{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:48:33Z","timestamp":1783734513193,"version":"3.55.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001637","name":"Trinity College Dublin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS065957"],"award-info":[{"award-number":["NS065957"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS066392"],"award-info":[{"award-number":["NS066392"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["AT008742"],"award-info":[{"award-number":["AT008742"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.neuropharm.2019.02.001","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T11:43:54Z","timestamp":1549280634000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["A ketogenic diet diminishes behavioral responses to cocaine in young adult male and female rats"],"prefix":"10.1016","volume":"149","author":[{"given":"Luis A.","family":"Martinez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan E.","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Ruskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Masino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2019.02.001_bib1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/adb.12156","article-title":"Plasma profile of pro-inflammatory cytokines and chemokines in cocaine users under outpatient treatment: influence of cocaine symptom severity and psychiatric co-morbidity","volume":"20","author":"Araos","year":"2015","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib2","doi-asserted-by":"crossref","first-page":"E1197","DOI":"10.1152\/ajpendo.00357.2009","article-title":"A very low carbohydrate ketogenic diet improves glucose tolerance in ob\/ob mice independently of weight loss","volume":"297","author":"Badman","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib3","first-page":"1","article-title":"Disruption of A2AR-D2R heteroreceptor complexes after A2AR transmembrane 5 peptide administration enhances cocaine self-administration in rats","author":"Borroto-Escuela","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib4","doi-asserted-by":"crossref","first-page":"9144","DOI":"10.1523\/JNEUROSCI.2252-05.2005","article-title":"Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens","volume":"25","author":"Boudreau","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ana.20899","article-title":"Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet","volume":"60","author":"Bough","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib6","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.seizure.2011.06.009","article-title":"Long-term follow-up of the ketogenic diet for refractory epilepsy: multicenter Argentinean experience in 216 pediatric patients","volume":"20","author":"Caraballo","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1360-0443.2006.01782.x","article-title":"Structural and metabolic brain changes in the striatum associated with methamphetamine abuse","volume":"102","author":"Chang","year":"2007","journal-title":"Addiction"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00213-006-0364-9","article-title":"Cocaine self-administration in rats with histories of cocaine exposure and discrimination","volume":"186","author":"Childs","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.eplepsyres.2017.11.005","article-title":"Ketogenic diet-induced extension of longevity in epileptic Kcna1-null mice is influenced by gender and age at treatment onset","volume":"140","author":"Chun","year":"2018","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1037\/pha0000019","article-title":"Effects of consuming a diet high in fat and\/or sugar on the locomotor effects of acute and repeated cocaine in male and female C57BL\/6J mice","volume":"23","author":"Collins","year":"2015","journal-title":"Exp. Clin. Psychopharmacol"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF00422974","article-title":"The role of forebrain dopamine systems in amphetamine induced stereotyped behavior in the rat","volume":"39","author":"Creese","year":"1974","journal-title":"Psychopharmacologia"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib12","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1038\/s41598-017-05542-3","article-title":"Non-ketogenic combination of nutritional strategies provides robust protection against seizures","volume":"7","author":"Dall\u00e9rac","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/syn.890180106","article-title":"Acute and chronic cocaine administration differentially alters striatal opioid and nuclear transcription factor mRNAs","volume":"18","author":"Daunais","year":"1994","journal-title":"Synapse"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuint.2015.12.006","article-title":"Cocaine and mitochondria-related signaling in the brain: a mechanistic view and future directions","volume":"92","author":"de Oliveira","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib15","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1089\/neu.2011.1822","article-title":"Ketogenic diet prevents alterations in brain metabolism in young but not adult rats after traumatic brain injury","volume":"28","author":"Deng-Bryant","year":"2011","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ana.410030410","article-title":"Chronic ketosis and cerebral metabolism","volume":"3","author":"DeVivo","year":"1978","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib17","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.neuropharm.2005.01.018","article-title":"Acute or repeated cocaine administration generates reactive oxygen species and induces antioxidant enzyme activity in dopaminergic rat brain structures","volume":"48","author":"Dietrich","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib18","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.biopsych.2005.04.046","article-title":"Neural and behavioral plasticity associated with the transition from controlled to escalated cocaine use","volume":"58","author":"Ferrario","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib19","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0166-2236(97)01096-5","article-title":"Adenosine\u2013dopamine receptor\u2013receptor interactions as an integrative mechanism in the basal ganglia","volume":"20","author":"Ferr\u00e9","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib20","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.2174\/138161208784480108","article-title":"An update on adenosine A2A-dopamine D2 receptor interactions. Implications for the function of G protein-coupled receptors","volume":"14","author":"Ferr\u00e9","year":"2008","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib21","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.neuropharm.2003.11.017","article-title":"Sex differences in cocaine-induced behavioral responses, pharmacokinetics, and monoamine