{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:46:15Z","timestamp":1790696775898,"version":"4.1.0"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.neuropharm.2017.04.006","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T18:00:20Z","timestamp":1491588020000},"page":"62-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone"],"prefix":"10.1016","volume":"119","author":[{"given":"Alyssa F.","family":"DeLarge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L.","family":"Erwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Winsauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2017.04.006_bib1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/adb.12038","article-title":"Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats","volume":"18","author":"Aarde","year":"2013","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib2","first-page":"1097","article-title":"Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum","volume":"120","author":"Angoa-Perez","year":"2012","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00008877-199302000-00008","article-title":"The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds","volume":"4","author":"Baker","year":"1993","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib4","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/npp.2011.304","article-title":"The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue","volume":"37","author":"Baumann","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib5","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/npp.2012.204","article-title":"Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products","volume":"38","author":"Baumann","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib6","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1124\/dmd.109.028506","article-title":"Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the rat","volume":"37","author":"Baumann","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature20153","article-title":"The effects of Delta9-tetrahydrocannabinol on the dopamine system","volume":"539","author":"Bloomfield","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejphar.2006.09.038","article-title":"Interactions between 3,4-methylenedioxymethamphetamine and sigma1 receptors","volume":"553","author":"Brammer","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/dta.155","article-title":"Analyses of second-generation 'legal highs' in the UK: initial findings","volume":"2","author":"Brandt","year":"2010","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.drugpo.2011.05.016","article-title":"Impact of a transient instability of the ecstasy market on health concerns and drug use patterns in The Netherlands","volume":"23","author":"Brunt","year":"2012","journal-title":"Int. J. Drug Policy"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib11","first-page":"3777","article-title":"Mephedrone related fatalities: a review","volume":"19","author":"Busardo","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/BF02244004","article-title":"Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat","volume":"100","author":"Caccia","year":"1990","journal-title":"Psychopharmacol. Berl."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0028-3908(97)00010-5","article-title":"Modulation of the discriminative stimulus properties of cocaine: comparison of the effects of fluoxetine with 5-HT1A and 5-HT1B receptor agonists","volume":"36","author":"Callahan","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.drugalcdep.2011.02.011","article-title":"A\u00a0web-based survey on mephedrone","volume":"118","author":"Carhart-Harris","year":"2011","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuropharm.2015.01.003","article-title":"Intravenous self-administration of mephedrone, methylone and MDMA in female rats","volume":"92","author":"Creehan","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF02244175","article-title":"Monoamine reuptake inhibitors enhance the discriminative state induced by cocaine in the rat","volume":"104","author":"Cunningham","year":"1991","journal-title":"Psychopharmacol. Berl."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib17","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1124\/jpet.104.071035","article-title":"Drug discrimination in methamphetamine-trained monkeys: effects of monoamine transporter inhibitors","volume":"311","author":"Czoty","year":"2004","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1124\/jpet.113.208538","article-title":"Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist","volume":"348","author":"Desai","year":"2014","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib19","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.bcp.2013.04.004","article-title":"Substituted methcathinones differ in transporter and receptor interactions","volume":"85","author":"Eshleman","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib20","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/npp.2012.233","article-title":"In\u00a0vivo effects of abused 'bath salt' constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice: drug discrimination, thermoregulation, and locomotor activity","volume":"38","author":"Fantegrossi","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/FBP.0b013e328364166d","article-title":"Locomotor stimulant and discriminative stimulus effects of 'bath salt' cathinones","volume":"24","author":"Gatch","year":"2013","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1527-3458.2004.tb00001.x","article-title":"Review of the pharmacological and clinical profile of rimcazole","volume":"10","author":"Gilmore","year":"2004","journal-title":"CNS. Drug Rev."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1471-4159.1996.66010243.x","article-title":"Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions","volume":"66","author":"Gudelsky","year":"1996","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.pbb.2007.10.003","article-title":"Actions of 3,4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons","volume":"90","author":"Gudelsky","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib25","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1124\/jpet.111.184119","article-title":"4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse","volume":"339","author":"Hadlock","year":"2011","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib26","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00213-015-4142-4","article-title":"Differential effects of 3,4-methylenedioxypyrovalerone (MDPV) and 4-methylmethcathinone (mephedrone) in rats trained to discriminate MDMA or a d-amphetamine\u00a0+ MDMA mixture","volume":"233","author":"Harvey","year":"2016","journal-title":"Psychopharmacol. Berl."