{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:52:04Z","timestamp":1792716724142,"version":"4.5.0"},"reference-count":259,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT130101215"],"award-info":[{"award-number":["FT130101215"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.neuropharm.2017.04.014","type":"journal-article","created":{"date-parts":[[2017,4,14]],"date-time":"2017-04-14T13:01:02Z","timestamp":1492174862000},"page":"87-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["The pharmacology of voltage-gated sodium channel activators"],"prefix":"10.1016","volume":"127","author":[{"given":"Jennifer R.","family":"Deuis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-1310","authenticated-orcid":false,"given":"Alexander","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde R.","family":"Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-9588","authenticated-orcid":false,"given":"Irina","family":"Vetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2017.04.014_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1085\/jgp.201511492","article-title":"The hitchhiker's guide to the voltage-gated sodium channel galaxy","volume":"147","author":"Ahern","year":"2016","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib2","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/hmg\/ddm160","article-title":"A\u00a0stop codon mutation in SCN9A causes lack of pain sensation","volume":"16","author":"Ahmad","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib3","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1126\/science.172.3987.995","article-title":"Batrachotoxin: chemistry and pharmacology","volume":"172","author":"Albuquerque","year":"1971","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib4","doi-asserted-by":"crossref","first-page":"12933","DOI":"10.1021\/bi030091n","article-title":"Synthesis and characterization of delta-atracotoxin-Ar1a, the lethal neurotoxin from venom of the Sydney funnel-web spider (Atrax robustus)","volume":"42","author":"Alewood","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib5","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1074\/jbc.M309576200","article-title":"A\u00a0delta-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles","volume":"279","author":"Barbier","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1073\/pnas.77.1.639","article-title":"Covalent labeling of protein components of the sodium channel with a photoactivable derivative of scorpion toxin","volume":"77","author":"Beneski","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1074\/jbc.273.1.80","article-title":"A\u00a0specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B","volume":"273","author":"Benzinger","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib8","doi-asserted-by":"crossref","first-page":"8353","DOI":"10.1016\/S0021-9258(17)39735-1","article-title":"Ciguatoxin is a novel type of Na+ channel toxin","volume":"259","author":"Bidard","year":"1984","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0169-328X(96)00163-5","article-title":"Spinal sensory neurons express multiple sodium channel alpha-subunit mRNAs","volume":"43","author":"Black","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib10","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neuron.2013.09.012","article-title":"Noncanonical roles of voltage-gated sodium channels","volume":"80","author":"Black","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-5793(02)03653-0","article-title":"The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins","volume":"532","author":"Bosmans","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.febslet.2004.10.017","article-title":"The poison Dart frog's batrachotoxin modulates Nav1.8","volume":"577","author":"Bosmans","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib13","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature07473","article-title":"Deconstructing voltage sensor function and pharmacology in sodium channels","volume":"456","author":"Bosmans","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.toxicon.2006.09.023","article-title":"Voltage-gated sodium channel modulation by scorpion alpha-toxins","volume":"49","author":"Bosmans","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib15","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0041-0101(03)00088-6","article-title":"Type B brevetoxins show tissue selectivity for voltage-gated sodium channels: comparison of brain, skeletal muscle and cardiac sodium channels","volume":"41","author":"Bottein Dechraoui","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fphar.2011.00053","article-title":"Na channel beta subunits: overachievers of the ion channel family","volume":"2","author":"Brackenbury","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib17","doi-asserted-by":"crossref","first-page":"9929","DOI":"10.1021\/bi700797f","article-title":"Structure and sodium channel activity of an excitatory I1-superfamily conotoxin","volume":"46","author":"Buczek","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib18","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1073\/pnas.090034797","article-title":"Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses","volume":"97","author":"Caldwell","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib19","doi-asserted-by":"crossref","first-page":"e0128578","DOI":"10.1371\/journal.pone.0128578","article-title":"The scorpion toxin Tf2 from Tityus fasciolatus promotes Nav1.3 opening","volume":"10","author":"Camargos","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib20","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/sj.bjp.0705793","article-title":"Voltage-dependent displacement of the scorpion toxin Ts3 from sodium channels and its implication on the control of inactivation","volume":"142","author":"Campos","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib21","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1113\/jphysiol.2010.186874","article-title":"Voltage-sensor mutations in channelopathies of skeletal muscle","volume":"588","author":"Cannon","year":"2010","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/1471-2202-11-154","article-title":"Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 alpha subunits","volume":"11","author":"Cao","year":"2010","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib23","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1073\/pnas.72.5.1782","article-title":"Cooperative activation of action potential Na+ ionophore by neurotoxins","volume":"72","author":"Catterall","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib24","doi-asserted-by":"crossref","first-page":"8660","DOI":"10.1016\/S0021-9258(19)75272-7","article-title":"Membrane potential-dependent binding of scorpion toxin to the action potential Na+ ionophore. Studies with a toxin derivative prepared by lactoperoxidase-catalyzed iodination","volume":"252","author":"Catterall","year":"1977","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)81133-2","article-title":"From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels","volume":"26","author":"Catterall","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib26","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1113\/jphysiol.2011.224204","article-title":"Voltage-gated sodium channels at 60: structure, function and pathophysiology","volume":"590","author":"Catterall","year":"2012","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1113\/expphysiol.2013.071969","article-title":"Structure and function of voltage-gated sodium channels at atomic resolution","volume":"99","author":"Catterall","year":"2014","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib28","doi-asserted-by":"crossref","first-page":"7393","DOI":"10.1016\/S0021-9258(17)34513-1","article-title":"Sea anemone toxin and scorpion toxin share a common receptor site associated with the action potential sodium ionophore","volume":"253","author":"Catterall","year":"1978","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1124\/pr.57.4.4","article-title":"International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib30","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","article-title":"Molecular mechanisms of neurotoxin action on voltage-gated sodium channels","volume":"82","author":"Cestele","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib31","first-page":"919","article-title":"Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II","volume":"21","author":"Cestele","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib32","doi-asserted-by":"crossref","first-page":"21332","DOI":"10.1074\/jbc.M603814200","article-title":"Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin","volume":"281","author":"Cestele","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib33","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1085\/jgp.20028679","article-title":"Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation","volume":"120","author":"Chanda","year":"2002","journal-title":"J.