{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:10:14Z","timestamp":1789625414187,"version":"build-2803163510"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004611","name":"Secret\u00e1rio de Ci\u00eancia, Tecnologia e Ensino Superior, Governo do Estado de Parana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004611","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003545","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.neuropharm.2016.02.019","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T21:54:21Z","timestamp":1455918861000},"page":"508-519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":178,"special_numbering":"C","title":["Naringenin reduces inflammatory pain in mice"],"prefix":"10.1016","volume":"105","author":[{"given":"Felipe A.","family":"Pinho-Ribeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Zarpelon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Fattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia F.","family":"Manchope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra S.","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubia","family":"Casagrande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-9283","authenticated-orcid":false,"suffix":"Jr.","given":"Waldiceu A.","family":"Verri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2016.02.019_bib1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1179\/1743132815Y.0000000079","article-title":"Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy","volume":"37","author":"Al-Rejaie","year":"2015","journal-title":"Neurol. Res."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-2999(02)01412-7","article-title":"Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by dipyrone","volume":"444","author":"Alves","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib3","doi-asserted-by":"crossref","first-page":"14062","DOI":"10.1523\/JNEUROSCI.3795-08.2008","article-title":"Nociceptors are interleukin-1beta sensors","volume":"28","author":"Binshtok","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib4","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1021\/np400222v","article-title":"Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines","volume":"76","author":"Borghi","year":"2013","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib5","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib6","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/jsfa.3959","article-title":"Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study","volume":"90","author":"Cavia-Saiz","year":"2010","journal-title":"J.\u00a0Sci. Food Agric."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1744-8069-8-10","article-title":"Stimulation of peripheral kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kgamma\/AKT\/nNOS\/NO signaling pathway","volume":"8","author":"Cunha","year":"2012","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib8","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1073\/pnas.0409225102","article-title":"A\u00a0cascade of cytokines mediates mechanical inflammatory hypernociception in mice","volume":"102","author":"Cunha","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1590\/S0100-879X2004000300018","article-title":"An electronic pressure-meter nociception paw test for mice","volume":"37","author":"Cunha","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib10","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1089\/1523086041361659","article-title":"Superoxide-related signaling cascade mediates nuclear factor-kappaB activation in acute inflammation","volume":"6","author":"Cuzzocrea","year":"2004","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.niox.2006.02.004","article-title":"Nitric oxide inhibits neutrophil migration by a mechanism dependent on ICAM-1: role of soluble guanylate cyclase","volume":"15","author":"Dal Secco","year":"2006","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib12","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1017\/S0007114512005594","article-title":"Protective effect of naringenin against experimental colitis via suppression of toll-like receptor 4\/NF-kappaB signalling","volume":"110","author":"Dou","year":"2013","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib13","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00011-015-0885-y","article-title":"Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-kappaB activation","volume":"64","author":"Fattori","year":"2015","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF01534269","article-title":"Modulation of carrageenan-induced hind paw edema by substance P","volume":"18","author":"Gilligan","year":"1994","journal-title":"Inflammation"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib15","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1523\/JNEUROSCI.5087-12.2013","article-title":"Induction of thermal hyperalgesia and synaptic long-term potentiation in the spinal cord lamina I by TNF-alpha and IL-1beta is mediated by glial cells","volume":"33","author":"Gruber-Schoffnegger","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib16","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1152\/jn.00652.2014","article-title":"The role of slow and persistent TTX-resistant sodium currents in acute tumor necrosis factor-alpha-mediated increase in nociceptors excitability","volume":"113","author":"Gudes","year":"2015","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1189\/jlb.0207123","article-title":"Involvement of LTB4 in zymosan-induced joint nociception in mice: participation of neutrophils and PGE2","volume":"83","author":"Guerrero","year":"2008","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib18","doi-asserted-by":"crossref","first-page":"14046","DOI":"10.1038\/srep14046","article-title":"Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents","volume":"5","author":"Guo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib19","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s13105-014-0369-5","article-title":"Role of naringenin in protection against diabetic hyperalgesia and tactile allodynia in male Wistar rats","volume":"70","author":"Hasanein","year":"2014","journal-title":"J.\u00a0Physiol. Biochem."