{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:18:06Z","timestamp":1791919086660,"version":"4.3.4"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Council of Scientific and Industrial Research, New Delhi, India","award":["37(1543)\/12-EMR II"],"award-info":[{"award-number":["37(1543)\/12-EMR II"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.neuropharm.2017.07.003","type":"journal-article","created":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T08:00:20Z","timestamp":1499500820000},"page":"13-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Sleep promoting potential of low dose \u03b1-Asarone in rat model"],"prefix":"10.1016","volume":"125","author":[{"given":"Arathi","family":"Radhakrishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Jayakumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velayudhan Mohan","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2253-2644","authenticated-orcid":false,"given":"Kamalesh K.","family":"Gulia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2017.07.003_bib1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/sj.npp.1380110","article-title":"Dynamics of slow wave activity and spindle frequency activity in the human sleep EEG: effect of midazolam and zopiclone","volume":"11","author":"Aeschbach","year":"1994","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib2","series-title":"International Classification of Sleep Disorders","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib3","first-page":"66","article-title":"Sleep and bodily functions: the physiological interplay between body homeostasis and sleep homeostasis","volume":"152","author":"Amici","year":"2014","journal-title":"Arch. Ital. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2165\/00003495-199448010-00004","article-title":"Guidelines for the rational use of benzodiazepines","volume":"48","author":"Ashton","year":"1994","journal-title":"Drugs"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/sleep\/26.3.313","article-title":"Sleep EEG power spectra, insomnia, and chronic use of benzodiazepines","volume":"26","author":"Bastian","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0006-8993(95)00590-M","article-title":"Stimulation of A1 adenosine receptors mimics the electroencephalographic effects of sleep deprivation","volume":"692","author":"Benington","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/sleep\/16.3.221","article-title":"Sleep deprivation in the rat: XVII. Effect of aspirin on elevated body temperature","volume":"16","author":"Bergmann","year":"1993","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib8","doi-asserted-by":"crossref","first-page":"R1071","DOI":"10.1152\/ajpregu.00294.2004","article-title":"Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation","volume":"287","author":"Bodosi","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib9","first-page":"359","article-title":"Anticonvulsive and protective effects of diazepam and midazolam in rats poisoned by highly toxic organophosphorus compounds","volume":"42","author":"Bokonjic","year":"1992","journal-title":"Arh. Hig. Rada. Toksikol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.smrv.2009.05.002","article-title":"Hyperarousal and insomnia: state of the science","volume":"14","author":"Bonnet","year":"2010","journal-title":"Sleep. Med. Rev."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5664\/jcsm.26815","article-title":"The scoring of arousal in sleep: reliability, validity, and alternatives","volume":"3","author":"Bonnet","year":"2007","journal-title":"J.\u00a0Clin. Sleep. Med."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0014-2999(91)90376-2","article-title":"Ultradian dynamics of sleep after a single dose of benzodiazepine hypnotics","volume":"195","author":"Borbely","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib13","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/sleep\/31.5.701","article-title":"Carotid blood flow during REM sleep","volume":"31","author":"Calasso","year":"2008","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib14","doi-asserted-by":"crossref","first-page":"e112849","DOI":"10.1371\/journal.pone.0112849","article-title":"Enhanced slow-save EEG activity and thermoregulatory impairment following the inhibition of the lateral hypothalamus in the rat","volume":"9","author":"Cerri","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib15","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fphar.2016.00072","article-title":"Biphasic effects of \u03b1-Asarone on immobility in the tail suspension test: evidence for the involvement of the noradrenergic and serotonergic systems in its antidepressant-like activity","volume":"7","author":"Chellian","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib16","first-page":"7","article-title":"Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound","volume":"65","author":"Chouinard","year":"2004","journal-title":"J.\u00a0Clin. Psychiatry"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib17","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1476-5381.1963.tb01480.x","article-title":"Effects of asarone and \u03b2-asarone on conditioned responses, fighting behaviour and convulsions","volume":"20","author":"Dandiya","year":"1963","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0022-3565(25)26820-3","article-title":"Actions of asarone on behavior, stress, and hyperpyrexia, and its interaction with central stimulants","volume":"145","author":"Dandiya","year":"1964","journal-title":"J.\u00a0Pharm. Exp. Ther."