{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:42:53Z","timestamp":1794026573480,"version":"4.8.0"},"reference-count":242,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011738","name":"Lee Kong Chian School of Medicine, Nanyang Technological University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.neuropharm.2017.07.002","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T19:30:22Z","timestamp":1499283022000},"page":"124-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"special_numbering":"C","title":["Venom-derived peptide inhibitors of voltage-gated potassium channels"],"prefix":"10.1016","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8893-0584","authenticated-orcid":false,"given":"Raymond S.","family":"Norton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. George","family":"Chandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2017.07.002_bib1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1196\/annals.1381.003","article-title":"CD4-positive effector memory T cells participate in disease expression in ANCA-associated vasculitis","volume":"1107","author":"Abdulahad","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nbd.2015.04.017","article-title":"A\u00a0recurrent KCNQ2 pore mutation causing early onset epileptic encephalopathy has a moderate effect on M current but alters subcellular localization of KV7 channels","volume":"80","author":"Abidi","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib3","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/0896-6273(95)90022-5","article-title":"Episodic ataxia results from voltage-dependent potassium channels with altered functions","volume":"15","author":"Adelman","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib4","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1016\/S0006-3495(94)80710-6","article-title":"The P-region and S6 of KV3.1 contribute to the formation of the ion conduction pathway","volume":"67","author":"Aiyar","year":"1994","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib5","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/0896-6273(95)90104-3","article-title":"Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins","volume":"15","author":"Aiyar","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib6","doi-asserted-by":"crossref","first-page":"31013","DOI":"10.1074\/jbc.271.49.31013","article-title":"The signature sequence of voltage-gated potassium channels projects into the external vestibule","volume":"271","author":"Aiyar","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib7","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1111\/bph.13349","article-title":"The concise guide to pharmacology 2015\/16: voltage-gated ion channels","volume":"172","author":"Alexander","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib8","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1212\/01.WNL.0000156945.39471.2C","article-title":"Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia","volume":"64","author":"Antozzi","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib9","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/sj.jid.5700717","article-title":"Targeting effector memory T cells with the small molecule KV1.3 blocker PAP-1 suppresses allergic contact dermatitis","volume":"127","author":"Azam","year":"2007","journal-title":"J.\u00a0investigative dermatology"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib10","doi-asserted-by":"crossref","first-page":"22923","DOI":"10.1074\/jbc.M100483200","article-title":"Coupling of voltage-dependent potassium channel inactivation and oxidoreductase active site of Kv\u03b2 subunits","volume":"276","author":"Bahring","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib11","doi-asserted-by":"crossref","first-page":"e00594","DOI":"10.7554\/eLife.00594","article-title":"Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel","volume":"2","author":"Banerjee","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.bpj.2010.12.3718","article-title":"Comparative study of the energetics of ion permeation in KV1.2 and KcsA potassium channels","volume":"100","author":"Bastug","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib13","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4049\/jimmunol.166.2.936","article-title":"Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation","volume":"166","author":"Beeton","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib14","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1124\/mol.104.008193","article-title":"Targeting effector memory T cells with a selective peptide inhibitor of KV1.3 channels for therapy of autoimmune diseases","volume":"67","author":"Beeton","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib15","doi-asserted-by":"crossref","first-page":"17414","DOI":"10.1073\/pnas.0605136103","article-title":"KV1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases","volume":"103","author":"Beeton","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib16","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1351\/pac198254101981","article-title":"Biologically active compounds from coelenterates","volume":"54","author":"Beress","year":"1982","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib17","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3390\/toxins4111082","article-title":"Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering","volume":"4","author":"Bergeron","year":"2012","journal-title":"Toxins"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.279.5349.403","article-title":"A\u00a0potassium channel mutation in neonatal human epilepsy","volume":"279","author":"Biervert","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib19","doi-asserted-by":"crossref","first-page":"45312","DOI":"10.1038\/srep45312","article-title":"Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease","volume":"7","author":"Bose","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib20","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature07473","article-title":"Deconstructing voltage sensor function and pharmacology in sodium channels","volume":"456","author":"Bosmans","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ng1094-136","article-title":"Episodic ataxia\/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1","volume":"8","author":"Browne","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0092-8674(00)81635-9","article-title":"Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain","volume":"95","author":"Morais Cabral","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-065X.2009.00816.x","article-title":"The functional network of ion channels in T lymphocytes","volume":"231","author":"Cahalan","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/annrheumdis-2016-209782","article-title":"Checkpoint immunotherapy: good for cancer therapy, bad for rheumatic diseases","volume":"76","author":"Calabrese","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib25","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.toxicon.2009.02.032","article-title":"Discovery and characterization of cnidarian peptide toxins that affect neuronal potassium ion channels","volume":"54","author":"Castaneda","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib26","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0041-0101(95)00013-C","article-title":"Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus","volume":"33","author":"Castaneda","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib27","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/prot.20425","article-title":"Solution structure of APETx1 from the sea anemone Anthopleura elegantissima: a new fold for an HERG toxin","volume":"59","author":"Chagot","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib28","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature19467","article-title":"Immunology: channelling potassium to fight cancer","volume":"537","author":"Chandy","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cbpa.2017.02.015","article-title":"Peptide blockers of KV1.3 channels in T cells as therapeutics for autoimmune disease","volume":"38","author":"Chandy","year":"2017","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib30","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1111\/febs.13294","article-title":"N-Terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel KV1.3","volume":"282","author":"Chang","year":"2015","journal-title":"FEBS J."