{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:37:35Z","timestamp":1791293855797,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"crossref","award":["2011\/03\/N\/NZ4\/02021"],"award-info":[{"award-number":["2011\/03\/N\/NZ4\/02021"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.neuropharm.2015.10.014","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T09:49:29Z","timestamp":1445766569000},"page":"506-518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI)"],"prefix":"10.1016","volume":"101","author":[{"given":"Anna","family":"Lesniak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaim G.","family":"Pick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Misicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej W.","family":"Lipkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Sacharczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2015.10.014_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0006-8993(94)90834-6","article-title":"The role of opioids in newborn pig fluid percussion brain injury","volume":"660","author":"Armstead","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0014-2999(92)90356-9","article-title":"Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D1 receptor stimulation","volume":"216","author":"Baamonde","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jts.20483","article-title":"Psychiatric diagnoses among Iraq and Afghanistan war veterans screened for deployment-related traumatic brain injury","volume":"23","author":"Carlson","year":"2010","journal-title":"J.\u00a0Trauma. Stress"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/jcp.21000","article-title":"Delta-, but not mu-, opioid receptor stabilizes K(+) homeostasis by reducing Ca(2+) influx in the cortex during acute hypoxia","volume":"212","author":"Chao","year":"2007","journal-title":"J.\u00a0Cell Physiol."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib5","first-page":"7","article-title":"Long-term effects of mild traumatic brain injury on cognitive performance","volume":"12","author":"Dean","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00008506-200401000-00019","article-title":"Clinical trials in traumatic brain injury: lessons for the future","volume":"16","author":"Doppenberg","year":"2004","journal-title":"J.\u00a0Neurosurg. Anesthesiol."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0006-8993(90)90505-6","article-title":"Local enkephalins tonically modulate dopamine release in the striatum: a microdialysis study","volume":"524","author":"Dourmap","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.neuro.30.051606.094328","article-title":"The medial temporal lobe and recognition memory","volume":"30","author":"Eichenbaum","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ana.410270111","article-title":"Opioid and nonopioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury","volume":"27","author":"Faden","year":"1990","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib10","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s00381-005-1142-4","article-title":"Management and classification of children with head injury","volume":"21","author":"Falk","year":"2005","journal-title":"Childs Nerv. Syst."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib11","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.3171\/foc.2000.8.1.152","article-title":"Do women fare worse? A metaanalysis of gender differences in outcome after traumatic brain injury","volume":"8","author":"Farace","year":"2000","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2174\/138945012799201612","article-title":"Current research on opioid receptor function","volume":"13","author":"Feng","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib13","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1089\/neu.1998.15.1037","article-title":"Effect of traumatic brain injury on mouse spatial and nonspatial learning in the Barnes circular maze","volume":"15","author":"Fox","year":"1998","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib14","doi-asserted-by":"crossref","first-page":"529S","DOI":"10.1080\/07315724.2004.10719396","article-title":"Magnesium attenuates post-traumatic depression\/anxiety following diffuse traumatic brain injury in rats","volume":"23","author":"Fromm","year":"2004","journal-title":"J.\u00a0Am. Coll. Nutr."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3171\/jns.1990.72.2.0252","article-title":"Possible protective effect of endogenous opioids in traumatic brain injury","volume":"72","author":"Hayes","year":"1990","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib16","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1007\/s00018-012-1167-2","article-title":"Neuroprotection against hypoxia\/ischemia: \u03b4-opioid receptor-mediated cellular\/molecular events","volume":"70","author":"He","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib17","doi-asserted-by":"crossref","first-page":"612","DOI":"10.2340\/16501977-0100","article-title":"Recovery in the first year after mild head injury: divergence of symptom status and self-perceived quality of life","volume":"39","author":"Heitger","year":"2007","journal-title":"J.\u00a0Rehabil. Med."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/neu.1993.10.405","article-title":"Mild experimental brain injury in the rat induces cognitive deficits associated with regional neuronal loss in the hippocampus","volume":"10","author":"Hicks","year":"1993","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib19","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/S0022-3565(25)38254-6","article-title":"Antinociceptive profile of biphalin, a dimeric enkephalin analog","volume":"265","author":"Horan","year":"1993","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib20","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.2174\/138161212803582441","article-title":"Non-analgesic effects of opioids: neuroprotection in the retina","volume":"18","author":"Husain","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib21","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1089\/neu.2008.0641","article-title":"Experimental traumatic brain injury induces a pervasive hyperanxious phenotype in rats","volume":"25","author":"Jones","year":"2008","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/npp.2011.244","article-title":"Endogenous opioids as physiological antidepressants: complementary role of \u03b4 receptors and dopamine","volume":"37","author":"Jutkiewicz","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib23","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3171\/jns.1990.73.6.0889","article-title":"Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury","volume":"73","author":"Katayama","year":"1990","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib24","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1007\/s11064-011-0568-1","article-title":"Neuroprotective