{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:58:34Z","timestamp":1777633114806,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute on Drug Abuse Intramural Research Programs"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.neuropharm.2015.07.009","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T01:35:14Z","timestamp":1437010514000},"page":"106-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking"],"prefix":"10.1016","volume":"99","author":[{"given":"J.R.","family":"Schank","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.S.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Damadzic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.D.","family":"Tapocik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.E.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.E.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.C.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Heilig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2015.07.009_bib1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0306-4522(91)90043-N","article-title":"Distribution, morphology and number of monoamine-synthesizing and substance P-containing neurons in the human dorsal raphe nucleus","volume":"42","author":"Baker","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib2","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1002\/cne.23080","article-title":"Individual neurons in the rat lateral habenular complex project mostly to the dopaminergic ventral tegmental area or to the serotonergic raphe nuclei","volume":"520","author":"Bernard","year":"2012","journal-title":"J.\u00a0Comp. neurology"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00213-013-3120-y","article-title":"The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research","volume":"229","author":"Bossert","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib4","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1073\/pnas.75.3.1582","article-title":"Serotonin and substance P coexist i, neurons of the rat's central nervous system","volume":"75","author":"Chan-Palay","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1152\/jn.00575.2010","article-title":"Nicotinic excitation of serotonergic projections from dorsal raphe to the nucleus accumbens","volume":"106","author":"Chang","year":"2011","journal-title":"J.\u00a0neurophysiology"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0006-8993(00)02494-X","article-title":"Noradrenergic neurons expressing substance P receptor (NK1) in the locus coeruleus complex: a double immunofluorescence study in the rat","volume":"873","author":"Chen","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00213-009-1741-y","article-title":"Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking","volume":"208","author":"Cippitelli","year":"2010","journal-title":"Psychopharmacol. Berl."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib8","doi-asserted-by":"crossref","first-page":"7730","DOI":"10.1523\/JNEUROSCI.22-17-07730.2002","article-title":"Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity","volume":"22","author":"Conley","year":"2002","journal-title":"J.\u00a0Neurosci. Official J. Soc. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib9","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/sj.npp.1301594","article-title":"Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission","volume":"33","author":"Ebner","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuroscience.2005.10.062","article-title":"Effects of environmental and pharmacological stressors on c-fos and corticotropin-releasing factor mRNA in rat brain: relationship to the reinstatement of alcohol seeking","volume":"138","author":"Funk","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib11","doi-asserted-by":"crossref","first-page":"15236","DOI":"10.1073\/pnas.0604419103","article-title":"Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress","volume":"103","author":"Hansson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib12","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1176\/appi.ajp.2013.12091163","article-title":"Determination of genotype combinations that can predict the outcome of the treatment of alcohol dependence using the 5-HT(3) antagonist ondansetron","volume":"170","author":"Johnson","year":"2013","journal-title":"Am. J. psychiatry"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib13","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1176\/appi.ajp.162.8.1403","article-title":"The neural basis of addiction: a pathology of motivation and choice","volume":"162","author":"Kalivas","year":"2005","journal-title":"Am. J. psychiatry"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.brainres.2004.08.022","article-title":"Reciprocal connections between subdivisions of the dorsal raphe and the nuclear core of the locus coeruleus in the rat","volume":"1026","author":"Kim","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00213-006-0346-y","article-title":"Effects of dexfenfluramine and 5-HT3 receptor antagonists on stress-induced reinstatement of alcohol seeking in rats","volume":"186","author":"Le","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib16","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1097\/00001756-200210070-00024","article-title":"Modulation of brain stem monoamines and gamma-aminobutyric acid by NK1 receptors in rats","volume":"13","author":"Ma","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib17","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1177\/34.6.2422252","article-title":"Inter- and intracellular relationship of substance P-containing neurons with serotonin and GABA in the dorsal raphe nucleus: combination of autoradiographic and immunocytochemical techniques","volume":"34","author":"Magoul","year":"1986","journal-title":"J.