\u00a0General Physiology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib34","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1113\/jphysiol.1965.sp007732","article-title":"Voltage clamp experiments on internally perfused giant axons","volume":"180","author":"Chandler","year":"1965","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib35","first-page":"423","article-title":"Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and Lqh alphaIT","volume":"439","author":"Chen","year":"2000","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib36","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1085\/jgp.117.6.505","article-title":"Interaction of scorpion alpha-toxins with cardiac sodium channels: binding properties and enhancement of slow inactivation","volume":"117","author":"Chen","year":"2001","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib37","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1046\/j.1460-9568.2002.02142.x","article-title":"Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3","volume":"16","author":"Chen","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib38","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00018-008-8135-x","article-title":"Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao","volume":"65","author":"Chen","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib39","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1086\/320609","article-title":"De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy","volume":"68","author":"Claes","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib40","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/j.1742-4658.2012.08545.x","article-title":"Investigation of the relationship between the structure and function of Ts2, a neurotoxin from Tityus serrulatus venom","volume":"279","author":"Cologna","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0014-5793(03)00666-5","article-title":"Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel","volume":"547","author":"Corzo","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib42","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1074\/jbc.M605403200","article-title":"Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels","volume":"282","author":"Corzo","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0041-0101(82)90138-6","article-title":"Two types of scorpion receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel","volume":"20","author":"Couraud","year":"1982","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib44","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature05413","article-title":"An SCN9A channelopathy causes congenital inability to experience pain","volume":"444","author":"Cox","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib45","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.6246586","article-title":"Levels of batrachotoxin and lack of sensitivity to its action in poison-dart frogs (Phyllobates)","volume":"208","author":"Daly","year":"1980","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib46","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0041-0101(94)90335-2","article-title":"An uptake system for dietary alkaloids in poison frogs (Dendrobatidae)","volume":"32","author":"Daly","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib47","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1021\/ja01079a026","article-title":"Batrachotoxin. The active principle of the Colombian arrow poison frog, Phyllobates bicolor","volume":"87","author":"Daly","year":"1965","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib48","doi-asserted-by":"crossref","first-page":"7093","DOI":"10.1021\/jm501981g","article-title":"Voltage-gated sodium channels: structure, function, pharmacology, and clinical indications","volume":"58","author":"de Lera Ruiz","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib49","doi-asserted-by":"crossref","first-page":"11829","DOI":"10.1074\/jbc.M116.721662","article-title":"Development of a muo-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic sodium channel NaV1.8","volume":"291","author":"Deuis","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib50","doi-asserted-by":"crossref","first-page":"40883","DOI":"10.1038\/srep40883","article-title":"Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a","volume":"7","author":"Deuis","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib51","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1021\/acschemneuro.5b00113","article-title":"Activation of kappa opioid receptors in cutaneous nerve endings by Conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia","volume":"6","author":"Deuis","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/toxins8030078","article-title":"Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-mediated pain","volume":"8","author":"Deuis","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib53","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.pain.2013.05.032","article-title":"An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways","volume":"154","author":"Deuis","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib54","first-page":"511","volume":"16","author":"Dib-Hajj","year":"2015","journal-title":"NaV1.9 a sodium channel linked Hum. pain. Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib55","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neulet.2010.08.077","article-title":"Isoform-specific and pan-channel partners regulate trafficking and plasma membrane stability; and alter sodium channel gating properties","volume":"486","author":"Dib-Hajj","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib56","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrn3404","article-title":"The Na(V)1.7 sodium channel: from molecule to man","volume":"14","author":"Dib-Hajj","year":"2013","journal-title":"Nature Reviews: Neuroscience"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib57","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0140-6736(05)66786-4","article-title":"Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine","volume":"366","author":"Dichgans","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib58","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrd2552","article-title":"High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology","volume":"7","author":"Dunlop","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib59","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1021\/cb400012k","article-title":"Chemical engineering and structural and pharmacological characterization of the \u03b1-scorpion toxin OD1","volume":"8","author":"Durek","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib60","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1021\/cb400012k","article-title":"Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1","volume":"8","author":"Durek","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib61","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1074\/mcp.M112.021469","article-title":"Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom","volume":"12","author":"Dutertre","year":"2013","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib62","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/brain\/aws225","article-title":"Neurological perspectives on voltage-gated sodium channels","volume":"135","author":"Eijkelkamp","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib63","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.biocel.2007.08.017","article-title":"Conotoxin modulation of voltage-gated sodium channels","volume":"40","author":"Ekberg","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib64","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1124\/mol.62.1.48","article-title":"Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies","volume":"62","author":"Escoubas","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib65","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/ana.22485","article-title":"Gain of function Nanu1.7 mutations in idiopathic small fiber neuropathy","volume":"71","author":"Faber","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib66","doi-asserted-by":"crossref","first-page":"19444","DOI":"10.1073\/pnas.1216080109","article-title":"Gain-of-function Nav1.8 mutations in painful neuropathy","volume":"109","author":"Faber","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib67","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/S0021-9258(17)41983-1","article-title":"A\u00a0new neurotoxin receptor site on sodium channels is identified by a conotoxin that affects sodium channel inactivation in molluscs and acts as an antagonist in rat brain","volume":"269","author":"Fainzilber","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib68","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s00424-007-0365-5","article-title":"A\u00a0comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglion neurons","volume":"455","author":"Farrag","year":"2008","journal-title":"Pfl\u00fcgers Archiv. Eur. J. Physiology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib69","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.neuron.2006.10.006","article-title":"SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes","volume":"52","author":"Fertleman","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib70","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.bcp.2008.03.019","article-title":"Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7","volume":"75","author":"Fiedler","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib71","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1085\/jgp.111.6.703","article-title":"Inactivation and secondary structure in the D4\/S4-5 region of the SkM1 sodium channel","volume":"111","author":"Filatov","year":"1998","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib72","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1021\/acsmedchemlett.5b00447","article-title":"Discovery of aryl sulfonamides as isoform-selective inhibitors of NaV1.7 with efficacy in rodent pain models","volume":"7","author":"Focken","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib73","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3390\/md10081812","article-title":"Sea anemone (Cnidaria, Anthozoa, Actiniaria) toxins: an overview","volume":"10","author":"Frazao","year":"2012","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib74","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/cne.21786","article-title":"Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons","volume":"510","author":"Fukuoka","year":"2008","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib75","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neures.2011.01.020","article-title":"Comparative study of voltage-gated sodium channel alpha-subunits in non-overlapping four neuronal populations in the rat dorsal root ganglion","volume":"70","author":"Fukuoka","year":"2011","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib76","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1073\/pnas.1324189111","article-title":"A\u00a0disulfide tether stabilizes the block of sodium channels by the conotoxin muO section sign-GVIIJ","volume":"111","author":"Gajewiak","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib77","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s004240050924","article-title":"Voltage-dependent gating of veratridine-modified RIIA Na+ channel alpha subunit expressed heterologously in CHO cells","volume":"438","author":"Ghatpande","year":"1999","journal-title":"Pfl\u00fcgers Archiv. Eur. J. Physiology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib78","doi-asserted-by":"crossref","first-page":"E5016","DOI":"10.1073\/pnas.1314557110","article-title":"Crystallographic insights into sodium-channel modulation by the beta4 subunit","volume":"110","author":"Gilchrist","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib79","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1046\/j.1471-4159.2000.0751735.x","article-title":"Structural implications on the interaction of scorpion alpha-like toxins with the sodium channel receptor site inferred from toxin iodination and pH-dependent binding","volume":"75","author":"Gilles","year":"2000","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib80","doi-asserted-by":"crossref","first-page":"584","DOI":"10.5694\/j.1326-5377.1986.tb139504.x","article-title":"Ciguatera in Australia. Occurrence, clinical features, pathophysiology and management","volume":"145","author":"Gillespie","year":"1986","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib81","doi-asserted-by":"crossref","first-page":"e105895","DOI":"10.1371\/journal.pone.0105895","article-title":"Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain","volume":"9","author":"Gingras","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib82","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1399-0004.2007.00790.x","article-title":"Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations","volume":"71","author":"Goldberg","year":"2007","journal-title":"Clin. Genet."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib83","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1749-6632.1999.tb11272.x","article-title":"Diversity of mammalian voltage-gated sodium channels","volume":"868","author":"Goldin","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib84","doi-asserted-by":"crossref","first-page":"7503","DOI":"10.1073\/pnas.83.19.7503","article-title":"Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes","volume":"83","author":"Goldin","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib85","doi-asserted-by":"crossref","first-page":"8034","DOI":"10.1074\/jbc.271.14.8034","article-title":"Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels","volume":"271","author":"Gordon","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib86","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/bs.ctm.2016.07.001","article-title":"Venom peptides from cone snails: pharmacological probes for voltage-gated sodium channels","volume":"78","author":"Green","year":"2016","journal-title":"Curr. Top. Membr."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib87","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ajem.2006.01.022","article-title":"Mad honey poisoning","volume":"24","author":"Gunduz","year":"2006","journal-title":"Am. J. Emerg. Med."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib88","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0014-5793(03)01175-X","article-title":"Isolation of delta-missulenatoxin-Mb1a, the major vertebrate-active spider delta-toxin from the venom of Missulena bradleyi (Actinopodidae)","volume":"554","author":"Gunning","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib89","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1073\/pnas.83.2.508","article-title":"Molecular model of the action potential sodium channel","volume":"83","author":"Guy","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib90","doi-asserted-by":"crossref","first-page":"8881","DOI":"10.1523\/JNEUROSCI.23-26-08881.2003","article-title":"Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury","volume":"23","author":"Hains","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib91","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1093\/brain\/awh623","article-title":"Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury","volume":"128","author":"Hains","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib92","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.2174\/138161208785777469","article-title":"Conus venoms - a rich source of peptide-based therapeutics","volume":"14","author":"Han","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib93","doi-asserted-by":"crossref","first-page":"13888","DOI":"10.1016\/S0021-9258(19)45312-X","article-title":"The saxitoxin receptor of the sodium channel from rat brain. Evidence for two nonidentical beta subunits","volume":"257","author":"Hartshorne","year":"1982","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib94","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.pain.2010.06.005","article-title":"TNF-alpha contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury","volume":"151","author":"He","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib95","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0140-6736(02)09968-3","article-title":"Sodium-channel defects in benign familial neonatal-infantile seizures","volume":"360","author":"Heron","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib96","doi-asserted-by":"crossref","first-page":"D653","DOI":"10.1093\/nar\/gkq1058","article-title":"ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures","volume":"39","author":"Herzig","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib97","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1085\/jgp.59.6.637","article-title":"The permeability of the sodium channel to metal cations in myelinated nerve","volume":"59","author":"Hille","year":"1972","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib98","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nature14958","article-title":"Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel","volume":"527","author":"Hite","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib99","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nn0602-856","article-title":"Na(x) channel involved in CNS sodium-level sensing","volume":"5","author":"Hiyama","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib100","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1113\/jphysiol.1952.sp004718","article-title":"The components of membrane conductance in the giant axon of