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib20","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3892\/br.2014.267","article-title":"Analgesic effects of naringenin in rats with spinal nerve ligation-induced neuropathic pain","volume":"2","author":"Hu","year":"2014","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib21","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.cellsig.2007.01.020","article-title":"TNF-alpha-induced NF-kappaB\/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway","volume":"19","author":"Jamaluddin","year":"2007","journal-title":"Cell Signal"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib22","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1523\/JNEUROSCI.3858-05.2006","article-title":"Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha","volume":"26","author":"Jin","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-cellbio-101011-155833","article-title":"TRP channels and pain","volume":"29","author":"Julius","year":"2013","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib24","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.3736\/jcim20121223","article-title":"Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain","volume":"10","author":"Kaulaskar","year":"2012","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib25","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1523\/JNEUROSCI.3338-07.2008","article-title":"Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord","volume":"28","author":"Kawasaki","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejphar.2006.08.007","article-title":"TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion","volume":"548","author":"Khattab","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neulet.2008.09.041","article-title":"Increased production of mitochondrial superoxide in the spinal cord induces pain behaviors in mice: the effect of mitochondrial electron transport complex inhibitors","volume":"447","author":"Kim","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mrfmmm.2009.09.007","article-title":"A\u00a0protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders","volume":"690","author":"Kim","year":"2010","journal-title":"Mutat. Res."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib29","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.pain.2013.06.043","article-title":"TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain","volume":"154","author":"Liu","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib30","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuropharm.2013.11.026","article-title":"Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2\/ARE signaling pathway","volume":"79","author":"Lou","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib32","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1590\/1414-431X20132894","article-title":"An interleukin-33\/ST2 signaling deficiency reduces overt pain-like behaviors in mice","volume":"46","author":"Magro","year":"2013","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0304-3940(00)01302-1","article-title":"Regulation and immunohistochemical localization of nitric oxide synthases and soluble guanylyl cyclase in mouse spinal cord following nociceptive stimulation","volume":"290","author":"Maihofner","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib34","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1021\/acs.jnatprod.5b00198","article-title":"Naringenin inhibits UVB irradiation-induced inflammation and oxidative stress in the skin of hairless mice","volume":"78","author":"Martinez","year":"2015","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib35","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.0705924104","article-title":"TRPA1 mediates formalin-induced pain","volume":"104","author":"McNamara","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib36","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1021\/np200989t","article-title":"Kaurenoic acid from Sphagneticola trilobata inhibits inflammatory pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway","volume":"75","author":"Mizokami","year":"2012","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib37","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/0196-9781(95)00037-K","article-title":"Substance P induces the expression of intercellular adhesion molecule-1 on vascular endothelial cells and enhances neutrophil transendothelial migration","volume":"16","author":"Nakagawa","year":"1995","journal-title":"Peptides"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib38","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1111\/bph.13129","article-title":"The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives","volume":"172","author":"Nassini","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib39","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1096\/fj.08-108159","article-title":"Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity","volume":"22","author":"Ndengele","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib40","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3109\/09637486.2015.1092019","article-title":"Serum levels of phytoestrogens as biomarkers of intake in Mexican women","volume":"66","author":"Palma-Duran","year":"2015","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib41","first-page":"204","article-title":"Naringenin attenuates the release of pro-inflammatory mediators from lipopolysaccharide-stimulated BV2 microglia by inactivating nuclear factor-kappaB and inhibiting mitogen-activated protein kinases","volume":"30","author":"Park","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/SHK.0b013e3181e37ea8","article-title":"Inhibition of guanylyl cyclase restores neutrophil migration and maintains bactericidal activity increasing survival in sepsis","volume":"35","author":"Paula-Neto","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib43","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1021\/np500563b","article-title":"Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-kappaB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway","volume":"77","author":"Possebon","year":"2014","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib44","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuroscience.2012.10.041","article-title":"Neuroprotective effect of naringenin is mediated through suppression of NF-kappaB signaling pathway in experimental stroke","volume":"230","author":"Raza","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cbi.2015.05.007","article-title":"Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-kappaB","volume":"237","author":"Ruiz-Miyazawa","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib46","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1073\/pnas.0308382101","article-title":"Peripheral analgesic blockade of hypernociception: activation of arginine\/NO\/cGMP\/protein kinase G\/ATP-sensitive K+ channel pathway","volume":"101","author":"Sachs","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/sj.bjp.0706836","article-title":"Atorvastatin inhibits inflammatory hypernociception","volume":"149","author":"Santodomingo-Garzon","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib48","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.tins.2009.01.010","article-title":"No