{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T12:03:01Z","timestamp":1768737781148,"version":"3.49.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.neuropharm.2016.04.003","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T03:13:47Z","timestamp":1460258027000},"page":"156-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"PA","title":["CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABAA receptor blockade in\u00a0the dorsomedial division of the ventromedial hypothalamus"],"prefix":"10.1016","volume":"113","author":[{"given":"Tayllon","family":"dos Anjos-Garcia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Luciano","family":"Falconi-Sobrinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-2620","authenticated-orcid":false,"given":"Norberto Cysne","family":"Coimbra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2016.04.003_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0301-0082(02)00080-1","article-title":"Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids","volume":"68","author":"Alger","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/syn.21814","article-title":"Recruitment of striatonigral disinhibitory and nigrotectal inhibitory GABAergic pathways during the organization of defensive behavior by mice in a dangerous environment with the venomous snake Bothrops alternatus (Reptilia, Viperidae)","volume":"69","author":"Almada","year":"2015","journal-title":"Synapse"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.neuroscience.2015.06.048","article-title":"Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro venomous pit viper","volume":"303","author":"Almada","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pbb.2013.02.012","article-title":"Role of TRPV1 receptors on panic-like behaviors mediated by the dorsolateral periaqueductal gray in rats","volume":"105","author":"Almeida-Santos","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/0269881114566259","article-title":"Role of endocannabinoid signalling in the dorsolateral periaqueductal grey in the modulation of distinct panic-like responses","volume":"29","author":"Batista","year":"2015","journal-title":"J.\u00a0Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuropharm.2012.10.024","article-title":"Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways","volume":"67","author":"Biagioni","year":"2013","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.neuropharm.2016.04.003_bib7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.euroneuro.2015.12.032","article-title":"5-Hydroxytryptamine1A receptors in the dorsomedial hypothalamus connected to dorsal raphe nucleus inputs modulate defensive behaviour and mediate innate fear-induced antinociception","volume":"26","author":"Biagioni","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbr.2015.10.059","article-title":"Neuroethological validation of an experimental apparatus to evaluate oriented and non-oriented escape behaviours: comparison between the polygonal arena with a burrow and the circular enclosure of an open-field test","volume":"298","author":"Biagioni","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1590\/S0100-879X2012007500037","article-title":"Panic-like defensive behavior but not fear-induced antinociception is differently organized by dorsomedial and posterior hypothalamic nuclei of Rattus norvegicus (Rodentia, Muridae)","volume":"45","author":"Biagioni","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0149-7634(01)00009-4","article-title":"Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic","volume":"25","author":"Blanchard","year":"2001","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0149-7634(96)00062-0","article-title":"Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries","volume":"21","author":"Blanchard","year":"1997","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.brainres.2005.05.068","article-title":"Fos-like immunoreactivity in the brain associated with freezing or escape induced by inhibition of either glutamic acid decarboxylase or GABAA receptors in the dorsal periaqueductal gray","volume":"1051","author":"Borelli","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.pbb.2003.12.009","article-title":"Effects of acute and chronic fluoxetine and diazepam on freezing behavior induced by electrical stimulation of dorsolateral and lateral columns of the periaqueductal gray matter","volume":"77","author":"Borelli","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0091-3057(86)90547-2","article-title":"Escape behavior produced by the blockade of glutamic acid decarboxylase (GAD) in mesencephalic central gray or medial hypothalamus","volume":"24","author":"Brand\u00e3o","year":"1986","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0031-9384(88)90038-8","article-title":"Defense reaction induced by microinjections of bicuculline into the inferior colliculus","volume":"44","author":"Brand\u00e3o","year":"1988","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.neubiorev.2014.03.020","article-title":"Executive and modulatory neural circuits of defensive reactions: implications for panic disorder","volume":"46","author":"Canteras","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/cne.903480103","article-title":"Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-Leucoagglutinin study in the rat","volume":"348","author":"Canteras","year":"1994","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib18","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/npp.2011.207","article-title":"Opposing roles for cannabinoid receptor Type-1 (CB1) and transient receptor potential vanilloid Type-1 channel (TRPV1) on the modulation of panic-like responses in rats","volume":"37","author":"Casarotto","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1017\/S1092852900020939","article-title":"Modulation of fear and anxiety by the endogenous cannabinoid system","volume":"12","author":"Chhatwal","year":"2007","journal-title":"CNS Spectr."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.expneurol.2005.08.022","volume":"197","author":"Coimbra","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib21","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1017\/S1461145713000163","volume":"16","author":"de Freitas","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"6","key":"10.1016\/j.neuropharm.2016.04.003_bib56","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1093\/cercor\/bht001","article-title":"NMDA and AMPA\/kainate glutamatergic receptors in the prelimbic medial prefrontal cortex modulate the elaborated defensive behavior and innate fear-induced antinociception elicited by GABAA receptor blockade in the medial hypothalamus","volume":"24","author":"de Freitas","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib22","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.lfs.2005.05.055","article-title":"Cannabinoid signalling","volume":"78","author":"Demuth","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0026-895X(25)09876-1","article-title":"Determination and characterization of a cannabinoid receptor in rat brain","volume":"34","author":"Devane","year":"1988","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0006-8993(84)90585-7","article-title":"Flight induced by infusion of bicuculline methiodide into periventricular structures","volume":"309","author":"Di Scala","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib25","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0028-3908(03)00235-1","article-title":"Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats","volume":"45","author":"Finn","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuropharm.2012.03.007","article-title":"The endocannabinoid and endovanilloid systems interact in the rat prelimbic medial prefrontal cortex to control anxiety-like behavior","volume":"63","author":"Foga\u00e7a","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.brainres.2009.09.096","article-title":"GABAA receptor blockade in dorsomedial and ventromedial nuclei of the hypothalamus evokes panic-like elaborated defensive behaviour followed by innate fear-induced