{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:07:36Z","timestamp":1781845656628,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Foundation of Polish Science, Poland"},{"name":"Ministry of Science and Higher Education, Poland"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.neuropharm.2015.10.040","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T02:58:14Z","timestamp":1446605894000},"page":"80-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model"],"prefix":"10.1016","volume":"102","author":[{"given":"Ewelina","family":"Rojewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Piotrowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wioletta","family":"Makuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Przewlocka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Mika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2015.10.040_bib1","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1038\/sj.bjp.0703250","article-title":"Role of kynurenines in the neurotoxic actions of kainic acid","volume":"129","author":"Behan","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A\u00a0peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fnins.2014.00012","article-title":"Kynurenines in CNS disease: regulation by inflammatory cytokines","volume":"8","author":"Campbell","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib4","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1046\/j.1471-4159.2002.01090.x","article-title":"Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures","volume":"82","author":"Carpenedo","year":"2002","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0006-8993(95)01063-7","article-title":"Time-related roles of excitatory amino acid receptors during persistent noxiously evoked responses of rat dorsal horn neurones","volume":"703","author":"Chapman","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib6","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0306-4522(00)00504-2","article-title":"Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis","volume":"102","author":"Chiarugi","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib7","doi-asserted-by":"crossref","first-page":"9694","DOI":"10.1523\/JNEUROSCI.2980-05.2005","article-title":"Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease","volume":"25","author":"Chin","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib9","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1111\/j.1526-4637.2010.00981.x","article-title":"NMDA receptor antagonists for the treatment of neuropathic pain","volume":"11","author":"Collins","year":"2010","journal-title":"Pain Med."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib10","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00004647-199907000-00007","article-title":"Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro61-8048) in models of focal or global brain ischemia","volume":"19","author":"Cozzi","year":"1999","journal-title":"J.\u00a0Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-4615-0135-0_4","article-title":"Quinolinic acid up-regulates chemokine production and chemokine receptor expression in astrocytes","volume":"527","author":"Croitoru-Lamoury","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib12","doi-asserted-by":"crossref","first-page":"36554","DOI":"10.1074\/jbc.M113.503813","article-title":"Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain","volume":"20","author":"Giorgini","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbr.2007.08.007","article-title":"Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys","volume":"186","author":"Gregoire","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4615-0135-0_12","article-title":"Expression of the kynurenine pathway enzymes in human microglia and macrophages","volume":"527","author":"Guillemin","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj3260351","article-title":"Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types","volume":"326","author":"Heyes","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbr.2004.05.006","article-title":"Inhibition of morphine analgesia by LPS: role of opioid and NMDA receptors and spinal glia","volume":"156","author":"Johnston","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0304-3959(93)90030-S","article-title":"Spinal cord morphology and antinociception after chronic intrathecal administration of excitatory amino acid antagonists in the rat","volume":"54","author":"Kristensen","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pain.2005.02.009","article-title":"Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation","volume":"115","author":"Ledeboer","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuropharm.2013.08.031","article-title":"Effects of selective and non-selective inhibitors of nitric oxide synthase on morphine- and endomorphin-1-induced analgesia in acute and neuropathic pain in rats","volume":"75","author":"Makuch","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/eujp.2001.0316","article-title":"Neuropathic pain: evidence matters","volume":"6","author":"McQuay","year":"2002","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib21","first-page":"297","article-title":"Modulation of microglia can attenuate neuropathic pain symptoms and enhance morphine effectiveness","volume":"60","author":"Mika","year":"2008","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib22","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ejphar.2007.01.013","article-title":"Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain","volume":"560","author":"Mika","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib23","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.pain.2008.02.015","article-title":"Interleukin-1 alpha has antiallodynic and antihyperalgesic activities in a rat neuropathic pain model","volume":"138","author":"Mika","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2009.09.030","article-title":"Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain","volume":"623","author":"Mika","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib52","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.neuroscience.2009.11.064","article-title":"Minocycline reduces the injury-induced expression of prodynorphin and pronociceptin in the dorsal root ganglion in a rat model of neuropathic pain","volume":"165","author":"Mika","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib25","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejphar.2013.01.072","article-title":"Importance of glial activation in neuropathic pain","volume":"716","author":"Mika","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrn2533","article-title":"Pathological