{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:02:04Z","timestamp":1789189324042,"version":"build-2803163510"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171127"],"award-info":[{"award-number":["81171127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100970"],"award-info":[{"award-number":["81100970"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370737"],"award-info":[{"award-number":["81370737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371422"],"award-info":[{"award-number":["81371422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science and Technology, Major Projects of New Drugs","award":["2012ZX09103301-028"],"award-info":[{"award-number":["2012ZX09103301-028"]}]},{"name":"Project of innovation and entrepreneurship training","award":["201410486085"],"award-info":[{"award-number":["201410486085"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.neuropharm.2015.07.007","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T11:07:43Z","timestamp":1436872063000},"page":"38-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"special_numbering":"C","title":["Vitexin reduces hypoxia\u2013ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model"],"prefix":"10.1016","volume":"99","author":[{"given":"Jia-Wei","family":"Min","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Jian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell M.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najeeb Bassam","family":"Bsoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Wen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2015.07.007_bib1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1747-0285.2012.01400.x","article-title":"Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats","volume":"80","author":"Abbasi","year":"2012","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib2","first-page":"184","article-title":"Effects of vitexin on scopolamine-induced memory impairment in rats","volume":"56","author":"Abbasi","year":"2013","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuint.2005.12.008","article-title":"Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats","volume":"48","author":"Althaus","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/hipo.450030302","article-title":"Hippocampal function in the rat: cognitive mapping or vicarious trial and error?","volume":"3","author":"Amsel","year":"1993","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib5","first-page":"2565","article-title":"Antioxidant effects of the orientin and vitexin in Trollius chinensis Bunge in D-galactose-aged mice","volume":"7","author":"An","year":"2012","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib6","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1523\/JNEUROSCI.0449-07.2007","article-title":"Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia","volume":"27","author":"Baranova","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib7","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1523\/JNEUROSCI.10-10-03449.1990","article-title":"The recovery of forelimb-placing behavior in rats with neonatal unilateral cortical damage involves the remaining hemisphere","volume":"10","author":"Barth","year":"1990","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib8","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1542\/peds.2004-0227","article-title":"The effect of chronic or intermittent hypoxia on cognition in childhood: a review of the evidence","volume":"114","author":"Bass","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/1531-8249(200009)48:3<285::AID-ANA2>3.0.CO;2-8","article-title":"Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain","volume":"48","author":"Bergeron","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib10","doi-asserted-by":"crossref","first-page":"39728","DOI":"10.1074\/jbc.M204619200","article-title":"Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance","volume":"277","author":"Bernaudin","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib11","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1021\/np400222v","article-title":"Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines","volume":"76","author":"Borghi","year":"2013","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib12","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/japplphysiol.00268.2006","article-title":"Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1alpha and its downstream target genes","volume":"101","author":"Calvert","year":"2006","journal-title":"J.\u00a0Appl. Physiol. (1985)"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ejphar.2012.10.017","article-title":"Anti-depressant-like effect of vitexin in BALB\/c mice and evidence for the involvement of monoaminergic mechanisms","volume":"699","author":"Can","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib14","doi-asserted-by":"crossref","first-page":"e21071","DOI":"10.1371\/journal.pone.0021071","article-title":"Antioxidant properties of the mung bean flavonoids on alleviating heat stress","volume":"6","author":"Cao","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib15","doi-asserted-by":"crossref","first-page":"13595","DOI":"10.1074\/jbc.C200694200","article-title":"Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function","volume":"278","author":"Chen","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib16","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1471-4159.2009.06362.x","article-title":"Matrix metalloproteinases inhibition provides neuroprotection against hypoxia-ischemia in the developing brain","volume":"111","author":"Chen","year":"2009","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.nbd.2008.05.020","article-title":"HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model","volume":"31","author":"Chen","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib18","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1161\/STROKEAHA.110.599118","article-title":"Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model","volume":"42","author":"Chen","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.expneurol.2008.10.016","article-title":"Prodeath or prosurvival: two facets of hypoxia inducible factor-1 in perinatal brain injury","volume":"216","author":"Chen","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.expneurol.2006.11.001","article-title":"Effects of anti-VEGF antibody on blood-brain barrier