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0014-2999(90)90555-K","article-title":"5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents","volume":"177","author":"Hekmatpanah","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib28","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1124\/jpet.111.185025","article-title":"Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and sigma receptors","volume":"339","author":"Hiranita","year":"2011","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib29","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1139\/y81-027","article-title":"Brain distribution and kinetics of desipramine in the rat","volume":"59","author":"Hrdina","year":"1981","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib30","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.drugalcdep.2012.05.011","article-title":"Contrasting effects of d-methamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxypyrovalerone, and 4-methylmethcathinone on wheel activity in rats","volume":"126","author":"Huang","year":"2012","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib31","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1177\/0269881116653106","article-title":"Mephedrone and 3,4-methylenedioxy-methamphetamine: comparative psychobiological effects as reported by recreational polydrug users","volume":"30","author":"Jones","year":"2016","journal-title":"J.\u00a0Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib32","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/syn.890180404","article-title":"In\u00a0vivo biogenic amine efflux in medial prefrontal cortex with imipramine, fluoxetine, and fluvoxamine","volume":"18","author":"Jordan","year":"1994","journal-title":"Synapse"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/hup.2297","article-title":"Substitutional potential of mephedrone: an analysis of the subjective effects","volume":"28","author":"Kapitany-Foveny","year":"2013","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/bcpt.12253","article-title":"Mephedrone, methylone and 3,4-methylenedioxypyrovalerone (MDPV) induce conditioned place preference in mice","volume":"115","author":"Karlsson","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0014-2999(03)01638-8","article-title":"Behavioral effects of rimcazole analogues alone and in combination with cocaine","volume":"468","author":"Katz","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib36","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1111\/j.1476-5381.2011.01499.x","article-title":"Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats","volume":"164","author":"Kehr","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib37","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/dta.313","article-title":"Cathinone derivatives: a review of their chemistry, pharmacology and toxicology","volume":"3","author":"Kelly","year":"2011","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib38","series-title":"Selected Pharmacological Methods. A Pharmacology Primer: Theory, Application, and Methods","first-page":"177","author":"Kenakin","year":"2004"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0024-3205(71)90245-1","article-title":"The metabolism and excretion of delta 9-tetrahydrocannabinol in the rat","volume":"10","author":"Klausner","year":"1971","journal-title":"Life Sci. I"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib40","first-page":"1015","article-title":"Discriminative stimulus properties of cocaine: enhancement by monoamine reuptake blockers","volume":"284","author":"Kleven","year":"1998","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib41","first-page":"444","article-title":"Acute effects of cocaine on spontaneous and discriminative motor functions: relation to route of administration and pharmacokinetics","volume":"257","author":"Lau","year":"1991","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib42","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/0006-2952(73)90028-2","article-title":"Metabolism and distribution of cannabinoids in rats after different methods of administration","volume":"22","author":"Leighty","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib43","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.neuroimage.2009.07.072","article-title":"Study on the neuroprotective effect of fluoxetine against MDMA-induced neurotoxicity on the serotonin transporter in rat brain using micro-PET","volume":"49","author":"Li","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib44","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.drugalcdep.2012.04.021","article-title":"Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation","volume":"126","author":"Lisek","year":"2012","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/hup.2423","article-title":"Deaths of individuals aged 16-24 years in the UK after using mephedrone","volume":"30","author":"Loi","year":"2015","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib46","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00426793","article-title":"A\u00a0comparison of the kinetics of d- and l-amphetamine in the brain of isolated and aggregated rats","volume":"58","author":"Lokiec","year":"1978","journal-title":"Psychopharmacol. Berl."