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib31","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.3390\/toxins7124877","article-title":"Computational studies of venom peptides targeting potassium channels","volume":"7","author":"Chen","year":"2015","journal-title":"Toxins"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1126\/science.1077771","article-title":"KCNQ1 gain-of-function mutation in familial atrial fibrillation","volume":"299","author":"Chen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10048-006-0071-z","article-title":"Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia","volume":"8","author":"Chen","year":"2007","journal-title":"Neurogenetics"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib34","doi-asserted-by":"crossref","first-page":"e60201","DOI":"10.1371\/journal.pone.0060201","article-title":"Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib35","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.toxicon.2011.07.016","article-title":"Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases","volume":"59","author":"Chi","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1158\/0008-5472.CAN-16-2372","article-title":"KV1.3 channels mark functionally competent CD8+ tumor-infiltrating lymphocytes in head and neck cancer","volume":"77","author":"Chimote","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib37","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.1093\/emboj\/16.17.5472","article-title":"Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias","volume":"16","author":"Chouabe","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib38","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0165-5728(01)00462-3","article-title":"Mononuclear phagocyte biophysiology influences brain transendothelial and tissue migration: implication for HIV-1-associated dementia","volume":"122","author":"Chung","year":"2002","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib39","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1212\/WNL.0000000000003309","article-title":"Dominant KCNA2 mutation causes episodic ataxia and pharmacoresponsive epilepsy","volume":"87","author":"Corbett","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0014-5793(02)03652-9","article-title":"A\u00a0large number of novel Ergtoxin-like genes and ERG K+-channels blocking peptides from scorpions of the genus Centruroides","volume":"532","author":"Corona","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib41","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00018-005-5405-8","article-title":"Mechanisms of valence selectivity in biological ion channels","volume":"63","author":"Corry","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib42","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1432-1033.1997.00192.x","article-title":"A\u00a0potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for KV1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity","volume":"244","author":"Cotton","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/toxins8100288","article-title":"Structural and functional elucidation of peptide Ts11 shows evidence of a novel subfamily of scorpion venom toxins","volume":"8","author":"Cremonez","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib44","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrd4081","article-title":"Metabolic disease: potassium channel blocker prevents obesity","volume":"12","author":"Crunkhorn","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/1573403X12666160301120217","article-title":"Drug-induced inhibition and trafficking disruption of ion channels: pathogenesis of QT abnormalities and drug-induced fatal arrhythmias","volume":"12","author":"Cubeddu","year":"2016","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib46","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0092-8674(95)90358-5","article-title":"A\u00a0molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome","volume":"80","author":"Curran","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib47","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1074\/jbc.272.7.4302","article-title":"On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures","volume":"272","author":"Dauplais","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib48","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s002329900093","article-title":"Ion channel expression in PMA-differentiated human THP-1 macrophages","volume":"152","author":"DeCoursey","year":"1996","journal-title":"J.\u00a0Membr. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib49","doi-asserted-by":"crossref","first-page":"12272","DOI":"10.1073\/pnas.211431298","article-title":"Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel","volume":"98","author":"Dedek","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib50","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1517\/14728222.9.3.571","article-title":"KV1.3 potassium channel blockade as an approach to insulin resistance","volume":"9","author":"Desir","year":"2005","journal-title":"Expert Opin. Ther. targets"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib51","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12026-013-8448-1","article-title":"Autoimmune effector memory T cells: the bad and the good","volume":"57","author":"Devarajan","year":"2013","journal-title":"Immunol. Res."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib52","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-3-540-87895-7_4","article-title":"Sea anemone toxins affecting potassium channels","volume":"46","author":"Diochot","year":"2009","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib53","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1074\/jbc.273.12.6744","article-title":"Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel KV3.4","volume":"273","author":"Diochot","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib54","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1124\/mol.64.1.59","article-title":"APETx1, a new toxin from the sea anemone Anthopleura elegantissima, blocks voltage-gated human ether-a-go-go-related gene potassium channels","volume":"64","author":"Diochot","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib55","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1021\/bi00431a033","article-title":"Determination of the three-dimensional solution structure of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: a study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing","volume":"28","author":"Driscoll","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib56","doi-asserted-by":"crossref","first-page":"22704","DOI":"10.1074\/jbc.M114.568642","article-title":"Targeting the ion channel KV1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life","volume":"289","author":"Edwards","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib57","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nature19364","article-title":"Ionic immune suppression within the tumour microenvironment limits T cell effector function","volume":"537","author":"Eil","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib58","doi-asserted-by":"crossref","first-page":"e0137611","DOI":"10.1371\/journal.pone.0137611","article-title":"Characterization of Kbot21 reveals novel side chain interactions of scorpion toxins inhibiting voltage-gated potassium channels","volume":"10","author":"ElFessi-Magouri","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib59","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0896-6273(03)00844-4","article-title":"KV1.3 channel gene-targeted deletion produces \u201cSuper-Smeller Mice\u201d with altered glomeruli, interacting scaffolding proteins, and biophysics","volume":"41","author":"Fadool","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib60","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-immunol-032414-112212","article-title":"Ion channels in innate and adaptive immunity","volume":"33","author":"Feske","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib61","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/jhg.2016.1","article-title":"De novo KCNH1 mutations in four patients with syndromic developmental delay, hypotonia and seizures","volume":"61","author":"Fukai","year":"2016","journal-title":"J.\u00a0Hum. