{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:31:57Z","timestamp":1789835517937,"version":"4.0.1"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"Department of Defense Congressionally-Directed Medical Research Program","doi-asserted-by":"crossref","award":["AR110109"],"award-info":[{"award-number":["AR110109"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Morrison Trust, and Lindow, Stephens & Treat, LLP"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH093320"],"award-info":[{"award-number":["MH093320"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UTHSCSA Undergraduate Research START-UP program","award":["GM097632"],"award-info":[{"award-number":["GM097632"]}]},{"name":"Voelcker Biomedical Research program"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.neuropharm.2014.10.024","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T02:03:52Z","timestamp":1415153032000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Acute dietary tryptophan manipulation differentially alters social behavior, brain serotonin and plasma corticosterone in three inbred mouse strains"],"prefix":"10.1016","volume":"90","author":[{"given":"Wynne Q.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey M.","family":"Smolik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla A.","family":"Barba-Escobedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Gamez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus J.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Javors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette C.","family":"Daws","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-8763","authenticated-orcid":false,"given":"Georgianna G.","family":"Gould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2014.10.024_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2302\/kjm.57.15","article-title":"Intersubjectivity, affective neuroscience, and the neurobiology of autistic spectrum disorders: a systematic review","volume":"57","author":"Aitken","year":"2008","journal-title":"Keio J. Med."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-2094-11-4","article-title":"Association of social and cognitive impairment and biomarkers in autism spectrum disorders","volume":"11","author":"Alabdali","year":"2014","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbr.2011.01.039","article-title":"Evaluation of object-based attention in mice","volume":"220","author":"Alkam","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1749-6632.1990.tb16893.x","article-title":"The hyperserotonemia of autism","volume":"600","author":"Anderson","year":"1990","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1023\/A:1025071014191","article-title":"Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies","volume":"33","author":"Arnold","year":"2003","journal-title":"J.\u00a0Autism Dev. Disord."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib6","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.neuropharm.2011.02.002","article-title":"Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors","volume":"60","author":"Azmitia","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib7","doi-asserted-by":"crossref","first-page":"18976","DOI":"10.1073\/pnas.0800466105","article-title":"Organic cation transporter 3: keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice","volume":"105","author":"Baganz","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib8","doi-asserted-by":"crossref","first-page":"15185","DOI":"10.1523\/JNEUROSCI.2740-10.2010","article-title":"Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun","volume":"30","author":"Baganz","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1192\/bjp.178.5.399","article-title":"Tryptophan depletion and its implications for psychiatry","volume":"178","author":"Bell","year":"2001","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib10","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.mehy.2009.05.001","article-title":"Reversal of autistic symptoms by removal of low-relative tryptophan foods: case report","volume":"73","author":"Beretich","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib11","doi-asserted-by":"crossref","first-page":"e35916","DOI":"10.1371\/journal.pone.0035916","article-title":"Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL\/6J and BALB\/cJ mice","volume":"7","author":"Biskup","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/2040-2392-4-16","article-title":"Decreased tryptophan metabolism in patients with autism spectrum disorders","volume":"4","author":"Boccuto","year":"2013","journal-title":"Mol. Autism"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnbeh.2014.00020","article-title":"Vitamin A status regulates glucocorticoid availability in Wistar rats: consequences on cognitive functions and hippocampal neurogenesis?","volume":"8","author":"Bonhomme","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neuropharm.2013.07.003","article-title":"Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice","volume":"75","author":"Bortolato","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib15","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.neuropharm.2011.12.009","article-title":"An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour","volume":"62","author":"Browne","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib16","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1176\/ajp.2006.163.12.2148","article-title":"5-HTTLPR Genotype-specific phenotype in children and adolescents with autism","volume":"163","author":"Brune","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1471-4159.2006.04247.x","article-title":"In\u00a0vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter function","volume":"100","author":"Callaghan","year":"2007","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib18","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/npp.2011.340","article-title":"Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes","volume":"37","author":"Camp","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib19","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1073\/pnas.0809449106","article-title":"Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes","volume":"106","author":"Carneiro","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijdevneu.2004.08.002","article-title":"Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism","volume":"23","author":"Chandana","year":"2005","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib22","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1097\/00004703-200604002-00015","article-title":"Elimination diets in autism spectrum disorders: any wheat amidst the chaff?","volume":"27","author":"Christison","year":"2006","journal-title":"J.