{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:22:47Z","timestamp":1791246167009,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002301","name":"Estonian Research Council","doi-asserted-by":"publisher","award":["IUT20-41"],"award-info":[{"award-number":["IUT20-41"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002301","name":"Estonian Research Council","doi-asserted-by":"publisher","award":["ETF9329"],"award-info":[{"award-number":["ETF9329"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.neuropharm.2015.02.019","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T01:15:44Z","timestamp":1424913344000},"page":"59-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Deletion of the Wolfram syndrome-related gene Wfs1 results in increased sensitivity to ethanol in female mice"],"prefix":"10.1016","volume":"95","author":[{"given":"Sirli","family":"Raud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riin","family":"Reimets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarja","family":"Loomets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"S\u00fctt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Altpere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanel","family":"Visnapuu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Innos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Luuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Plaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vallo","family":"Volke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Vasar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2015.02.019_bib1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbr.2006.08.015","article-title":"Gender specific effects of ethanol in mice, lacking CCK2 receptors","volume":"175","author":"Abramov","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/alcalc\/agt163","article-title":"GABRA2 variant is associated with increased stimulation and \u2018high\u2019 following alcohol administration","volume":"49","author":"Arias","year":"2014","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/sj.bjp.0706056","article-title":"Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors","volume":"144","author":"Atack","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1124\/jpet.105.089920","article-title":"TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates","volume":"316","author":"Atack","year":"2006","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib5","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/S0014-2999(99)00678-0","article-title":"Ethanol markedly increases \u201cGABAergic\u201d neurosteroids in alcohol-preferring rats","volume":"384","author":"Barbaccia","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1124\/jpet.110.171645","article-title":"Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive \u03b12-containing GABA(A) receptors","volume":"336","author":"Blednov","year":"2011","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib7","doi-asserted-by":"crossref","first-page":"e85525","DOI":"10.1371\/journal.pone.0085525","article-title":"GABAA receptors containing \u03c11 subunits contribute to in\u00a0vivo effects of ethanol in mice","volume":"9","author":"Blednov","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib8","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.bcp.2004.07.023","article-title":"\u03b3-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions","volume":"68","author":"Boehm","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1124\/jpet.106.104406","article-title":"An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice","volume":"319","author":"Borghese","year":"2006","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib10","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0091-3057(93)90124-C","article-title":"A\u00a0genetic comparison of behavioral actions of ethanol and nicotine in the mirrored chamber","volume":"45","author":"Cao","year":"1993","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1530-0277.2007.00563.x","article-title":"Normal acute behavioral responses to moderate\/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice","volume":"32","author":"Chandra","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib13","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/sj.npp.1300750","article-title":"A\u00a0conceptualization of integrated actions of ethanol contributing to its GABAmimetic profile: a commentary","volume":"30","author":"Criswell","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib14","series-title":"The Amygdala","first-page":"213","article-title":"The role of the amygdala in conditioned and unconditioned fear and anxiety","author":"Davis","year":"2000"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib15","doi-asserted-by":"crossref","first-page":"e47135","DOI":"10.1371\/journal.pone.0047135","article-title":"Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration","volume":"7","author":"Dixon","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02431535","article-title":"Time course of ethanol's effects on locomotor activity, exploration and anxiety in mice","volume":"96","author":"Durcan","year":"1988","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/01.ypg.0000185027.89816.d9","article-title":"Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis","volume":"16","author":"Fehr","year":"2006","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib18","series-title":"Experimental Approaches to Anxiety and Depression","first-page":"25","article-title":"Behavioural detection of anxiolytic action","author":"File","year":"1992"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib63","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10048-003-0143-2","article-title":"Genetic animal models of anxiety","volume":"4","author":"Finn","year":"2003","journal-title":"Neurogenetics"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib19","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"1997"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s002130050685","article-title":"The role of GABAA receptors in the acute and chronic effects of ethanol","volume":"139","author":"Grobin","year":"1998","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib21","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1530-0277.1995.tb01496.x","article-title":"Ethanol increases GABAA responses in cells stably transfected with receptor subunits","volume":"19","author":"Harris","year":"1995","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0028-3908(98)00177-4","article-title":"Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor","volume":"38","author":"Homanics","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1017\/S1461145704004791","article-title":"Polymorphisms in wolframin (WFS1) gene are possibly related to increased risk for mood disorders","volume":"8","author":"Koido","year":"2005","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s002130100855","article-title":"Cholecystokinin2 receptor-deficient mice display altered function of brain dopaminergic system","volume":"158","author":"K\u00f5ks","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1054-3589(06)54009-8","article-title":"A\u00a0role for GABA in alcohol dependence","volume":"54","author":"Koob","year":"2006","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib26","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1124\/jpet.102.048124","article-title":"Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics","volume":"305","author":"Kralic","year":"2003","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib27","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00213-009-1562-z","article-title":"The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress","volume":"205","author":"Kumar","year":"2009","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib28","doi-asserted-by":"crossref","first-page":"e22636","DOI":"10.1371\/journal.pone.0022636","article-title":"An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol","volume":"6","author":"Lasek","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.euroneuro.2012.10.011","article-title":"Brain, networks, depression, and more European","volume":"23","author":"Leistedt","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pneurobio.2014.08.001","article-title":"Brain areas that influence general anesthesia","volume":"122","author":"Leung","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib31","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/npp.2013.291","article-title":"Association of gamma-aminobutyric acid A receptor \u03b12 gene (GABRA2) with alcohol use disorder","volume":"39","author":"Li","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib32","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The