levels","volume":"46","author":"Festa","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.brainres.2006.01.038","article-title":"Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine","volume":"1077","author":"Filip","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2174\/092986712803414231","article-title":"The Importance of the adenosine A2A receptor-dopamine D2 receptor interaction in drug addiction","volume":"19","author":"Filip","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2016.00044","article-title":"A closer look at the effects of repeated cocaine exposure on adaptive decision-making under conditions that promote goal-directed control","volume":"7","author":"Halbout","year":"2016","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pediatrneurol.2007.02.008","article-title":"The neuropharmacology of the ketogenic diet","volume":"36","author":"Hartman","year":"2007","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF02244782","article-title":"Behavioral and neurochemical sensitization following cocaine self-administration","volume":"115","author":"Hooks","year":"1994","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.expneurol.2011.09.001","article-title":"Ketogenic diet-induced peroxisome proliferator-activated receptor-\u03b3 activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures","volume":"232","author":"Jeong","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuron.2010.09.002","article-title":"Metabolic control of vesicular glutamate transport and release","volume":"68","author":"Juge","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/syn.890050104","article-title":"Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens","volume":"5","author":"Kalivas","year":"1990","journal-title":"Synapse"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib30","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1194\/jlr.M046755","article-title":"Ketogenic diet sensitizes glucose control of hippocampal excitability","volume":"55","author":"Kawamura","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0022-3565(25)38675-1","article-title":"Fischer and Lewis rat strains show differential cocaine effects in conditioned place preference and behavioral sensitization but not in locomotor activity or conditioned taste aversion","volume":"269","author":"Kosten","year":"1994","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"29","key":"10.1016\/j.neuropharm.2019.02.001_bib32","first-page":"1","article-title":"Anxiolytic effect of exogenous ketone supplementation is abolished by adenosine A1 receptor inhibition in Wistar albino Glaxo\/Rijswijk rats","volume":"12","author":"Kov\u00e1cs","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/1566524015666150330163724","article-title":"Purinergic signaling and energy homeostasis in psychiatric disorders","volume":"15","author":"Lindberg","year":"2015","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib34","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.neuropharm.2015.08.007","article-title":"Kssetogenic diet prevents epileptogenesis and disease progression in adult mice and rats","volume":"99","author":"Lusardi","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib35","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1523\/JNEUROSCI.16-03-01230.1996","article-title":"Cocaine alters cerebral metabolism within the ventral striatum and limbic cortex of monkeys","volume":"16","author":"Lyons","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib36","doi-asserted-by":"crossref","first-page":"7996","DOI":"10.1523\/JNEUROSCI.18-19-07996.1998","article-title":"Decreased presynaptic sensitivity to adenosine after cocaine withdrawal","volume":"18","author":"Manzoni","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib37","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.brainres.2007.01.079","article-title":"Increase in A2A receptors in the nucleus accumbens after extended cocaine self-administration and its disappearance after cocaine withdrawal","volume":"1143","author":"Marcellino","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1528-1167.2006.00911.x","article-title":"Discontinuing the ketogenic diet in seizure-free children: recurrence and risk factors","volume":"48","author":"Martinez","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbr.2014.05.052","article-title":"Estradiol facilitation of cocaine-induced locomotor sensitization in female rats requires activation of mGluR5","volume":"271","author":"Martinez","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib40","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/157015909789152164","article-title":"Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity","volume":"7","author":"Masino","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib41","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tins.2008.02.009","article-title":"Are purines mediators of the anticonvulsant\/neuroprotective effects of ketogenic diets?","volume":"31","author":"Masino","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib42","first-page":"229","article-title":"Purines and neuronal excitability: links to the ketogenic diet","volume":"100","author":"Masino","year":"2012","journal-title":"Epilepsy Res., Special Issue on Dietary treatments for epilepsy & neurological disorders"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib43","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1172\/JCI57813","article-title":"A ketogenic diet suppresses seizures in mice through adenosine A1 receptors","volume":"121","author":"Masino","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib44","doi-asserted-by":"crossref","DOI":"10.1111\/j.1528-1167.2010.02871.x","article-title":"Mechanisms of ketogenic diet action","volume":"51","author":"Masino","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib45","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.drugalcdep.2015.11.024","article-title":"Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10","volume":"158","author":"Moreira","year":"2016","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib46","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0387-7604(83)80042-4","article-title":"Effects of ketogenic diet on electroconvulsive threshold and brain contents of adenosine nucleotides","volume":"5","author":"Nakazawa","year":"1983","journal-title":"Brain Dev."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib47","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1743-7075-3-7","article-title":"Comparison of isocaloric very low carbohydrate\/high saturated fat and high carbohydrate\/low saturated fat diets on body composition and cardiovascular risk","volume":"3","author":"Noakes","year":"2006","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib48","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.metabol.2014.10.004","article-title":"Comparison of a carbohydrate-free diet vs. fasting on plasma glucose, insulin and glucagon in type 2 diabetes","volume":"64","author":"Nuttall","year":"2015","journal-title":"Metabolism"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib49","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbagen.2008.12.005","article-title":"The effects of a ketogenic diet on ATP concentrations and the number of hippocampal mitochondria in Aldh5a1\u2212\/\u2212 mice","volume":"1790","author":"Nylen","year":"2009","journal-title":"Biochim. Biophys. Acta BBA - Gen. Subj."