{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:01:43Z","timestamp":1782309703948,"version":"3.54.5"},"reference-count":103,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["ZIA-AA000218"],"award-info":[{"award-number":["ZIA-AA000218"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIAAA Division of Intramural Clinical and Biological Research"},{"name":"NIDA Intramural Research Program"},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["#17325"],"award-info":[{"award-number":["#17325"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH Intramural Research Program"},{"name":"NIAAA"},{"name":"NIDA"},{"name":"NIAAA"},{"name":"NIH Clinical Center"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.neuropharm.2018.04.011","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T15:43:41Z","timestamp":1523720621000},"page":"230-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-4212","authenticated-orcid":false,"given":"Mehdi","family":"Farokhnia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikela B.","family":"Sheskier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary R.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April N.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Singley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Bouhlal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timmy","family":"Ton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Leggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2018.04.011_bib1","first-page":"67","article-title":"Ability of baclofen in reducing alcohol craving and intake: II\u2013Preliminary clinical evidence","volume":"24","author":"Addolorato","year":"2000","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/alcalc\/37.5.504","article-title":"Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study","volume":"37","author":"Addolorato","year":"2002","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib3","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0140-6736(07)61814-5","article-title":"Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study","volume":"370","author":"Addolorato","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1465-3362.2008.00023.x","article-title":"Hormones and drinking behaviour: new findings on ghrelin, insulin, leptin and volume-regulating hormones. An ESBRA Symposium report","volume":"28","author":"Addolorato","year":"2009","journal-title":"Drug Alcohol Rev."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib5","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1097\/01.ALC.0000176356.97620.84","article-title":"Suppression of the HPA axis stress-response: implications for relapse","volume":"29","author":"Adinoff","year":"2005","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fnins.2014.00140","article-title":"GABAB receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence","volume":"8","author":"Agabio","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopsycho.2017.11.012","article-title":"Stress response pathways, appetite regulation, and drug addiction","volume":"131","author":"al'Absi","year":"2018","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neuroscience.2011.03.003","article-title":"Adolescent alcohol exposure alters the central brain circuits known to regulate the stress response","volume":"182","author":"Allen","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib9","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.2169\/internalmedicine.49.3918","article-title":"Positive effect of baclofen on body weight reduction in obese subjects: a pilot study","volume":"49","author":"Arima","year":"2010","journal-title":"Intern. Med."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib10","first-page":"353","article-title":"GABAB receptor blockade prevents antiepileptic action of ghrelin in the rat Hippocampus","volume":"3","author":"Ataie","year":"2013","journal-title":"Adv. Pharmaceut. Bull."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuropharm.2017.01.037","article-title":"Alcohol, stress, and glucocorticoids: from risk to dependence and relapse in alcohol use disorders","volume":"122","author":"Blaine","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00359-017-1168-6","article-title":"Influence of leptin and GABAB-receptor agonist and antagonist on neurons of the hypothalamic infundibular nucleus in the chicken","volume":"203","author":"Bogatyrev","year":"2017","journal-title":"J\u00a0Comp Physiol A Neuroethol Sens Neural Behav Physiol"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib13","doi-asserted-by":"crossref","first-page":"E157","DOI":"10.1152\/ajpendo.00615.2006","article-title":"GABAB receptors and glucose homeostasis: evaluation in GABAB receptor knockout mice","volume":"294","author":"Bonaventura","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib14","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejphar.2011.12.013","article-title":"Effects of GABAB receptor agonists and antagonists on glycemia regulation in mice","volume":"677","author":"Bonaventura","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1113\/jphysiol.2004.066563","article-title":"GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin","volume":"559","author":"Braun","year":"2004","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib16","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1021\/jm5018913","article-title":"Activation of the gamma-aminobutyric acid type B (GABA(B)) receptor by agonists and positive allosteric modulators","volume":"58","author":"Brown","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib17","series-title":"GABAB Receptor","first-page":"75","article-title":"Distribution and localization of the GABAB receptor","author":"Castelli","year":"2016"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib18","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/npp.2012.190","article-title":"Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala","volume":"38","author":"Cruz","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.tips.2004.11.004","article-title":"Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression","volume":"26","author":"Cryan","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib20","first-page":"263","article-title":"The role of GABAA receptors in mediating the effects of alcohol in the central nervous system","volume":"28","author":"Davies","year":"2003","journal-title":"J.