{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:57:55Z","timestamp":1787320675194,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["16-34-01016"],"award-info":[{"award-number":["16-34-01016"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["14-50-00069"],"award-info":[{"award-number":["14-50-00069"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.neuropharm.2018.10.034","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T22:19:38Z","timestamp":1540333178000},"page":"184-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Activation of trace amine-associated receptor 1 attenuates schedule-induced polydipsia in rats"],"prefix":"10.1016","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9251-9923","authenticated-orcid":false,"given":"Ilya","family":"Sukhanov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artem","family":"Dorotenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-7910","authenticated-orcid":false,"given":"Antonina","family":"Dolgorukova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6510-6250","authenticated-orcid":false,"given":"Marius C.","family":"Hoener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul R.","family":"Gainetdinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton Yu.","family":"Bespalov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2018.10.034_bib1","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.2147\/NDT.S62785","article-title":"Animal models of obsessive-compulsive disorder: utility and limitations","volume":"11","author":"Alonso","year":"2015","journal-title":"Neuropsychiatric Dis. Treat."},{"issue":"Suppl. 1","key":"10.1016\/j.neuropharm.2018.10.034_bib2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuropharm.2005.06.007","article-title":"Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats","volume":"49","author":"Bespalov","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tips.2016.01.008","article-title":"Drug tolerance: a known unknown in translational neuroscience","volume":"37","author":"Bespalov","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.biopsych.2016.10.012","article-title":"Tracev amine-associated receptor 1 agonists as narcolepsy therapeutics","volume":"82","author":"Black","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib5","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1073\/pnas.151105198","article-title":"Trace amines: identification of a family of mammalian G protein-coupled receptors","volume":"98","author":"Borowsky","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fphar.2018.00222","article-title":"The trace amine-associated receptor 1 agonist 3-iodothyronamine induces biased signaling at the serotonin 1b receptor","volume":"9","author":"Br\u00e4unig","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib7","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1124\/mol.60.6.1181","article-title":"Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor","volume":"60","author":"Bunzow","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib2a","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fpsyt.2018.00043","article-title":"Behavioral phenotyping of dopamine transporter knockout rats: compulsive traits, motor stereotypies, and anhedonia","volume":"9","author":"Cinque","year":"2018","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib8","doi-asserted-by":"crossref","first-page":"16928","DOI":"10.1523\/JNEUROSCI.2502-11.2011","article-title":"Genetic deletion of trace amine 1 receptors reveals their role in auto-inhibiting the actions of ecstasy (MDMA)","volume":"31","author":"Di Cara","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fnins.2015.00039","article-title":"The trace amine-associated receptor 1 modulates Methamphetamine's neurochemical and behavioral effects","volume":"9","author":"Cotter","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00008877-199402000-00004","article-title":"The effects of amphetamine, phencyclidine, dopaminergic antagonists and atypical neuroleptics on schedule-induced polydipsia (SIP) are distinguishable","volume":"5","author":"Didriksen","year":"1994","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.neuropharm.2015.02.010","article-title":"Postsynaptic D2 dopamine receptor supersensitivity in the striatum of mice lacking TAAR1","volume":"93","author":"Espinoza","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib13","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1038\/npp.2015.65","article-title":"TAAR1 modulates cortical glutamate NMDA receptor function","volume":"40","author":"Espinoza","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1126\/science.133.3447.195","article-title":"Production of polydipsia in normal rats by an intermittent food schedule","volume":"133","author":"Falk","year":"1961","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib15","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/npp.2016.233","article-title":"The trace amine-associated receptor 1 agonist RO5256390 blocks compulsive, binge-like eating in rats","volume":"42","author":"Ferragud","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib16","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/pr.117.015305","article-title":"Trace amines and their receptors","volume":"70","author":"Gainetdinov","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib17","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/npp.2015.61","article-title":"Trace amine-associated receptor 1 regulation of methamphetamine intake and related traits","volume":"40","author":"Harkness","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib18","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1007\/s00213-013-3345-9","article-title":"The amphetamine sensitization model of schizophrenia symptoms and its effect on schedule-induced polydipsia in the rat","volume":"231","author":"Hawken","year":"2014","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.schres.2010.07.022","article-title":"Increased