\u00a0Dev. Behav. Pediatr."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ajmg.b.30168","article-title":"Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2)","volume":"135B","author":"Coon","year":"2005","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib24","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.lfs.2004.06.032","article-title":"Serotonergic disturbances in autistic disorder: L-5-hydroxytryptophan administration to autistic youngsters increases the blood concentrations of serotonin in patients but not in controls","volume":"76","author":"Croonenberghs","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib25","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/archgenpsychiatry.2012.513","article-title":"Serotonin and the neural processing of facial emotions in adults with autism: an fMRI study using acute tryptophan depletion","volume":"69","author":"Daly","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pharmthera.2011.03.013","article-title":"Ontogeny and regulation of the serotonin transporter: providing insights into human disorders","volume":"131","author":"Daws","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib27","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nprot.2006.20","article-title":"Digging and marble burying in mice: simple methods for in\u00a0vivo identification of biological impacts","volume":"1","author":"Deacon","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib28","first-page":"22","article-title":"Monoamine depletion studies: implications for antidepressant discontinuation syndrome","volume":"67","author":"Delgado","year":"2006","journal-title":"J.\u00a0Clin. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib29","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.biopsych.2010.12.033","article-title":"Tryptophan depletion and emotional processing in healthy volunteers at high risk for depression","volume":"69","author":"Feder","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.neuroscience.2012.03.010","article-title":"Brain growth trajectories in mouse strains with central and peripheral serotonin differences: relevance to autism models","volume":"210","author":"Flood","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib31","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jpsychires.2011.10.003","article-title":"Sub-chronic dietary tryptophan depletion \u2013 an animal model of depression with improved face and good construct validity","volume":"46","author":"Franklin","year":"2012","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib32","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.euroneuro.2014.02.004","article-title":"Blood serotonin levels in autism spectrum disorder: a systematic review and meta-analysis","volume":"24","author":"Gabriele","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib33","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.bcp.2006.03.015","article-title":"Metabolism of oxidants by blood from different mouse strains","volume":"71","author":"Giustarini","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1471-4159.2010.07104.x","article-title":"Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf\/J mouse social behavior","volume":"116","author":"Gould","year":"2011","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib35","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.psyneuen.2013.09.003","article-title":"Enhanced novelty-induced corticosterone spike and upregulated serotonin 5-HT1A and cannabinoid CB1 receptors in adolescent BTBR mice","volume":"39","author":"Gould","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib36","article-title":"Impairment of interstrain social recognition during territorial aggressive behavior in oxytocin receptor-null mice","author":"Hattori","year":"2014","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1089\/cap.2008.037","article-title":"Retrial of selective serotonin reuptake inhibitors in children with pervasive developmental disorders: a retrospective chart review","volume":"19","author":"Henry","year":"2009","journal-title":"J.\u00a0Child. Adolesc. Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib38","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s10803-008-0606-2","article-title":"Does nutritional intake differ between children with autism spectrum disorders and children with typical development?","volume":"39","author":"Herndon","year":"2009","journal-title":"J.\u00a0Autism Dev. Disord."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib39","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.encep.2007.10.011","article-title":"Substitutive and dietetic approaches in childhood autistic disorder: interests and limits","volume":"34","author":"Hjiej","year":"2008","journal-title":"Encephale"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib40","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.physbeh.2010.11.012","article-title":"Natural & synthetic corticosteroids inhibit uptake 2-mediated transport in CNS neurons","volume":"104","author":"Hill","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.brainres.2006.12.095","article-title":"Neonatal serotonin depletion alters behavioral responses to spatial change and novelty","volume":"1139","author":"Hohmann","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib42","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1176\/appi.ajp.2011.10050764","article-title":"A\u00a0double-blind placebo-controlled trial of fluoxetine for repetitive behaviors and global severity in adult autism spectrum disorders","volume":"169","author":"Hollander","year":"2012","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib43","doi-asserted-by":"crossref","first-page":"10534","DOI":"10.1523\/JNEUROSCI.5687-11.2013","article-title":"Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression","volume":"33","author":"Horton","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib44","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000118045","article-title":"Blood serotonin and free tryptophan concentration in autistic children","volume":"11","author":"Hoshino","year":"1984","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib45","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0387-7604(86)80064-X","article-title":"Plasma free tryptophan concentration in autistic children","volume":"8","author":"Hoshino","year":"1986","journal-title":"Brain Dev."