{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:30:44Z","timestamp":1790303444028,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Science and Technological Project","award":["2015SF017"],"award-info":[{"award-number":["2015SF017"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31300899"],"award-info":[{"award-number":["31300899"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.neuropharm.2016.07.014","type":"journal-article","created":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T19:08:41Z","timestamp":1468696121000},"page":"25-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"PA","title":["Activation and blockade of prelimbic 5-HT6 receptors produce different effects on depressive-like behaviors in unilateral 6-hydroxydopamine-induced Parkinson's rats"],"prefix":"10.1016","volume":"110","author":[{"given":"Yu-Ming","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Na","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Xue","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Qi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2016.07.014_bib1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.pbb.2011.09.008","article-title":"Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline","volume":"100","author":"Arakawa","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines","volume":"7","author":"Berton","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00213-010-1798-7","article-title":"Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats","volume":"213","author":"Carr","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1750-1326-8-14","article-title":"Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits","volume":"8","author":"Carvalho","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib5","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1097\/00001756-199905140-00010","article-title":"Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex","volume":"10","author":"Casanovas","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib6","doi-asserted-by":"crossref","first-page":"9917","DOI":"10.1523\/JNEUROSCI.21-24-09917.2001","article-title":"Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: involvement of serotonin-1A, GABAA, and glutamate receptors","volume":"21","author":"Celada","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-510X(93)90074-9","article-title":"Reduction in cortical 5-HT3 binding sites following a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle in rats","volume":"115","author":"Cicin-Sain","year":"1993","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib8","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0893-133X(01)00265-2","article-title":"The 5-HT6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus","volume":"25","author":"Dawson","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib9","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.nbd.2011.10.023","article-title":"Emerging dysfunctions consequent to combined monoaminergic depletions in parkinsonism","volume":"45","author":"Delaville","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib10","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/FBP.0b013e32833e7e80","article-title":"Behavioral and neurochemical effects of chronic L-DOPA treatment on non-motor sequelae in the hemiparkinsonian rat","volume":"21","author":"Eskow Jaunarajs","year":"2010","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib11","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuroscience.2011.06.011","article-title":"In\u00a0vivo effect of 5-HT 7 receptor agonist on pyramidal neurons in medial frontal cortex of normal and 6-hydroxydopamine-lesioned rats: an electrophysiological study","volume":"190","author":"Fan","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib12","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0306-4522(02)00939-9","article-title":"Altered spontaneous discharge rate and pattern of basal ganglia output neurons in the circling (ci2) rat mutant","volume":"118","author":"Fedrowitz","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0006-8993(96)01224-3","article-title":"Immunolocalization of serotonin 5-HT6 receptor-like material in the rat central nervous system","volume":"746","author":"Gerard","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/(SICI)1098-2396(199607)23:3<164::AID-SYN5>3.0.CO;2-6","article-title":"Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats","volume":"23","author":"Gerard","year":"1996","journal-title":"Synapse"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib15","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.neuroscience.2010.05.059","article-title":"In\u00a0vivo modulation of the firing activity of putative slow-and fast-spiking interneurons in the medial prefrontal cortex by 5-HT3 receptors in 6-hydroxydopamine-induced parkinsonian rats","volume":"169","author":"Gui","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0028-3908(03)00139-4","article-title":"In\u00a0vivo inhibition of neuronal activity in the rat ventromedial prefrontal cortex by midbrain raphe nuclei: role of 5-HT 1A receptors","volume":"45","author":"Haj\u00f3s","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0306-4522(98)00157-2","article-title":"An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat","volume":"87","author":"Haj\u00f3s","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib18","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jpsychires.2009.12.010","article-title":"Effects of different stimulation parameters on the antidepressant-like response of medial prefrontal cortex deep brain stimulation in rats","volume":"44","author":"Hamani","year":"2010","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.biopsych.2009.08.025","article-title":"Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats","volume":"67","author":"Hamani","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib20","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1460-9568.2010.07414.x","article-title":"Deep brain stimulation in clinical trials and animal models of depression","volume":"32","author":"Hamani","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib21","first-page":"68","article-title":"Antibodies and antisense oligonucleotide for probing the distribution and putative functions of central 5-HT6 receptors","volume":"21","author":"Hamon","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neuropharm.2015.01.024","article-title":"Activation of serotonin2C receptors in the lateral habenular nucleus increases the expression of depression-related behaviors in the hemiparkinsonian rat","volume":"93","author":"Han","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neubiorev.2003.09.003","article-title":"The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics","volume":"27","author":"Heidbreder","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib24","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.lfs.2009.01.019","article-title":"Procognitive 5-HT 6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease","volume":"84","author":"Hirano","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bbr.2014.04.053","article-title":"Anxiolytic effects of prelimbic 5-HT 1A receptor activation in the hemiparkinsonian rat","volume":"277","author":"Hui","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neuroscience.2014.03.033","article-title":"Activation of prelimbic 5-HT 1A receptors produces antidepressant-like effects in a unilateral rat model of Parkinson's