\u00a0Psychiatry Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neuroscience.2011.02.019","article-title":"Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride and sucrose intake in rats","volume":"183","author":"De Oliveira","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fendo.2013.00103","article-title":"Glutamate and GABA in appetite regulation","volume":"4","author":"Delgado","year":"2013","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib23","series-title":"Effects of Baclofen and Ghrelin on Food Intake in Non-deprived Rats","author":"Ebenezer","year":"2012"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0361-9230(96)00188-8","article-title":"Baclofen pretreatment attenuates the suppressant effect of intraperitoneal administration of cholecystokinin (CCK) on food intake in rats","volume":"41","author":"Ebenezer","year":"1996","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2012.05.021","article-title":"Effects of intraperitoneal administration of the GABAB receptor positive allosteric modulator 2,6-di tert-butyl-4-(2-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) on food intake in non-deprived rats","volume":"690","author":"Ebenezer","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib26","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1476-5381.1990.tb14120.x","article-title":"Effect of intracerebroventricular administration of the GABAB-receptor agonist baclofen on operant feeding in satiated pigs","volume":"101","author":"Ebenezer","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib27","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1358\/mf.2004.26.8.863728","article-title":"Effects of the GABAB receptor agonists baclofen and 3-aminopropylphosphinic acid (3-APA) on food intake in rats","volume":"26","author":"Ebenezer","year":"2004","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib28","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ejphar.2007.05.022","article-title":"The effects of intraperitoneal administration of the GABA(B) receptor agonist baclofen on food intake in CFLP and C57BL\/6 mice","volume":"569","author":"Ebenezer","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0028-3908(92)90158-L","article-title":"The effect of systemic administration of baclofen on food intake in rats","volume":"31","author":"Ebenezer","year":"1992","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib30","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.psyneuen.2012.11.009","article-title":"The glucagon-like peptide 1 analogue Exendin-4 attenuates alcohol mediated behaviors in rodents","volume":"38","author":"Egecioglu","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib31","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s40263-014-0178-y","article-title":"Role of appetite-regulating peptides in the pathophysiology of addiction: implications for pharmacotherapy","volume":"28","author":"Engel","year":"2014","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib32","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1210\/en.2014-1412","article-title":"Insulin action on GABA neurons is a critical regulator of energy balance but not fertility in mice","volume":"155","author":"Evans","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib33","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3109\/00365513.2011.586131","article-title":"Time-dependent effect of GABA on glucose-stimulated insulin secretion from isolated islets in rat","volume":"71","author":"Faraji","year":"2011","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib34","article-title":"Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals","author":"Farokhnia","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.71","article-title":"Biobehavioral effects of baclofen in anxious alcohol-dependent individuals: a randomized, double-blind, placebo-controlled, laboratory study","volume":"7","author":"Farokhnia","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuropharm.2014.06.016","article-title":"GABAB receptors as a therapeutic strategy in substance use disorders: focus on positive allosteric modulators","volume":"88","author":"Filip","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib37","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cmet.2013.08.004","article-title":"Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin","volume":"18","author":"Fujikawa","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib38","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.neuron.2006.09.006","article-title":"Leptin regulation of the mesoaccumbens dopamine pathway","volume":"51","author":"Fulton","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejphar.2016.06.020","article-title":"Role of Hypothalamic-Pituitary-Adrenal axis and corticotropin-releasing factor stress system on cue-induced relapse to alcohol seeking","volume":"788","author":"Galesi","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib40","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1113\/jphysiol.2005.098962","article-title":"The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line","volume":"569","author":"Gameiro","year":"2005","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib41","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fncel.2014.00235","article-title":"Leptin