Loligo","volume":"116","author":"Hodgkin","year":"1952","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib101","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1113\/jphysiol.1952.sp004717","article-title":"Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo","volume":"116","author":"Hodgkin","year":"1952","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib102","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1113\/jphysiol.1952.sp004719","article-title":"The dual effect of membrane potential on sodium conductance in the giant axon of Loligo","volume":"116","author":"Hodgkin","year":"1952","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib103","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1113\/jphysiol.1952.sp004764","article-title":"A\u00a0quantitative description of membrane current and its application to conduction and excitation in nerve","volume":"117","author":"Hodgkin","year":"1952","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib104","article-title":"Scorpion toxin peptide action at the ion channel subunit level","author":"Housley","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib105","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.peptides.2015.03.012","article-title":"Molecular basis of the inhibition of the fast inactivation of voltage-gated sodium channel Nav1.5 by tarantula toxin Jingzhaotoxin-II","volume":"68","author":"Huang","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib106","doi-asserted-by":"crossref","first-page":"42810","DOI":"10.1038\/srep42810","article-title":"Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1","volume":"7","author":"Inserra","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib107","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0041-0101(96)00143-2","article-title":"Halcurin, a polypeptide toxin from the sea anemone Halcurias sp., with a structural resemblance to type 1 and 2 toxins","volume":"35","author":"Ishida","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib108","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2170\/jjphysiol.49.457","article-title":"Point-mutations related to the loss of batrachotoxin binding abolish the grayanotoxin effect in Na(+) channel isoforms","volume":"49","author":"Ishii","year":"1999","journal-title":"Jpn. J. Physiology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib109","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1172\/JCI40801","article-title":"Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents","volume":"120","author":"Jarecki","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib110","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0022-3565(24)37263-5","article-title":"Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons","volume":"284","author":"Jeglitsch","year":"1998","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib111","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1046\/j.1471-4159.2003.01685.x","article-title":"Novel excitatory Conus peptides define a new conotoxin superfamily","volume":"85","author":"Jimenez","year":"2003","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib112","article-title":"delta-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails","volume":"vol. 282","author":"Jin","year":"2015"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib113","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1021\/bi00544a010","article-title":"Binding of scorpion toxins to rat brain synaptosomal fraction. Effects of membrane potential, ions, and other neurotoxins","volume":"19","author":"Jover","year":"1980","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib114","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0006-291X(80)80082-9","article-title":"Two types of scorpion neurotoxins characterized by their binding to two separate receptor sites on rat brain synaptosomes","volume":"95","author":"Jover","year":"1980","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib115","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00424-010-0814-4","article-title":"Sodium channelopathies of skeletal muscle result from gain or loss of function","volume":"460","author":"Jurkat-Rott","year":"2010","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib116","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1085\/jgp.200709946","article-title":"Ion channels as drug targets: the next GPCRs","volume":"131","author":"Kaczorowski","year":"2008","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib117","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jmb.2014.07.027","article-title":"From foe to friend: using animal toxins to investigate ion channel function","volume":"427","author":"Kalia","year":"2015","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib118","doi-asserted-by":"crossref","first-page":"30531","DOI":"10.1074\/jbc.M110.150888","article-title":"Partial agonist and antagonist activities of a mutant scorpion \u03b2-toxin on sodium channels","volume":"285","author":"Karbat","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib119","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0169-328X(02)00388-1","article-title":"Downregulation of voltage-gated potassium channel alpha gene expression in dorsal root ganglia following chronic constriction injury of the rat sciatic nerve","volume":"105","author":"Kim","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib120","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0014-5793(99)01715-9","article-title":"On site of action of grayanotoxin in domain 4 segment 6 of rat skeletal muscle sodium channel","volume":"465","author":"Kimura","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib121","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0026-895X(24)12315-2","article-title":"Novel site on sodium channel alpha-subunit responsible for the differential sensitivity of grayanotoxin in skeletal and cardiac muscle","volume":"60","author":"Kimura","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib122","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.toxicon.2008.05.020","article-title":"A\u00a0rational nomenclature for naming peptide toxins from spiders and other venomous animals","volume":"52","author":"King","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib123","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.toxicon.2010.07.010","article-title":"Structure, function and evolution of three-finger toxins: mini proteins with multiple targets","volume":"56","author":"Kini","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib124","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1124\/mol.59.6.1457","article-title":"Novel wasp toxin discriminates between neuronal and cardiac sodium channels","volume":"59","author":"Kinoshita","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib125","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.toxicon.2012.04.337","article-title":"Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads","volume":"60","author":"Klint","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib126","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1006\/bbrc.1998.9299","article-title":"Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms","volume":"250","author":"Konno","year":"1998","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib127","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0304-3940(00)01017-X","article-title":"Molecular determinants of binding of a wasp toxin (PMTXs) and its analogs in the Na+ channels proteins","volume":"285","author":"Konno","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib128","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1085\/jgp.110.4.391","article-title":"Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains","volume":"110","author":"Kontis","year":"1997","journal-title":"J.\u00a0General Physiology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib129","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1085\/jgp.114.2.167","article-title":"Movement of voltage sensor S4 in domain 4 is tightly coupled to sodium channel fast inactivation and gating charge immobilization","volume":"114","author":"Kuhn","year":"1999","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbagen.2005.01.008","article-title":"Expression of the standard scorpion alpha-toxin AaH II and AaH II mutants leading to the identification of some key bioactive elements","volume":"1723","author":"Legros","year":"2005","journal-title":"Biochimica Biophysica Acta (BBA) - General Subj."