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib62","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0006-3495(84)84080-1","article-title":"Calcium- and voltage-activated potassium channels in human macrophages","volume":"46","author":"Gallin","year":"1984","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib63","doi-asserted-by":"crossref","first-page":"18866","DOI":"10.1016\/S0021-9258(17)46707-X","article-title":"Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels","volume":"268","author":"Garcia-Calvo","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib64","doi-asserted-by":"crossref","first-page":"25393","DOI":"10.1074\/jbc.273.39.25393","article-title":"Delineation of the functional site of \u03b1-dendrotoxin. The functional topographies of dendrotoxins are different but share a conserved core with those of other KV1 potassium channel-blocking toxins","volume":"273","author":"Gasparini","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib65","doi-asserted-by":"crossref","first-page":"11461","DOI":"10.1021\/bi970253d","article-title":"A\u00a0new potassium channel toxin from the sea anemone Heteractis magnifica: isolation, cDNA cloning, and functional expression","volume":"36","author":"Gendeh","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib66","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1038\/jid.2013.141","article-title":"Blocking potassium channels (KV1.3): a new treatment option for alopecia areata?","volume":"133","author":"Gilhar","year":"2013","journal-title":"J.\u00a0Investigative Dermatology"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib67","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/epi.13020","article-title":"Familial neonatal seizures in 36 families: clinical and genetic features correlate with outcome","volume":"56","author":"Grinton","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib68","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1126\/science.289.5476.123","article-title":"Structure of the cytoplasmic \u03b2 subunit-T1 assembly of voltage-dependent K+ channels","volume":"289","author":"Gulbis","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib69","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1021\/bi300060n","article-title":"Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of KV1.3 potassium channels of human T lymphocytes","volume":"51","author":"Gurrola","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib70","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/dmrr.979","article-title":"Effect of genetic variation in KV1.3 on olfactory function","volume":"25","author":"Guthoff","year":"2009","journal-title":"Diabetes\/Metabolism Res. Rev."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib71","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1124\/pr.57.4.10","article-title":"International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels","volume":"57","author":"Gutman","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib72","doi-asserted-by":"crossref","first-page":"19058","DOI":"10.1074\/jbc.M802054200","article-title":"Structural basis of a potent peptide inhibitor designed for KV1.3 channel, a therapeutic target of autoimmune disease","volume":"283","author":"Han","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib73","doi-asserted-by":"crossref","first-page":"9479","DOI":"10.1073\/pnas.0400733101","article-title":"Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages","volume":"101","author":"Hanley","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib74","doi-asserted-by":"crossref","first-page":"11687","DOI":"10.1021\/bi0111698","article-title":"Binding of correolide to the KV1.3 potassium channel: characterization of the binding domain by site-directed mutagenesis","volume":"40","author":"Hanner","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib75","first-page":"B4946","article-title":"The role of T cell potassium channels, KV1.3 and KCa3.1, in the inflammatory cascade in ulcerative colitis","volume":"61","author":"Hansen","year":"2014","journal-title":"Dan. Med. J."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib76","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/tri.12080","article-title":"Targeting the KV1.3 potassium channel for immunosuppression in vascularized composite allotransplantation - a pilot study","volume":"26","author":"Hautz","year":"2013","journal-title":"Transpl. Int."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib77","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1046\/j.1540-8167.2005.40621.x","article-title":"Short QT syndrome and atrial fibrillation caused by mutation in KCNH2","volume":"16","author":"Hong","year":"2005","journal-title":"J.\u00a0Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib78","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cardiores.2005.06.023","article-title":"De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero","volume":"68","author":"Hong","year":"2005","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10126-005-5093-2","article-title":"Peptide toxins in sea anemones: structural and functional aspects","volume":"8","author":"Honma","year":"2006","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib80","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.peptides.2007.12.010","article-title":"Novel peptide toxins from the sea anemone Stichodactyla haddoni","volume":"29","author":"Honma","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib81","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.neuron.2007.02.010","article-title":"Structural insight into KCNQ (KV7) channel assembly and channelopathy","volume":"53","author":"Howard","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib82","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.ejpn.2016.03.011","article-title":"Severe early-onset epileptic encephalopathy due to mutations in the KCNA2 gene: expansion of the genotypic and phenotypic spectrum","volume":"20","author":"Hundallah","year":"2016","journal-title":"Eur. J. Paediatr. Neurology"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib83","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1093\/brain\/awq213","article-title":"Antibodies to KV1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia","volume":"133","author":"Irani","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib84","doi-asserted-by":"crossref","first-page":"24639","DOI":"10.1074\/jbc.C900990199","article-title":"Single amino acid substitutions in \u03ba-conotoxin PVIIA disrupt interaction with the shaker K+ channel","volume":"275","author":"Jacobsen","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib85","series-title":"Formatting Flexibility of Nanobodies\u00ae Is Ideally Suited for Ion Channels: anti-KV1.3 Case Study","author":"Janssen","year":"2014"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib86","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.toxicon.2012.03.024","article-title":"Toxin modulators and blockers of hERG K+ channels","volume":"60","author":"Jimenez-Vargas","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2017.09.025","article-title":"Arthropod toxins acting on neuronal potassium channels","author":"Jim\u00e9nez-Vargas","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib88","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1073\/pnas.1017539108","article-title":"Voltage-gated potassium channel KCNV2 (KV8.2) contributes to epilepsy susceptibility","volume":"108","author":"Jorge","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib89","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.toxicon.2004.03.024","article-title":"Toxin determinants required for interaction with voltage-gated K+ channels","volume":"43","author":"Jouirou","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib90","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1038\/srep06733","article-title":"Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome","volume":"4","author":"Juang","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib91","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jmb.2014.07.027","article-title":"From foe to friend: using animal toxins to investigate ion channel function","volume":"427","author":"Kalia","year":"2015","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib92","doi-asserted-by":"crossref","first-page":"32697","DOI":"10.1074\/jbc.273.49.32697","article-title":"ShK-Dap22, a potent KV1.3-specific immunosuppressive polypeptide","volume":"273","author":"Kalman","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib93","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1432-1033.1996.0491r.x","article-title":"Chemical synthesis and characterization of maurotoxin, a short scorpion toxin with four disulfide bridges that acts on K+ channels","volume":"242","author":"Kharrat","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib94","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1093\/brain\/awl084","article-title":"Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations","volume":"129","author":"Kleopa","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib95","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1055\/s-0037-1601857","article-title":"Vitamin B6-responsive epilepsy due to a novel KCNQ2 mutation","volume":"48","author":"Klotz","year":"2017","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib96","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.crohns.2014.04.003","article-title":"Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis","volume":"8","author":"Koch Hansen","year":"2014","journal-title":"J.