{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:36:19Z","timestamp":1768707379837,"version":"3.49.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Gary R. Helman Postdoctoral Research Fellowship"},{"name":"Robertson Therapeutic Development Fund"},{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.neuropharm.2018.07.025","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T17:34:42Z","timestamp":1532367282000},"page":"174-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Naltrexone and nalmefene attenuate cocaine place preference in male mice"],"prefix":"10.1016","volume":"140","author":[{"given":"Kyle A.","family":"Windisch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Reed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Jeanne","family":"Kreek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2018.07.025_bib1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1124\/jpet.106.101998","article-title":"Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice","volume":"318","author":"Ansonoff","year":"2006","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1369-1600.2010.00311.x","article-title":"Rapamycin attenuates the expression of cocaine-induced place preference and behavioral sensitization","volume":"17","author":"Bailey","year":"2012","journal-title":"Addiction Biol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib3","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1038\/sj.npp.1300811","article-title":"Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?","volume":"30","author":"Bart","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/314533a0","article-title":"Opposite motivational effects of endogenous opioids in brain and periphery","volume":"314","author":"Bechara","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s002130050815","article-title":"Effects of test conditions on the outcome of place conditioning with morphine and naltrexone in mice","volume":"141","author":"Bespalov","year":"1999","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib6","doi-asserted-by":"crossref","first-page":"PL85","DOI":"10.1016\/0024-3205(92)90105-X","article-title":"Opioidergic modulation of cocaine conditioned place preferences","volume":"50","author":"Bilsky","year":"1992","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib7","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1038\/npp.2013.143","article-title":"Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers","volume":"38","author":"Comer","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib8","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/BF02245810","article-title":"The effects of the kappa agonist U-50,488 on cocaine-induced conditioned and unconditioned behaviors and Fos immunoreactivity","volume":"120","author":"Crawford","year":"1995","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00213-015-4121-9","article-title":"Alterations of naltrexone-induced conditioned place avoidance by pre-exposure to high fructose corn syrup or heroin in Sprague-Dawley rats","volume":"233","author":"Daniels","year":"2016","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib10","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0090-9556(25)06085-4","article-title":"The urinary excretion profiles of naltrexone in man, monkey, rabbit, and rat","volume":"4","author":"Dayton","year":"1976","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0091-3057(90)90019-E","article-title":"Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors","volume":"37","author":"deHaven-Hudkins","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib12","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0022-3565(25)24578-5","article-title":"Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats","volume":"244","author":"Di Chiara","year":"1988","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/j.1552-4604.1987.tb02191.x","article-title":"Nalmefene: safety and kinetics after single and multiple oral doses of a new opioid antagonist","volume":"27","author":"Dixon","year":"1987","journal-title":"J.\u00a0Clin. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib14","first-page":"p.pyy034","article-title":"Structurally-related kappa opioid receptor agonists with substantial differential signaling bias: neuroendocrine and behavioral effects in C57BL6 mice","author":"Dunn","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/clpt.1986.220","article-title":"Prolonged blockade of opioid effect with oral nalmefene","volume":"40","author":"Gal","year":"1986","journal-title":"Clin. Pharmacol. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib16","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1021\/jm701060e","article-title":"Synthesis and biological evaluation of alpha- and beta-6-amido derivatives of 17-cyclopropylmethyl-3, 14beta-dihydroxy-4, 5alpha-epoxymorphinan: potential alcohol-cessation agents","volume":"51","author":"Ghirmai","year":"2008","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/YIC.0000000000000069","article-title":"Treatment of cocaine craving with as-needed nalmefene, a partial kappa opioid receptor agonist: first clinical experience","volume":"30","author":"Grosshans","year":"2015","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib18","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1007\/s00213-014-3571-9","article-title":"Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking in alcohol-preferring (P) and Long Evans rats","volume":"231","author":"Henderson-Redmond","year":"2014","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s002130050688","article-title":"Naltrexone treatment of comorbid alcohol and cocaine use disorders","volume":"139","author":"Hersh","year":"1998","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(89)90989-X","article-title":"Opioid mediation of cocaine-induced hyperactivity and reinforcement","volume":"497","author":"Houdi","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib21","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1038\/sj.npp.1300790","article-title":"Prolonged central mu-opioid receptor occupancy after single and repeated nalmefene dosing","volume":"30","author":"Ingman","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib22","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/j.1460-9568.2006.05041.x","article-title":"Neurokinin receptor antagonism attenuates cocaine's behavioural activating effects yet potentiates its dopamine-enhancing action in the nucleus accumbens core","volume":"24","author":"Jocham","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ejphar.2006.06.077","article-title":"The antinociceptive effect of salvinorin A in mice","volume":"545","author":"John","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib24","first-page":"1726","article-title":"Longer occupancy