{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:50:46Z","timestamp":1789642246160,"version":"4.0.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS081082"],"award-info":[{"award-number":["NS081082"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AG046153"],"award-info":[{"award-number":["AG046153"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AG000216"],"award-info":[{"award-number":["AG000216"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"CIRM","doi-asserted-by":"publisher","award":["PC108086"],"award-info":[{"award-number":["PC108086"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.neuropharm.2017.11.007","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T10:00:50Z","timestamp":1509962450000},"page":"26-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["A novel curcumin derivative for the treatment of diabetic neuropathy"],"prefix":"10.1016","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8030-9566","authenticated-orcid":false,"given":"Daniel J.","family":"Daugherty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Marquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel A.","family":"Calcutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2017.11.007_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4103\/0973-1482.171370","article-title":"Research on curcumin: a meta-analysis of potentially malignant disorders","volume":"12","author":"Ara","year":"2016","journal-title":"J.\u00a0Cancer Res. Ther."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0304-3959(94)00188-K","article-title":"Phantom limb pain: are cutaneous nociceptors and spinothalamic neurons involved in the signaling and maintenance of spontaneous and touch-evoked pain? A case report","volume":"60","author":"Baron","year":"1995","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neulet.2008.06.079","article-title":"Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice","volume":"442","author":"Beiswenger","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jns5.12072","article-title":"Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab)","volume":"19","author":"Biessels","year":"2014","journal-title":"J.\u00a0Peripher Nerv. Syst."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/bs.irn.2016.02.011","article-title":"The perfect clinical trial","volume":"127","author":"Bril","year":"2016","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib6","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.neuron.2016.09.049","article-title":"Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination","volume":"92","author":"Brill","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrd2476","article-title":"Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials","volume":"8","author":"Calcutt","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib8","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1172\/JCI88321","article-title":"Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy","volume":"127","author":"Calcutt","year":"2017","journal-title":"J.\u00a0Clin. Investigation"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib9","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s12031-015-0566-x","article-title":"A\u00a0potent multi-functional neuroprotective derivative of tetramethylpyrazine","volume":"56","author":"Chen","year":"2015","journal-title":"J.\u00a0Mol. Neurosci."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib10","doi-asserted-by":"crossref","first-page":"e27865","DOI":"10.1371\/journal.pone.0027865","article-title":"A\u00a0novel neurotrophic drug for cognitive enhancement and Alzheimer's disease","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib11","series-title":"Eph-ephrin Signaling in Nervous System Development","author":"Cramer","year":"2016"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib12","doi-asserted-by":"crossref","first-page":"937","DOI":"10.18632\/aging.100838","article-title":"A\u00a0comprehensive multiomics approach toward understanding the relationship between aging and dementia","volume":"7","author":"Currais","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib13","doi-asserted-by":"crossref","first-page":"431980","DOI":"10.1155\/2009\/431980","article-title":"The roles of streptozotocin neurotoxicity and neutral endopeptidase in murine experimental diabetic neuropathy","volume":"2009","author":"Davidson","year":"2009","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ejphar.2015.08.015","article-title":"Effect of combination therapy consisting of enalapril, alpha-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat\/low dose streptozotocin treated rat","volume":"765","author":"Davidson","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib16","article-title":"Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans","volume":"12","author":"Eleazu","year":"2013","journal-title":"J.\u00a0Diabetes Metabolic Disord."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib42","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0006-8993(93)91496-F","article-title":"Insulin and insulin-like growth factor I enhance regeneration in cultured adult rat sensory neurones","volume":"607","author":"Fernyhough","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2265.2005.02376.x","article-title":"Diabetic neuropathy is associated with activation of the TNF-alpha system in subjects with type 1 diabetes mellitus","volume":"63","author":"Gonzalez-Clemente","year":"2005","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib43","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10787-016-0275-2","article-title":"Anti-inflammatory effect of AMPK signaling pathway in rat model of diabetic neuropathy","volume":"24","author":"Hasanvand","year":"2016","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib18","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.amjms.2015.12.017","article-title":"Curcumin rescues diabetic renal fibrosis by targeting superoxide-mediated wnt signaling pathways","volume":"351","author":"Ho","year":"2016","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1586\/14737175.2015.1044981","article-title":"Clinical development of curcumin