\u00a0Crohn's Colitis"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib97","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.4049\/jimmunol.158.11.5120","article-title":"Blockade of the voltage-gated potassium channel KV1.3 inhibits immune responses in\u00a0vivo","volume":"158","author":"Koo","year":"1997","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib98","doi-asserted-by":"crossref","first-page":"e76740","DOI":"10.1371\/journal.pone.0076740","article-title":"Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes","volume":"8","author":"Koshy","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib99","doi-asserted-by":"crossref","first-page":"12623","DOI":"10.1074\/jbc.M113.517037","article-title":"Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma","volume":"289","author":"Koshy","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib100","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10930-013-9513-2","article-title":"1.2 A X-ray structure of the renal potassium channel KV1.3 T1 domain","volume":"32","author":"Kremer","year":"2013","journal-title":"Protein J."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib101","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/31978","article-title":"Crystal structure of the tetramerization domain of the Shaker potassium channel","volume":"392","author":"Kreusch","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib102","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)80556-5","article-title":"KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness","volume":"96","author":"Kubisch","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib103","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2014.07.003","article-title":"KV1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of KV1.3 is effective in the SCID mouse psoriasis\u2013xenograft model","volume":"55","author":"Kundu-Raychaudhuri","year":"2014","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib104","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.4155\/fmc.14.98","article-title":"Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics","volume":"6","author":"Kuyucak","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib105","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1134\/S0006297915130118","article-title":"Diversity of potassium channel ligands: focus on scorpion toxins","volume":"80","author":"Kuzmenkov","year":"2015","journal-title":"Biochem. Biokhimiia"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib106","article-title":"Kalium: a database of potassium channel toxins from scorpion venom","volume":"2016","author":"Kuzmenkov","year":"2016","journal-title":"Database J. Biol. Databases Curation"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib107","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nsb0494-246","article-title":"Proteinase inhibitor homologues as potassium channel blockers","volume":"1","author":"Lancelin","year":"1994","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib108","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nature04649","article-title":"Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR","volume":"440","author":"Lange","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib109","doi-asserted-by":"crossref","first-page":"11963","DOI":"10.1021\/bi026400b","article-title":"Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, KV1.3","volume":"41","author":"Lanigan","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib110","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/jhg.2016.154","article-title":"Novel KCNB1 mutation associated with non-syndromic intellectual disability","volume":"62","author":"Latypova","year":"2017","journal-title":"J.\u00a0Hum. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib111","doi-asserted-by":"crossref","first-page":"34333","DOI":"10.1038\/srep34333","article-title":"Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels","volume":"6","author":"Lau","year":"2016","journal-title":"Sci. Rep."},{"issue":"Pt 1","key":"10.1016\/j.neuropharm.2017.07.002_bib112","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bj3280321","article-title":"A\u00a0four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom","volume":"328","author":"Lebrun","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib113","doi-asserted-by":"crossref","first-page":"15441","DOI":"10.1073\/pnas.0507651102","article-title":"Structure of the KVAP voltage-dependent K+ channel and its dependence on the lipid membrane","volume":"102","author":"Lee","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib114","doi-asserted-by":"crossref","first-page":"C345","DOI":"10.1152\/ajpcell.00091.2005","article-title":"Voltage-gated potassium channel KV1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism","volume":"290","author":"Li","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib115","doi-asserted-by":"crossref","first-page":"29479","DOI":"10.1074\/jbc.M112.379594","article-title":"Selective inhibition of CCR7- effector memory T cell activation by a novel peptide targeting KV1.3 channel in a rat experimental autoimmune encephalomyelitis model","volume":"287","author":"Li","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib116","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.3892\/mmr.2016.4859","article-title":"Association of the hERG mutation with long-QT syndrome type 2, syncope and epilepsy","volume":"13","author":"Li","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib117","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3389\/fimmu.2014.00504","article-title":"T\u00a0cells in vascular inflammatory diseases","volume":"5","author":"Lintermans","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib118","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1152\/jn.00785.2011","article-title":"Modulation of neuronal sodium channels by the sea anemone peptide BDS-I","volume":"107","author":"Liu","year":"2012","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib119","first-page":"937","article-title":"Binding of the sea anemone polypeptide BDS II to the voltage-gated sodium channel","volume":"24","author":"Llewellyn","year":"1991","journal-title":"Biochem. Int."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib120","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1126\/science.1116269","article-title":"Crystal structure of a mammalian voltage-dependent Shaker family K+ channel","volume":"309","author":"Long","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib121","doi-asserted-by":"crossref","first-page":"L862","DOI":"10.1152\/ajplung.00095.2003","article-title":"KV1.3 potassium channels in human alveolar macrophages","volume":"285","author":"Mackenzie","year":"2003","journal-title":"Am. J. Physiology. Lung Cell. Mol. Physiology"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib122","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10540-004-7190-2","article-title":"Nobel Lecture. Potassium channels and the atomic basis of selective ion conduction","volume":"24","author":"MacKinnon","year":"2004","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib123","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1111\/j.1538-7836.2012.04837.x","article-title":"The unique contribution of ion channels to platelet and megakaryocyte function","volume":"10","author":"Mahaut-Smith","year":"2012","journal-title":"J.