of opioid receptors by nalmefene compared to naloxone as measured in\u00a0vivo by a dual-detector system","volume":"38","author":"Kim","year":"1997","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib25","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0006-3223(92)90223-M","article-title":"Intravenous cocaine challenges during naltrexone maintenance: a preliminary study","volume":"32","author":"Kosten","year":"1992","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib26","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0024-3205(89)90589-4","article-title":"Role of opioid antagonists in treating intravenous cocaine abuse","volume":"44","author":"Kosten","year":"1989","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib27","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0022-3565(24)37399-9","article-title":"Alterations in locomotor activity during chronic cocaine administration: effect on dopamine receptors and interaction with opioids","volume":"285","author":"Kunko","year":"1998","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib28","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/bcp.12805","article-title":"Population pharmacokinetics of nalmefene in healthy subjects and its relation to mu-opioid receptor occupancy","volume":"81","author":"Kyhl","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib29","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/sj.npp.1300529","article-title":"Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in development of cocaine-induced behavioral sensitization in mice","volume":"30","author":"Lesscher","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF00451687","article-title":"Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine","volume":"98","author":"Lett","year":"1989","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib31","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/jps.2600650521","article-title":"Tritiated naltrexone binding in plasma from several species and tissue distribution in mice","volume":"65","author":"Ludden","year":"1976","journal-title":"J.\u00a0Pharmaceut. Sci."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib32","first-page":"2445","article-title":"Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain","volume":"7","author":"Mansour","year":"1987","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0166-2236(88)90093-8","article-title":"Anatomy of CNS opioid receptors","volume":"11","author":"Mansour","year":"1988","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib34","first-page":"175","article-title":"Binding of a new opiate antagonist, nalmefene, to rat brain membranes","volume":"7","author":"Michel","year":"1985","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib35","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0090-9556(25)06015-5","article-title":"Disposition of (15,16-3H)naltrexone in the central nervous system of the rat","volume":"4","author":"Misra","year":"1976","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0091-3057(98)00150-6","article-title":"The effects of the naltrexone implant on rodent social interactions and cocaine-induced conditioned place preference","volume":"62","author":"Mitchem","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0376-8716(97)00134-8","article-title":"Effects of naltrexone on cue-elicited craving for alcohol and cocaine","volume":"49","author":"Modesto-Lowe","year":"1997","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF00432214","article-title":"Aversive properties of naloxone in non-dependent (naive) rats may involve blockade of central beta-endorphin","volume":"86","author":"Mucha","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib39","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3109\/00498259609046748","article-title":"Disposition of the opioid antagonist, nalmefene, in rat and dog","volume":"26","author":"Murthy","year":"1996","journal-title":"Xenobiotica"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0740-5472(98)00039-7","article-title":"The effects of naltrexone on alcohol and cocaine use in dually addicted patients","volume":"16","author":"Oslin","year":"1999","journal-title":"J.\u00a0Subst. Abuse Treat."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib41","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0091-3057(92)90373-N","article-title":"Naltrexone-induced aversions: assessment by place conditioning, taste reactivity, and taste avoidance paradigms","volume":"41","author":"Parker","year":"1992","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib42","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jsat.2007.05.011","article-title":"Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence","volume":"34","author":"Pettinati","year":"2008","journal-title":"J.\u00a0Subst. Abuse Treat."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib43","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00213-008-1296-3","article-title":"Role of medial prefrontal, entorhinal, and occipital 5-HT in cocaine-induced place preference and hyperlocomotion: evidence for multiple dissociations","volume":"201","author":"Pum","year":"2008","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib44","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1037\/1064-1297.8.3.434","article-title":"Determination of the place conditioning and locomotor effects of amperozide in rats: a comparison with cocaine","volume":"8","author":"Rademacher","year":"2000","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3940(02)00950-3","article-title":"Effects of the selective mu(1)-opioid receptor antagonist, naloxonazine, on cocaine-induced conditioned place preference and locomotor behavior in rats","volume":"332","author":"Rademacher","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib46","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1126\/science.2820058","article-title":"Cocaine receptors on dopamine transporters are related to self-administration of cocaine","volume":"237","author":"Ritz","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib47","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0090-9556(25)00291-0","article-title":"Metabolism and choleretic effect of naltrexone in the isolated perfused rat liver","volume":"8","author":"Rodgers","year":"1980","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib48","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0022-3565(25)10640-X","article-title":"Behavioral and biochemical evidence of opioidergic involvement in cocaine sensitization","volume":"274","author":"Sala","year":"1995","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib49","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.drugalcdep.2013.12.015","article-title":"A\u00a0two-phased screening paradigm for evaluating candidate medications for cocaine cessation or relapse prevention: modafinil, levodopa-carbidopa, naltrexone","volume":"136","author":"Schmitz","year":"2014","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib50","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3109\/10550490903077929","article-title":"High-dose naltrexone therapy for cocaine-alcohol dependence","volume":"18","author":"Schmitz","year":"2009","journal-title":"Am. J. Addict."