antinociception","volume":"1305","author":"Freitas","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib28","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1152\/physrev.00004.2003","article-title":"Role of endogenous cannabinoids in synaptic signaling","volume":"83","author":"Freund","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib29","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1523\/JNEUROSCI.11-02-00563.1991","article-title":"Characterization and localization of cannabinoid receptors in rat brain: a quantitative in\u00a0vitro autoradiographic study","volume":"11","author":"Herkenham","year":"1991","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib30","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1523\/JNEUROSCI.19-11-04544.1999","article-title":"Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons","volume":"19","author":"Katona","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib31","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.neuropharm.2012.02.008","article-title":"Differential role of CB1 and TRPV1 receptors on anandamide modulation of defensive responses induced by nitric oxide in the dorsolateral periaqueductal gray","volume":"62","author":"Lisboa","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib32","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1046\/j.1460-9568.1999.00847.x","article-title":"Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain","volume":"11","author":"Marsicano","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neubiorev.2004.03.005","article-title":"A\u00a0two-dimensional neuropsychology of defense: fear\/anxiety and defensive distance","volume":"28","author":"McNaughton","year":"2004","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib34","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/npp.2008.98","article-title":"Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels","volume":"34","author":"Micale","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0091-3057(87)90005-0","article-title":"GABA-benzodiazepine modulation of aversion in the medial hypothalamus of the rat","volume":"28","author":"Milani","year":"1987","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib36","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.neuropharm.2006.10.013","article-title":"Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray","volume":"52","author":"Moreira","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0031-9384(66)90064-3","article-title":"Injection of solutions into cerebral tissue: relation between volume and diffusion","volume":"1","author":"Myers","year":"1966","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.euroneuro.2011.04.004","article-title":"CB1 receptor antagonism\/inverse agonism increases motor system excitability in humans","volume":"22","author":"Oliviero","year":"2012","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib39","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"issue":"4","key":"10.1016\/j.neuropharm.2016.04.003_bib40","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/pr.110.003004","article-title":"International union of basic and clinical pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2","volume":"62","author":"Pertwee","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/(SICI)1097-4547(19980201)51:3<391::AID-JNR12>3.0.CO;2-A","article-title":"Immunohistochemical localization of the neural cannabinoid receptor in rat brain","volume":"51","author":"Pettit","year":"1998","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib42","series-title":"Methods of Behavior Analysis in Neuroscience","article-title":"Conditioned place preference","author":"Prus","year":"2009"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib43","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0091-6773(72)80073-7","article-title":"Intracranial chemical injection and behavior: a critical review","volume":"7","author":"Routtenberg","year":"1972","journal-title":"Behav. Biol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib44","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neuropharm.2007.06.024","article-title":"CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour","volume":"54","author":"Rubino","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib45","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0165-6147(00)01805-8","article-title":"Modulation of transmitter release via presynaptic cannabinoid receptors","volume":"22","author":"Schlicker","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib46","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0014-2999(85)90599-0","article-title":"Behavioral effects of microinjections of SR 95103, a new GABA-A antagonist, into the medial hypothalamus or the mesencephalic central gray","volume":"117","author":"Schmitt","year":"1985","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib47","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/0006-3223(94)90086-8","article-title":"Effects of treatment with imipramine and clonazepam on an animal model of panic disorder","volume":"36","author":"Shekhar","year":"1994","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib48","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/3-540-26573-2_11","article-title":"Effects of cannabinoids on neurotransmission","author":"Szabo","year":"2005","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0306-4522(97)00436-3","article-title":"Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system","volume":"83","author":"Tsou","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib50","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1177\/0269881113493363","article-title":"The role of 5-HT1A receptors in the anti-aversive effects of cannabidiol on panic attack-like behaviors evoked in the presence of the wild snake Epicrates cenchria crassus (Reptilia, Boidae)","volume":"27","author":"Twardowschy","year":"2013","journal-title":"J.\u00a0Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib51","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbr.2015.07.013","article-title":"Relevance of dorsomedial hypothalamus, dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal gray matter in the organization of freezing or oriented and non-oriented escape emotional behaviors","volume":"293","author":"Ullah","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib52","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/npp.2011.188","article-title":"Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates cenchria crassus confrontation paradigm","volume":"37","author":"Uribe-Mari\u00f1o","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2016.04.003_bib53","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3171\/2009.9.JNS09577","article-title":"Induction of panic attack by stimulation of the ventromedial hypothalamus","volume":"112","author":"Wilent","year":"2010","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib54","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1152\/jn.01023.2006","article-title":"TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons","volume":"97","author":"Xing","year":"2007","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuropharm.2016.04.003_bib55","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1097\/FBP.0b013e3283123c83","article-title":"Cannabinoid CB1 receptors of the rat central amygdala mediate anxiety-like behavior: interaction with the opioid system","volume":"19","author":"Zarrindast","year":"2008","journal-title":"Behav. Pharmacol."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390816301393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390816301393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T10:18:38Z","timestamp":1748859518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390816301393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":56,"alternative-id":["S0028390816301393"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2016.04.003","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABAA receptor blockade in\u00a0the dorsomedial division of the ventromedial hypothalamus","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2016.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}