\u00a0Thrombosis Haemostasis JTH"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib124","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000447461","article-title":"Novel KCNQ3 mutation in a large family with benign familial neonatal epilepsy: a rare cause of neonatal seizures","volume":"7","author":"Maljevic","year":"2016","journal-title":"Mol. Syndromol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib125","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nchembio.1271","article-title":"Side pockets provide the basis for a new mechanism of KV channel-specific inhibition","volume":"9","author":"Marzian","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib126","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1684\/epd.2016.0830","article-title":"Epilepsy in KCNH1-related syndromes","volume":"18","author":"Mastrangelo","year":"2016","journal-title":"Epileptic Disord. Int. Epilepsy J. Videotape"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib127","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.immuni.2008.07.015","article-title":"Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by KV1.3 channel block","volume":"29","author":"Matheu","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib128","doi-asserted-by":"crossref","first-page":"6803","DOI":"10.4049\/jimmunol.181.10.6803","article-title":"Ion channels modulating mouse dendritic cell functions","volume":"181","author":"Matzner","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib129","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1113\/jphysiol.2010.188136","article-title":"KV1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count","volume":"588","author":"McCloskey","year":"2010","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib130","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1073\/pnas.1216867110","article-title":"Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of KV7.2 potassium channel subunits","volume":"110","author":"Miceli","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib131","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1523\/JNEUROSCI.4423-14.2015","article-title":"Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of KV7.2 and KV7.3 potassium channel subunits","volume":"35","author":"Miceli","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib132","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1111\/epi.12887","article-title":"A\u00a0novel KCNQ3 mutation in familial epilepsy with focal seizures and intellectual disability","volume":"56","author":"Miceli","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib133","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0014-5793(98)00403-7","article-title":"Primary structure of a potassium channel toxin from the sea anemone Actinia equina","volume":"427","author":"Minagawa","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib134","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/bcp.12932","article-title":"Plant cystine-knot peptides: pharmacological perspectives","volume":"83","author":"Molesini","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib135","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0969-2126(01)00214-3","article-title":"Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A","volume":"3","author":"Monks","year":"1995","journal-title":"Structure"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib136","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s12967-014-0342-7","article-title":"Melanoma expression of matrix metalloproteinase-23 is associated with blunted tumor immunity and poor responses to immunotherapy","volume":"12","author":"Moogk","year":"2014","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib137","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/BJ20041379","article-title":"K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom","volume":"385","author":"Mouhat","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib138","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.2174\/138161208785777441","article-title":"Animal toxins acting on voltage-gated potassium channels","volume":"14","author":"Mouhat","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib139","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/ana.20884","article-title":"Potassium channels KV1.3 and KV1.5 are expressed on blood-derived dendritic cells in the central nervous system","volume":"60","author":"Mullen","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib140","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/ng.3144","article-title":"A\u00a0recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy","volume":"47","author":"Muona","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib141","doi-asserted-by":"crossref","first-page":"6784","DOI":"10.1021\/acs.jmedchem.5b00495","article-title":"Pharmaceutical optimization of peptide toxins for ion channel targets: potent, selective, and long-lived antagonists of KV1.3","volume":"58","author":"Murray","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib142","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1684\/epd.2016.0859","article-title":"Myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK) is caused by heterozygous KCNC1 mutations","volume":"18","author":"Nascimento","year":"2016","journal-title":"Epileptic Disord. Int. Epilepsy J. Videotape"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib143","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF00236434","article-title":"Lipopolysaccharide induction of outward potassium current expression in human monocyte-derived macrophages: lack of correlation with secretion","volume":"125","author":"Nelson","year":"1992","journal-title":"J.\u00a0Membr. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib144","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/ng0297-186","article-title":"A\u00a0novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome","volume":"15","author":"Neyroud","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib145","doi-asserted-by":"crossref","first-page":"e16191","DOI":"10.1371\/journal.pone.0016191","article-title":"The N-terminal tail of hERG contains an amphipathic \u03b1-helix that regulates channel deactivation","volume":"6","author":"Ng","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib146","first-page":"1","article-title":"Potassium channel expression and function in microglia: plasticity and possible species variations","author":"Nguyen","year":"2017","journal-title":"Channels"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib147","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/glia.23078","article-title":"Differential KV1.3, KCa3.1, and Kir2.1 expression in \u201cclassically\u201d and \u201calternatively\u201d activated microglia","volume":"65","author":"Nguyen","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib148","doi-asserted-by":"crossref","first-page":"346","DOI":"10.4049\/jimmunol.179.1.346","article-title":"Altered dynamics of KV1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus","volume":"179","author":"Nicolaou","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib149","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0041-0101(91)90205-6","article-title":"Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel","volume":"29","author":"Norton","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib150","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.toxicon.2009.02.035","article-title":"Structures of sea anemone toxins","volume":"54","author":"Norton","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib151","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/S0041-0101(98)00149-4","article-title":"The cystine knot structure of ion channel toxins and related polypeptides","volume":"36","author":"Norton","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib152","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.2174\/0929867043363947","article-title":"Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases","volume":"11","author":"Norton","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib153","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0041-0101(98)00206-2","article-title":"TsTX-IV, a short chain four-disulfide-bridged neurotoxin from Tityus serrulatus venom which acts on Ca2+-activated K+ channels","volume":"37","author":"Novello","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib154","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/cvr\/cvt028","article-title":"A\u00a0novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation","volume":"98","author":"Olesen","year":"2013","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib155","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/ana.24929","article-title":"Myoclonus epilepsy and ataxia due to KCNC1 mutation: analysis of 20 cases and K+ channel properties","volume":"81","author":"Oliver","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2016.05.029","article-title":"Dalazatide (ShK-186), a first-in-class peptide inhibitor of KV1.3 potassium channels, demonstrates safety, tolerability and proof of concept of efficacy in patients with active plaque psoriasis","author":"Olsen","year":"2016","journal-title":"J.