disruption in focal cerebral ischemia","volume":"204","author":"Chi","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1016-8478(23)17423-1","article-title":"Vitexin, an HIF-1alpha inhibitor, has anti-metastatic potential in PC12 cells","volume":"22","author":"Choi","year":"2006","journal-title":"Mol. Cells"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pbb.2013.04.014","article-title":"Anti-nociceptive effect of vitexin mediated by the opioid system in mice","volume":"109","author":"Demir Ozkay","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/35088074","article-title":"Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades","volume":"412","author":"Digicaylioglu","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib24","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1016\/j.fct.2011.09.040","article-title":"Vitexin protects against myocardial ischemia\/reperfusion injury in Langendorff-perfused rat hearts by attenuating inflammatory response and apoptosis","volume":"49","author":"Dong","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib25","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1142\/S0192415X13500845","article-title":"Cardioprotection of vitexin on myocardial ischemia\/reperfusion injury in rat via regulating inflammatory cytokines and MAPK pathway","volume":"41","author":"Dong","year":"2013","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib26","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMra041996","article-title":"Neonatal brain injury","volume":"351","author":"Ferriero","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"Suppl.\u00a07","key":"10.1016\/j.neuropharm.2015.07.007_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1528-1167.2005.00302.x","article-title":"Protecting neurons","volume":"46","author":"Ferriero","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib28","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","article-title":"Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1","volume":"16","author":"Forsythe","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib29","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1210\/jcem-68-4-707","article-title":"Antithyroid and goitrogenic effects of millet: role of C-glycosylflavones","volume":"68","author":"Gaitan","year":"1989","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib30","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1742-7843.2006.pto_507.x","article-title":"Antispasmodic effects of Rooibos tea (Aspalathus linearis) is mediated predominantly through K+ -channel activation","volume":"99","author":"Gilani","year":"2006","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jpeds.2009.03.040","article-title":"Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic-ischemic brain injury","volume":"155","author":"Glass","year":"2009","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib32","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jep.2011.01.025","article-title":"Antinociceptive activity of ethanolic extract and isolated compounds of Urtica circularis","volume":"134","author":"Gorzalczany","year":"2011","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib33","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ajog.2008.06.094","article-title":"A\u00a0systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy","volume":"199","author":"Graham","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/ptr.2021","article-title":"Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents","volume":"21","author":"Hajdu","year":"2007","journal-title":"Phytother. Res."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/exnr.1999.7160","article-title":"HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia","volume":"159","author":"Halterman","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib36","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.nbd.2006.08.006","article-title":"Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease","volume":"24","author":"Hartman","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib37","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1523\/JNEUROSCI.4555-04.2005","article-title":"Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage","volume":"25","author":"Helton","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib38","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib39","first-page":"224","article-title":"The inhibitory effect of vitexin on the agonist-induced regulation of vascular contractility","volume":"69","author":"Je","year":"2014","journal-title":"Pharmazie"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2006.05.049","article-title":"Hypoxic preconditioning produces differential expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and its regulatory enzyme HIF prolyl hydroxylase 2 in neonatal rat brain","volume":"404","author":"Jones","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib41","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1124\/mol.106.027029","article-title":"Hypoxia-inducible factor-1 (HIF-1)","volume":"70","author":"Ke","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF02977715","article-title":"The isolation and antioxidative effects of vitexin from Acer palmatum","volume":"28","author":"Kim","year":"2005","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib43","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1161\/STROKEAHA.114.006170","article-title":"NR2B phosphorylation at tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia","volume":"45","author":"Knox","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.nbd.2012.10.024","article-title":"Enhanced NMDA receptor tyrosine phosphorylation and increased brain injury following neonatal hypoxia-ischemia in mice with neuronal Fyn overexpression","volume":"51","author":"Knox","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib45","first-page":"119","article-title":"Inhibition of tobacco mosaic virus infection by quercetin and vitexin","volume":"52","author":"Krcatovic","year":"2008","journal-title":"Acta Virol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbr.2003.11.002","article-title":"Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia-ischemia in rats","volume":"153","author":"Kumral","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib47","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.fct.2010.03.052","article-title":"The compound isolated from