disease","volume":"268","author":"Hui","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pneurobio.2011.08.004","article-title":"The serotonergic system in Parkinson's disease","volume":"95","author":"Huot","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib28","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib29","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/syn.10288","article-title":"5-HT6 receptor antagonist SB271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex","volume":"51","author":"Lacroix","year":"2004","journal-title":"Synapse"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib30","doi-asserted-by":"crossref","first-page":"7429","DOI":"10.1523\/JNEUROSCI.2314-05.2005","article-title":"Prefrontal control of the amygdala","volume":"25","author":"Likhtik","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib31","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.neuropharm.2015.03.031","article-title":"Serotonin6 receptors in the dorsal hippocampus regulate depressive-like behaviors in unilateral 6-hydroxydopamine-lesioned Parkinson's rats","volume":"95","author":"Liu","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib32","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s00702-009-0274-1","article-title":"Beyond tremor and rigidity: non-motor features of Parkinson's disease","volume":"116","author":"L\u00f6hle","year":"2009","journal-title":"J.\u00a0Neural Transm."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0306-4522(95)00417-3","article-title":"Projections of the medial and lateral prefrontal cortices to the amygdala: a phaseolus vulgaris leucoagglutinin study in the rat","volume":"71","author":"McDonald","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.bbr.2012.09.053","article-title":"Upregulation of CB1 receptor binding in the ventromedial prefrontal cortex promotes proactive stress-coping strategies following chronic stress exposure","volume":"237","author":"McLaughlin","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib35","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0026-895X(25)13616-X","article-title":"Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs","volume":"43","author":"Monsma","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00213-011-2297-1","article-title":"The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration","volume":"217","author":"Nikiforuk","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib37","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0361-9230(84)90232-6","article-title":"Organization of raphe-cortical projections in rat: a quantitative retrograde study","volume":"13","author":"O'Hearn","year":"1984","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib38","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib39","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0306-4522(97)00268-6","article-title":"Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods","volume":"82","author":"Peyron","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.npp.1301574","article-title":"Stress, depression, and neuroplasticity: a convergence of mechanisms","volume":"33","author":"Pittenger","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0026-895X(25)13130-1","article-title":"Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase","volume":"44","author":"Plassat","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib42","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0006-8993(02)02360-0","article-title":"The distribution of 5-HT 6 receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT 6 receptor antagonist [125I] SB-258585","volume":"934","author":"Roberts","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib44","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0022-3565(25)38596-4","article-title":"Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors","volume":"268","author":"Roth","year":"1994","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib45","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1006\/bbrc.1993.1619","article-title":"A\u00a0novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation","volume":"193","author":"Ruat","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00702-005-0368-3","article-title":"Serotonergic mechanisms in Parkinson's disease: opposing results from preclinical and clinical data","volume":"113","author":"Scholtissen","year":"2006","journal-title":"J.\u00a0Neural Transm."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib47","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0031-9384(03)00143-4","article-title":"Reinforcement value of sucrose measured by progressive ratio operant licking in the rat","volume":"79","author":"Sclafani","year":"2003","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib48","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bbr.2010.06.018","article-title":"Acute reversible inactivation of the ventral medial prefrontal cortex induces antidepressant-like effects in rats","volume":"214","author":"Scopinho","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib49","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/cne.902900205","article-title":"Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with phaseolus vulgaris leucoagglutinin","volume":"290","author":"Sesack","year":"1989","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib50","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/hipo.20824","article-title":"Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats","volume":"21","author":"Shirayama","year":"2011","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib51","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.neuropharm.2008.02.006","article-title":"Direct enhancement of hippocampal dopamine or serotonin levels as a pharmacodynamic measure of combined antidepressant\u2013anticonvulsant action","volume":"54","author":"Smolders","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib52","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1111\/j.1601-183X.2006.00228.x","article-title":"A\u00a0hitchhiker's guide to behavioral analysis in laboratory rodents","volume":"5","author":"Sousa","year":"2006","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib53","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0306-4522(81)90146-9","article-title":"Distribution of serotonin-immunoreactivity in the central nervous system of the rat\u2013cell bodies and terminals","volume":"6","author":"Steinbusch","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib54","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1523\/JNEUROSCI.3110-06.2007","article-title":"Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation","volume":"27","author":"Svenningsson","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib55","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.neuroscience.2008.08.035","article-title":"Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease","volume":"156","author":"Tadaiesky","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib56","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/1098-1063(2000)10:4<411::AID-HIPO7>3.0.CO;2-A","article-title":"Hippocampo-prefrontal cortex pathway: anatomical and electrophysiological characteristics","volume":"10","author":"Thierry","year":"2000","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib57","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.neubiorev.2010.06.006","article-title":"Reconsidering anhedonia in depression: lessons from translational