\u00a0Invest. Dermatol"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib157","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1093\/hmg\/ddl143","article-title":"KV1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation","volume":"15","author":"Olson","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib158","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/ana.24080","article-title":"Dominant-negative effects of KCNQ2 mutations are associated with epileptic encephalopathy","volume":"75","author":"Orhan","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib159","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1155\/2011\/264747","article-title":"Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population","volume":"31","author":"Ota","year":"2011","journal-title":"Dis. Markers"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib160","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/pro.5560031022","article-title":"A\u00a0common structural motif incorporating a cystine knot and a triple-stranded \u03b2-sheet in toxic and inhibitory polypeptides","volume":"3","author":"Pallaghy","year":"1994","journal-title":"Protein Sci."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib161","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/humu.23149","article-title":"Diagnostic targeted resequencing in 349 patients with drug-resistant pediatric epilepsies identifies causative mutations in 30 different genes","volume":"38","author":"Parrini","year":"2017","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib162","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bcp.2011.03.023","article-title":"A\u00a0bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties","volume":"82","author":"Peigneur","year":"2011","journal-title":"Biochem. Pharmacol"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib163","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1096\/fj.12-218479","article-title":"A\u00a0natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins","volume":"26","author":"Peigneur","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib164","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/cge.12542","article-title":"Ataxia and myoclonic epilepsy due to a heterozygous new mutation in KCNA2: proposal for a new channelopathy","volume":"87","author":"Pena","year":"2015","journal-title":"Clin. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib165","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/neuonc\/not221","article-title":"Blockade of KV1.3 channels ameliorates radiation-induced brain injury","volume":"16","author":"Peng","year":"2014","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib166","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1399-3011.1995.tb01068.x","article-title":"Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone","volume":"46","author":"Pennington","year":"1995","journal-title":"Int. J. Peptide Protein Res."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib167","doi-asserted-by":"crossref","first-page":"16407","DOI":"10.1021\/bi962463g","article-title":"An essential binding surface for ShK toxin interaction with rat brain potassium channels","volume":"35","author":"Pennington","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib168","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1124\/mol.108.052704","article-title":"Engineering a stable and selective peptide blocker of the KV1.3 channel in T lymphocytes","volume":"75","author":"Pennington","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib169","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1016\/j.febslet.2012.09.038","article-title":"A\u00a0C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel KV1.3","volume":"586","author":"Pennington","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib170","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/ejhg.2017.3","article-title":"Loss of Function of KCNC1 is associated with intellectual disability without seizures","volume":"25","author":"Poirier","year":"2017","journal-title":"Eur. J. Hum. Genet. EJHG"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib171","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.toxicon.2013.07.012","article-title":"Scorpion venom components that affect ion-channels function","volume":"76","author":"Quintero-Hernandez","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib172","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0896-6273(00)80030-6","article-title":"Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis","volume":"16","author":"Ranganathan","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib173","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1517\/14728220903018957","article-title":"KV1.3 potassium channels as a therapeutic target in multiple sclerosis","volume":"13","author":"Rangaraju","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib174","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1074\/jbc.M109.071266","article-title":"Potassium channel modulation by a toxin domain in matrix metalloprotease 23","volume":"285","author":"Rangaraju","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib175","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3233\/JAD-141704","article-title":"Potassium channel KV1.3 is highly expressed by microglia in human Alzheimer's disease","volume":"44","author":"Rangaraju","year":"2015","journal-title":"J.\u00a0Alzheimer's Dis. JAD"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib176","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1021\/jp300639x","article-title":"Affinity and selectivity of ShK toxin for the KV1 potassium channels from free energy simulations","volume":"116","author":"Rashid","year":"2012","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib177","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1021\/jp410950h","article-title":"Free energy simulations of binding of HsTx1 toxin to KV1 potassium channels: the basis of Kv1.3\/Kv1.1 selectivity","volume":"118","author":"Rashid","year":"2014","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib178","doi-asserted-by":"crossref","first-page":"e78712","DOI":"10.1371\/journal.pone.0078712","article-title":"A\u00a0potent and selective peptide blocker of the KV1.3 channel: prediction from free-energy simulations and experimental confirmation","volume":"8","author":"Rashid","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib179","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1038\/srep04509","article-title":"A\u00a0potent and KV1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases","volume":"4","author":"Rashid","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib180","doi-asserted-by":"crossref","first-page":"21885","DOI":"10.1074\/jbc.274.31.21885","article-title":"Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin","volume":"274","author":"Rauer","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib181","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.expneurol.2016.06.011","article-title":"Targeting KV1.3 channels to reduce white matter pathology after traumatic brain injury","volume":"283","author":"Reeves","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib182","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.biophys.34.040204.144655","article-title":"Ion conduction and selectivity in K+ channels","volume":"34","author":"Roux","year":"2005","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib183","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.str.2014.07.016","article-title":"Structural basis of a KV7.1 potassium channel gating module: studies of the intracellular C-terminal domain in complex with calmodulin","volume":"22","author":"Sachyani","year":"2014","journal-title":"Structure"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib184","doi-asserted-by":"crossref","first-page":"15199","DOI":"10.1038\/srep15199","article-title":"De novo KCNB1 mutations in infantile epilepsy inhibit repetitive neuronal firing","volume":"5","author":"Saitsu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib185","doi-asserted-by":"crossref","first-page":"12321","DOI":"10.1074\/jbc.M111.329607","article-title":"New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing","volume":"287","author":"Saucedo","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib186","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1021\/bi9730341","article-title":"Three-dimensional structure of \u03ba-conotoxin PVIIA, a novel potassium channel-blocking toxin from cone snails","volume":"37","author":"Savarin","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib187","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1110\/ps.8.12.2672","article-title":"Structural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: solution structure of the potassium channel inhibitor HsTX1","volume":"8","author":"Savarin","year":"1999","journal-title":"Protein Sci."