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib131","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1124\/mol.106.024034","article-title":"Subtype specificity of scorpion beta-toxin Tz1 interaction with voltage-gated sodium channels is determined by the pore loop of domain 3","volume":"70","author":"Leipold","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib132","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1016\/j.febslet.2005.05.077","article-title":"Molecular interaction of delta-conotoxins with voltage-gated sodium channels","volume":"579","author":"Leipold","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib133","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1124\/mol.65.3.685","article-title":"Combinatorial interaction of scorpion toxins Lqh-2, Lqh-3, and LqhalphaIT with sodium channel receptor sites-3","volume":"65","author":"Leipold","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib134","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbr.2009.11.023","article-title":"Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice","volume":"208","author":"Leo","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib135","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1085\/jgp.201310984","article-title":"Interactions among DIV voltage-sensor movement, fast inactivation, and resurgent Na current induced by the NaVbeta4 open-channel blocking peptide","volume":"142","author":"Lewis","year":"2013","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib136","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.toxicon.2006.07.019","article-title":"Ciguatera: australian perspectives on a global problem","volume":"48","author":"Lewis","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib137","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1124\/pr.111.005322","article-title":"Conus venom peptide pharmacology","volume":"64","author":"Lewis","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib138","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jhazmat.2016.10.056","article-title":"Global occurrence of pyrethroid insecticides in sediment and the associated toxicological effects on benthic invertebrates: an overview","volume":"324","author":"Li","year":"2017","journal-title":"J.\u00a0Hazard. Mater."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib139","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0026-895X(24)12342-5","article-title":"The batrachotoxin receptor on the voltage-gated sodium channel is guarded by the channel activation gate","volume":"61","author":"Li","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib140","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nsmb.2768","article-title":"Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain","volume":"21","author":"Li","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib141","doi-asserted-by":"crossref","first-page":"7599","DOI":"10.1073\/pnas.121085898","article-title":"Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels","volume":"98","author":"Li","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib142","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1212\/WNL.0b013e3181f8812e","article-title":"SCN2A mutation associated with neonatal epilepsy, late-onset episodic ataxia, myoclonus, and pain","volume":"75","author":"Liao","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib143","doi-asserted-by":"crossref","first-page":"27076","DOI":"10.1074\/jbc.273.42.27076","article-title":"delta-Atracotoxins from australian funnel-web spiders compete with scorpion alpha-toxin binding but differentially modulate alkaloid toxin activation of voltage-gated sodium channels","volume":"273","author":"Little","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib144","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1126\/science.aag2981","article-title":"Asymmetric synthesis of batrachotoxin: enantiomeric toxins show functional divergence against NaV","volume":"354","author":"Logan","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib145","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0014-5793(87)80252-1","article-title":"Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage-dependent Na+ channel","volume":"219","author":"Lombet","year":"1987","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib146","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/bs.apha.2015.12.006","article-title":"Sodium channels in pain and cancer: new therapeutic opportunities","volume":"75","author":"Luiz","year":"2016","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib147","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/mol.106.022970","article-title":"Potent modulation of the voltage-gated sodium channel Nav1.7 by OD1, a toxin from the scorpion Odonthobuthus doriae","volume":"70","author":"Maertens","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib148","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/mol.106.022970","article-title":"Potent modulation of the voltage-gated sodium channel Nav1. 7 by OD1, a toxin from the scorpion Odonthobuthus doriae","volume":"70","author":"Maertens","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib149","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1474-4422(10)70059-4","article-title":"Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders","volume":"9","author":"Mantegazza","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib150","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1002\/1873-3468.12357","article-title":"The scorpion toxin Bot IX is a potent member of the \u03b1-like family and has a unique N-terminal sequence extension","volume":"590","author":"Martin-Eauclaire","year":"2016","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib151","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ncomms2077","article-title":"Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing","volume":"3","author":"McCusker","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib152","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1074\/jbc.273.2.1121","article-title":"A\u00a0critical role for the S4-S5 intracellular loop in domain IV of the sodium channel alpha-subunit in fast inactivation","volume":"273","author":"McPhee","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib153","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cardiores.2005.04.003","article-title":"Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes","volume":"67","author":"Meadows","year":"2005","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib154","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1161\/CIRCULATIONAHA.106.659086","article-title":"SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome","volume":"116","author":"Medeiros-Domingo","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib155","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1177\/107385840100700208","article-title":"Sodium channels and neurological disease: insights from Scn8a mutations in the mouse","volume":"7","author":"Meisler","year":"2001","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib156","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.celrep.2013.12.033","article-title":"Pain without nociceptors? Nav1.7-independent pain mechanisms","volume":"6","author":"Minett","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib157","first-page":"9","article-title":"Role in fast inactivation of conserved amino acids in the IV\/S4-S5 loop of the human muscle Na+ channel","volume":"214","author":"Mitrovic","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib158","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.toxicon.2009.02.028","article-title":"Sea anemone toxins affecting voltage-gated sodium channels\u2013molecular and evolutionary features","volume":"54","author":"Moran","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib159","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1042\/BJ20070233","article-title":"Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na+ channels","volume":"406","author":"Moran","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib160","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/19336950.2015.1120392","article-title":"Modulation of human Nav1.7 channel gating by synthetic alpha-scorpion toxin OD1 and its analogs","volume":"10","author":"Motin","year":"2016","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib161","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1021\/acs.jmedchem.5b01947","article-title":"Single residue substitutions that confer voltage-gated sodium ion channel subtype selectivity in the NaV1.7 inhibitory peptide GpTx-1","volume":"59","author":"Murray","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib162","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0041-0101(85)90031-5","article-title":"The chemistry of brevetoxins: a review","volume":"23","author":"Nakanishi","year":"1985","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib163","doi-asserted-by":"crossref","first-page":"140192","DOI":"10.1098\/rsob.140192","article-title":"A\u00a0new look at sodium channel beta subunits","volume":"5","author":"Namadurai","year":"2015","journal-title":"Open Biol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib164","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0041-0101(96)00089-X","article-title":"Selective alteration of sodium channel gating by Australian funnel-web spider