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib46","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1542\/peds.2012-0900L","article-title":"Nutrient intake from food in children with autism","volume":"130","author":"Hyman","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib47","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1177\/0269881108099424","article-title":"The effects of acute tryptophan depletion on affective behaviour and cognition in Brown Norway and Sprague Dawley rats","volume":"24","author":"Jans","year":"2010","journal-title":"J.\u00a0Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib48","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1742-4682-5-10","article-title":"Origin of the blood hyperserotonemia of autism","volume":"5","author":"Janu\u0161onis","year":"2008","journal-title":"Theor. Biol. Med. Model."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib49","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/jn\/106.9.1361","article-title":"Amino acid requirements of the growing mouse","volume":"106","author":"John","year":"1976","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib50","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1007\/s10803-014-2095-9","article-title":"Relationships between feeding problems, behavioral characteristics and nutritional quality in children with ASD","volume":"44","author":"Johnson","year":"2014","journal-title":"J.\u00a0Autism Dev. Disord."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib51","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neures.2005.12.008","article-title":"Behavioural anomalies in mice evoked by \u201cTokyo\u201d disruption of the Vitamin D receptor gene","volume":"54","author":"Kalueff","year":"2006","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib52","doi-asserted-by":"crossref","first-page":"e48975","DOI":"10.1371\/journal.pone.0048975","article-title":"Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism","volume":"7","author":"Kane","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib53","first-page":"472","article-title":"Autism, an extreme challenge to integrative medicine: Part 2. Medical management","volume":"7","author":"Kidd","year":"2002","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib54","first-page":"CR488","article-title":"Determination of tryptophan in urine of autistic and healthy children by gas chromatography\/mass spectrometry","volume":"16","author":"Ka\u0142uzna-Czaplinska","year":"2010","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib55","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S1734-1140(12)70927-1","article-title":"Drug therapy in autism: a present and future perspective","volume":"64","author":"Kumar","year":"2012","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib56","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2891-7-2","article-title":"Nutritional therapies for mental disorders","volume":"7","author":"Lakhan","year":"2008","journal-title":"Nutr. J."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib57","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ridd.2005.03.003","article-title":"Neurochemical correlates of autistic disorder: a review of the literature","volume":"27","author":"Lam","year":"2006","journal-title":"Res. Dev. Disabil."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib58","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1601-183X.2009.00506.x","article-title":"Oxytocin and the oxytocin receptor underlie intrastrain, but not interstrain, social recognition","volume":"8","author":"Macbeth","year":"2009","journal-title":"Genes. Brain Behav."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib59","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.physbeh.2014.01.036","article-title":"Effects of developmental hyperserotonemia on juvenile play behavior, oxytocin and serotonin receptor expression in the hypothalamus are age and sex dependent","volume":"128","author":"Madden","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib60","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1469-8749.2008.03027.x","article-title":"Serotonin and dopamine transporter binding in children with autism determined by SPECT","volume":"50","author":"Makkonen","year":"2008","journal-title":"Dev. Med. Child. Neurol."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib61","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jada.2009.01.013","article-title":"What is the current status of research concerning use of a gluten-free, casein-free diet for children diagnosed with autism?","volume":"109","author":"Marcason","year":"2009","journal-title":"J.\u00a0Am. Diet. Assoc."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib62","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1177\/0883073813498821","article-title":"Food Selectivity in autism spectrum disorders: systematic review","volume":"29","author":"Mar\u00ed-Bauset","year":"2014","journal-title":"J.\u00a0Child. Neurol."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib63","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0006-3223(93)90011-2","article-title":"Acute tryptophan depletion in autistic disorder: a controlled case study","volume":"33","author":"McDougle","year":"1993","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib64","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/archpsyc.1996.01830110029004","article-title":"Effects of tryptophan depletion in drug-free adults with autistic disorder","volume":"53","author":"McDougle","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib65","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.brainres.2007.10.063","article-title":"Further studies in the developmental hyperserotonemia model (DHS) of autism: social, behavioral and peptide changes","volume":"1189","author":"McNamara","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib66","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbr.2006.07.030","article-title":"Mouse behavior tasks relevant to autism: phenotypes of 10 inbred strains","volume":"176","author":"Moy","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib67","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4137\/IJTR.S1022","article-title":"Production and peripheral roles of 5-HTP, a precursor of serotonin","volume":"2","author":"Nakamura","year":"2009","journal-title":"Int. J. Tryptophan Res."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib68","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/archgenpsychiatry.2009.137","article-title":"Brain serotonin and dopamine transporter bindings in adults with high-functioning autism","volume":"67","author":"Nakamura","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib69","first-page":"474","article-title":"Autistic children exhibit distinct plasma amino acid profile","volume":"50","author":"Naushad","year":"2013","journal-title":"Indian J. Biochem. Biophys."