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib188","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12104-009-9166-4","article-title":"NMR assignments of a 48 kDa tetramer of the T1 domain of the mammalian voltage gated potassium channel KV1.4","volume":"3","author":"Schreier","year":"2009","journal-title":"Biomol. NMR Assign."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib189","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/jnc.13891","article-title":"Margatoxin-bound quantum dots as a novel inhibitor of the voltage-gated ion channel KV1.3","volume":"140","author":"Schwartz","year":"2017","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib190","doi-asserted-by":"crossref","first-page":"25121","DOI":"10.1074\/jbc.270.42.25121","article-title":"Kalicludines and kaliseptine. Two different classes of sea anemone toxins for voltage sensitive K+ channels","volume":"270","author":"Schweitz","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib191","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/09680519010070030901","article-title":"A\u00a0K+ channel is involved in LPS signaling","volume":"7","author":"Seydel","year":"2001","journal-title":"J.\u00a0Endotoxin Res."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib192","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.peptides.2008.04.021","article-title":"Characterization of a new KV1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch","volume":"29","author":"Shijin","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib193","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ng.3153","article-title":"Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy","volume":"47","author":"Simons","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib194","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng0198-25","article-title":"A\u00a0novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns","volume":"18","author":"Singh","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib195","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1093\/brain\/awg286","article-title":"KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum","volume":"126","author":"Singh","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib196","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.nbd.2006.07.001","article-title":"A\u00a0KV4.2 truncation mutation in a patient with temporal lobe epilepsy","volume":"24","author":"Singh","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib197","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12881-015-0200-3","article-title":"First de novo KCND3 mutation causes severe KV4.3 channel dysfunction leading to early onset cerebellar ataxia, intellectual disability, oral apraxia and epilepsy","volume":"16","author":"Smets","year":"2015","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib198","doi-asserted-by":"crossref","first-page":"30040","DOI":"10.1074\/jbc.M111258200","article-title":"\u03ba-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity","volume":"277","author":"Srinivasan","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib199","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1021\/bi201713z","article-title":"Looking over toxin-K+ channel interactions. Clues from the structural and functional characterization of \u03b1-KTx toxin Tc32, a KV1.3 channel blocker","volume":"51","author":"Stehling","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib200","article-title":"Dalazatide, an inhibitor of the KV1.3 channel on activated effector memory T cells, has immunotherapy potential against systemic lupus erythematosus","volume":"3","author":"Stevens","year":"2016","journal-title":"Lupus Sci. Med."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib201","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng.3239","article-title":"De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy","volume":"47","author":"Syrbe","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib202","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1006\/jmbi.2000.3609","article-title":"Solution structure of hanatoxin1, a gating modifier of voltage-dependent K+ channels: common surface features of gating modifier toxins","volume":"297","author":"Takahashi","year":"2000","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib203","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.clim.2017.03.014","article-title":"Prolonged immunomodulation in inflammatory arthritis using the selective KV1.3 channel blocker HsTX1[R14A] and its PEGylated analog","volume":"180","author":"Tanner","year":"2017","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib204","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1124\/jpet.112.191890","article-title":"Durable pharmacological responses from the peptide drug ShK-186, a specific KV1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease","volume":"342","author":"Tarcha","year":"2012","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib205","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1085\/jgp.201511444","article-title":"A\u00a0novel epileptic encephalopathy mutation in KCNB1 disrupts KV2.1 ion selectivity, expression, and localization","volume":"146","author":"Thiffault","year":"2015","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib206","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.seizure.2015.01.003","article-title":"Further evidence of the association between LQT syndrome and epilepsy in a family with KCNQ1 pathogenic variant","volume":"25","author":"Tiron","year":"2015","journal-title":"Seizure"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib207","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/ana.24263","article-title":"De novo KCNB1 mutations in epileptic encephalopathy","volume":"76","author":"Torkamani","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib208","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0014-5793(03)00216-3","article-title":"Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin","volume":"539","author":"Torres","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib209","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph1016s61","article-title":"Predicting drug-induced QT prolongation and torsades de pointes: a review of preclinical endpoint measures","volume":"61","author":"Townsend","year":"2013","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib210","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/mds.26737","article-title":"Dominant-negative mutation p.Arg324Thr in KCNA1 impairs KV1.1 channel function in episodic ataxia","volume":"31","author":"Tristan-Clavijo","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib211","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1210\/jc.2005-0725","article-title":"A\u00a0new variant in the human KV1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance","volume":"91","author":"Tschritter","year":"2006","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib212","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/ijo.2008.77","article-title":"KV1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice","volume":"32","author":"Tucker","year":"2008","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib213","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-3-642-14426-4_12","article-title":"The olfactory bulb: a metabolic sensor of brain insulin and glucose concentrations via a voltage-gated potassium channel","volume":"52","author":"Tucker","year":"2010","journal-title":"Results Probl. Cell Differ."