and protective roles of glia in chronic pain","volume":"10","author":"Milligan","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-1-4615-0135-0_15","article-title":"Studies on the neuroprotective action of kynurenine mono-oxygenase inhibitors in post-ischemic brain damage","volume":"527","author":"Moroni","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib28","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.neuropharm.2004.10.019","article-title":"Kynurenine3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampus","volume":"48","author":"Moroni","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-2999(92)90067-E","article-title":"Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice","volume":"212","author":"N\u00e4sstr\u00f6m","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib30","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.bbrc.2007.10.197","article-title":"GPR35 is a functional receptor in rat dorsal root ganglion neurons","volume":"365","author":"Ohshiro","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3940(95)12022-V","article-title":"The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive","volume":"199","author":"Ossipov","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0006-8993(98)00292-3","article-title":"Spinal opioid mu receptor expression in lumbar spinal cord of rats following nerve injury","volume":"795","author":"Porreca","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib33","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.2174\/1381612054865055","article-title":"Opioids in neuropathic pain","volume":"11","author":"Przewlocki","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib34","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.1523\/JNEUROSCI.22-22-09980.2002","article-title":"The role of spinal neuroimmune activation in morphine tolerance\/hyperalgesia in neuropathic and shamoperated rats","volume":"22","author":"Raghavendra","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib35","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/jpet.103.052407","article-title":"Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy","volume":"306","author":"Raghavendra","year":"2003","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1054-3589(08)60173-8","article-title":"Quinolinic acid in neurological disease: opportunities for novel drug discovery","volume":"30","author":"Reinhard","year":"1994","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib37","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuropharm.2014.08.001","article-title":"Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats","volume":"86","author":"Rojewska","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1744-8069-10-47","article-title":"Expression profiling of genes modulated by minocycline in a rat model of neuropathic pain","volume":"10","author":"Rojewska","year":"2014","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jneuroim.2014.09.020","article-title":"Involvement of pro- and antinociceptive factors in minocycline analgesia in rat neuropathic pain model","volume":"277","author":"Rojewska","year":"2014","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib40","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1021\/jm970467t","article-title":"Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl) benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase","volume":"40","author":"R\u00f6ver","year":"1997","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib41","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.neuroscience.2006.05.043","article-title":"Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington's disease","volume":"141","author":"Ryu","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib42","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1471-4159.1993.tb05836.x","article-title":"Mechanism of delayed increases in Kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia","volume":"60","author":"Saito","year":"1993","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib43","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrn3257","article-title":"Kynurenines in the mammalian brain: when physiology meets pathology","volume":"13","author":"Schwarcz","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib44","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/glia.20526","article-title":"Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease","volume":"55","author":"Simmons","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib45","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0161-5890(01)00104-3","article-title":"Neuroinvasion by pathogens: a key role of the complement system","volume":"38","author":"Speth","year":"2002","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.neuropharm.2015.10.040_bib46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/10715760000300021","article-title":"Characterisation of the major autoxidation products of 3-hydroxykynurenine under physiological conditions","volume":"32","author":"Vazquez","year":"2000","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pep.2013.11.015","article-title":"Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification","volume":"95","author":"Wilson","year":"2014","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib48","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0031-9384(76)90029-9","article-title":"Chronic catheterization of the spinal subarachnoid space","volume":"17","author":"Yaksh","year":"1976","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2015.10.040_bib49","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/glia.20092","article-title":"A\u00a0novel mechanism of FK506-mediated neuroprotection: downregulation of cytokine expression in glial cells","volume":"49","author":"Zawadzka","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2015.10.040_bib51","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cell.2011.05.020","article-title":"Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration","volume":"145","author":"Zwilling","year":"2011","journal-title":"Cell"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815301635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815301635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T03:20:31Z","timestamp":1567308031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390815301635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":52,"alternative-id":["S0028390815301635"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.10.040","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.10.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}