{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:33:26Z","timestamp":1781249606558,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Major International Joint Research Project of National Natural Science Foundation of China","award":["81420108028"],"award-info":[{"award-number":["81420108028"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31760249"],"award-info":[{"award-number":["31760249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Science and Technology Project of Hainan Province","award":["ZDKJ2016002"],"award-info":[{"award-number":["ZDKJ2016002"]}]},{"name":"Changjiang Scholars and Innovative Research Team in University","award":["IRT_15R15"],"award-info":[{"award-number":["IRT_15R15"]}]},{"DOI":"10.13039\/501100006769","name":"RSF","doi-asserted-by":"publisher","award":["16-14-00215"],"award-info":[{"award-number":["16-14-00215"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"RFBR","doi-asserted-by":"publisher","award":["18-04-01366"],"award-info":[{"award-number":["18-04-01366"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.neuropharm.2018.07.019","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T19:15:55Z","timestamp":1531854955000},"page":"226-237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Species specificity of rat and human \u03b17 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists"],"prefix":"10.1016","volume":"139","author":[{"given":"Jinpeng","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Kudryavtsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Kasheverov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiao","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongting","family":"Zhangsun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Tsetlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2018.07.019_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1152\/physrev.00015.2008","article-title":"Mammalian nicotinic acetylcholine receptors: from structure to function","volume":"89","author":"Albuquerque","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib2","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1074\/jbc.M109.071183","article-title":"A\u00a0synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists","volume":"285","author":"Armishaw","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.1471-4159.2012.07867.x","article-title":"Molecular basis for the differential sensitivity of rat and human alpha9alpha10 nAChRs to alpha-conotoxin RgIA","volume":"122","author":"Azam","year":"2012","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib4","doi-asserted-by":"crossref","first-page":"7522","DOI":"10.1074\/jbc.271.13.7522","article-title":"A\u00a0new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors","volume":"271","author":"Cartier","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib5","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nsmb951","article-title":"Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant","volume":"12","author":"Celie","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib6","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0028-3908(03)00189-8","article-title":"The nicotinic alpha 4 beta 2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices","volume":"45","author":"Chen","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.07.019_bib7","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1124\/mol.116.104240","article-title":"Understanding the bases of function and modulation of alpha7 nicotinic receptors: implications for drug discovery","volume":"90","author":"Corradi","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib8","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1517\/13543776.2015.1054095","article-title":"Therapeutic conotoxins: a US patent literature survey","volume":"25","author":"Durek","year":"2015","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neuropharm.2017.06.011","article-title":"Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms","volume":"127","author":"Dutertre","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.07.019_bib10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bcp.2015.07.032","article-title":"Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection","volume":"97","author":"Egea","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib11","doi-asserted-by":"crossref","first-page":"16019","DOI":"10.1021\/bi048918g","article-title":"Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes","volume":"43","author":"Ellison","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2018.07.019_bib12","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1074\/jbc.M204565200","article-title":"Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites","volume":"278","author":"Ellison","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib13","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bcp.2011.11.006","article-title":"RegIIA: an alpha4\/7-conotoxin from the venom of Conus regius that potently blocks alpha3beta4 nAChRs","volume":"83","author":"Franco","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-3-540-30880-5_4","article-title":"Hyperhydroxylation: a new strategy for neuronal targeting by venomous marine molluscs","volume":"43","author":"Franco","year":"2006","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib15","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1111\/bph.13931","article-title":"alpha9-containing nicotinic acetylcholine receptors and the modulation of pain","volume":"175","author":"Hone","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pharmthera.2012.08.012","article-title":"Nicotinic acetylcholine receptors: from basic science to therapeutics","volume":"137","author":"Hurst","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1124\/jpet.108.142943","article-title":"Alpha-conotoxin Arenatus IB[V11L,V16D] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors","volume":"327","author":"Innocent","year":"2008","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib18","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1124\/mol.115.100503","article-title":"Molecular basis for differential sensitivity of alpha-conotoxin RegIIA at rat and human neuronal nicotinic acetylcholine receptors","volume":"88","author":"Kompella","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib19","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1074\/jbc.M114.605592","article-title":"Alanine scan of alpha-conotoxin RegIIA reveals a selective alpha3beta4 nicotinic acetylcholine receptor antagonist","volume":"290","author":"Kompella","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib20","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.3390\/md12052970","article-title":"Conotoxins targeting nicotinic acetylcholine receptors: an overview","volume":"12","author":"Lebbe","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.neuropharm.2018.07.019_bib21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40409-016-0083-6","article-title":"In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds","volume":"22","author":"Lebbe","year":"2016","journal-title":"J.