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0306-4603(00)00098-8","article-title":"Naltrexone and relapse prevention treatment for cocaine-dependent patients","volume":"26","author":"Schmitz","year":"2001","journal-title":"Addict. Behav."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib52","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/10550490490480982","article-title":"Treatment of cocaine-alcohol dependence with naltrexone and relapse prevention therapy","volume":"13","author":"Schmitz","year":"2004","journal-title":"Am. J. Addict."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib53","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0022-3565(25)09578-3","article-title":"Sensitization to the conditioned rewarding effects of cocaine: pharmacological and temporal characteristics","volume":"273","author":"Shippenberg","year":"1995","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib54","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-3565(25)12305-7","article-title":"kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine","volume":"276","author":"Shippenberg","year":"1996","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib55","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0014-2999(97)01614-2","article-title":"Sensitization to the conditioned rewarding effects of morphine and cocaine: differential effects of the \u03ba-opioid receptor agonist U69593","volume":"345","author":"Shippenberg","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib56","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1038\/npp.2009.28","article-title":"Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior","volume":"34","author":"Simmons","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib57","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0091-3057(03)00157-6","article-title":"Effects of naltrexone and isradipine, alone or in combination, on cocaine responses in humans","volume":"75","author":"Sofuoglu","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib58","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1124\/mol.114.096503","article-title":"A\u00a0novel method for analyzing extremely biased agonism at G protein-coupled receptors","volume":"87","author":"Stahl","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib59","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1254\/jjp.58.435","article-title":"The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference","volume":"58","author":"Suzuki","year":"1992","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib60","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12609","article-title":"Time-dependent regional brain distribution of methadone and naltrexone in the treatment of opioid addiction","author":"Teklezgi","year":"2018","journal-title":"Addiction Biol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib61","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0014-2999(88)90602-4","article-title":"Effects of beta-funaltrexamine on ingestive behaviors in the rat","volume":"153","author":"Ukai","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib62","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.euroneuro.2010.03.005","article-title":"The high affinity dopamine uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization","volume":"20","author":"Velazquez-Sanchez","year":"2010","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib63","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0090-9556(25)06161-6","article-title":"Metabolism and disposition of naltrexone in man after oral and intravenous administration","volume":"9","author":"Wall","year":"1981","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib64","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0022-3565(25)21159-4","article-title":"Effects of naltrexone on response to intravenous cocaine, hydromorphone and their combination in humans","volume":"279","author":"Walsh","year":"1996","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib65","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.bmcl.2009.02.078","article-title":"Syntheses of novel high affinity ligands for opioid receptors","volume":"19","author":"Wentland","year":"2009","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib66","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1124\/jpet.114.216820","article-title":"The G protein-biased kappa-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in\u00a0vivo","volume":"352","author":"White","year":"2015","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.07.025_bib67","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.alcohol.2008.11.003","article-title":"Potency of naltrexone to reduce ethanol self-administration in rats is greater for subcutaneous versus intraperitoneal injection","volume":"43","author":"Williams","year":"2009","journal-title":"Alcohol"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib68","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00213-003-1688-3","article-title":"Effect of the endogenous kappa opioid agonist dynorphin A(1-17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL\/6J mice","volume":"172","author":"Zhang","year":"2004","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib69","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00213-003-1716-3","article-title":"Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL\/6J mice","volume":"173","author":"Zhang","year":"2004","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.07.025_bib70","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00213-004-2087-0","article-title":"Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors","volume":"179","author":"Zhang","year":"2005","journal-title":"Psychopharmacology (Berlin)"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818304039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818304039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T23:43:39Z","timestamp":1751759019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390818304039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":70,"alternative-id":["S0028390818304039"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.07.025","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naltrexone and nalmefene attenuate cocaine place preference in male mice","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}