{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:43:05Z","timestamp":1775839385809,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funding Authority for Studies and Projects (FINEP, Brazil)"},{"name":"CNPq fellowship","award":["305986\/2016-3"],"award-info":[{"award-number":["305986\/2016-3"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.neuropharm.2018.06.022","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T18:46:13Z","timestamp":1529433973000},"page":"52-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Chronic sleep restriction increases pain sensitivity over time in a periaqueductal gray and nucleus accumbens dependent manner"],"prefix":"10.1016","volume":"139","author":[{"given":"Natalia F.","family":"Sardi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayla K.","family":"Lazzarim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius A.","family":"Guilhen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata S.","family":"Marc\u00edlio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila S.","family":"Natume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thain\u00e1 C.","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9602-4880","authenticated-orcid":false,"given":"Marcelo M.S.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glaucia","family":"Tobaldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2018.06.022_bib1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nm.4329","article-title":"Decreased alertness due to sleep loss increases pain sensitivity in mice","volume":"23","author":"Alexandre","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.sleh.2017.10.006","article-title":"Prevalence and comorbidity of sleep conditions in Australian adults: 2016 Sleep Health Foundation national survey","volume":"4","author":"Appleton","year":"2018","journal-title":"Sleep Health"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib3","first-page":"1","article-title":"Prevalence of sleep deprivation in patients with chronic neck and back pain: a retrospective evaluation of 1016 patients","volume":"6","author":"Artner","year":"2013","journal-title":"J.\u00a0Pain Res."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib4","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nn.3153","article-title":"Corticostriatal functional connectivity predicts transition to chronic back pain","volume":"15","author":"Baliki","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib5","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/cne.901870304","article-title":"The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation","volume":"187","author":"Basbaum","year":"1979","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pain.2008.08.008","article-title":"Descending facilitation from the brainstem determines behavioural and neuronal hypersensitivity following nerve injury and efficacy of pregabalin","volume":"140","author":"Bee","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0301-0082(95)00009-K","article-title":"Functional characteristics of the midbrain periaqueductal gray","volume":"46","author":"Behbehani","year":"1995","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib8","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1152\/physrev.00032.2011","article-title":"Control of sleep and wakefulness","volume":"92","author":"Brown","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib9","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1523\/JNEUROSCI.22-12-05129.2002","article-title":"Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain","volume":"22","author":"Burgess","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.sleep.2013.08.787","article-title":"Prevalence of insomnia symptoms in a general population sample of young children and preadolescents: gender effects","volume":"15","author":"Calhoun","year":"2014","journal-title":"Sleep Med."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-3959(93)90161-H","article-title":"Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence","volume":"52","author":"Coderre","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.pbb.2009.07.005","article-title":"Systemic amitriptyline administration does not prevent the increased thermal response induced by paradoxical sleep deprivation","volume":"94","author":"Damasceno","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib13","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1111\/ejn.13015","article-title":"Nucleus accumbens dopaminergic neurotransmission switches its modulatory action in chronification of inflammatory hyperalgesia","volume":"42","author":"Dias","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrn1431","article-title":"State-dependent opioid control of pain","volume":"5","author":"Fields","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib15","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1523\/JNEUROSCI.19-16-07175.1999","article-title":"Pain-induced analgesia mediated by mesolimbic reward circuits","volume":"19","author":"Gear","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib16","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.expneurol.2011.03.021","article-title":"Nucleus accumbens facilitates nociception","volume":"229","author":"Gear","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11916-013-0361-8","article-title":"Conditioned pain modulation: a predictor for development and treatment of neuropathic pain","volume":"17","author":"Granovsky","year":"2013","journal-title":"Curr. Pain Headache Rep."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib18","first-page":"844","article-title":"Sleep fragmentation hypersensitizes healthy young women to deep and superficial experimental pain","volume":"18","author":"Iacovides","year":"2017","journal-title":"J.\u00a0Pain"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0306-4522(01)00521-8","article-title":"A\u00a0differential involvement of the shell and core subterritories of the nucleus accumbens of rats in attentional processes","volume":"111","author":"Jongen-Relo","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib20","first-page":"2475","article-title":"Prevalence of sleep disturbance in chronic pain","volume":"18","author":"Karaman","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib21","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.conb.2013.02.001","article-title":"Role of the basal ganglia in the control of sleep and wakefulness","volume":"23","author":"Lazarus","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib22","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1523\/JNEUROSCI.12-08-02973.1992","article-title":"NMDA and non-NMDA receptor-mediated increase of c-fos mRNA in dentate gyrus neurons involves calcium influx via different routes","volume":"12","author":"Lerea","year":"1992","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1523\/JNEUROSCI.2244-05.2006","article-title":"Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter","volume":"26","author":"Lu","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib24","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1111\/pme.12220","article-title":"Sex differences in the stability of conditioned pain modulation (CPM) among patients with chronic pain","volume":"14","author":"Martel","year":"2013","journal-title":"Pain Med."