potentiates GABAergic synaptic transmission in the developing rodent hippocampus","volume":"8","author":"Guimond","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib42","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0960-0760(93)90317-P","article-title":"Involvement of GABAB receptors in the regulation of the hypothalamo-pituitary-adrenocortical (HPA) axis in rats","volume":"46","author":"Hausler","year":"1993","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib43","first-page":"441","article-title":"Neural pathways of stress integration: relevance to alcohol abuse","volume":"34","author":"Herman","year":"2012","journal-title":"Alcohol Res"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib44","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2265.1995.tb02033.x","article-title":"The effects of alcoholism on the hypothalamic-pituitary-adrenal axis: interaction with endogenous opioid peptides","volume":"43","author":"Inder","year":"1995","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib45","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/bies.201300178","article-title":"Beyond inhibition: GABA synapses tune the neuroendocrine stress axis","volume":"36","author":"Inoue","year":"2014","journal-title":"Bioessays"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib46","doi-asserted-by":"crossref","first-page":"17166","DOI":"10.1523\/JNEUROSCI.0897-13.2013","article-title":"GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet","volume":"33","author":"Ito","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neulet.2012.05.036","article-title":"The role of GABAergic system on the inhibitory effect of ghrelin on food intake in neonatal chicks","volume":"520","author":"Jonaidi","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib48","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.cmet.2013.08.015","article-title":"Leptin, GABA, and glucose control","volume":"18","author":"Kahn","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1501723","article-title":"A\u00a0novel GABA-mediated corticotropin-releasing hormone secretory mechanism in the median eminence","volume":"2","author":"Kakizawa","year":"2016","journal-title":"Sci Adv"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib50","article-title":"Activation of amylin receptors attenuates alcohol-mediated behaviours in rodents","author":"Kalafateli","year":"2018","journal-title":"Addiction Biol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib51","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3164\/jcbn.11-85","article-title":"Inhibition of deprivation-induced food intake by GABA(A) antagonists: roles of the hypothalamic, endocrine and alimentary mechanisms","volume":"51","author":"Kamatchi","year":"2012","journal-title":"J.\u00a0Clin. Biochem. Nutr."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.131","article-title":"Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses","volume":"3","author":"Keizer","year":"2015","journal-title":"Pharmacol Res Perspect"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib53","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00213-002-1255-3","article-title":"Alcohol self-administration, craving and HPA-axis activity: an intriguing relationship","volume":"164","author":"Kiefer","year":"2002","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib54","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00213-002-1255-3","article-title":"Alcohol self-administration, craving and HPA-axis activity: an intriguing relationship","volume":"164","author":"Kiefer","year":"2002","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib55","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1054-3589(06)54009-8","article-title":"A\u00a0role for GABA in alcohol dependence","volume":"54","author":"Koob","year":"2006","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib56","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.brainres.2009.11.008","article-title":"The role of CRF and CRF-related peptides in the dark side of addiction","volume":"1314","author":"Koob","year":"2010","journal-title":"Brain Res."},{"issue":"Pt B","key":"10.1016\/j.neuropharm.2018.04.011_bib57","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.neuropharm.2013.05.024","article-title":"Addiction as a stress surfeit disorder","volume":"76","author":"Koob","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib58","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2337\/db14-0668","article-title":"GLP-1 and exendin-4 transiently enhance GABAA receptor-mediated synaptic and tonic currents in rat hippocampal CA3 pyramidal neurons","volume":"64","author":"Korol","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib59","first-page":"121","article-title":"The effects of baclofen on the feeding behaviour and body weight of vagally stimulated rats","volume":"56","author":"Krolczyk","year":"2005","journal-title":"J.