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib47","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0028-3908(01)00116-2","article-title":"Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters","volume":"41","author":"Matsumoto","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib48","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0014-2999(99)00113-2","article-title":"Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity","volume":"370","author":"McCracken","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib49","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0091-3057(91)90005-M","article-title":"3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine","volume":"38","author":"McKenna","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib50","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0376-8716(03)00011-5","article-title":"Discriminative stimulus effects of (-)-ephedrine in rats: analysis with catecholamine transporter and receptor ligands","volume":"70","author":"McMahon","year":"2003","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib94","article-title":"Bath salts: a newly recognized cause of acute kidney injury","volume":"2012","author":"McNeely","year":"2012","journal-title":"Case. Rep. Nephrol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib51","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/jm050797a","article-title":"1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors","volume":"49","author":"Meltzer","year":"2006","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib52","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.toxlet.2011.10.010","article-title":"Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat","volume":"208","author":"Meng","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib53","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0014-2999(91)90355-T","article-title":"Selective sigma ligands block stimulant effects of cocaine","volume":"201","author":"Menkel","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib54","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1124\/jpet.114.214288","article-title":"Differential substitution for the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine and methylphenidate in rats","volume":"350","author":"Mori","year":"2014","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib55","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1177\/0269881113490325","article-title":"High levels of intravenous mephedrone (4-methylmethcathinone) self-administration in rats: neural consequences and comparison with methamphetamine","volume":"27","author":"Motbey","year":"2013","journal-title":"J.\u00a0Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib56","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1369-1600.2011.00384.x","article-title":"Mephedrone (4-methylmethcathinone, 'meow'): acute behavioural effects and distribution of Fos expression in adolescent rats","volume":"17","author":"Motbey","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib57","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s13181-012-0243-1","article-title":"\u201cBath salts\u201d and \u201cplant food\u201d products: the experience of one regional US poison center","volume":"9","author":"Murphy","year":"2013","journal-title":"J.\u00a0Med. Toxicol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib58","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuropharm.2005.04.016","article-title":"Involvement of sigma (sigma) receptors in the acute actions of methamphetamine: receptor binding and behavioral studies","volume":"49","author":"Nguyen","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib59","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.sbi.2010.05.007","article-title":"Substrate and drug binding sites in LeuT","volume":"20","author":"Nyola","year":"2010","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib60","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1038\/npp.2016.75","article-title":"Human pharmacology of mephedrone in comparison with MDMA","volume":"41","author":"Papaseit","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib61","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/bs.irn.2015.02.006","article-title":"\u201cNatural amphetamine\u201d Khat: a cultural tradition or a drug of abuse?","volume":"120","author":"Patel","year":"2015","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib62","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.pbb.2010.03.006","article-title":"Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents","volume":"95","author":"Paterson","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib63","first-page":"718","article-title":"Quantification of synthetic cathinones in rat brain using HILIC-ESI-MS\/MS","volume":"40","author":"Peters","year":"2016","journal-title":"J.\u00a0Anal. Toxicol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib64","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.pbb.2006.09.006","article-title":"Effects of pregnanolone in rats discriminating cocaine","volume":"85","author":"Quinton","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drugalcdep.2014.12.005","article-title":"Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter","volume":"147","author":"Reith","year":"2015","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib66","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s002130051022","article-title":"Self-administration of cocaine analogs by rats","volume":"144","author":"Roberts","year":"1999","journal-title":"Psychopharmacol. Berl."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib67","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/npp.2014.325","article-title":"'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function","volume":"40","author":"Saha","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib68","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00213-010-2070-x","article-title":"Mephedrone (4-methylmethcathinone; 'meow meow'): chemical, pharmacological and clinical issues","volume":"214","author":"Schifano","year":"2011","journal-title":"Psychopharmacol. Berl."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib69","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0091-3057(98)00103-8","article-title":"Effect of 3,4-methylenedioxymethamphetamine (MDMA) on hippocampal dopamine and serotonin","volume":"61","author":"Shankaran","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib70","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1476-5381.2012.02145.x","article-title":"Pharmacological characterization of designer cathinones in\u00a0vitro","volume":"168","author":"Simmler","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib71","doi-asserted-by":"crossref","first-page":"288","DOI":"10.12659\/AJCR.889381","article-title":"\u201cBath salts\u201d induced severe reversible cardiomyopathy","volume":"14","author":"Sivagnanam","year":"2013","journal-title":"Am. J. Case. Rep."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib72","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12399","article-title":"Cocaine-like discriminative stimulus effects of alpha-pyrrolidinovalerophenone, methcathinone and their 3,4-methylenedioxy or 4-methyl analogs in rhesus monkeys","author":"Smith","year":"2016","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib73","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00213-010-1789-8","article-title":"Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D(2)-induced formation of anandamide","volume":"209","author":"Solinas","year":"2010","journal-title":"Psychopharmacol. Berl."