the leaves of Phyllostachys nigra protects oxidative stress-induced retinal ganglion cells death","volume":"48","author":"Lee","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib48","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00401-008-0339-5","article-title":"The requirement of extracellular signal-related protein kinase pathway in the activation of hypoxia inducible factor 1 alpha in the developing rat brain after hypoxia-ischemia","volume":"115","author":"Li","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0378-8741(01)00410-X","article-title":"Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge","volume":"79","author":"Li","year":"2002","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.brainres.2009.05.071","article-title":"Neuroprotective effect of memantine combined with topiramate in hypoxic-ischemic brain injury","volume":"1282","author":"Liu","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib51","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.phymed.2009.12.010","article-title":"The pharmacokinetics of C-glycosyl flavones of Hawthorn leaf flavonoids in rat after single dose oral administration","volume":"17","author":"Ma","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib52","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.brainres.2006.08.030","article-title":"Adult neurological function following neonatal hypoxia-ischemia in a mouse model of the term neonate: water maze performance is dependent on separable cognitive and motor components","volume":"1118","author":"McAuliffe","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib53","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1113\/jphysiol.2004.069757","article-title":"Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice","volume":"560","author":"Milkiewicz","year":"2004","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib54","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/j.phytochem.2011.08.021","article-title":"Changes in wheat leaf phenolome in response to cold acclimation","volume":"72","author":"Moheb","year":"2011","journal-title":"Phytochemistry"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib55","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1161\/01.STR.28.11.2281","article-title":"Vulnerability to cerebral hypoxic-ischemic insult in neonatal but not in adult rats is in parallel with disruption of the blood-brain barrier","volume":"28","author":"Muramatsu","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib56","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1097\/00005072-199708000-00009","article-title":"Role of vascular endothelial growth factor in blood-brain barrier breakdown and angiogenesis in brain trauma","volume":"56","author":"Nag","year":"1997","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib57","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1474-4422(04)00679-9","article-title":"Stroke in newborn infants","volume":"3","author":"Nelson","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib58","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/sj.jcbfm.9600048","article-title":"Mechanisms of hyperbaric oxygen-induced neuroprotection in a rat model of subarachnoid hemorrhage","volume":"25","author":"Ostrowski","year":"2005","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib59","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.foodchem.2012.11.112","article-title":"Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells","volume":"138","author":"Papi","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib60","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.saa.2012.11.001","article-title":"Experimental and DFT studies on the antioxidant activity of a C-glycoside from Rhynchosia capitata","volume":"103","author":"Praveena","year":"2013","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib61","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jep.2007.06.003","article-title":"The spasmolytic effect of Aloysia citriodora, Palau (South American cedron) is partially due to its vitexin but not isovitexin on rat duodenums","volume":"113","author":"Ragone","year":"2007","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib62","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000085979","article-title":"Hypoxia preconditioning in the brain","volume":"27","author":"Ran","year":"2005","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib63","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/153537020322800304","article-title":"Expression of the prodynorphin gene after experimental brain injury and its role in behavioral dysfunction","volume":"228","author":"Redell","year":"2003","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib64","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib65","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.cellbio.15.1.551","article-title":"Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1","volume":"15","author":"Semenza","year":"1999","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib66","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0006-2952(99)00292-0","article-title":"Expression of hypoxia-inducible factor 1: mechanisms and consequences","volume":"59","author":"Semenza","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib67","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1152\/jappl.2000.88.4.1474","article-title":"HIF-1: mediator of physiological and pathophysiological responses to hypoxia","volume":"88","author":"Semenza","year":"2000","journal-title":"J.