\u00a0Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib22","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.pharmthera.2009.03.009","article-title":"A\u00a0cog in cognition: how the alpha 7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits","volume":"122","author":"Leiser","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib23","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nn.2908","article-title":"Ligand-binding domain of an alpha7-nicotinic receptor chimera and its complex with agonist","volume":"14","author":"Li","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib24","doi-asserted-by":"crossref","first-page":"E4026","DOI":"10.1073\/pnas.1503617112","article-title":"Cloning, synthesis, and characterization of alphaO-conotoxin GeXIVA, a potent alpha9alpha10 nicotinic acetylcholine receptor antagonist","volume":"112","author":"Luo","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib25","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1096\/fj.13-244103","article-title":"A\u00a0novel alpha4\/7-conotoxin LvIA from Conus lividus that selectively blocks alpha3beta2 vs. alpha6\/alpha3beta2beta3 nicotinic acetylcholine receptors","volume":"28","author":"Luo","year":"2014","journal-title":"Faseb. J."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib26","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1074\/jbc.M112.427898","article-title":"Characterization of a novel alpha-conotoxin from conus textile that selectively targets alpha6\/alpha3beta2beta3 nicotinic acetylcholine receptors","volume":"288","author":"Luo","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib27","doi-asserted-by":"crossref","first-page":"9655","DOI":"10.1021\/jm401254c","article-title":"Characterization of a novel alpha-conotoxin TxID from Conus textile that potently blocks rat alpha3beta4 nicotinic acetylcholine receptors","volume":"56","author":"Luo","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.autneu.2013.12.007","article-title":"The cholinergic anti-inflammatory pathway: a critical review","volume":"182","author":"Martelli","year":"2014","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib29","doi-asserted-by":"crossref","first-page":"42555","DOI":"10.1074\/jbc.M111.286583","article-title":"Creating an alpha7 nicotinic acetylcholine recognition domain from the acetylcholine-binding protein: crystallographic and ligand selectivity analyses","volume":"286","author":"Nemecz","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib30","doi-asserted-by":"crossref","first-page":"31173","DOI":"10.1074\/jbc.R600020200","article-title":"Conus peptides: biodiversity-based discovery and exogenomics","volume":"281","author":"Olivera","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib31","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.3390\/ijms13022219","article-title":"Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology","volume":"13","author":"Pohanka","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib32","doi-asserted-by":"crossref","first-page":"E1825","DOI":"10.1073\/pnas.1621433114","article-title":"Inhibition of alpha9alpha10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain","volume":"114","author":"Romero","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0928-4257(98)80145-9","article-title":"Molecular dissection of subunit interfaces in the nicotinic acetylcholine receptor","volume":"92","author":"Sine","year":"1998","journal-title":"J.\u00a0Physiol. Paris"},{"key":"10.1016\/j.neuropharm.2018.07.019_bib34","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1073\/pnas.0507889103","article-title":"Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP","volume":"103","author":"Ulens","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2018.07.019_bib35","doi-asserted-by":"crossref","first-page":"6628","DOI":"10.1021\/bi7004202","article-title":"Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor antagonist","volume":"46","author":"Whiteaker","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuropharm.2018.07.019_bib36","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.3390\/md11093537","article-title":"Optimal cleavage and oxidative folding of alpha-conotoxin TxIB as a therapeutic candidate peptide","volume":"11","author":"Wu","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.neuropharm.2018.07.019_bib37","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3390\/molecules19010966","article-title":"Influence of disulfide connectivity on structure and bioactivity of alpha-conotoxin TxIA","volume":"19","author":"Wu","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.neuropharm.2018.07.019_bib1a","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1093\/bioinformatics\/btw514","article-title":"PRODIGY: a web server for predicting the binding affinity of protein-protein complexes","volume":"32","author":"Xue","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuropharm.2018.07.019_bib38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuropharm.2017.04.015","article-title":"alphaO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human alpha9alpha10 subtype","volume":"127","author":"Zhangsun","year":"2017","journal-title":"Neuropharmacology"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818303873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818303873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T20:24:48Z","timestamp":1693772688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390818303873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":39,"alternative-id":["S0028390818303873"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.07.019","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Species specificity of rat and human \u03b17 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}