no, no pain? the role of nitric oxide and cGMP in spinal pain processing","volume":"32","author":"Schmidtko","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-3959(98)00124-9","article-title":"Effect of peripheral nerve injury on cGMP and nitric oxide synthase levels in rat dorsal root ganglia: time course and coexistence","volume":"78","author":"Shi","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib50","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.expneurol.2014.05.028","article-title":"Peripheral prostaglandin E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal trafficking of EP4 receptors","volume":"261","author":"St-Jacques","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib51","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00210-014-1030-0","article-title":"The ruthenium nitric oxide donor, [Ru(HEDTA)NO], inhibits acute nociception in mice by modulating oxidative stress, cytokine production and activating the cGMP\/PKG\/ATP-sensitive potassium channel signaling pathway","volume":"387","author":"Staurengo-Ferrari","year":"2014","journal-title":"Naunyn Schmiedeb. Arch. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib52","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1038\/sj.bjp.0704014","article-title":"Role of the haeme oxygenase\/carbon monoxide pathway in mechanical nociceptor hypersensitivity","volume":"132","author":"Steiner","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib53","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1111\/bph.12076","article-title":"Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3","volume":"168","author":"Straub","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib54","first-page":"247","article-title":"Anti-inflammatory and side effects of cyclooxygenase inhibitors","volume":"59","author":"Suleyman","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib55","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/sj.bjp.0707640","article-title":"Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain","volume":"153","author":"Ting","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib56","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejphar.2007.01.029","article-title":"Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: inhibition of cytokine production-dependent mechanism","volume":"562","author":"Valerio","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib57","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejphar.2008.04.010","article-title":"Role of IL-18 in overt pain-like behaviour in mice","volume":"588","author":"Verri","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib58","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00210-008-0360-1","article-title":"Targeting endothelin ETA and ETB receptors inhibits antigen-induced neutrophil migration and mechanical hypernociception in mice","volume":"379","author":"Verri","year":"2009","journal-title":"Naunyn Schmiedeb. Arch. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib59","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib60","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/ard.2009.122655","article-title":"IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy","volume":"69","author":"Verri","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib61","series-title":"Studies in Natural Products Chemistry","first-page":"297","article-title":"Flavonoids as anti-inflammatory and analgesic drugs: mechanisms of action and perspectives in the development of pharmaceutical forms","author":"Verri","year":"2012"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib62","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neuron.2011.02.051","article-title":"TRPM3 is a nociceptor channel involved in the detection of noxious heat","volume":"70","author":"Vriens","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2016.02.019_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2008.03.004","article-title":"Involvement of the nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway in the antihyperalgesic effects of bovine lactoferrin in a model of neuropathic pain","volume":"1209","author":"Wang","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib64","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1124\/jpet.103.064154","article-title":"A\u00a0newly identified role for superoxide in inflammatory pain","volume":"309","author":"Wang","year":"2004","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib65","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.bjp.0701148","article-title":"Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha","volume":"121","author":"Woolf","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib66","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2015.08.015","article-title":"Superoxide anion-induced pain and inflammation depends on TNFalpha\/TNFR1 signaling in mice","volume":"605","author":"Yamacita-Borin","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib67","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1021\/jf0484632","article-title":"Antioxidant activity of citrus limonoids, flavonoids, and coumarins","volume":"53","author":"Yu","year":"2005","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib68","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/bph.12110","article-title":"IL-33\/ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E2","volume":"169","author":"Zarpelon","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib69","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1096\/fj.14-267146","article-title":"Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain","volume":"30","author":"Zarpelon","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.neuropharm.2016.02.019_bib70","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neulet.2013.12.019","article-title":"Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord","volume":"560","author":"Zhao","year":"2014","journal-title":"Neurosci. Lett."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002839081630051X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002839081630051X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:51:08Z","timestamp":1758437468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002839081630051X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":70,"alternative-id":["S002839081630051X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2016.02.019","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naringenin reduces inflammatory pain in mice","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2016.02.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}