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.pbiomolbio.2009.10.002","article-title":"The vanilloid transient receptor potential channel TRPV4: from structure to disease","volume":"103","author":"Everaerts","year":"2010","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/sleep\/12.1.13","article-title":"Sleep deprivation in the rat: III. Total sleep deprivation","volume":"12","author":"Everson","year":"1989","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib21","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S1388-2457(99)00147-9","article-title":"Independent sleep EEG slow-wave and spindle band dynamics associated with 4 weeks of continuous application of short-half-life hypnotics in healthy subjects","volume":"110","author":"Feige","year":"1999","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0013-4694(78)90266-3","article-title":"Period amplitude analysis of 0.5\u20133c\/sec activity in non-REM sleep of young adults Electroencephalogr","volume":"44","author":"Feinberg","year":"1978","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib23","doi-asserted-by":"crossref","first-page":"R198","DOI":"10.1152\/ajpregu.1991.261.1.R198","article-title":"Sleep deprivation in rats: effects on EEG power spectra, vigilance states, and cortical temperature","volume":"261","author":"Franken","year":"1991","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib24","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/BF00374625","article-title":"Cortical temperature and EEG slow-wave activity in the rat: analysis of vigilance state related changes","volume":"420","author":"Franken","year":"1992","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0031-9384(93)90297-S","article-title":"Effects of 12-h sleep deprivation and of 12-h cold exposure on sleep regulation and cortical temperature in the rat","volume":"54","author":"Franken","year":"1993","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib26","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1152\/ajpregu.1995.268.6.R1365","article-title":"Effect of elevated ambient temperature on sleep, EEG spectra, and brain temperature in the rat","volume":"268","author":"Gao","year":"1995","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1087-0792(03)00023-6","article-title":"Thermoregulation as a sleep signalling system","volume":"8","author":"Gilbert","year":"2004","journal-title":"Sleep. Med. Rev."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib28","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.physbeh.2005.05.001","article-title":"Ambient temperature related sleep changes in rats neonatally treated with capsaicin","volume":"85","author":"Gulia","year":"2005","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.physbeh.2014.11.019","article-title":"Increased ultrasonic vocalizations and risk-taking in rat pups of sleep-deprived dams","volume":"139","author":"Gulia","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib30","series-title":"Sleep Disorders Medicine Part 2","article-title":"Approach to sleep disorders in the traditional school of Indian medicine. Complementary and alternative medicine","author":"Gulia","year":"2017"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib31","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3109\/13880209.2012.751616","article-title":"Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome of Acorus tatarinowii","volume":"51","author":"Han","year":"2013","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib32","first-page":"147","article-title":"Thermoregulation during sleep and hibernation","volume":"15","author":"Heller","year":"1976","journal-title":"Int. Rev. Physiol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropharm.2012.09.001","article-title":"Alpha-asarone from Acorus gramineus alleviates epilepsy by modulating A-type GABA receptors","volume":"65","author":"Huang","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib34","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/sleep\/21.6.587","article-title":"Effect of NMDA lesion of the medial preoptic neurons on sleep and other functions","volume":"21","author":"John","year":"1998","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib35","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1001\/jama.1979.03290420018017","article-title":"Rebound insomnia. A potential hazard following withdrawal of certain benzodiazepines","volume":"241","author":"Kales","year":"1979","journal-title":"JAMA"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1749-6632.1997.tb51706.x","article-title":"Thermoregulation and","volume":"813","author":"Krueger","year":"1997","journal-title":"Sleep. Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.smrv.2015.02.006","article-title":"Sleep medicine in Ayurveda","volume":"25","author":"Kumar","year":"2016","journal-title":"Sleep. Med. Rev."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.smrv.2008.02.003","article-title":"The relationship between insomnia and body temperatures","volume":"12","author":"Lack","year":"2008","journal-title":"Sleep. Med. Rev."