toxins","volume":"34","author":"Nicholson","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s004240050612","article-title":"Characterisation of the effects of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, on sodium channel activation and inactivation","volume":"436","author":"Nicholson","year":"1998","journal-title":"Pfl\u00fcgers Archiv. Eur. J. Physiology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib166","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/320188a0","article-title":"Existence of distinct sodium channel messenger RNAs in rat brain","volume":"320","author":"Noda","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib167","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/312121a0","article-title":"Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence","volume":"312","author":"Noda","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib168","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0041-0101(91)90205-6","article-title":"Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel","volume":"29","author":"Norton","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib169","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/ana.24331","article-title":"Sodium channel slow inactivation as a therapeutic target for myotonia congenita","volume":"77","author":"Novak","year":"2015","journal-title":"Ann. Neurology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib170","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev-physiol-021014-071846","article-title":"Sodium channel beta subunits: emerging targets in channelopathies","volume":"77","author":"O'Malley","year":"2015","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib171","doi-asserted-by":"crossref","first-page":"33323","DOI":"10.1074\/jbc.M404344200","article-title":"Binding specificity of sea anemone toxins to Nav 1.1-1.6 sodium channels: unexpected contributions from differences in the IV\/S3-S4 outer loop","volume":"279","author":"Oliveira","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib172","doi-asserted-by":"crossref","first-page":"8281","DOI":"10.1021\/ja00136a031","article-title":"Antillatoxin: an exceptionally ichthyotoxic cyclic lipopeptide from the tropical cyanobacterium Lyngbya majuscula","volume":"117","author":"Orjala","year":"1995","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib173","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nature17976","article-title":"Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain","volume":"534","author":"Osteen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib174","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2010.06.050","article-title":"Electrophysiology and beyond: multiple roles of Na+ channel beta subunits in development and disease","volume":"486","author":"Patino","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib175","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nature11077","article-title":"Crystal structure of a voltage-gated sodium channel in two potentially inactivated states","volume":"486","author":"Payandeh","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib176","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature10238","article-title":"The crystal structure of a voltage-gated sodium channel","volume":"475","author":"Payandeh","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib177","doi-asserted-by":"crossref","first-page":"572","DOI":"10.2741\/4121","article-title":"Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects","volume":"18","author":"Pedraza Escalona","year":"2013","journal-title":"Front. Biosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib178","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neuropharm.2015.03.027","article-title":"A\u00a0gamut of undiscovered electrophysiological effects produced by Tityus serrulatus toxin 1 on NaV-type isoforms","volume":"95","author":"Peigneur","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib179","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neuropharm.2015.03.027","article-title":"A\u00a0gamut of undiscovered electrophysiological effects produced by Tityus serrulatus toxin 1 on NaV-type isoforms","volume":"95","author":"Peigneur","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib180","first-page":"909","article-title":"Brevetoxin modulates neuronal sodium channels in two cell lines derived from rat brain","volume":"20","author":"Purkerson","year":"1999","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib181","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1523\/JNEUROSCI.17-12-04517.1997","article-title":"Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons","volume":"17","author":"Raman","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib182","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0896-6273(00)80969-1","article-title":"Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice","volume":"19","author":"Raman","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib183","first-page":"349","article-title":"Modification of alpha subunit of RIIA sodium channels by aconitine","volume":"439","author":"Rao","year":"2000","journal-title":"Pfl\u00fcgers Archiv. Eur. J. Physiology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib184","doi-asserted-by":"crossref","first-page":"15950","DOI":"10.1074\/jbc.271.27.15950","article-title":"Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit","volume":"271","author":"Rogers","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib185","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/cbdv.200590035","article-title":"Solution structure of delta-Am2766: a highly hydrophobic delta-conotoxin from Conus amadis that inhibits inactivation of neuronal voltage-gated sodium channels","volume":"2","author":"Sarma","year":"2005","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib186","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/35059098","article-title":"The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities","volume":"409","author":"Sato","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib187","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0041-0101(98)00080-4","article-title":"New toxins acting on sodium channels from the scorpion Leiurus quinquestriatus hebraeus suggest a clue to mammalian vs insect selectivity","volume":"36","author":"Sautiere","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib188","doi-asserted-by":"crossref","first-page":"20326","DOI":"10.1074\/jbc.M600565200","article-title":"Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Nav1.6 channel. Significance in mice Purkinje neurons","volume":"281","author":"Schiavon","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib189","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1742-4658.2009.07533.x","article-title":"Voltage-gated sodium channel isoform-specific effects of pompilidotoxins","volume":"277","author":"Schiavon","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib190","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal4326","article-title":"Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution","volume":"355","author":"Shen","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib191","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1186\/1756-3305-7-450","article-title":"Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - a review","volume":"7","author":"Silva","year":"2014","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib192","doi-asserted-by":"crossref","first-page":"6704","DOI":"10.1073\/pnas.1118058109","article-title":"Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current","volume":"109","author":"Sittl","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib193","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.bbamem.2015.03.021","article-title":"Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference","volume":"1848","author":"Slowik","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib194","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.toxicon.2006.09.020","article-title":"Site-3 sea anemone toxins: molecular probes of gating mechanisms in voltage-dependent sodium channels","volume":"49","author":"Smith","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib195","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00246-012-0303-y","article-title":"Cardiac sodium channel Nav1.5 mutations and cardiac arrhythmia","volume":"33","author":"Song","year":"2012","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib196","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2011.00071","article-title":"Neurotoxins and their binding areas on voltage-gated sodium channels","volume":"2","author":"Stevens","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib197","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0022-3565(24)37963-7","article-title":"Differential actions of pacific ciguatoxin-1 on sodium channel subtypes in mammalian sensory neurons","volume":"288","author":"Strachan","year":"1999","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib198","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/339597a0","article-title":"Structural parts involved in activation and inactivation of the sodium channel","volume":"339","author":"Stuhmer","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib199","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1073\/pnas.111065098","article-title":"A\u00a0missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction","volume":"98","author":"Sugawara","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib200","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4155\/ppa.14.39","article-title":"Inhibitors of voltage-gated sodium channel Nav1.7: patent applications since 2010","volume":"3","author":"Sun","year":"2014","journal-title":"Pharm. Pat. Anal."