neuroscience","volume":"35","author":"Treadway","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib58","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/syn.20255","article-title":"Excitatory response of prefrontal cortical fast-spiking interneurons to ventral tegmental area stimulation in\u00a0vivo","volume":"59","author":"Tseng","year":"2006","journal-title":"Synapse"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib59","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/syn.10279","article-title":"Differential projections of the infralimbic and prelimbic cortex in the rat","volume":"51","author":"Vertes","year":"2004","journal-title":"Synapse"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib60","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.biopsych.2004.04.010","article-title":"Effects of cyclic adenosine monophosphate response element binding protein overexpression in the basolateral amygdala on behavioral models of depression and anxiety","volume":"56","author":"Wallace","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib61","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.neuroscience.2008.12.051","article-title":"Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal firing of the midbrain raphe nuclei 5-HT neurons and a decrease of their response to 5-HT 1A receptor stimulation in the rat","volume":"159","author":"Wang","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib62","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.neuroscience.2009.04.069","article-title":"The firing activity of pyramidal neurons in medial prefrontal cortex and their response to 5-hydroxytryptamine-1A receptor stimulation in a rat model of Parkinson's disease","volume":"162","author":"Wang","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib63","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.expneurol.2009.05.029","article-title":"In\u00a0vivo effects of activation and blockade of 5-HT2A\/2C receptors in the firing activity of pyramidal neurons of medial prefrontal cortex in a rodent model of Parkinson's disease","volume":"219","author":"Wang","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib64","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0306-4522(94)00439-C","article-title":"Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistry","volume":"64","author":"Ward","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib65","first-page":"664","article-title":"Study into a possible mechanism responsible for the antidepressant-like activity of the selective 5-HT6 receptor antagonist SB-399885 in rats","volume":"59","author":"Wesolowska","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib66","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S1734-1140(10)70315-7","article-title":"Potential role of the 5-HT6 receptor in depression and anxiety: an overview of preclinical data","volume":"62","author":"Weso\u0142owska","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib67","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.neuropharm.2007.01.007","article-title":"Effects of the brain-penetrant and selective 5-HT 6 receptor antagonist SB-399885 in animal models of anxiety and depression","volume":"52","author":"Weso\u0142owska","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib68","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ejphar.2007.12.013","article-title":"The selective 5-HT6 receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats","volume":"582","author":"Weso\u0142owska","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib69","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/FBP.0b013e3282d28f9c","article-title":"Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats","volume":"18","author":"Wesolowska","year":"2007","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib70","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1568007043482561","article-title":"5-HT6 receptors","volume":"3","author":"Woolley","year":"2004","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib71","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/S0024-3205(98)00092-7","article-title":"Central distribution and function of 5-HT6 receptor subtype in the rat brain","volume":"62","author":"Yoshioka","year":"1998","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib72","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5607\/en.2011.20.4.159","article-title":"The serotonin-6 receptor as a novel therapeutic target","volume":"20","author":"Yun","year":"2011","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib73","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11920-002-0016-7","article-title":"Depression in Parkinson's disease","volume":"4","author":"Zesiewicz","year":"2002","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib74","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neuroscience.2015.10.016","article-title":"Activation and blockade of serotonin7 receptors in the prelimbic cortex regulate depressive-like behaviors in a 6-hydroxydopamine-induced Parkinson's disease rat model","volume":"311","author":"Zhang","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2016.07.014_bib75","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.brainres.2011.01.086","article-title":"The pyramidal neurons in the medial prefrontal cortex show decreased response to 5-hydroxytryptamine-3 receptor stimulation in a rodent model of Parkinson's disease","volume":"1384","author":"Zhang","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib76","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2009.11.052","article-title":"Unilateral lesion of the nigrostriatal pathway decreases the response of interneurons in medial prefrontal cortex to 5-HT2A\/2C receptor stimulation in the rat","volume":"1312","author":"Zhang","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib77","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s10072-014-1669-9","article-title":"Decreased response of interneurons in the medial prefrontal cortex to 5-HT1A receptor activation in the rat 6-hydroxydopamine Parkinson model","volume":"35","author":"Zhang","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib78","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1002\/cne.22605","article-title":"Distribution, level, pharmacology, regulation, and signaling of 5-HT6 receptors in rats and marmosets with special reference to an experimental model of parkinsonism","volume":"519","author":"Zhang","year":"2011","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2016.07.014_bib79","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00213-011-2356-7","article-title":"Antidepressant-like properties of sarizotan in experimental Parkinsonism","volume":"218","author":"Zhang","year":"2011","journal-title":"Psychopharmacology"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390816303008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390816303008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T01:40:29Z","timestamp":1749001229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390816303008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":79,"alternative-id":["S0028390816303008"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2016.07.014","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation and blockade of prelimbic 5-HT6 receptors produce different effects on depressive-like behaviors in unilateral 6-hydroxydopamine-induced Parkinson's rats","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2016.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}