\u00a0Physiol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib60","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.regpep.2004.08.026","article-title":"Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter","volume":"128","author":"Larsen","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib61","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/j.1476-5381.2008.00081.x","article-title":"The anorexic agents, sibutramine and fenfluramine, depress GABA(B)-induced inhibitory postsynaptic potentials in rat mesencephalic dopaminergic cells","volume":"156","author":"Ledonne","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib62","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1038\/ncomms7618","article-title":"Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons","volume":"6","author":"Lee","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib63","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1530-0277.2007.00589.x","article-title":"Insulin but not insulin growth factor-1 correlates with craving in currently drinking alcohol-dependent patients","volume":"32","author":"Leggio","year":"2008","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib64","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.pbb.2012.11.013","article-title":"A\u00a0human laboratory pilot study with baclofen in alcoholic individuals","volume":"103","author":"Leggio","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib65","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.pbb.2008.03.006","article-title":"GABA(A) receptors and alcohol","volume":"90","author":"Lobo","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib66","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10571-008-9263-4","article-title":"GABA(B) receptors in neuroendocrine regulation","volume":"28","author":"Lux-Lantos","year":"2008","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib67","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.2174\/1381612821666150619091858","article-title":"GABAB agonists for the treatment of alcohol use disorder","volume":"21","author":"Mirijello","year":"2015","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib68","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.yfrne.2009.10.004","article-title":"Metabolic hormones, dopamine circuits, and feeding","volume":"31","author":"Narayanan","year":"2010","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib69","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s002130100919","article-title":"Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis","volume":"160","author":"O'Malley","year":"2002","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib70","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1046\/j.1365-2826.2001.00662.x","article-title":"GABAergic nature of hypothalamic leptin target neurones in the ventromedial arcuate nucleus","volume":"13","author":"Ovesjo","year":"2001","journal-title":"J.\u00a0Neuroendocrinol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib71","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejphar.2004.09.002","article-title":"The effects of intraperitoneal and intracerebroventricular administration of the GABAB receptor antagonist CGP 35348 on food intake in rats","volume":"503","author":"Patel","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib72","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejphar.2008.10.059","article-title":"The effects of acute multiple intraperitoneal injections of the GABAB receptor agonist baclofen on food intake in rats","volume":"601","author":"Patel","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib73","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2008.07.018","article-title":"The effects of chronic intraperitoneal administration of the GABA B receptor agonist baclofen on food intake in rats","volume":"593","author":"Patel","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib74","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1517\/17460441.2014.956076","article-title":"Targeting GABAB receptors for anti-abuse drug discovery","volume":"9","author":"Phillips","year":"2014","journal-title":"Expet Opin. Drug Discov."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib75","article-title":"Elucidation of the neural circuits activated by a GABAB receptor positive modulator: relevance to anxiety","author":"Pizzo","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib76","first-page":"235","article-title":"Metabolic consequences of alcohol dependency","volume":"16","author":"Preedy","year":"1997","journal-title":"Adverse Drug React. Toxicol. Rev."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib77","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1073\/pnas.0437926100","article-title":"Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons","volume":"100","author":"Roberto","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib78","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1016\/j.febslet.2007.09.011","article-title":"Peripherally administered baclofen reduced food intake and body weight in db\/db as well as diet-induced obese mice","volume":"581","author":"Sato","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib79","doi-asserted-by":"crossref","first-page":"8657","DOI":"10.1523\/JNEUROSCI.2739-05.2005","article-title":"Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems","volume":"25","author":"Sato","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib80","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1172\/JCI75276","article-title":"The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss","volume":"124","author":"Secher","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib81","doi-asserted-by":"crossref","first-page":"383","DOI":"10.31887\/DCNS.2006.8.4\/ssmith","article-title":"The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress","volume":"8","author":"Smith","year":"2006","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib82","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tins.2014.02.006","article-title":"Stress and alcohol interactions: animal studies and clinical significance","volume":"37","author":"Spanagel","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib83","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3390\/biom5042223","article-title":"Impact of alcohol on glycemic control and insulin