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib70","series-title":"Nutrient Requirements of Laboratory Animals","first-page":"80","article-title":"Nutrient requirements of the mouse","author":"National Research Council","year":"1995"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib71","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1096\/fj.13-246546","article-title":"Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism","volume":"28","author":"Patrick","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib72","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/HRP.0000000000000030","article-title":"Psychopharmacological interventions in autism spectrum disorder","volume":"22","author":"Politte","year":"2014","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib73","first-page":"1","article-title":"Laboratory animal diets: a critical part of your in\u00a0vivo research","volume":"4","author":"Ricci","year":"2005","journal-title":"Anim. Lab. News"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib74","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1111\/jcpp.12108","article-title":"Candidate gene associations with withdrawn behavior","volume":"54","author":"Rubin","year":"2013","journal-title":"J.\u00a0Child. Psychol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib75","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00213-013-3290-7","article-title":"Biomarkers in autism spectrum disorder: the old and the new","volume":"231","author":"Ruggeri","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib76","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2217\/bmm.14.11","article-title":"Aberrant tryptophan metabolism: the unifying biochemical basis for autism spectrum disorders?","volume":"8","author":"Schwartz","year":"2014","journal-title":"Biomark. Med."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib77","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nrn2851","article-title":"Behavioural phenotyping assays for mouse models of autism","volume":"11","author":"Silverman","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib78","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fnbeh.2014.00282","article-title":"Comparison of inbred mouse substrains reveals segregation of maladaptive fear phenotypes","volume":"8","author":"Temme","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib79","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1177\/0148607111436280","article-title":"Fried-potato diet causes vitamin A deficiency in an autistic child","volume":"36","author":"Tanoue","year":"2012","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib80","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1271\/bbb.110190","article-title":"Dietary vitamin E deficiency increases anxiety-like behavior in juvenile and adult rats","volume":"75","author":"Terada","year":"2011","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib81","first-page":"46","article-title":"The biology of tryptophan depletion and mood disorders","volume":"47","author":"Toker","year":"2010","journal-title":"Isr. J. Psychiatry Relat. Sci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib82","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3177\/jnsv.51.175","article-title":"Chronic reduction in dietary tryptophan leads to changes in the emotional response to stress in mice","volume":"51","author":"Uchida","year":"2005","journal-title":"J.\u00a0Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib83","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3389\/fnhum.2013.00606","article-title":"A\u00a0\u201cbottom-up\u201d approach to aetiological research in autism spectrum disorders","volume":"7","author":"Unwin","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib84","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuint.2009.08.010","article-title":"Acute tryptophan depletion in C57BL\/6 mice does not induce central serotonin reduction or affective behavioural changes","volume":"56","author":"van Donkelaar","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib85","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/mp.2011.9","article-title":"Mechanism of acute tryptophan depletion: is it only serotonin?","volume":"16","author":"van Donkelaar","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib86","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1073\/pnas.1112345109","article-title":"Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior","volume":"109","author":"Veenstra-VanderWeele","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib87","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pedhc.2008.12.001","article-title":"Pharmacologic treatment for the core deficits and associated symptoms of autism in children","volume":"23","author":"West","year":"2009","journal-title":"J.\u00a0Pediatr. Health Care"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib88","doi-asserted-by":"crossref","first-page":"302","DOI":"10.5694\/mja12.11667","article-title":"Is autism one or multiple disorders?","volume":"28","author":"Whitehouse","year":"2013","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib89","first-page":"CD004677","article-title":"Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders","volume":"8","author":"Williams","year":"2013","journal-title":"Cochrane DB Syst. Rev."},{"key":"10.1016\/j.neuropharm.2014.10.024_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2014.02.021","article-title":"The developmental disruptions of serotonin signaling may be involved in autism during early brain development","volume":"267C","author":"Yang","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2014.10.024_bib91","doi-asserted-by":"crossref","first-page":"8.26.1","DOI":"10.1002\/0471142301.ns0826s56","article-title":"Automated three-chambered social approach task for mice","volume":"56","author":"Yang","year":"2011","journal-title":"Curr. Protoc. Neurosci."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814003992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390814003992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T13:00:03Z","timestamp":1598446803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390814003992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":90,"alternative-id":["S0028390814003992"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.10.024","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute dietary tryptophan manipulation differentially alters social behavior, brain serotonin and plasma corticosterone in three inbred mouse strains","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2014.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}