{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:12:32Z","timestamp":1791400352950,"version":"4.3.3"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.neuropharm.2015.12.014","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T09:15:51Z","timestamp":1450862151000},"page":"20-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model"],"prefix":"10.1016","volume":"106","author":[{"given":"R\u00e9gis","family":"Parmentier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Perier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Akaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minnamaija","family":"Lintunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pertti","family":"Panula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Sheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2015.12.014_bib1","doi-asserted-by":"crossref","first-page":"14423","DOI":"10.1523\/JNEUROSCI.2604-09.2009","article-title":"Orexin\/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models","volume":"29","author":"Anaclet","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib2","series-title":"Principles End Practice of Sleep Medicine","first-page":"377","article-title":"Sleep homeostasis and models of sleep regulation","author":"Borbely","year":"2000"},{"key":"10.1016\/j.neuropharm.2015.12.014_bib3","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1523\/JNEUROSCI.22-11-04686.2002","article-title":"Involvement of 5-HT1A receptors in homeostatic and stress-induced adaptive regulations of paradoxical sleep: studies in 5-HT1A knock-out mice","volume":"22","author":"Boutrel","year":"2002","journal-title":"J.\u00a0Neurosci."},{"issue":"6","key":"10.1016\/j.neuropharm.2015.12.014_bib4","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0301-0082(00)00039-3","article-title":"The physiology of brain histamine","volume":"63","author":"Brown","year":"2001","journal-title":"Prog. Neurobiol."},{"issue":"3","key":"10.1016\/j.neuropharm.2015.12.014_bib5","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1152\/physrev.00032.2011","article-title":"Control of sleep and wakefulness","volume":"92","author":"Brown","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1476-5381.1988.tb11406.x","article-title":"Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist","volume":"93","author":"Calcutt","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation","volume":"98","author":"Chemelli","year":"1999","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.neuropharm.2015.12.014_bib8","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1046\/j.1460-9568.1999.00760.x","article-title":"Effects of microdialysis application of monoamines on the EEG and behavioural states in the cat mesopontine tegmentum","volume":"11","author":"Crochet","year":"1999","journal-title":"Eur J. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib9","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1460-9568.2004.03546.x","article-title":"Changes in motoric, exploratory and emotional behaviours and neuronal acetylcholine content and 5-HT turnover in histidine decarboxylase-KO mice","volume":"20","author":"Dere","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib10","series-title":"The Pharmacological Basis of Therapeutics","first-page":"605","article-title":"Histamine and 5-hydroxytryptamine (serotonin) and their antagonists","author":"Douglas","year":"1985"},{"key":"10.1016\/j.neuropharm.2015.12.014_bib11","doi-asserted-by":"crossref","first-page":"9273","DOI":"10.1523\/JNEUROSCI.21-23-09273.2001","article-title":"Orexin\/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus","volume":"21","author":"Eriksson","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib12","first-page":"155","article-title":"Genetic determinants of sleep regulation in inbred mice","volume":"22","author":"Franken","year":"1999","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.neuropharm.2015.12.014_bib13","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/npp.2012.266","article-title":"Increased histaminergic neurotransmission and sleep-wake alterations: study in histamine H3-receptor knock-out mice","volume":"38","author":"Gondard","year":"2013","journal-title":"Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.neuropharm.2015.12.014_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00424-011-0996-4","article-title":"Waking with the hypothalamus","volume":"463","author":"Haas","year":"2012","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib15","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","article-title":"Histamine in the nervous system","volume":"88","author":"Haas","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00001756-199107000-00007","article-title":"Differential effects of M2 and M3 muscarinic antagonists on the sleep-wake cycle","volume":"2","author":"Imeri","year":"1991","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2015.12.014_bib18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00001756-199601310-00010","article-title":"Muscarinic receptor subtypes in the medial preoptic area and sleep-wake cycles","volume":"7","author":"Imeri","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2015.12.014_bib19","doi-asserted-by":"crossref","first-page":"13316","DOI":"10.1073\/pnas.93.23.13316","article-title":"Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors","volume":"93","author":"Inoue","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0079-6123(03)45011-5","article-title":"Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex","volume":"145","author":"Jones","year":"2004","journal-title":"Prog. Brain Res."