{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:49:02Z","timestamp":1790009342654,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473192"],"award-info":[{"award-number":["81473192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2010CB529802"],"award-info":[{"award-number":["2010CB529802"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.neuropharm.2015.08.047","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T12:00:22Z","timestamp":1441368022000},"page":"137-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Molecular basis of toxicity of N-type calcium channel inhibitor MVIIA"],"prefix":"10.1016","volume":"101","author":[{"given":"Fei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2015.08.047_bib1","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.bbamem.2013.01.019","article-title":"Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels","volume":"1828","author":"Adams","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0041-008X(91)90095-V","article-title":"A\u00a0goldfish model for evaluation of the neurotoxicity of omega-conotoxin GVIA and screening of monoclonal antibodies","volume":"108","author":"Adeyemo","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib3","series-title":"Proceedings of the ACM\/IEEE Conference on Supercomputing (SC06), Tampa, Florida, November 11\u201317","article-title":"Scalable algorithms for molecular dynamics simulations on commodity clusters","author":"Bowers","year":"2006"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib4","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1021\/bi4003327","article-title":"Complex structures between the N-type calcium channel (CaV2.2) and \u03c9-conotoxin GVIA predicted via molecular dynamics","volume":"52","author":"Chen","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib5","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1021\/np030099y","article-title":"The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus","volume":"66","author":"Dai","year":"2003","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib6","doi-asserted-by":"crossref","first-page":"12641","DOI":"10.1074\/jbc.M609087200","article-title":"Helix-helix interactions between homo- and heterodimeric \u03b3-carboxyglutamate-containing conantokin peptides and their derivatives","volume":"282","author":"Dai","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib7","doi-asserted-by":"crossref","first-page":"18978","DOI":"10.1073\/pnas.0904407106","article-title":"Simultaneous prediction of protein folding and docking at high resolution","volume":"106","author":"Das","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib8","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.neuropharm.2014.01.017","article-title":"Huwentoxin-XVI, an analgesic, highly reversible mammalian N-type calcium channel antagonist from Chinese tarantula Ornithoctonushuwena","volume":"79","author":"Deng","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib9","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/372272a0","article-title":"Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin","volume":"372","author":"Ellinor","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib10","doi-asserted-by":"crossref","first-page":"15728","DOI":"10.1074\/jbc.M100406200","article-title":"Residue Gly1326 of the N-type calcium channel \u03b11B subunit controls reversibility of \u03c9-conotoxin GVIA and MVIIA block","volume":"276","author":"Feng","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1124\/jpet.107.125047","article-title":"Prolonged attenuation of amygdala-kindled seizure measures in rats by convection-enhanced delivery of the N-type calcium channel antagonists omega-conotoxin GVIA and omega-conotoxin MVIIA","volume":"323","author":"Gasior","year":"2007","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0896-6273(92)90221-X","article-title":"A\u00a0new Conus peptide ligand for mammalian presynaptic Ca2+ channels","volume":"9","author":"Hillyard","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/bph.12251","article-title":"Spinal actions of \u03c9-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model","volume":"170","author":"Jayamanne","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib14","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0028-3908(02)00053-9","article-title":"Inhibitory effects of cilnidipine on peripheral and brain N-type Ca2+ channels expressed in BHK cells","volume":"42","author":"Kato","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib15","doi-asserted-by":"crossref","first-page":"10256","DOI":"10.1021\/bi00032a020","article-title":"Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin MVIIA","volume":"34","author":"Kohno","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1744-8069-6-97","article-title":"Analgesic effect of highly reversible \u03c9-conotoxin FVIA on N-type Ca2+ channels","volume":"6","author":"Lee","year":"2010","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/B978-0-444-63380-4.00004-4","article-title":"Recent progress in the discovery and development of N-type calcium channel modulators for the treatment of pain","volume":"53","author":"Lee","year":"2014","journal-title":"Prog. Med. Chem."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib18","doi-asserted-by":"crossref","first-page":"35335","DOI":"10.1074\/jbc.M002252200","article-title":"Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes","volume":"275","author":"Lewis","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib19","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1152\/jn.00048.2004","article-title":"Alternative splicing in the voltage-sensing region of N-type Cav2.2 channels modulates channel kinetics","volume":"92","author":"Lin","year":"2004","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0304-3959(02)00303-2","article-title":"Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T","volume":"101","author":"Malmberg","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib21","doi-asserted-by":"crossref","first-page":"34705","DOI":"10.1074\/jbc.M310848200","article-title":"The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels","volume":"279","author":"Mould","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib23","doi-asserted-by":"crossref","first-page":"8076","DOI":"10.1021\/bi00025a013","article-title":"Structure-activity analysis of a Conus peptide blocker of N-type neuronal calcium channels","volume":"34","author":"Nadasdi","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib24","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1021\/bi982980u","article-title":"Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus","volume":"38","author":"Nielsen","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib25","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1006\/jmbi.1999.2817","article-title":"Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loopsplice hybrids at N and P\/Q-type calcium channels","volume":"289","author":"Nielsen","year":"1999","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/(SICI)1099-1352(200003\/04)13:2<55::AID-JMR488>3.0.CO;2-O","article-title":"Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels","volume":"13","author":"Nielsen","year":"2000","journal-title":"J.\u00a0Mol. Recognit."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib27","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1476-5381.2012.02069.x","article-title":"P\/Q-type calcium channel modulators","volume":"167","author":"Nimmrich","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib28","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1021\/bi00382a004","article-title":"Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom","volume":"26","author":"Olivera","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib29","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"\u0160ali","year":"1993","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib30","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s40263-013-0107-5","article-title":"Intrathecal ziconotide: a review of its use in patients with chronic pain refractory to other systemic or intrathecal analgesics","volume":"27","author":"Sanford","year":"2013","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0014-2999(02)02247-1","article-title":"Actions of intrathecal omega-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat","volume":"451","author":"Scott","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(90)91074-S","article-title":"A\u00a0novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury","volume":"43","author":"Seltzer","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib33","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0028-3908(96)84634-X","article-title":"Omega-conotoxin-MVIID blocks anomega-conotoxin-GVIA-sensitive, high-threshold Ca2+ current in fish retinal ganglion cells","volume":"35","author":"Tabata","year":"1996","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib34","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.2174\/156802612802652457","article-title":"Therapeutic potential of cone snail venom peptides (conopeptides)","volume":"12","author":"Vetter","year":"2012","journal-title":"Curr. Topics Med. Chem."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib35","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/sj.bjp.0706223","article-title":"SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons","volume":"145","author":"Wen","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib36","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0028-3908(93)90007-P","article-title":"Characterization of the purified N-type Ca2+ channel and the cation sensitivity of omega-conotoxin GVIA binding","volume":"32","author":"Witcher","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2015.08.047_bib37","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/BF03185760","article-title":"Three-dimensional solution structure of \u03c9-conotoxin SO-3 determined by 1HNMR","volume":"48","author":"Yan","year":"2003","journal-title":"Chin. Sci. Bull."},{"key":"10.1016\/j.neuropharm.2015.08.047_bib38","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nature11054","article-title":"Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel","volume":"486","author":"Zhang","year":"2012","journal-title":"Nature"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815300927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815300927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T17:04:56Z","timestamp":1751043896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390815300927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":37,"alternative-id":["S0028390815300927"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.08.047","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular basis of toxicity of N-type calcium channel inhibitor MVIIA","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.08.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}