\u00a0Appl. Physiol. (1985)"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib68","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa1112066","article-title":"Childhood outcomes after hypothermia for neonatal encephalopathy","volume":"366","author":"Shankaran","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib69","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1602\/neurorx.1.1.26","article-title":"Hypoxic preconditioning protects against ischemic brain injury","volume":"1","author":"Sharp","year":"2004","journal-title":"NeuroRx"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib70","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/pr.2014.53","article-title":"Hypoxic preconditioning protection is eliminated in HIF-1alpha knockout mice subjected to neonatal hypoxia-ischemia","volume":"76","author":"Sheldon","year":"2014","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib71","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1750-3639.2007.00104.x","article-title":"Vascular endothelial growth factor and nitric oxide production in response to hypoxia in the choroid plexus in neonatal brain","volume":"18","author":"Sivakumar","year":"2008","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib72","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12975-013-0312-z","article-title":"Erythropoietin inhibits HIF-1alpha expression via upregulation of PHD-2 transcription and translation in an in\u00a0vitro model of hypoxia-ischemia","volume":"5","author":"Souvenir","year":"2014","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib73","first-page":"6669","article-title":"HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors","volume":"61","author":"Sowter","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib74","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0140-6736(03)14412-1","article-title":"Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states","volume":"362","author":"Stenzel-Poore","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib75","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1161\/01.STR.26.6.1093","article-title":"Cerebral hypoxia-ischemia stimulates cytokine gene expression in perinatal rats","volume":"26","author":"Szaflarski","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib76","doi-asserted-by":"crossref","first-page":"15988","DOI":"10.1074\/jbc.M112.428789","article-title":"Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model","volume":"288","author":"Tian","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib77","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1523\/JNEUROSCI.5323-07.2008","article-title":"The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes","volume":"28","author":"Vangeison","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib78","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1749-6632.1997.tb48634.x","article-title":"A\u00a0model of perinatal hypoxic-ischemic brain damage","volume":"835","author":"Vannucci","year":"1997","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib79","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib80","doi-asserted-by":"crossref","first-page":"re12","DOI":"10.1126\/stke.3062005re12","article-title":"Integration of oxygen signaling at the consensus HRE","volume":"2005","author":"Wenger","year":"2005","journal-title":"Sci. STKE"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib81","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainresbull.2014.09.007","article-title":"Orosomucoid1: involved in vascular endothelial growth factor-induced blood-brain barrier leakage after ischemic stroke in mouse","volume":"109","author":"Wu","year":"2014","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib82","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11010-013-1862-9","article-title":"Neuroprotective effects of vitexin by inhibition of NMDA receptors in primary cultures of mouse cerebral cortical neurons","volume":"386","author":"Yang","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib83","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/ptr.4841","article-title":"The novel p53-dependent metastatic and apoptotic pathway induced by vitexin in human oral cancer OC2 cells","volume":"27","author":"Yang","year":"2013","journal-title":"Phytother. Res."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib84","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1124\/mol.107.036418","article-title":"Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression","volume":"72","author":"Yeh","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib85","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/0973-1296.75899","article-title":"Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China","volume":"7","author":"Zhang","year":"2011","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib86","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1556\/APhysiol.99.2012.3.8","article-title":"Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia\/ischemia","volume":"99","author":"Zhang","year":"2012","journal-title":"Acta Physiol. Hung."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib87","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI9369","article-title":"VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain","volume":"106","author":"Zhang","year":"2000","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib88","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00004647-200204000-00002","article-title":"Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia","volume":"22","author":"Zhang","year":"2002","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib89","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00004647-200404000-00007","article-title":"Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage","volume":"24","author":"Zhou","year":"2004","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib90","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1097\/CAD.0b013e328364e8d3","article-title":"Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway","volume":"24","author":"Zhou","year":"2013","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.neuropharm.2015.07.007_bib91","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1158\/1078-0432.CCR-09-0661","article-title":"Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth","volume":"15","author":"Zhou","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.neuropharm.2015.07.007_bib92","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/pca.1348","article-title":"Analysis of C-glycosyl flavonoids from South American Passiflora species by HPLC-DAD and HPLC-MS","volume":"23","author":"Zucolotto","year":"2012","journal-title":"Phytochem. Anal."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815300137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815300137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T23:40:04Z","timestamp":1717976404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390815300137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":92,"alternative-id":["S0028390815300137"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.07.007","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitexin reduces hypoxia\u2013ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}