},{"issue":"11","key":"10.1016\/j.neuropharm.2015.12.014_bib21","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.tips.2005.09.009","article-title":"From waking to sleeping: neuronal and chemical substrates","volume":"26","author":"Jones","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib22","first-page":"166","article-title":"The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle","volume":"64","author":"Jouvet","year":"1972","journal-title":"Ergeb Physiol."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib23","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0022-3565(24)37840-1","article-title":"Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist","volume":"287","author":"Ligneau","year":"1998","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib24","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1053\/smrv.2000.0116","article-title":"Brain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on the posterior hypothalamus and histaminergic neurons","volume":"4","author":"Lin","year":"2000","journal-title":"Sleep. Med. Rev."},{"issue":"15","key":"10.1016\/j.neuropharm.2015.12.014_bib25","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00018-011-0631-8","article-title":"The waking brain: an update","volume":"68","author":"Lin","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib26","series-title":"Cortical EEG and Sleep-wake Cycle in Histamine H1-receptor Knockout Mice. Program No. 474.8. 2002 Neuroscience Meeting Planner","author":"Lin","year":"2002"},{"key":"10.1016\/j.neuropharm.2015.12.014_bib27","first-page":"469","article-title":"Role of hypothalamic histaminergic systems in the regulation of the states of vigilance in the cat","volume":"303","author":"Lin","year":"1986","journal-title":"C.\u00a0R. Acad. Sci."},{"issue":"1","key":"10.1016\/j.neuropharm.2015.12.014_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1124\/jpet.110.170134","article-title":"Histamine H3 receptors and sleep-wake regulation","volume":"336","author":"Lin","year":"2011","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib29","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1046\/j.1460-9568.1998.00240.x","article-title":"Postnatal expression of H1-receptor mRNA in the rat brain: correlation to L-histidine decarboxylase expression and local upregulation in limbic seizures","volume":"10","author":"Lintunen","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0301-0082(92)90012-4","article-title":"Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity","volume":"39","author":"McCormick","year":"1992","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0079-6123(08)62412-7","article-title":"Actions of acetylcholine in the cerebral cortex and thalamus and implications for function","volume":"98","author":"McCormick","year":"1993","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib32","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1073\/pnas.1012456108","article-title":"Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice","volume":"108","author":"Mochizuki","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib33","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0014-2999(91)90911-9","article-title":"Effects of selective activation or blockade of the histamine H3 receptor on sleep and wakefulness","volume":"205","author":"Monti","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib34","first-page":"1","article-title":"The sleep-waking cycle","volume":"64","author":"Moruzzi","year":"1972","journal-title":"Ergeb Physiol."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib35","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1476-5381.1991.tb12418.x","article-title":"Sedation and histamine H1-receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene","volume":"104","author":"Nicholson","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF00614191","article-title":"Antihistamines: impaired performance and the tendency to sleep","volume":"30","author":"Nicholson","year":"1986","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.neuropharm.2015.12.014_bib37","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1124\/pr.114.010249","article-title":"International Union of basic and clinical pharmacology. XCVIII. Histamine receptors","volume":"67","author":"Panula","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib38","series-title":"Proceedings of the European Histamine Research Society 35th Annual Meeting, Delphi, Greece","article-title":"Characteristics of cortical EEG and sleep-wake cycle in histamine H1-receptor knockout mice","author":"Parmentier","year":"2006"},{"key":"10.1016\/j.neuropharm.2015.12.014_bib39","doi-asserted-by":"crossref","first-page":"7695","DOI":"10.1523\/JNEUROSCI.22-17-07695.2002","article-title":"Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep-wake control","volume":"22","author":"Parmentier","year":"2002","journal-title":"J.\u00a0Neurosci."},{"issue":"2","key":"10.1016\/j.neuropharm.2015.12.014_bib40","first-page":"54","article-title":"Deregulation of miR-183 and KIAA0101 in aggressive and malignant pituitary Tumors","volume":"10","author":"Roche","year":"2015","journal-title":"Front. Med."