{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:57:04Z","timestamp":1785898624570,"version":"3.56.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:00:00Z","timestamp":1552608000000},"content-version":"am","delay-in-days":318,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.neuropharm.2018.01.021","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T23:04:20Z","timestamp":1521155060000},"page":"75-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Cannabinoids induce apathetic and impulsive patterns of choice through CB1 receptors and TRPV1 channels"],"prefix":"10.1016","volume":"133","author":[{"given":"Zahra","family":"Fatahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Reisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Rainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Haghparast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7324-4303","authenticated-orcid":false,"given":"Abbas","family":"Khani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2018.01.021_bib1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00213-009-1532-5","article-title":"Anxiolytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the medial prefrontal cortex of rats","volume":"205","author":"Aguiar","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/npp.2011.207","article-title":"Opposing roles for cannabinoid receptor type-1 (CB(1)) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats","volume":"37","author":"Casarotto","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib3","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1369-1600.2012.00498.x","article-title":"Individual differences in decision making and reward processing predict changes in cannabis use: a prospective functional magnetic resonance imaging study","volume":"18","author":"Cousijn","year":"2013","journal-title":"Addict Biol"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.drugalcdep.2013.05.020","article-title":"Neural mechanisms of risky decision-making and reward response in adolescent onset cannabis use disorder","volume":"133","author":"De Bellis","year":"2013","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00213-012-2908-5","article-title":"Impulsivity, attention, memory, and decision-making among adolescent marijuana users","volume":"226","author":"Dougherty","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib6","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1038\/sj.npp.1300715","article-title":"Acute delta9-tetrahydrocannabinol-induced deficits in reversal learning: neural correlates of affective inflexibility","volume":"30","author":"Egerton","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/cercor\/bhj136","article-title":"Immunocytochemical distribution of the cannabinoid CB1 receptor in the primate neocortex: a regional and laminar analysis","volume":"17","author":"Eggan","year":"2007","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib8","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuropharm.2012.03.007","article-title":"The endocannabinoid and endovanilloid systems interact in the rat prelimbic medial prefrontal cortex to control anxiety-like behavior","volume":"63","author":"Fogaca","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jmp.2009.10.002","article-title":"Cognitive mechanisms underlying risky decision-making in chronic cannabis users","volume":"54","author":"Fridberg","year":"2010","journal-title":"J.\u00a0Math. Psychol."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.drugalcdep.2011.08.015","article-title":"Neuropsychological deficits associated with cannabis use in young adults","volume":"121","author":"Grant","year":"2012","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib11","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1080\/13803395.2012.668874","article-title":"Motivational and cognitive inhibitory control in recreational cannabis users","volume":"34","author":"Griffith-Lendering","year":"2012","journal-title":"J.\u00a0Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000189788","article-title":"Decision making of heavy cannabis users on the Iowa Gambling Task: stronger association with THC of hair analysis than with personality traits of the tridimensional personality questionnaire","volume":"15","author":"Hermann","year":"2009","journal-title":"Eur. Addiction Res."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib13","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s00213-014-3841-6","article-title":"Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making","volume":"232","author":"Khani","year":"2015","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib14","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/sj.npp.1300620","article-title":"Acute marijuana effects on human risk taking","volume":"30","author":"Lane","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/ADM.0000000000000079","article-title":"A\u00a0preliminary comparison of cannabis use in subsyndromal gamblers: select neurocognitive and behavioral differences based on use","volume":"8","author":"Leppink","year":"2014","journal-title":"J.\u00a0Addiction Med."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000435934","article-title":"Supraspinal transient receptor potential subfamily V member 1 (TRPV1) in pain and psychiatric disorders","volume":"30","author":"Madasu","year":"2015","journal-title":"Mod Trends Pharmacopsychiatri"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0306-4522(92)90409-U","article-title":"Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry","volume":"48","author":"Mailleux","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib18","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/npp.2008.98","article-title":"Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels","volume":"34","author":"Micale","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib19","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1369-1600.2008.00104.x","article-title":"The endocannabinoid system: emotion, learning and addiction","volume":"13","author":"Moreira","year":"2008","journal-title":"Addict Biol"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.drugalcdep.2012.02.011","article-title":"Impulsivity differences in recreational cannabis users and binge drinkers in a university population","volume":"124","author":"Moreno","year":"2012","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib21","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2003.10.001","article-title":"[3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution","volume":"995","author":"Roberts","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib23","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/cercor\/bhm161","article-title":"Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex","volume":"18","author":"Rubino","year":"2008","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib24","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/nn1756","article-title":"Separate neural pathways process different decision costs","volume":"9","author":"Rudebeck","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/FBP.0b013e3283095234","article-title":"Attenuation of anxiety-related behaviour after the antagonism of transient receptor potential vanilloid type 1 channels in the rat ventral hippocampus","volume":"19","author":"Santos","year":"2008","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib26","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00213-011-2486-y","article-title":"Reflection impulsivity in adolescent cannabis users: a comparison with alcohol-using and non-substance-using adolescents","volume":"219","author":"Solowij","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib27","doi-asserted-by":"crossref","first-page":"13739","DOI":"10.1523\/JNEUROSCI.3258-07.2007","article-title":"Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways","volume":"27","author":"Starowicz","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib28","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1192\/bjp.bp.106.024521","article-title":"Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophrenia","volume":"190","author":"Szeszko","year":"2007","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.euroneuro.2008.11.004","article-title":"Modulation of anxiety-like behaviour by Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray","volume":"19","author":"Terzian","year":"2009","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.neuropharm.2018.01.021_bib30","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0083-6729(09)81015-7","article-title":"Anandamide and the vanilloid receptor (TRPV1)","volume":"81","author":"Toth","year":"2009","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib31","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0026-895X(24)23200-4","article-title":"Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in\u00a0vitro","volume":"57","author":"Vaughan","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.01.021_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.drugalcdep.2004.04.009","article-title":"Long-term heavy marijuana users make costly decisions on a gambling task","volume":"76","author":"Whitlow","year":"2004","journal-title":"Drug Alcohol Depend."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818300212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818300212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T20:46:04Z","timestamp":1751489164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390818300212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":32,"alternative-id":["S0028390818300212"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.01.021","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabinoids induce apathetic and impulsive patterns of choice through CB1 receptors and TRPV1 channels","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}