{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:41:08Z","timestamp":1789123268792,"version":"build-2803163510"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004434","name":"Universit\u00e0 degli Studi di Firenze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.neuropharm.2018.04.001","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T23:26:23Z","timestamp":1522970783000},"page":"444-454","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Antidepressant-like actions by silencing of neuronal ELAV-like RNA-binding proteins HuB and HuC in a model of depression in male mice"],"prefix":"10.1016","volume":"135","author":[{"given":"Maria Domenica","family":"Sanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Quattrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-9844","authenticated-orcid":false,"given":"Nicoletta","family":"Galeotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2018.04.001_bib1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neubiorev.2008.08.007","article-title":"Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology","volume":"33","author":"Balu","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib2","first-page":"2451","article-title":"ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism","volume":"25","author":"Berto","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuropharm.2015.10.034","article-title":"BDNF - a key transducer of antidepressant effects","volume":"102","author":"Bj\u00f6rkholm","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib4","doi-asserted-by":"crossref","first-page":"12889","DOI":"10.1523\/JNEUROSCI.1309-11.2011","article-title":"Vulnerability to depression: from brain neuroplasticity to identification of biomarkers","volume":"31","author":"Blugeot","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib5","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1261\/rna.039164.113","article-title":"Emerging complexity of the HuD\/ELAVl4 gene; implications for neuronal development, function, and dysfunction","volume":"19","author":"Bronicki","year":"2013","journal-title":"RNA"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tins.2005.06.005","article-title":"The many faces of CREB","volume":"28","author":"Carlezon","year":"2005","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4103\/0976-500X.119726","article-title":"How to calculate sample size in animal studies?","volume":"4","author":"Charan","year":"2013","journal-title":"J.\u00a0Pharmacol. Pharmacother."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-neuro-062912-114322","article-title":"RNA protein interaction in neurons","volume":"36","author":"Darnell","year":"2013","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","article-title":"Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety\/depression","volume":"62","author":"David","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib11","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1523\/JNEUROSCI.3703-13.2014","article-title":"Prenatal deletion of the RNA-binding protein HuD disrupts postnatal cortical circuit maturation and behavior","volume":"34","author":"DeBoer","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1126\/science.1222941","article-title":"Depression and hippocampal neurogenesis: a road to remission?","volume":"338","author":"Eisch","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib14","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/sj.npp.1300111","article-title":"The phospholipase C-IP3 pathway is involved in muscarinic antinociception","volume":"28","author":"Galeotti","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib15","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/bies.20658","article-title":"CREB, neurogenesis and depression","volume":"29","author":"Gass","year":"2007","journal-title":"Bioessays"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib16","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1073\/pnas.92.10.4557","article-title":"A\u00a0conserved family of elav-like genes in vertebrates","volume":"92","author":"Good","year":"1995","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib17","doi-asserted-by":"crossref","first-page":"e842","DOI":"10.1016\/j.pbb.2006.11.021","article-title":"Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper","volume":"85","author":"Gr\u00f8nli","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib18","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1007\/s00018-008-8252-6","article-title":"Diverse molecular function of Hu proteins","volume":"65","author":"Hinman","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib19","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuron.2012.07.009","article-title":"Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability","volume":"75","author":"Ince-Dunn","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib20","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/nn.3262","article-title":"Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders","volume":"15","author":"Kheirbek","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pharmthera.2007.07.001","article-title":"Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies","volume":"117","author":"Kozisek","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib22","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1159\/000350094","article-title":"Molecular mechanisms of depression: perspectives on new treatment strategies","volume":"31","author":"Lang","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbr.2014.01.039","article-title":"Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats","volume":"264","author":"Liu","year":"2014","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.neuropharm.2018.04.001_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017562","article-title":"Novel control by the CA3 region of the hippocampus on neurogenesis in the dentate gyrus of the adult rat","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nrn1867","article-title":"Adult neurogenesis and functional\u2028plasticity in neuronal circuits","volume":"7","author":"Lledo","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bbr.2015.10.006","article-title":"Unpredictable chronic mild stress exerts anxiogenic-like effects and activates neurons in the dorsal and caudal region and in the lateral wings of the dorsal raphe nucleus","volume":"297","author":"Lopes","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib27","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1111\/bph.12955","article-title":"Implementing guidelines on reporting research using animals (ARRIVE etc.) new requirements for publication in BJP","volume":"172","author":"McGrath","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/da.20192","article-title":"Depressive, anxiety, and somatoform disorders in primary care: prevalence and recognition","volume":"24","author":"Mergl","year":"2007","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.conb.2014.08.012","article-title":"The current state of the neurogenic theory of depression and anxiety","volume":"30","author":"Miller","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/hipo.20155","article-title":"Stress and adult neurogenesis","volume":"16","author":"Mirescu","year":"2006","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib31","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.lfs.2012.09.023","article-title":"Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice","volume":"91","author":"Mutlu","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00439-005-1259-2","article-title":"Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease","volume":"117","author":"Noureddine","year":"2005","journal-title":"Hum. Genet."