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib41","series-title":"The Diencephalon and Sleep","first-page":"171","article-title":"The posterior hypothalamus in the regulation of wakefulness and paradoxical sleep","author":"Sakai","year":"1990"},{"key":"10.1016\/j.neuropharm.2015.12.014_bib42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1460-9568.1997.tb01619.x","article-title":"Critical role for M3 muscarinic receptors in paradoxical sleep generation in the cat","volume":"9","author":"Sakai","year":"1997","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1991.71.1.1","article-title":"Histaminergic transmission in the mammalian brain","volume":"71","author":"Schwartz","year":"1991","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib44","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1365-2222.1996.tb00649.x","article-title":"Comparison of the central nervous system effects produced by six H1-receptor antagonists","volume":"26","author":"Simons","year":"1996","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.neuropharm.2015.12.014_bib45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/383024a0","article-title":"Awakening the brain","volume":"383","author":"Steriade","year":"1996","journal-title":"Nature"},{"issue":"40","key":"10.1016\/j.neuropharm.2015.12.014_bib46","doi-asserted-by":"crossref","first-page":"10292","DOI":"10.1523\/JNEUROSCI.2341-06.2006","article-title":"Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse","volume":"26","author":"Takahashi","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib48","series-title":"Principles and Practice of Sleep Medicine","first-page":"72","article-title":"Phylogeny of sleep regulation","author":"Tobler","year":"2000"},{"issue":"1","key":"10.1016\/j.neuropharm.2015.12.014_bib49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuron.2013.12.025","article-title":"Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration","volume":"81","author":"Tononi","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2015.12.014_bib50","first-page":"112","article-title":"Enregistrement chronique des activit\u00e9s \u00e9lectriques c\u00e9r\u00e9brales, musculaires et oculaires chez la souris","volume":"165","author":"Valatx","year":"1971","journal-title":"C\u00a0R. Seances Soc. Biol."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib51","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0006-8993(74)90009-2","article-title":"Facteurs g\u00e9n\u00e9tiques dans le determinisme du cycle veille-sommeil chez la souris","volume":"69","author":"Valatx","year":"1974","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0013-4694(92)90164-D","article-title":"The electrocorticogram in relation to physiology and behavior: a new analysis","volume":"82","author":"Vanderwolf","year":"1992","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib53","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0166-4328(03)00091-3","article-title":"Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats","volume":"144","author":"Vanni-Mercier","year":"2003","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.neuropharm.2015.12.014_bib54","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0304-3940(91)90222-F","article-title":"Carbachol microinjections in the mediodorsal pontine tegmentum are unable to induce paradoxical sleep after caudal pontine and prebulbar transections in the cat","volume":"130","author":"Vanni-Mercier","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib55","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0006-8993(91)91064-8","article-title":"Cholinergic antagonists and REM sleep generation","volume":"543","author":"Velazquez-Moctezuma","year":"1991","journal-title":"Brain Res."},{"issue":"40","key":"10.1016\/j.neuropharm.2015.12.014_bib57","doi-asserted-by":"crossref","first-page":"13555","DOI":"10.1523\/JNEUROSCI.1445-15.2015","article-title":"TASK channels on basal forebrain cholinergic neurons modulate electrocortical signatures of arousal by histamine","volume":"35","author":"Vu","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/B978-0-444-53839-0.00002-8","article-title":"Electrophysiological correlates of sleep homeostasis in freely behaving rats","volume":"193","author":"Vyazovskiy","year":"2011","journal-title":"Prog. Brain Res."},{"issue":"Suppl.\u00a03","key":"10.1016\/j.neuropharm.2015.12.014_bib59","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1365-2222.1999.00008.x-i1","article-title":"New findings in pharmacological effects induced by antihistamines: from PET studies to knock-out mice","volume":"29","author":"Yanai","year":"1999","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.neuropharm.2015.12.014_bib60","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1113\/jphysiol.2010.203257","article-title":"L-Dopa activates histaminergic neurons","volume":"589","author":"Yanovsky","year":"2011","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2015.12.014_bib61","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1021\/jm00398a028","article-title":"Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists","volume":"31","author":"Young","year":"1988","journal-title":"J.\u00a0Med. Chem."},{"issue":"1","key":"10.1016\/j.neuropharm.2015.12.014_bib62","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neuron.2015.06.003","article-title":"Wakefulness is governed by GABA and histamine cotransmission","volume":"87","author":"Yu","year":"2015","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.neuropharm.2015.12.014_bib63","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1460-9568.2008.06115.x","article-title":"The histamine H1-receptor mediates the motivational effects of novelty","volume":"27","author":"Zlomuzica","year":"2008","journal-title":"Eur. J. Neurosci."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815302100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390815302100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T22:34:36Z","timestamp":1748730876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390815302100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":60,"alternative-id":["S0028390815302100"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.12.014","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2015.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}