternative-id":["S0028390814003670"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.09.031","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ht31 peptide inhibited inflammatory pain by blocking NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.09.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}