{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:51:25Z","timestamp":1792662685102,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.neuropharm.2018.11.020","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T12:24:45Z","timestamp":1542716685000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Neuroprotection by cannabidiol and hypothermia in a piglet model of newborn hypoxic-ischemic brain damage"],"prefix":"10.1016","volume":"146","author":[{"given":"Lorena","family":"Barata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Arruza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Jos\u00e9","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Aleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Vierge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Criado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sobrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Cepri\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guti\u00e9rrez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-3545","authenticated-orcid":false,"given":"Jos\u00e9","family":"Mart\u00ednez-Orgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2018.11.020_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1161\/STROKEAHA.114.007330","article-title":"Brain cell death is reduced with cooling by 3.5 C to 5 C but increased with cooling by 8.5 C in a piglet asphyxia model","volume":"46","author":"Alonso-Alconada","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.neuropharm.2018.11.020_bib2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1203\/PDR.0b013e318186e5dd","article-title":"Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets","volume":"64","author":"Alvarez","year":"2008","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/ther.2016.0003","article-title":"Effect of hypothermia and targeted temperature management on drug disposition and response following cardiac arrest: a comprehensive review of preclinical and clinical investigations","volume":"6","author":"Anderson","year":"2016","journal-title":"Ther. Hypothermia Temp. Manag."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib4","article-title":"Electroencephalogram as a prognostic tool in neonates with hypoxic-ischemic Encephalopathy\u202f: a systematic review","volume":"11","author":"Blanco","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.neuropharm.2018.11.020_bib5","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.nbd.2009.10.023","article-title":"The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB2 and adenosine receptors","volume":"37","author":"Castillo","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.siny.2010.02.002","article-title":"Synergistic neuroprotective therapies with hypothermia","volume":"15","author":"Cilio","year":"2010","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.clp.2013.10.005","article-title":"Mechanisms of hypothermic neuroprotection","volume":"41","author":"Drury","year":"2014","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/ana.22387","article-title":"Xenon augmented hypothermia reduces early lactate\/N-acetylaspartate and cell death in perinatal asphyxia","volume":"70","author":"Faulkner","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib9","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/pr.2016.149","article-title":"Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets","volume":"80","author":"Garberg","year":"2016","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib10","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000047101","article-title":"Glutamate in cerebral tissue of asphyxiated neonates during the first week of life demonstrated in vivo using proton magnetic resonance spectroscopy","volume":"79","author":"Groenendaal","year":"2001","journal-title":"Neonatology"},{"key":"10.1016\/j.neuropharm.2018.11.020_bib11","first-page":"474","article-title":"Cochrane review: cooling for newborns with hypoxic ischaemic encephalopathy. Evidence-based child heal","volume":"5","author":"Jacobs","year":"2010","journal-title":"A Cochrane Rev. J."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.lfs.2011.05.018","article-title":"Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes","volume":"89","author":"Jiang","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib13","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S1474-4422(11)70016-3","article-title":"Treatment advances in neonatal neuroprotection and neurointensive care","volume":"10","author":"Johnston","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib14","doi-asserted-by":"crossref","DOI":"10.1177\/0271678X18797328","article-title":"Perinatal hypoxic-ischemic brain injury in large animal models: relevance to human neonatal encephalopathy","author":"Koehler","year":"2018","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib15","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1203\/PDR.0b013e3182276b11","article-title":"Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs","volume":"70","author":"Lafuente","year":"2011","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fnins.2016.00323","article-title":"Effects of cannabidiol and hypothermia on short-term brain damage in new-born piglets after acute hypoxia-ischemia","volume":"10","author":"Lafuente","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.clp.2016.04.007","article-title":"Neonatal encephalopathy","volume":"43","author":"McAdams","year":"2016","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib18","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1002\/cbdv.200790147","article-title":"Cannabidiol--recent advances","volume":"4","author":"Mechoulam","year":"2007","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijdevneu.2007.08.015","article-title":"Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia","volume":"26","author":"Mueller-Burke","year":"2008","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib20","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.neuropharm.2012.05.034","article-title":"Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function","volume":"63","author":"Pazos","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.11.020_bib21","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neuropharm.2013.03.027","article-title":"Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors","volume":"71","author":"Pazos","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2018.11.020_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2016.08.018","article-title":"Neonatal microglia: the cornerstone of brain fate","author":"Pierre","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2018.11.020_bib23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/brain\/aws285","article-title":"Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model","volume":"136","author":"Robertson","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.neuropharm.2018.11.020_bib24","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12974-017-0821-x","article-title":"Systemic pro-inflammatory cytokine status following therapeutic hypothermia in a piglet hypoxia-ischemia model","volume":"14","author":"Rocha-Ferreira","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuropharm.2018.11.020_bib25","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1097\/00001756-199710200-00033","article-title":"Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins","volume":"8","author":"Thoresen","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2018.11.020_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/506320","article-title":"Molecular mechanisms of neonatal brain injury","author":"Thornton","year":"2012","journal-title":"Neurol. Res. Int."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818308554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818308554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:51:24Z","timestamp":1758437484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390818308554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":26,"alternative-id":["S0028390818308554"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.11.020","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotection by cannabidiol and hypothermia in a piglet model of newborn hypoxic-ischemic brain damage","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2018.11.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}