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/15563659309000371","article-title":"Ciguatera","volume":"31","author":"Swift","year":"1993","journal-title":"J.\u00a0Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib202","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0014-5793(00)01339-9","article-title":"Isolation and pharmacological characterisation of delta-atracotoxin-Hv1b, a vertebrate-selective sodium channel toxin","volume":"470","author":"Szeto","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib203","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1085\/jgp.108.2.89","article-title":"Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker","volume":"108","author":"Tang","year":"1996","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib204","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.toxicon.2015.12.009","article-title":"Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels","volume":"111","author":"Tao","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib205","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.toxicon.2012.12.001","article-title":"Molecular determinants for the tarantula toxin jingzhaotoxin-I interacting with potassium channel Kv2.1","volume":"63","author":"Tao","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib206","doi-asserted-by":"crossref","first-page":"e53220","DOI":"10.1371\/journal.pone.0053220","article-title":"A\u00a0novel missense mutation, I890T, in the pore region of cardiac sodium channel causes Brugada syndrome","volume":"8","author":"Tarradas","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib207","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/molbev\/msv350","article-title":"Convergent substitutions in a sodium channel suggest multiple origins of toxin resistance in poison frogs","volume":"33","author":"Tarvin","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib208","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1021\/acschemneuro.6b00212","article-title":"Inhibition of sodium ion channel function with truncated forms of batrachotoxin","volume":"7","author":"Toma","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib209","doi-asserted-by":"crossref","first-page":"19904","DOI":"10.1016\/S0021-9258(17)32105-1","article-title":"Identification of peptide components of the brevetoxin receptor site of rat brain sodium channels","volume":"269","author":"Trainer","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib210","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/jmg.2005.035667","article-title":"Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar atrophy, ataxia, and mental retardation","volume":"43","author":"Trudeau","year":"2006","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib211","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.expneurol.2013.11.011","article-title":"Kv2 dysfunction after peripheral axotomy enhances sensory neuron responsiveness to sustained input","volume":"251","author":"Tsantoulas","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib212","doi-asserted-by":"crossref","first-page":"8147","DOI":"10.1073\/pnas.86.20.8147","article-title":"Inhibition of inactivation of single sodium channels by a site-directed antibody","volume":"86","author":"Vassilev","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib213","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pharmthera.2016.11.015","article-title":"NaV1.7 as a pain target - from gene to pharmacology","volume":"172","author":"Vetter","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib214","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.2174\/156802612802652457","article-title":"Therapeutic potential of cone snail venom peptides (conopeptides)","volume":"12","author":"Vetter","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib215","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.bcp.2012.02.022","article-title":"Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells","volume":"83","author":"Vetter","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib216","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1038\/emboj.2012.207","article-title":"Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling","volume":"31","author":"Vetter","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib217","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/10606820490270410","article-title":"Comparison of the pharmacological properties of rat Na(V)1.8 with rat Na(V)1.2a and human Na(V)1.5 voltage-gated sodium channel subtypes using a membrane potential sensitive dye and FLIPR","volume":"10","author":"Vickery","year":"2004","journal-title":"Recept. Channels"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib218","doi-asserted-by":"crossref","first-page":"21356","DOI":"10.1074\/jbc.M309594200","article-title":"NMR solution structures of delta-conotoxin EVIA from Conus ermineus that selectively acts on vertebrate neuronal Na+ channels","volume":"279","author":"Volpon","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib219","first-page":"705","article-title":"Modification of wild-type and batrachotoxin-resistant muscle mu1 Na+ channels by veratridine","volume":"439","author":"Wang","year":"2000","journal-title":"Pfl\u00fcgers Archiv. Eur. J. Physiology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib220","doi-asserted-by":"crossref","first-page":"15426","DOI":"10.1073\/pnas.1112320108","article-title":"Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib221","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00204-009-0453-8","article-title":"Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents","volume":"83","author":"Wang","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib222","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.toxicon.2008.08.018","article-title":"JZTX-IV, a unique acidic sodium channel toxin isolated from the spider Chilobrachys jingzhao","volume":"52","author":"Wang","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib223","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.bcp.2008.09.008","article-title":"Jingzhaotoxin-II, a novel tarantula toxin preferentially targets rat cardiac sodium channel","volume":"76","author":"Wang","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib224","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/s004240050187","article-title":"Slow inactivation of muscle mu1 Na+ channels in permanently transfected mammalian cells","volume":"432","author":"Wang","year":"1996","journal-title":"Pfl\u00fcgers Archiv. Eur. J. Physiology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib225","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1124\/mol.59.5.1100","article-title":"Disparate role of Na(+) channel D2-S6 residues in batrachotoxin and local anesthetic action","volume":"59","author":"Wang","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib226","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0006-3495(00)76390-9","article-title":"Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities","volume":"79","author":"Wang","year":"2000","journal-title":"Biophysical J."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib227","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1073\/pnas.95.5.2653","article-title":"Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin","volume":"95","author":"Wang","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib228","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1016\/S0006-3495(99)77465-5","article-title":"Batrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6","volume":"76","author":"Wang","year":"1999","journal-title":"Biophysical J."