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib214","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1365-2826.2012.02314.x","article-title":"Diet-induced obesity resistance of KV1.3-\/- mice is olfactory bulb dependent","volume":"24","author":"Tucker","year":"2012","journal-title":"J.\u00a0Neuroendocrinol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib215","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nsb0496-317","article-title":"Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone","volume":"3","author":"Tudor","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib216","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/ced.12097","article-title":"KV1.3 blockers ameliorate allergic contact dermatitis by preferentially suppressing effector memory T cells in a rat model","volume":"38","author":"Ueyama","year":"2013","journal-title":"Clin. Exp. Dermatol"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib217","doi-asserted-by":"crossref","first-page":"E2239","DOI":"10.1073\/pnas.1221206110","article-title":"Selective KV1.3 channel blocker as therapeutic for obesity and insulin resistance","volume":"110","author":"Upadhyay","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib218","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1359\/jbmr.0301213","article-title":"Selective blockade of voltage-gated potassium channels reduces inflammatory bone resorption in experimental periodontal disease","volume":"19","author":"Valverde","year":"2004","journal-title":"J.\u00a0Bone Min. Res."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib219","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1124\/mol.112.078006","article-title":"Vm24, a natural immunosuppressive peptide, potently and selectively blocks KV1.3 potassium channels of human T cells","volume":"82","author":"Varga","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib220","doi-asserted-by":"crossref","first-page":"46307","DOI":"10.1074\/jbc.M304388200","article-title":"Differential voltage-dependent K+ channel responses during proliferation and activation in macrophages","volume":"278","author":"Vicente","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib221","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cell.2017.03.048","article-title":"Cryo-EM structure of the open human ether-a-go-go-related K+ channel hERG","volume":"169","author":"Wang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib222","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng0196-17","article-title":"Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias","volume":"12","author":"Wang","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib223","doi-asserted-by":"crossref","first-page":"11501","DOI":"10.1073\/pnas.1612803113","article-title":"Rational design of a KV1.3 channel-blocking antibody as a selective immunosuppressant","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib224","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF00375097","article-title":"Modification of cardiac Na+ channels by anthopleurin-A: effects on gating and kinetics","volume":"424","author":"Wasserstrom","year":"1993","journal-title":"Eur. J. Physiol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib225","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/ng1758","article-title":"Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes","volume":"38","author":"Waters","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib226","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ana.22644","article-title":"KCNQ2 encephalopathy: emerging phenotype of a neonatal epileptic encephalopathy","volume":"71","author":"Weckhuysen","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib227","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.aaf8070","article-title":"Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism","volume":"353","author":"Whicher","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib228","doi-asserted-by":"crossref","first-page":"29431","DOI":"10.1038\/srep29431","article-title":"Mapping the interaction anatomy of BmP02 on KV1.3 channel","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib229","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1172\/JCI16921","article-title":"The voltage-gated KV1.3 K+ channel in effector memory T cells as new target for MS","volume":"111","author":"Wulff","year":"2003","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib230","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4049\/jimmunol.173.2.776","article-title":"K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity","volume":"173","author":"Wulff","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib231","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nrd2983","article-title":"Voltage-gated potassium channels as therapeutic targets","volume":"8","author":"Wulff","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib232","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1073\/pnas.0308450100","article-title":"The voltage-gated potassium channel KV1.3 regulates peripheral insulin sensitivity","volume":"101","author":"Xu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib233","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.hrthm.2007.01.029","article-title":"Human KCNQ1 S140G mutation is associated with atrioventricular blocks","volume":"4","author":"Yang","year":"2007","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib234","doi-asserted-by":"crossref","first-page":"e36379","DOI":"10.1371\/journal.pone.0036379","article-title":"The antibody targeting the E314 peptide of human KV1.3 pore region serves as a novel, potent and specific channel blocker","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib235","doi-asserted-by":"crossref","first-page":"15834","DOI":"10.1021\/bi051656d","article-title":"Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex","volume":"44","author":"Yu","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib236","doi-asserted-by":"crossref","first-page":"e3414","DOI":"10.1371\/journal.pone.0003414","article-title":"Discovery of a distinct superfamily of Kunitz-type toxin (KTT) from tarantulas","volume":"3","author":"Yuan","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib237","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1124\/mol.107.035840","article-title":"APETx1 from sea anemone Anthopleura elegantissima is a gating modifier peptide toxin of the human ether-a-go-go-related potassium channel","volume":"72","author":"Zhang","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib238","doi-asserted-by":"crossref","first-page":"9306","DOI":"10.1002\/anie.201603052","article-title":"Autocrine-based selection of drugs that target ion channels from combinatorial venom peptide libraries","volume":"55","author":"Zhang","year":"2016","journal-title":"Angew. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib239","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.2174\/1568026616666160315142920","article-title":"Progress in research of KV1.1 and KV1.3 channels as therapeutic targets","volume":"16","author":"Zhao","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.neuropharm.2017.07.002_bib240","doi-asserted-by":"crossref","first-page":"e27548","DOI":"10.1371\/journal.pone.0027548","article-title":"SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venom","volume":"6","author":"Zhao","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib241","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.toxicon.2011.11.016","article-title":"Two dyad-free Shaker-type K+ channel blockers from scorpion venom","volume":"59","author":"Zhu","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.neuropharm.2017.07.002_bib242","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/brain\/122.5.817","article-title":"A\u00a0novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy","volume":"122","author":"Zuberi","year":"1999","journal-title":"Brain"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002839081730309X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002839081730309X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T09:15:48Z","timestamp":1750497348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002839081730309X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":242,"alternative-id":["S002839081730309X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2017.07.002","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Venom-derived peptide inhibitors of voltage-gated potassium channels","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2017.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}