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib74","first-page":"53","article-title":"Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys","volume":"275","author":"Spealman","year":"1995","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib75","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/jpet.115.229559","article-title":"Abuse-Related neurochemical effects of para-substituted methcathinone analogs in rats: microdialysis studies of nucleus accumbens dopamine and serotonin","volume":"356","author":"Suyama","year":"2016","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib76","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00213-006-0576-z","article-title":"The effects of fluoxetine on the subjective and physiological effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans","volume":"189","author":"Tancer","year":"2007","journal-title":"Psychopharmacol. Berl."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib77","first-page":"1041","article-title":"Pharmacological characterization of the novel discriminative stimulus effects of a low dose of cocaine","volume":"270","author":"Terry","year":"1994","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib78","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1901\/jeab.1983.39-175","article-title":"Drug effects on repeated acquisition: comparison of cumulative and non-cumulative dosing","volume":"39","author":"Thompson","year":"1983","journal-title":"J.\u00a0Exp. Anal. Behav."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib79","doi-asserted-by":"crossref","first-page":"L129","DOI":"10.1016\/0024-3205(92)90466-3","article-title":"Sigma (sigma) antagonist BMY 14802 prevents methamphetamine-induced sensitization","volume":"50","author":"Ujike","year":"1992","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib80","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-2999(95)00693-1","article-title":"Sigma Receptor antagonists block the development of sensitization to cocaine","volume":"296","author":"Ujike","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib81","first-page":"717","article-title":"Antiphencyclidine monoclonal antibody therapy significantly changes phencyclidine concentrations in brain and other tissues in rats","volume":"278","author":"Valentine","year":"1996","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib82","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.neuropharm.2015.08.030","article-title":"Intravenous self-administration of entactogen-class stimulants in male rats","volume":"99","author":"Vandewater","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib83","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00213-012-2855-1","article-title":"Comparison of the behavioral and cardiovascular effects of mephedrone with other drugs of abuse in rats","volume":"225","author":"Varner","year":"2013","journal-title":"Psychopharmacol. Berl."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib84","first-page":"567","article-title":"Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats","volume":"52","author":"Veilleux-Lemieux","year":"2013","journal-title":"J.\u00a0Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib85","first-page":"382","article-title":"Pharmacokinetics of methylphenidate in man, rat and monkey","volume":"226","author":"Wargin","year":"1983","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib86","series-title":"Metabolism of Heroin and its pharmacologic implications","first-page":"25","author":"Way","year":"1965"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib87","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/jcph.742","article-title":"Mephedrone and 3,4-methylenedioxypyrovalerone (MDPV): synthetic cathinones with serious health implications","volume":"56","author":"White","year":"2016","journal-title":"J.\u00a0Clin. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib88","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1111\/j.1360-0443.2011.03502.x","article-title":"Mephedrone: use, subjective effects and health risks","volume":"106","author":"Winstock","year":"2011","journal-title":"Addiction"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib89","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1360-0443.2010.03130.x","article-title":"Mephedrone, new kid for the chop?","volume":"106","author":"Winstock","year":"2011","journal-title":"Addiction"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib90","doi-asserted-by":"crossref","first-page":"e44652","DOI":"10.1371\/journal.pone.0044652","article-title":"Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats","volume":"7","author":"Wright","year":"2012","journal-title":"PLoS. One"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib91","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3109\/15563650.2012.729667","article-title":"Monitoring a toxicological outbreak using Internet search query data","volume":"50","author":"Yin","year":"2012","journal-title":"Clin. Toxicol. (Phila)"},{"key":"10.1016\/j.neuropharm.2017.04.006_bib92","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0969-8051(02)00306-2","article-title":"Pharmacokinetics and brain distribution in non human primate of R(-)[123I]DOI, A 5HT(2A\/2C) serotonin agonist","volume":"29","author":"Zea-Ponce","year":"2002","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.neuropharm.2017.04.006_bib93","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1126\/science.1147614","article-title":"LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake","volume":"317","author":"Zhou","year":"2007","journal-title":"Science"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390817301478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390817301478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T17:59:24Z","timestamp":1535911164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390817301478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":94,"alternative-id":["S0028390817301478"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2017.04.006","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2017.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}