in neurodegenerative disease","volume":"15","author":"Hu","year":"2015","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib20","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1038\/emm.2016.81","article-title":"Regulation and function of AMPK in physiology and diseases","volume":"48","author":"Jeon","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/cpmo.11","article-title":"Peripheral neuropathy in mouse models of diabetes","volume":"6","author":"Jolivalt","year":"2016","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib22","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1002\/jnr.21787","article-title":"Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin","volume":"86","author":"Jolivalt","year":"2008","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib23","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.nano.2013.01.001","article-title":"SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: an insight into its mechanism for neuroprotection","volume":"9","author":"Joshi","year":"2013","journal-title":"Nanomedicine"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0306-4522(02)00372-X","article-title":"Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats","volume":"114","author":"Khan","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib25","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/B978-0-444-53480-4.00034-5","article-title":"Painful neuropathy: mechanisms","volume":"126","author":"Lee-Kubli","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib26","doi-asserted-by":"crossref","first-page":"377","DOI":"10.7150\/ijms.5224","article-title":"Curcumin attenuates diabetic neuropathic pain by downregulating TNF-alpha in a rat model","volume":"10","author":"Li","year":"2013","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1055\/s-2006-924012","article-title":"C-reactive protein is a strong independent predictor of death in type 2 diabetes: association with multiple facets of the metabolic syndrome","volume":"114","author":"Linnemann","year":"2006","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/bs.irn.2016.03.008","article-title":"Wherefore art thou, O treatment for diabetic neuropathy?","volume":"127","author":"Malik","year":"2016","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2010.07.004","article-title":"Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats","volume":"331","author":"Peeyush Kumar","year":"2011","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/bs.irn.2016.02.020","article-title":"Neuropathy in the DCCT\/EDIC-what was done then and what we would do better now","volume":"127","author":"Pop-Busui","year":"2016","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib31","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1021\/cn500051h","article-title":"Back to the future with phenotypic screening","volume":"5","author":"Prior","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/alzrt179","article-title":"The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice","volume":"5","author":"Prior","year":"2013","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib33","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jalz.2016.03.016","article-title":"Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery","volume":"12","author":"Prior","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2147\/JPR.S21751","article-title":"High TNF-alpha plasma levels and macrophages iNOS and TNF-alpha expression as risk factors for painful diabetic neuropathy","volume":"4","author":"Purwata","year":"2011","journal-title":"J.\u00a0Pain Res."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1530\/JOE-14-0335","article-title":"Resveratrol and curcumin enhance pancreatic beta-cell function by inhibiting phosphodiesterase activity","volume":"223","author":"Rouse","year":"2014","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib36","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/brain\/aws097","article-title":"Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes","volume":"135","author":"Roy Chowdhury","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ptr.2070","article-title":"Effect of insulin and its combination with resveratrol or curcumin in attenuation of diabetic neuropathic pain: participation of nitric oxide and TNF-alpha","volume":"21","author":"Sharma","year":"2007","journal-title":"Phytotherapy Res."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib38","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/bs.irn.2016.03.006","article-title":"Glucotoxic mechanisms and related therapeutic approaches","volume":"127","author":"Yagihashi","year":"2016","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib39","doi-asserted-by":"crossref","first-page":"E844","DOI":"10.1152\/ajpendo.00029.2011","article-title":"Inactivation of TNF-alpha ameliorates diabetic neuropathy in mice","volume":"301","author":"Yamakawa","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.neuropharm.2017.11.007_bib40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0304-3959(96)03177-6","article-title":"Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence","volume":"68","author":"Yeomans","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2017.11.007_bib41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/bs.irn.2016.03.007","article-title":"Sensory neurodegeneration in diabetes: beyond glucotoxicity","volume":"127","author":"Zochodne","year":"2016","journal-title":"Int. Rev. Neurobiol."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390817305178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390817305178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T13:51:38Z","timestamp":1570283498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390817305178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":43,"alternative-id":["S0028390817305178"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2017.11.007","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel curcumin derivative for the treatment of diabetic neuropathy","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2017.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}