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0006-8993(94)90060-4","article-title":"Pregnenolone enhances EEG delta activity during non-rapid eye movement sleep in the rat, in contrast to midazolam","volume":"646","author":"Lancel","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0893-133X(95)00157-9","article-title":"Role of GABAA receptors in sleep regulation differential effects of muscimol and midazolam on sleep in rats","volume":"15","author":"Lancel","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib41","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1152\/jn.1997.77.3.1624","article-title":"Muscimol and midazolam do not potentiate each other's effects on sleep EEG in the rat","volume":"77","author":"Lancel","year":"1997","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/sleep\/15.1.13","article-title":"Sleep deprivation in the rat: XV. Ambient temperature choice in paradoxical sleep-deprived rats","volume":"15","author":"Landis","year":"1992","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib43","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1002\/ptr.4596","article-title":"Anxiolytic-like effect of \u03b1-Asarone in mice","volume":"26","author":"Liu","year":"2012","journal-title":"Phytother. Res."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejps.2014.06.006","article-title":"Distribution of \u03b1-asarone in brain following three different routes of administration in rats","volume":"63","author":"Lu","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib45","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fneur.2012.00102","article-title":"Basal forebrain thermoregulatory mechanism modulates auto-regulated sleep","volume":"3","author":"Mallick","year":"2012","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib46","series-title":"Scientific Integrity","first-page":"368","author":"Macrina","year":"2005"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1053\/smrv.2001.0170","article-title":"Brain structures and mechanisms involved in the generation of NREM sleep: focus on the preoptic hypothalamus","volume":"5","author":"McGinty","year":"2001","journal-title":"Sleep. Med. Rev."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib48","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.2042-7158.1967.tb08060.x","article-title":"The mechanism of the tranquillizing action of asarone from Acorus calamus Linn","volume":"19","author":"Menon","year":"1967","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib49","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1046\/j.1460-9568.1998.00189.x","article-title":"Spectral characteristics of sleep EEG in chronic insomnia","volume":"10","author":"Merica","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib50","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1037\/h0024563","article-title":"Psychological and physiological differences between good and poor sleepers","volume":"72","author":"Monroe","year":"1967","journal-title":"J.\u00a0Abnorm. Psychol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib51","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2869.1992.tb00033.x","article-title":"Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat","volume":"1","author":"Monti","year":"1992","journal-title":"J.\u00a0Sleep. Res."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib52","first-page":"467","article-title":"Sleep stages and EEG power spectrum in relation to acoustical stimulus arousal threshold in the rat","volume":"16","author":"Neckelmann","year":"1993","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib53","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nn913","article-title":"The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway","volume":"5","author":"Nelson","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib54","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0925-4927(00)00045-7","article-title":"Towards a neurobiology of dysfunctional arousal in depression: the relationship between beta EEG power and regional cerebral glucose metabolism during NREM sleep","volume":"98","author":"Nofzinger","year":"2000","journal-title":"Psychiat. Res. Neuroim"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib55","first-page":"157","article-title":"Thermoregulation and sleep","volume":"8","author":"Obal","year":"1984","journal-title":"Exp. Brain. Res."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib56","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00581494","article-title":"Changes in the brain and core temperatures in relation to the various arousal states in rats in the light and dark periods of the day","volume":"404","author":"Obal","year":"1985","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib57","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/sleep\/14.4.285","article-title":"Sleep deprivation in the rat: XIV. Comparison of waking hypothalamic and peritoneal temperatures","volume":"14","author":"Obermeyer","year":"1991","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib58","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1053\/smrv.2002.0186","article-title":"Epidemiology of insomnia: what we know and what we still need to learn","volume":"6","author":"Ohayon","year":"2002","journal-title":"Sleep. Med. Rev."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib59","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neures.2010.08.011","article-title":"Activities of \u03b1-Asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties","volume":"68","author":"Pages","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib60","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/00000542-199710000-00029","article-title":"Effect of midazolam on propofol-induced positive affective state assessed by place conditioning in rats","volume":"87","author":"Pain","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib61","first-page":"1","article-title":"A\u00a0review on the role of medicinal plants in the management of Anidra","volume":"1","author":"Panara","year":"2013","journal-title":"Int. Ayurvedic. Med. J."