\u00a0Histochem. Cytochem. Official J. Histochem. Soc."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/(SICI)1096-9861(19960115)364:3<402::AID-CNE2>3.0.CO;2-8","article-title":"Lower brainstem catecholamine afferents to the rat dorsal raphe nucleus","volume":"364","author":"Peyron","year":"1996","journal-title":"J.\u00a0Comp. neurology"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/cne.23662","article-title":"Efferent pathways of the mouse lateral habenula","volume":"523","author":"Quina","year":"2015","journal-title":"J.\u00a0Comp. neurology"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib20","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1111\/j.1530-0277.2008.00717.x","article-title":"Prediction of serotonergic treatment efficacy using age of onset and type A\/B typologies of alcoholism","volume":"32","author":"Roache","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib21","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/npp.2013.309","article-title":"The role of the Neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking","volume":"39","author":"Schank","year":"2013","journal-title":"Neuropsychopharmacol. Official Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00213-011-2201-z","article-title":"Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429","volume":"218","author":"Schank","year":"2011","journal-title":"Psychopharmacol. Berl."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib23","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.biopsych.2012.12.027","article-title":"Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats","volume":"73","author":"Schank","year":"2013","journal-title":"Biol. psychiatry"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib24","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1097\/00001756-199912160-00044","article-title":"Serotonin and substance P co-exist in dorsal raphe neurons of the human brain","volume":"10","author":"Sergeyev","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib25","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1111\/j.1471-4159.2008.05596.x","article-title":"Modulation of basal and stress-induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L-822429","volume":"106","author":"Singewald","year":"2008","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib26","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11920-007-0050-6","article-title":"The role of stress in addiction relapse","volume":"9","author":"Sinha","year":"2007","journal-title":"Curr. psychiatry Rep."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib27","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/BF02246222","article-title":"Effect of the 5-HT3 antagonist ondansetron on voluntary ethanol intake in rats and mice maintained on a limited access procedure","volume":"117","author":"Tomkins","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/FBP.0b013e3283242ff4","article-title":"The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice","volume":"20","author":"Umathe","year":"2009","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib29","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/cne.903130409","article-title":"A\u00a0PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat","volume":"313","author":"Vertes","year":"1991","journal-title":"J.\u00a0Comp. neurology"},{"key":"10.1016\/j.neuropharm.2015.07.009_bib30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jchemneu.2006.01.007","article-title":"Differential projections of dorsal raphe nucleus neurons to the lateral septum and striatum","volume":"31","author":"Waselus","year":"2006","journal-title":"J.\u00a0Chem. Neuroanat."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib31","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1037\/0003-066X.59.4.224","article-title":"Relapse prevention for alcohol and drug problems: that was Zen, this is Tao","volume":"59","author":"Witkiewitz","year":"2004","journal-title":"Am. Psychol."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainresbull.2013.10.007","article-title":"Substance P receptor antagonist in lateral habenula improves rat depression-like behavior","volume":"100","author":"Yang","year":"2014","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib33","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/j.1460-9568.2012.08037.x","article-title":"Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior","volume":"35","author":"Yoshimoto","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib34","doi-asserted-by":"crossref","first-page":"311A","DOI":"10.1111\/j.1530-0277.1996.tb01799.x","article-title":"Possibility of 5-HT3 receptor involvement in alcohol dependence: a microdialysis study of nucleus accumbens dopamine and serotonin release in rats with chronic alcohol consumption","volume":"20","author":"Yoshimoto","year":"1996","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2015.07.009_bib35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbr.2014.09.016","article-title":"The role of lateral habenula-dorsal raphe nucleus circuits in higher brain functions and psychiatric illness","volume":"277","author":"Zhao","year":"2015","journal-title":"Behav. Brain Res."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815300150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815300150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T11:05:12Z","timestamp":1617620712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390815300150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":35,"alternative-id":["S0028390815300150"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.07.009","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}