action","volume":"5","author":"Steiner","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib84","first-page":"468","article-title":"Stress and the HPA axis: role of glucocorticoids in alcohol dependence","volume":"34","author":"Stephens","year":"2012","journal-title":"Alcohol Res"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib85","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1523\/JNEUROSCI.17-11-04434.1997","article-title":"GABA in the nucleus accumbens shell participates in the central regulation of feeding behavior","volume":"17","author":"Stratford","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.68","article-title":"The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence","volume":"5","author":"Suchankova","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib87","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.nut.2007.08.008","article-title":"Relationship between stress, eating behavior, and obesity","volume":"23","author":"Torres","year":"2007","journal-title":"Nutrition"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib88","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.2337\/db14-0849","article-title":"GLP-1 receptor activation modulates appetite-and reward-related brain areas in humans","volume":"63","author":"van Bloemendaal","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib89","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1017\/S0029665112000614","article-title":"Contribution of the mesolimbic dopamine system in mediating the effects of leptin and ghrelin on feeding","volume":"71","author":"van Zessen","year":"2012","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib90","first-page":"1","article-title":"Food and drug reward: overlapping circuits in human obesity and addiction","volume":"11","author":"Volkow","year":"2012","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib91","doi-asserted-by":"crossref","first-page":"E1201","DOI":"10.1152\/ajpendo.00459.2006","article-title":"Glucagon-like peptide-1 stimulates GABA formation by pancreatic beta-cells at the level of glutamate decarboxylase","volume":"292","author":"Wang","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(02)13011-7","article-title":"GABA and GABA receptors in the central nervous system and other organs","volume":"213","author":"Watanabe","year":"2002","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib93","first-page":"41","article-title":"Total body water and blood alcohol levels: updating the fundamentals","volume":"vol. 1","author":"Watson","year":"1989"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib94","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.pharmthera.2005.11.002","article-title":"Ethanol modulation of GABAergic transmission: the view from the slice","volume":"111","author":"Weiner","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib95","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pbb.2006.04.015","article-title":"Effects of baclofen on operant performance for food pellets and vegetable shortening after a history of binge-type behavior in non-food deprived rats","volume":"84","author":"Wojnicki","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib96","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1124\/jpet.104.075663","article-title":"Differential GABAB receptor modulation of ethanol effects on GABA(a) synaptic activity in hippocampal CA1 neurons","volume":"312","author":"Wu","year":"2005","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib97","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1210\/en.2011-2071","article-title":"Role of GABA release from leptin receptor-expressing neurons in body weight regulation","volume":"153","author":"Xu","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib98","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0197-0186(84)90022-6","article-title":"GABA and endocrine regulation relation to neurologic-psychiatric disorders","volume":"6","author":"Yondea","year":"1984","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib99","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/bs.irn.2017.08.002","article-title":"The role of the ghrelin system in drug addiction","volume":"136","author":"Zallar","year":"2017","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neuropharm.2018.04.011_bib100","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0306-3623(89)90110-9","article-title":"Food intake suppressant effect of baclofen in rats","volume":"20","author":"Zarrindast","year":"1989","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib101","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuropharm.2014.05.044","article-title":"Alcohol: a stimulant activating brain stress responsive systems with persistent neuroadaptation","volume":"87","author":"Zhou","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib102","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/sj.npp.1300395","article-title":"Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers","volume":"29","author":"Zimmermann","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.04.011_bib103","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/PSY.0b013e31821a196f","article-title":"Leptin as a neuroactive agent","volume":"73","author":"Zupancic","year":"2011","journal-title":"Psychosom. Med."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818301667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818301667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T16:34:25Z","timestamp":1660926865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390818301667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":103,"alternative-id":["S0028390818301667"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.04.011","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}