use of a plus-maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib33","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.2467382","article-title":"Ethanol inhibits NMDA-activated ion current in hippocampal neurons","volume":"243","author":"Lovinger","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib34","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1523\/JNEUROSCI.10-04-01372.1990","article-title":"NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat","volume":"10","author":"Lovinger","year":"1990","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib35","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1126\/science.290.5489.131","article-title":"Molecular and neuronal substrate for the selective attenuation of anxiety","volume":"290","author":"L\u00f6w","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib36","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/cne.21777","article-title":"Distribution of Wfs1 protein in the central nervous system of the mouse and its relation to clinical symptoms of the Wolfram syndrome","volume":"509","author":"Luuk","year":"2008","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib37","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bbr.2008.11.007","article-title":"Wfs1-deficient mice display impaired behavioural adaptation in stressful environment","volume":"198","author":"Luuk","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib38","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/syn.10085","article-title":"Gabaergic modulation of the stress response in frontal cortex and amygdala","volume":"45","author":"Martijena","year":"2002","journal-title":"Synapse"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib39","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/75761","article-title":"Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype","volume":"3","author":"McKernan","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib40","first-page":"1708","article-title":"GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol","volume":"25","author":"Mihalek","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib41","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/38738","article-title":"Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors","volume":"389","author":"Mihic","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib42","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1111\/j.1460-9568.2006.04775.x","article-title":"Both alpha2 and alpha3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm","volume":"23","author":"Morris","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib43","first-page":"100","article-title":"Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice","volume":"18","author":"Navarro","year":"2006","journal-title":"Psicothema"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib44","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1192\/bjp.179.5.390","article-title":"New insights into the role of the GABAA\u2014benzodiazepine receptor in psychiatric disorder","volume":"179","author":"Nutt","year":"2001","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib45","series-title":"Affective Neuroscience: the Foundations of Human and Animal Emotions","author":"Panksepp","year":"1998"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib46","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neulet.2009.05.054","article-title":"Relation between increased anxiety and reduced expression of alpha1 and alpha2 subunits of GABA(A) receptors in Wfs1-deficient mice","volume":"460","author":"Raud","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib47","doi-asserted-by":"crossref","first-page":"10159","DOI":"10.1523\/JNEUROSCI.3004-04.2004","article-title":"Increased GABA release in the central amygdala of ethanol-dependent rats","volume":"24","author":"Roberto","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib48","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0091-3057(95)00138-M","article-title":"Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety","volume":"52","author":"Rodgers","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib49","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.pharmtox.44.101802.121429","article-title":"Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics","volume":"44","author":"Rudolph","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib50","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jneumeth.2010.03.026","article-title":"A\u00a0rotarod test for evaluation of motor skill learning","volume":"189","author":"Shiotsuki","year":"2010","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib51","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng0597-19","article-title":"Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice","volume":"16","author":"Simpson","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib52","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0278-5846(89)90024-9","article-title":"Anticonflict and rotarod impairing effects of alprazolam and diazepam in rat after acute and subchronic administration","volume":"13","author":"S\u00f6derpalm","year":"1989","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib53","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/npp.2010.224","article-title":"Differential effects of the dual orexin receptor antagonist almorexant and the GABAA-\u03b11 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat","volume":"36","author":"Steiner","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0741-8329(93)90046-Q","article-title":"Comparison of alcohol-preferring (P) and nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol","volume":"10","author":"Stewart","year":"1993","journal-title":"Alcohol"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib55","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0741-8329(89)90006-2","article-title":"The effects of ethanol and Ro 15-4513 on elevated plus-maze and rotarod performance in long-sleep and short-sleep mice","volume":"6","author":"Stinchcomb","year":"1989","journal-title":"Alcohol"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib56","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/sj.mp.4001681","article-title":"Wolframin mutations and hospitalization for psychiatric illness","volume":"10","author":"Swift","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib57","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/0140-6736(90)92157-D","article-title":"Psychiatric findings in Wolfram syndrome homozygotes","volume":"336","author":"Swift","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.neuropharm.2015.02.019_bib58","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0022-3565(25)12126-5","article-title":"U-90042, a sedative\/hypnotic compound that interacts differentially with the GABAA receptor subtypes","volume":"275","author":"Tang","year":"1995","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib59","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1369-1600.2012.00457.x","article-title":"GABRA2 markers moderate the subjective effects of alcohol","volume":"18","author":"Uhart","year":"2013","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib60","doi-asserted-by":"crossref","first-page":"15218","DOI":"10.1073\/pnas.2435171100","article-title":"Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans","volume":"100","author":"Wallner","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib61","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.pharmthera.2005.11.002","article-title":"Ethanol modulation of GABAergic transmission: the view from the slice","volume":"111","author":"Weiner","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuropharm.2015.02.019_bib62","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1124\/jpet.106.106161","article-title":"Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol","volume":"319","author":"Werner","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815000660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815000660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T01:35:29Z","timestamp":1747704929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390815000660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":62,"alternative-id":["S0028390815000660"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.02.019","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deletion of the Wolfram syndrome-related gene Wfs1 results in increased sensitivity to ethanol in female mice","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.02.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}