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02246405","article-title":"Polysomnographic effects of hypnotic drugs","volume":"126","author":"Parrino","year":"1996","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib63","first-page":"123","article-title":"Interaction between sleep and thermoregulation","volume":"1","author":"Parmeggiani","year":"1977","journal-title":"Waking Sleep."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib64","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0006-8993(02)02591-X","article-title":"Systemic hemodynamic changes raising brain temperature in REM sleep","volume":"940","author":"Parmeggiani","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib65","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1997"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib66","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/sleep\/24.1.110","article-title":"Beta\/Gamma EEG cctivity in patients with primary and secondary insomnia and good sleeper controls","volume":"24","author":"Perlis","year":"2001","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib67","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainres.2014.11.021","article-title":"Sleep deprivation during late pregnancy produces hyperactivity and increased risk-taking behavior in offspring","volume":"1596","author":"Radhakrishnan","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib68","series-title":"Conceptual Foundation of Ayurvedic Pharmacology","first-page":"29","author":"Rajasekharan","year":"1995"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib69","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4314\/ajtcam.v4i3.31226","article-title":"Indian systems of medicine: a brief profile","volume":"4","author":"Ravishankar","year":"2007","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib70","first-page":"68","article-title":"Sleep deprivation in the rat: X. Integration and discussion of the findings","volume":"12","author":"Rechtschaffen","year":"1989","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib71","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/sleep\/22.1.11","article-title":"Effects of method, duration, and sleep stage on rebounds from sleep deprivation in the rat","volume":"22","author":"Rechtschaffen","year":"1999","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib72","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.5665\/sleep.2242","article-title":"Cold hands, warm feet: sleep deprivation disrupts thermoregulation and its association with vigilance","volume":"35","author":"Romeijn","year":"2012","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib73","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nature04284","article-title":"Hypothalamic regulation of sleep and circadian rhythm","volume":"437","author":"Saper","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/sleep\/21.1.7","article-title":"Effects of paradoxical sleep deprivation on thermoregulation in the rat","volume":"21","author":"Shaw","year":"1997","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib75","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/15563650701517442","article-title":"Dose-related illusions and hallucinations with zaleplon","volume":"46","author":"Stone","year":"2008","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib76","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bbr.2016.11.040","article-title":"Dynamic changes in sleep pattern during post-partum in normal pregnancy in rat model","volume":"320","author":"Sivadas","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib77","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1093\/sleep\/29.9.1174","article-title":"Attenuated thermoregulatory response to mild thermal challenge in subjects with sleep-onset insomnia","volume":"29","author":"van den Heuvel","year":"2006","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2017.07.003_bib78","doi-asserted-by":"crossref","first-page":"103S","DOI":"10.1111\/j.1365-2125.1983.tb02279.x","article-title":"Effect of midazolam on sleep of insomniacs","volume":"16","author":"Vogel","year":"1983","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2014.00040","article-title":"Identification of both GABAA receptors and voltage-activated Na+ channels as molecular targets of anticonvulsant \u03b1-asarone","volume":"5","author":"Wang","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib80","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1113\/jphysiol.1996.sp021486","article-title":"Effects of GABA agonists and antagonists on temperature sensitive neurons in the rat hypothalamus","volume":"494.1","author":"Yakimova","year":"1996","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2017.07.003_bib81","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0306-3623(88)90065-1","article-title":"GABAA and GABAB receptor sites involvement in rat thermoregulation","volume":"19","author":"Zarrindast","year":"1988","journal-title":"Gen. Pharmacol.-Vasc. S."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390817303106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390817303106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T16:46:22Z","timestamp":1750524382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390817303106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":81,"alternative-id":["S0028390817303106"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2017.07.003","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sleep promoting potential of low dose \u03b1-Asarone in rat model","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2017.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}