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2010.05.067","article-title":"Peri-adolescence isolation rearing alters social behavior and nociception in rats","volume":"480","author":"Meng","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0301-0082(02)00009-6","article-title":"Descending control of pain","volume":"66","author":"Millan","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuroscience.2014.10.049","article-title":"Effect of pain chronification and chronic pain on an endogenous pain modulation circuit in rats","volume":"286","author":"Miranda","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1523\/JNEUROSCI.03-01-00189.1983","article-title":"Neural projections from nucleus accumbens to globus pallidus, substantia innominata, and lateral preoptic-lateral hypothalamic area: an anatomical and electrophysiological investigation in the rat","volume":"3","author":"Mogenson","year":"1983","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/art.33346","article-title":"Sleep problems and risk of fibromyalgia: longitudinal data on an adult female population in Norway","volume":"64","author":"Mork","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib30","first-page":"E257","article-title":"Prevalence of specific types of pain diagnoses in a sample of United States adults","volume":"20","author":"Murphy","year":"2017","journal-title":"Pain Physician"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/nyas.13447","article-title":"Dreamless: the silent epidemic of REM sleep loss","volume":"1406","author":"Naiman","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbr.2006.12.016","article-title":"Pain hypersensitivity induced by paradoxical sleep deprivation is not due to altered binding to brain mu-opioid receptors","volume":"178","author":"Nascimento","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/sleep\/16.1.1","article-title":"Immediate early gene expression in brain during sleep deprivation: preliminary observations","volume":"16","author":"O'Hara","year":"1993","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neures.2017.04.008","article-title":"The control of sleep and wakefulness by mesolimbic dopamine systems","volume":"118","author":"Oishi","year":"2017","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib35","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41467-017-00781-4","article-title":"Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice","volume":"8","author":"Oishi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib36","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s11926-011-0204-8","article-title":"Do sleep disorders contribute to pain sensitivity?","volume":"13","author":"Okifuji","year":"2011","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib37","series-title":"Netter's Essential Histology","author":"Ovalle","year":"2013"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib38","doi-asserted-by":"crossref","first-page":"e921","DOI":"10.1542\/peds.2014-1696","article-title":"Insufficient sleep in adolescents and young adults: an update on causes and consequences","volume":"134","author":"Owens","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib39","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2174\/1874312901206010296","article-title":"Is the deficit in pain inhibition in fibromyalgia influenced by sleep impairments?","volume":"6","author":"Paul-Savoie","year":"2012","journal-title":"Open Rheumatol. J."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib40","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib41","first-page":"409","article-title":"A\u00a0method for measurement of analgesic activity on inflamed tissue","volume":"111","author":"Randall","year":"1957","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib42","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1126\/science.164.3878.444","article-title":"Surgery in the rat during electrical analgesia induced by focal brain stimulation","volume":"164","author":"Reynolds","year":"1969","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/j.pain.0000000000001066","article-title":"Nucleus Accumbens mediates\u00a0the pronociceptive effect of sleep deprivation: the role of adenosine A2A and dopamine D2 receptors","volume":"159","author":"Sardi","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib44","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib45","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.pain.2013.04.046","article-title":"One night of total sleep deprivation promotes a state of generalized hyperalgesia: a surrogate pain model to study the relationship of insomnia and pain","volume":"154","author":"Schuh-Hofer","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib46","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/sleep\/25.6.677","article-title":"Telemetric recording of sleep and home cage activity in mice","volume":"25","author":"Tang","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib47","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pain.2009.08.029","article-title":"Sleep restriction attenuates amplitudes and attentional modulation of pain-related evoked potentials, but augments pain ratings in healthy volunteers","volume":"148","author":"Tiede","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib48","first-page":"422","article-title":"Ascending nociceptive control contributes to the antinociceptive effect of acupuncture in a rat model of acute pain","volume":"15","author":"Tobaldini","year":"2014","journal-title":"J.\u00a0Pain"},{"key":"10.1016\/j.neuropharm.2018.06.022_bib49","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1007\/s12035-014-9059-0","article-title":"The pronociceptive effect of paradoxical sleep deprivation in rats: evidence for a role of descending pain modulation mechanisms","volume":"53","author":"Tomim","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jneumeth.2016.01.009","article-title":"Using Actiwatch to monitor circadian rhythm disturbance in Huntington' disease: a cautionary note","volume":"265","author":"Townhill","year":"2016","journal-title":"J.\u00a0Neurosci. Meth."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib51","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41467-017-02765-w","article-title":"Regulation of REM and non-REM sleep by periaqueductal GABAergic neurons","volume":"9","author":"Weber","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib52","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pbb.2013.08.003","article-title":"Spinal D-amino acid oxidase contributes to mechanical pain hypersensitivity induced by sleep deprivation in the rat","volume":"111","author":"Wei","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fnana.2013.00043","article-title":"Projections of nucleus accumbens adenosine A2A receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation","volume":"7","author":"Zhang","year":"2013","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neuropharm.2018.06.022_bib54","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818303113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818303113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T18:38:30Z","timestamp":1565289510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390818303113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":54,"alternative-id":["S0028390818303113"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.06.022","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic sleep restriction increases pain sensitivity over time in a periaqueductal gray and nucleus accumbens dependent manner","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}