potential of biphalin, multireceptor opioid peptide, against excitotoxic injury in hippocampal organotypic culture","volume":"36","author":"Kawalec","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib25","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.brainres.2009.06.104","article-title":"Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway","volume":"1292","author":"Ke","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1212\/WNL.0000000000000105","article-title":"Myoinositol and glutamate complex neurometabolite abnormality after mild traumatic brain injury","volume":"82","author":"Kierans","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib27","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.acthis.2008.05.002","article-title":"Differences in immunoreactivities of Ki-67 and doublecortin in the adult hippocampus in three strains of mice","volume":"111","author":"Kim","year":"2009","journal-title":"Acta Histochem."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib28","first-page":"545","article-title":"Antinociception after intrathecal biphalin application in rats: a reevaluation and novel, rapid method to confirm correct catheter tip position","volume":"57","author":"Kosson","year":"2005","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib29","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0196-9781(82)90173-5","article-title":"Double-enkephalins \u2013 synthesis, activity on guinea-pig ileum, and analgesic effect","volume":"3","author":"Lipkowski","year":"1982","journal-title":"Peptides"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib30","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/0024-3205(87)90065-8","article-title":"Bivalent opioid peptide analogues with reduced distances between pharmacophores","volume":"40","author":"Lipkowski","year":"1987","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0143-4179(95)90051-9","article-title":"Effects of mu opioid agonist and antagonist on neurological outcome following traumatic brain injury in the rat","volume":"29","author":"Lyeth","year":"1995","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib71","doi-asserted-by":"crossref","first-page":"18326","DOI":"10.1073\/pnas.0605077103","article-title":"Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration","volume":"103","author":"Luo","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib32","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0006-8993(87)90505-1","article-title":"Alterations in regional concentrations of endogenous opioids following traumatic brain injury in the cat","volume":"425","author":"McIntosh","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib33","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jalz.2014.04.003","article-title":"Military-related traumatic brain injury and neurodegeneration","volume":"10","author":"McKee","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/02699050801888824","article-title":"Prevalence of traumatic brain injury among children, adolescents and young adults: prospective evidence from a birth cohort","volume":"22","author":"McKinlay","year":"2008","journal-title":"Brain Inj."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib36","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.apmr.2010.05.017","article-title":"Position statement: definition of traumatic brain injury","volume":"91","author":"Menon","year":"2010","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib37","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1089\/neu.2005.22.1003","article-title":"Mild traumatic brain injury induces persistent cognitive deficits and behavioral disturbances in mice","volume":"22","author":"Milman","year":"2005","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib38","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1016\/j.bmcl.2005.03.067","article-title":"Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers","volume":"15","author":"Mollica","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib39","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1080\/02699050110065286","article-title":"The association between mild traumatic brain injury and psychiatric conditions","volume":"15","author":"Mooney","year":"2001","journal-title":"Brain Inj."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib40","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1097\/01.TA.0000127767.83267.33","article-title":"The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial","volume":"56","author":"Mosenthal","year":"2004","journal-title":"J.\u00a0Trauma"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib41","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1089\/089771503770195830","article-title":"Effects of daily versus weekly testing and pre-training on the assessment of neurologic impairment following diffuse traumatic brain injury in rats","volume":"20","author":"O'Connor","year":"2003","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib42","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/00000542-200010000-00029","article-title":"Activation of mu- and delta-opioid receptors causes presynaptic inhibition of glutamatergic excitation in neocortical neurons","volume":"93","author":"Ostermeier","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0143-4179(96)90054-2","article-title":"Endogenous neuropeptides in patients with acute traumatic head injury, I: cerebrospinal fluid beta-endorphin levels are increased within 24 hours following the trauma","volume":"30","author":"Pasaoglu","year":"1996","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib44","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1017\/S1355617700655066","article-title":"Factors influencing outcome following mild traumatic brain injury in adults","volume":"6","author":"Ponsford","year":"2000","journal-title":"J.\u00a0Int. Neuropsychol. Soc."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib45","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/adb.12030","article-title":"Association between the A107V substitution in the \u03b4-opioid receptors and ethanol drinking in mice selected for high and low analgesia","volume":"19","author":"Sacharczuk","year":"2014","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF01067837","article-title":"Water-maze learning in the mouse correlates with variation in hippocampal morphology","volume":"18","author":"Schwegler","year":"1988","journal-title":"Behav. Genet."