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib229","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.toxicon.2009.04.018","article-title":"Actions of sea anemone type 1 neurotoxins on voltage-gated sodium channel isoforms","volume":"54","author":"Wanke","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib230","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1523\/JNEUROSCI.20-20-07743.2000","article-title":"Nav2\/NaG channel is involved in control of salt-intake behavior in the CNS","volume":"20","author":"Watanabe","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib231","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nrn2023","article-title":"Axonal conduction and injury in multiple sclerosis: the role of sodium channels","volume":"7","author":"Waxman","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib232","doi-asserted-by":"crossref","first-page":"10910","DOI":"10.1073\/pnas.89.22.10910","article-title":"A\u00a0cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation","volume":"89","author":"West","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib233","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.aaf8070","article-title":"Structure of the voltage-gated K(+) channel Eag1 reveals an alternative voltage sensing mechanism","volume":"353","author":"Whicher","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib234","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0169-328X(00)00289-8","article-title":"Comparative distribution of voltage-gated sodium channel proteins in human brain","volume":"88","author":"Whitaker","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib235","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1124\/jpet.110.178343","article-title":"Navbeta subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier muO-conotoxin MrVIB","volume":"338","author":"Wilson","year":"2011","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"issue":"32\u201340","key":"10.1016\/j.neuropharm.2017.04.014_bib236","first-page":"40","article-title":"Ion channel activities implicated in pathological pain","volume":"261","author":"Wood","year":"2004","journal-title":"Novartis Found. Symp."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib237","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1113\/jphysiol.2001.012915","article-title":"Comparison of aconitine-modified human heart (hH1) and rat skeletal (mu1) muscle Na+ channels: an important role for external Na+ ions","volume":"538","author":"Wright","year":"2002","journal-title":"J.\u00a0Physiology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib238","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad2395","article-title":"Structure of the voltage-gated calcium channel Cav1.1 complex","volume":"350","author":"Wu","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib239","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1124\/mol.114.092338","article-title":"Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins","volume":"86","author":"Xiao","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib240","doi-asserted-by":"crossref","first-page":"12069","DOI":"10.1074\/jbc.M411651200","article-title":"Jingzhaotoxin-I, a novel spider neurotoxin preferentially inhibiting cardiac sodium channel inactivation","volume":"280","author":"Xiao","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib241","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad0286","article-title":"Sodium channel Nax is a regulator in epithelial sodium homeostasis","volume":"7","author":"Xu","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib242","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1124\/mol.58.4.692","article-title":"An analysis of the variations in potency of grayanotoxin analogs in modifying frog sodium channels of differing subtypes","volume":"58","author":"Yakehiro","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib243","doi-asserted-by":"crossref","first-page":"24568","DOI":"10.1074\/jbc.M109.030841","article-title":"Synthesis, solution structure, and phylum selectivity of a spider delta-toxin that slows inactivation of specific voltage-gated sodium channel subtypes","volume":"284","author":"Yamaji","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib244","doi-asserted-by":"crossref","DOI":"10.3390\/toxins8100303","article-title":"The snake with the Scorpion's sting: novel three-finger toxin sodium channel activators from the venom of the long-glanded blue coral snake (calliophis bivirgatus)","volume":"8","author":"Yang","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib245","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/jmg.2003.012153","article-title":"Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia","volume":"41","author":"Yang","year":"2004","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib246","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nn1754","article-title":"Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy","volume":"9","author":"Yu","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib247","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/aps.2015.108","article-title":"High throughput screening technologies for ion channels","volume":"37","author":"Yu","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib248","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1469-7793.2001.00777.x","article-title":"State-dependent action of grayanotoxin I on Na(+) channels in frog ventricular myocytes","volume":"534","author":"Yuki","year":"2001","journal-title":"J.\u00a0Physiology"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib249","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.peptides.2011.07.008","article-title":"Characterization of selectivity and pharmacophores of type 1 sea anemone toxins by screening seven Na(v) sodium channel isoforms","volume":"34","author":"Zaharenko","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib250","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/j.bbamcr.2016.02.014","article-title":"The role of mutations in the SCN5A gene in cardiomyopathies","volume":"1863","author":"Zaklyazminskaya","year":"2016","journal-title":"Biochimica Biophysica Acta"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib251","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0041-0101(02)00361-6","article-title":"Purification and characterization of raventoxin-I and raventoxin-III, two neurotoxic peptides from the venom of the spider Macrothele raveni","volume":"41","author":"Zeng","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib252","doi-asserted-by":"crossref","first-page":"33641","DOI":"10.1074\/jbc.M111.282509","article-title":"Structure-function map of the receptor site for beta-scorpion toxins in domain II of voltage-gated sodium channels","volume":"286","author":"Zhang","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib253","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/bph.12051","article-title":"Co-expression of Na(V)beta subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking mu-conotoxins","volume":"168","author":"Zhang","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.04.014_bib254","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nature11054","article-title":"Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel","volume":"486","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib255","doi-asserted-by":"crossref","DOI":"10.3390\/md14020036","article-title":"Development of a rapid throughput assay for identification of hNav1.7 antagonist using unique efficacious sodium channel agonist, antillatoxin","volume":"14","author":"Zhao","year":"2016","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib256","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.biochi.2013.05.009","article-title":"Two recombinant alpha-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na(+) channels","volume":"95","author":"Zhu","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib257","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.012054","article-title":"Evolutionary diversification of Mesobuthus alpha-scorpion toxins affecting sodium channels","volume":"11","author":"Zhu","year":"2012","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib258","first-page":"449","article-title":"Voltage-gated sodium channels in the mammalian heart","author":"Zimmer","year":"2014","journal-title":"Glob. Cardiol. Sci. Pract. 2014"},{"key":"10.1016\/j.neuropharm.2017.04.014_bib259","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.pain.2013.06.015","article-title":"Analgesic treatment of ciguatoxin-induced cold allodynia","volume":"154","author":"Zimmermann","year":"2013","journal-title":"Pain"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390817301557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390817301557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:50:56Z","timestamp":1758437456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390817301557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":259,"alternative-id":["S0028390817301557"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2017.04.014","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pharmacology of voltage-gated sodium channel activators","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2017.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}