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib56","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2004"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib33","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1523\/JNEUROSCI.0237-07.2007","article-title":"Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates","volume":"27","author":"Perera","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbr.2004.04.008","article-title":"Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress","volume":"155","author":"Pothion","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2017.01.019","article-title":"HuD-mediated distinct BDNF regulatory pathways promote regeneration after nerve injury","volume":"1659","author":"Sanna","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2016.11.001","article-title":"Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression","volume":"128","author":"Sanna","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib37","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuropharm.2016.11.023","article-title":"Behavioural phenotype of histamine H4 receptor knockout mice: focus on central neuronal functions","volume":"114","author":"Sanna","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib38","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.expneurol.2014.05.017","article-title":"Increased expression of the RNA-binding protein HuD promotes neuroregeneration in antiretroviral neuropathy","volume":"261","author":"Sanna","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib39","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib40","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0079-6123(07)63034-9","article-title":"The CA3 \"backprojection\" to the dentate gyrus","volume":"163","author":"Scharfman","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib41","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00429-013-0532-8","article-title":"Atrophy of pyramidal neurons and increased stress-induced glutamate levels in CA3 following chronic suppression of adult neurogenesis","volume":"219","author":"Schloesser","year":"2013","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib42","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.psyneuen.2009.10.002","article-title":"High susceptibility to chronic social stress is associated with a depression-like phenotype","volume":"35","author":"Schmidt","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2017.05.013","article-title":"Stress and loss of adult neurogenesis differentially reduce hippocampal volume","author":"Schoenfeld","year":"2017","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2826.2006.01516.x","article-title":"Neuroendocrinological mechanisms of actions of antidepressant drugs","volume":"19","author":"Sch\u00fcle","year":"2007","journal-title":"J.\u00a0Neuroendocrinol."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib45","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hipo.20751","article-title":"Stress-induced dynamic routing of hippocampal connectivity: a hypothesis","volume":"12","author":"Segal","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib46","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1523\/JNEUROSCI.22-08-03251.2002","article-title":"Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression","volume":"22","author":"Shirayama","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/bcpt.12581","article-title":"Protein kinase C activation as a potential therapeutic strategy in Alzheimer's disease: is there a role for Embryonic Lethal Abnormal Vision-like proteins?","volume":"119","author":"Talman","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib48","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.neuropharm.2012.04.022","article-title":"Differential environmental regulation along the septo-temporal axis of the hippocampus","volume":"63","author":"Tanti","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib49","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.pnpbp.2007.08.001","article-title":"Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: effects of citalopram","volume":"32","author":"T\u00f5nissaar","year":"2008","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib50","doi-asserted-by":"crossref","first-page":"E4995","DOI":"10.1073\/pnas.1513780112","article-title":"Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis","volume":"112","author":"Wang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib51","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hipo.450020410","article-title":"Phenytoin prevents stress- and corticosterone-induced atrophy of CA3 pyramidal neurons","volume":"2","author":"Watanabe","year":"1992","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib52","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib53","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jad.2017.06.006","article-title":"Mapping the relationship between anxiety, anhedonia, and depression","volume":"221","author":"Winer","year":"2017","journal-title":"J.\u00a0Affect. Disord."},{"key":"10.1016\/j.neuropharm.2018.04.001_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020468","article-title":"Genome-wide association study of schizophrenia in Japanese population","volume":"6","author":"Yamada","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2018.04.001_bib55","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/jnc.12266","article-title":"A\u00a0HuD-ZBP1 ribonucleoprotein complex localizes GAP43 mRNA into axons through its 3\u2019 untranslated region AU-rich regulatory element","volume":"126","author":"Yoo","year":"2013","journal-title":"J.\u00a0Neurochem."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818301552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818301552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T11:15:33Z","timestamp":1617621333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390818301552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":56,"alternative-id":["S0028390818301552"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.04.001","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antidepressant-like actions by silencing of neuronal ELAV-like RNA-binding proteins HuB and HuC in a model of depression in male mice","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}