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib47","doi-asserted-by":"crossref","first-page":"e112019","DOI":"10.1371\/journal.pone.0112019","article-title":"Identification of serum microRNA signatures for diagnosis of mild traumatic brain injury in a closed head injury model","volume":"9","author":"Sharma","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib48","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0028-3908(93)90085-H","article-title":"Met-enkephalin-Arg6-Phe7 in spinal cord and brain following traumatic injury to the spinal cord: influence of p-chlorophenylalanine. An experimental study in rat using the radioimmunoassay technique","volume":"32","author":"Sharma","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib49","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11682-012-9156-5","article-title":"A\u00a0review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury","volume":"6","author":"Shenton","year":"2012","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib50","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1176\/appi.ajp.2009.08111676","article-title":"Depression and cognitive complaints following mild traumatic brain injury","volume":"166","author":"Silver","year":"2009","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib51","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neulet.2012.01.051","article-title":"Evaluation of late cognitive impairment and anxiety states following traumatic brain injury in mice: the effect of minocycline","volume":"511","author":"Siopi","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib52","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/02699050500456410","article-title":"Human spatial navigation deficits after traumatic brain injury shown in the arena maze, a virtual Morris Water Maze","volume":"20","author":"Skelton","year":"2006","journal-title":"Brain Inj."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib53","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/j.1471-4159.1990.tb04963.x","article-title":"The effects of opioid peptides on dopamine release in the nucleus accumbens: an in\u00a0vivo microdialysis study","volume":"55","author":"Spanagel","year":"1990","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib55","first-page":"195","article-title":"Delta opioid peptide [D-Ala(2),D-Leu(5)]enkephalin promotes cell survival","volume":"7","author":"Su","year":"2000","journal-title":"J.\u00a0Biomed. Sci."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib56","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4103\/1673-5374.131567","article-title":"The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury","volume":"9","author":"Sun","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib57","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.brainres.2006.10.032","article-title":"Apoprotic changes in the cortex an hippocampus following minimal brain trauma in mice","volume":"1130","author":"Tashlykov","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib58","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0140-6736(74)91639-0","article-title":"Assessment of coma and impaired consciousness. A practical scale","volume":"13","author":"Teasdale","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib59","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/msj.20099","article-title":"Cognitive rehabilitation following traumatic brain injury: assessment to treatment","volume":"76","author":"Tsaousides","year":"2009","journal-title":"Mt. Sinai J. Med."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib60","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF01067075","article-title":"Differences between inbred strains of mice in Morris water maze performance","volume":"18","author":"Upchurch","year":"1988","journal-title":"Behav. Genet."},{"issue":"43 Suppl.","key":"10.1016\/j.neuropharm.2015.10.014_bib61","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/16501960410023633","article-title":"Mandate of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury","author":"von Holst","year":"2004","journal-title":"J.\u00a0Rehabil. Med."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib62","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1523\/JNEUROSCI.21-06-01923.2001","article-title":"Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels","volume":"21","author":"Wolf","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1517\/14728210902769601","article-title":"Emerging treatments for traumatic brain injury","volume":"14","author":"Xiong","year":"2009","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2015.03.022","article-title":"In\u00a0vitro and in\u00a0vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment","volume":"1609","author":"Yang","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib65","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1124\/jpet.111.184127","article-title":"Characterization of neuroprotective effects of biphalin, an opioid receptor agonist, in a model of focal brain ischemia","volume":"339","author":"Yang","year":"2011","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib66","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.brainres.2011.01.083","article-title":"Opioid receptor agonists reduce brain edema in stroke","volume":"1383","author":"Yang","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib67","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0006-8993(00)02906-1","article-title":"delta-, but not mu- and kappa-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury","volume":"885","author":"Zhang","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib68","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1089\/neu.2010.1579","article-title":"Neurogenesis in adult human brain after traumatic brain injury","volume":"30","author":"Zheng","year":"2013","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuropharm.2015.10.014_bib69","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neulet.2005.10.099","article-title":"Morphine protects for head trauma induced cognitive deficits in mice","volume":"394","author":"Zohar","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2015.10.014_bib70","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0306-4522(03)00048-4","article-title":"Closed head minimal traumatic brain injury produces long-term cognitive deficits in mice","volume":"118","author":"Zohar","year":"2003","journal-title":"Neuroscience"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815301374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815301374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:56:19Z","timestamp":1762214179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390815301374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":69,"alternative-id":["S0028390815301374"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.10.014","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI)","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}