{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:00:55Z","timestamp":1785380455852,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA011322"],"award-info":[{"award-number":["DA011322"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA021696"],"award-info":[{"award-number":["DA021696"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 104-2923-B002-006-MY3"],"award-info":[{"award-number":["MOST 104-2923-B002-006-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST103-2321-B002-035"],"award-info":[{"award-number":["MOST103-2321-B002-035"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST104-2314-B002-053-MY3"],"award-info":[{"award-number":["MOST104-2314-B002-053-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST104-2325-B002-010"],"award-info":[{"award-number":["MOST104-2325-B002-010"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST104-2745-B002-004"],"award-info":[{"award-number":["MOST104-2745-B002-004"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX104-10251NI"],"award-info":[{"award-number":["NHRI-EX104-10251NI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.neuropharm.2016.02.018","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T02:54:36Z","timestamp":1455936876000},"page":"577-586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid\/CB1 signaling in the mouse periaqueductal gray"],"prefix":"10.1016","volume":"105","author":[{"given":"Hsin-Jung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Yang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cheng","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Fang","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ling","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Mackie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-940X","authenticated-orcid":false,"given":"Lih-Chu","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2016.02.018_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0960-894X(02)00851-X","article-title":"Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B","volume":"13","author":"Asahi","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.peptides.2013.07.012","article-title":"Involvement of orexin-2 receptors in the ventral tegmental area and nucleus accumbens in the antinociception induced by the lateral hypothalamus stimulation in rats","volume":"47","author":"Azhdari-Zarmehri","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib3","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.pbb.2014.03.017","article-title":"Orexin-A microinjection into the rostral ventromedial medulla causes antinociception on formalin test","volume":"122","author":"Azhdari-Zarmehri","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib4","first-page":"280","article-title":"Intra-periaqueductal gray matter microinjection of orexin-A decreases formalin-induced nociceptive behaviors in adult male rats","volume":"12","author":"Azhdari Zarmehri","year":"2011","journal-title":"J.\u00a0Pain"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0304-3959(90)90070-T","article-title":"The effect of GABA and its antagonists on midbrain periaqueductal gray neurons in the rat","volume":"40","author":"Behbehani","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2165\/00003088-197601030-00004","article-title":"The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone","volume":"1","author":"Berkowitz","year":"1976","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3959(00)00470-X","article-title":"Orexin-A, an hypothalamic peptide with analgesic properties","volume":"92","author":"Bingham","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A\u00a0rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.neures.2006.11.009","article-title":"Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats","volume":"57","author":"Chang","year":"2007","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib10","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1124\/jpet.103.056663","article-title":"Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain","volume":"307","author":"Cheng","year":"2003","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib11","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.2174\/138161210793292483","article-title":"Orexins\/hypocretins: pain regulation and cellular actions","volume":"16","author":"Chiou","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1021\/jm00079a016","article-title":"Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor","volume":"35","author":"D'Ambra","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib13","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.96.2.748","article-title":"Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems","volume":"96","author":"Date","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainres.2012.08.013","article-title":"Intra-paragigantocellularis lateralis injection of orexin-A has an antinociceptive effect on hot plate and formalin tests in rat","volume":"1478","author":"Erami","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib16","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"1997"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib17","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/j.1460-9568.2009.06952.x","article-title":"Hypocretin\/orexin contributes to the expression of some but not all forms of stress and arousal","volume":"30","author":"Furlong","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0014-2999(96)00279-8","article-title":"123I-labeled AM251: a radioiodinated ligand which binds in\u00a0vivo to mouse brain cannabinoid CB1 receptors","volume":"307","author":"Gatley","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.neuropharm.2010.12.026","article-title":"Direct inhibition of hypocretin\/orexin neurons in the lateral hypothalamus by nociceptin\/orphanin FQ blocks stress-induced analgesia in rats","volume":"60","author":"Gerashchenko","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib20","doi-asserted-by":"crossref","first-page":"9457","DOI":"10.1523\/JNEUROSCI.0013-12.2012","article-title":"Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-alpha initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia","volume":"32","author":"Gregg","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib21","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1097\/00001756-199609020-00012","article-title":"Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide","volume":"7","author":"Grisel","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainres.2004.09.059","article-title":"Electroacupuncture induces c-Fos expression in the rostral ventrolateral medulla and periaqueductal gray in cats: relation to opioid