schedule-induced polydipsia in the rat following subchronic treatment with MK-801","volume":"125","author":"Hawken","year":"2011","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib20","article-title":"Effects of the trace amine associated receptor 1 agonist RO5263397 on abuse-related behavioral indices of methamphetamine in rats","volume":"18","author":"Jing","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib22","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ygeno.2004.11.010","article-title":"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors","volume":"85","author":"Lindemann","year":"2005","journal-title":"Genomics"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib23","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1124\/jpet.107.132647","article-title":"Trace amine-associated receptor 1 modulates dopaminergic activity","volume":"324","author":"Lindemann","year":"2008","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib24","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1523\/JNEUROSCI.2006-16.2016","article-title":"Role of TAAR1 within the subregions of the mesocorticolimbic dopaminergic system in cocaine-seeking behavior","volume":"37","author":"Liu","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00213-007-1059-6","article-title":"Individual differences in schedule-induced polydipsia and the role of gabaergic and dopaminergic systems","volume":"197","author":"L\u00f3pez-Grancha","year":"2008","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib27","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0022-3565(25)23811-3","article-title":"Polydipsia and dopamine: behavioral effects of dopamine D1 and D2 receptor agonists and antagonists","volume":"271","author":"Mittleman","year":"1994","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib28","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00213-011-2570-3","article-title":"Schedule-induced polydipsia as a model of compulsive behavior: neuropharmacological and neuroendocrine bases","volume":"219","author":"Moreno","year":"2012","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib1a","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/adb.12410","article-title":"A partial trace amine-associated receptor 1 agonist exhibits properties consistent with a methamphetamine substitution treatment","volume":"22","author":"Pei","year":"2017","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib29","series-title":"Curr Protoc Neurosci Chapter 9, Unit 9 27","article-title":"Schedule- induced polydipsia: a rat model of obsessive-compulsive disorder","author":"Platt","year":"2008"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib30","doi-asserted-by":"crossref","first-page":"8485","DOI":"10.1073\/pnas.1103029108","article-title":"TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity","volume":"108","author":"Revel","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib31","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1038\/npp.2012.109","article-title":"Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine","volume":"37","author":"Revel","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib32","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.biopsych.2012.05.014","article-title":"Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics","volume":"72","author":"Revel","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib33","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/mp.2012.57","article-title":"A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight","volume":"18","author":"Revel","year":"2013","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0091-3057(85)90487-3","article-title":"Intravenous self-administration of nicotine: with and without schedule-induction","volume":"22","author":"Slifer","year":"1985","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib37","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1017\/S1461145714000509","article-title":"TAAR1-dependent effects of apomorphine in mice","volume":"17","author":"Sukhanov","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib38","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.phrs.2015.11.002","article-title":"Increased context-dependent conditioning to amphetamine in mice lacking TAAR1","volume":"103","author":"Sukhanov","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2014.02.024","article-title":"The trace amine associated receptor 1 agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in rats","volume":"566","author":"Thorn","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2018.10.034_bib40","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1517\/13543784.6.10.1369","article-title":"Animal models with potential applications for screening compounds for the treatment of obsessive-compulsive disorder","volume":"6","author":"Woods-Kettelberger","year":"1997","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.neuropharm.2018.10.034_bib41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1124\/jpet.106.116863","article-title":"Rhesus monkey trace amine- associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro","volume":"321","author":"Xie","year":"2007","journal-title":"J. Pharmacol. Exp. Therapeut."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818308219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818308219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:54:08Z","timestamp":1758437648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390818308219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":38,"alternative-id":["S0028390818308219"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.10.034","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of trace amine-associated receptor 1 attenuates schedule-induced polydipsia in rats","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.10.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}