containing neurons","volume":"1030","author":"Guo","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib23","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1016\/j.bmcl.2003.08.038","article-title":"N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist","volume":"13","author":"Hirose","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib24","doi-asserted-by":"crossref","first-page":"14600","DOI":"10.1523\/JNEUROSCI.2671-11.2011","article-title":"Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition","volume":"31","author":"Ho","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib25","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/nature03658","article-title":"An endocannabinoid mechanism for stress-induced analgesia","volume":"435","author":"Hohmann","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nm.2075","article-title":"A\u00a0key role for orexin in panic anxiety","volume":"16","author":"Johnson","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib27","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1124\/jpet.105.093286","volume":"316","author":"Maione","year":"2006","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.1190","article-title":"Differential expression of orexin receptors 1 and 2 in the rat brain","volume":"435","author":"Marcus","year":"2001","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib29","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.peptides.2005.01.001","article-title":"Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice","volume":"26","author":"Mobarakeh","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib30","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.brainres.2015.07.050","article-title":"Microinjection of orexin-A into the rat locus coeruleus nucleus induces analgesia via cannabinoid type-1 receptors","volume":"1624","author":"Mohammad-Pour Kargar","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib31","first-page":"291","article-title":"Strain-dependent effects of morphine injected into the periaqueductal gray area of mice","volume":"24","author":"Nunes-de-Souza","year":"1991","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib32","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib33","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib34","doi-asserted-by":"crossref","first-page":"15575","DOI":"10.1523\/JNEUROSCI.3138-09.2009","article-title":"Altered sleep homeostasis after restraint stress in 5-HTT knock-out male mice: a role for hypocretins","volume":"29","author":"Rachalski","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.pbb.2013.02.011","article-title":"Involvement of orexin-1 receptors in the ventral tegmental area and the nucleus accumbens in antinociception induced by lateral hypothalamus stimulation in rats","volume":"105","author":"Sadeghi","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib36","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1126\/science.3131879","article-title":"Expression of c-fos protein in brain: metabolic mapping at the cellular level","volume":"240","author":"Sagar","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib37","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.regpep.2003.12.014","article-title":"Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons","volume":"118","author":"Sakamoto","year":"2004","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib38","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib39","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/sj.bjp.0703953","article-title":"SB-334867-A: the first selective orexin-1 receptor antagonist","volume":"132","author":"Smart","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib40","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0306-4522(97)00436-3","article-title":"Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system","volume":"83","author":"Tsou","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib41","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1124\/pr.109.001321","article-title":"Orexin\/Hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system","volume":"61","author":"Tsujino","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib42","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1523\/JNEUROSCI.19-08-03171.1999","article-title":"Hypothalamic hypocretin (orexin): robust innervation of the spinal cord","volume":"19","author":"van den Pol","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib43","doi-asserted-by":"crossref","first-page":"12198","DOI":"10.1073\/pnas.96.21.12198","article-title":"Pain modulation by release of the endogenous cannabinoid anandamide","volume":"96","author":"Walker","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib44","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/00001756-200501190-00002","article-title":"Persistent pain and stress activate pain-inhibitory orexin pathways","volume":"16","author":"Watanabe","year":"2005","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2016.02.018_bib45","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1460-9568.2008.06074.x","article-title":"Neural correlates of arousal-induced circadian clock resetting: hypocretin\/orexin and the intergeniculate leaflet","volume":"27","author":"Webb","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib46","first-page":"2471","article-title":"Hypocretin\/orexin and nociceptin\/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia","volume":"118","author":"Xie","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib47","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-8993(76)91009-X","article-title":"Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray","volume":"114","author":"Yaksh","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.02.018_bib48","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1097\/00001756-200207190-00027","article-title":"Activation of orexin neurones after noxious but not conditioned fear stimuli in rats","volume":"13","author":"Zhu","year":"2002","journal-title":"Neuroreport"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390816300545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390816300545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:22:24Z","timestamp":1713399744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390816300545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":48,"alternative-id":["S0028390816300545"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2016.02.018","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid\/CB1 signaling in the mouse periaqueductal gray","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2016.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}