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib50","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1528-1157.1999.tb00766.x","article-title":"Ketosis and epilepsy: 31P spectroscopic imaging at 4.1 T","volume":"40","author":"Pan","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib51","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/j.1528-1167.2009.02488.x","article-title":"Long-term outcomes of children treated with the ketogenic diet in the past","volume":"51","author":"Patel","year":"2010","journal-title":"Epilepsia"},{"issue":"Part A","key":"10.1016\/j.neuropharm.2019.02.001_bib52","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neuropharm.2016.06.002","article-title":"Estradiol impacts the endocannabinoid system in female rats to influence behavioral and structural responses to cocaine","volume":"110","author":"Peterson","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib53","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neuropharm.2016.06.024","article-title":"Ibudilast attenuates expression of behavioral sensitization to cocaine in male and female rats","volume":"109","author":"Poland","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib54","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0165-0173(93)90013-P","article-title":"The neural basis of drug craving: an incentive-sensitization theory of addiction","volume":"18","author":"Robinson","year":"1993","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib55","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1046\/j.1460-9568.1999.00576.x","article-title":"Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine","volume":"11","author":"Robinson","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib56","series-title":"Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease","first-page":"196","article-title":"Metabolic therapy and pain","author":"Ruskin","year":"2016"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib57","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.physbeh.2016.10.023","article-title":"Ketogenic diets improve behaviors associated with autism spectrum disorder in a sex-specific manner in the EL mouse","volume":"168","author":"Ruskin","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171643","article-title":"Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder","volume":"12","author":"Ruskin","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib59","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.physbeh.2011.04.001","article-title":"A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6\/2 1J mouse model of Huntington's disease","volume":"103","author":"Ruskin","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib60","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jpain.2012.12.015","article-title":"Ketogenic diets and thermal pain: dissociation of hypoalgesia, elevated ketones, and lowered glucose in rats","volume":"14","author":"Ruskin","year":"2013","journal-title":"J. Pain"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib61","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/epi.13729","article-title":"An examination of biochemical parameters and their association with response to ketogenic dietary therapies","volume":"58","author":"Schoeler","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib62","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0006-8993(98)00546-0","article-title":"Gender differences in kappa-opioid modulation of cocaine-induced behavior and NMDA-evoked dopamine release","volume":"801","author":"Sershen","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib63","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0091-3057(97)00021-X","article-title":"Effects of diet on sensitization to cocaine-induced stereotypy in female rats","volume":"58","author":"Shumsky","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib64","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.expneurol.2016.08.006","article-title":"Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy","volume":"287","author":"Simeone","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib65","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0022-3565(24)38106-6","article-title":"Female gonadal hormones differentially modulate cocaine-induced behavioral sensitization in Fischer, Lewis, and Sprague-Dawley rats","volume":"289","author":"Sircar","year":"1999","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib66","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s11064-011-0410-9","article-title":"Acute cocaine increases interleukin-1\u03b2 mRNA and immunoreactive cells in the cortex and nucleus accumbens","volume":"36","author":"Sorg","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib67","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.brainresbull.2016.07.001","article-title":"Ketogenic diet prevents neuronal firing increase within the substantia nigra during pentylenetetrazole-induced seizure in rats","volume":"125","author":"Viggiano","year":"2016","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib68","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuropharm.2004.07.019","article-title":"The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies","volume":"47","author":"Volkow","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2019.02.001_bib69","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1172\/JCI65636","article-title":"Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis","volume":"123","author":"Williams-Karnesky","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib70","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1007\/s00394-015-1040-9","article-title":"Low-carbohydrate, high-fat diets have sex-specific effects on bone health in rats","volume":"55","author":"Zengin","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.neuropharm.2019.02.001_bib71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2202-7-29","article-title":"A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis","volume":"7","author":"Zhao","year":"2006","journal-title":"BMC Neurosci."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818305513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390818305513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:52:47Z","timestamp":1758437567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390818305513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":71,"alternative-id":["S0028390818305513"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2019.02.001","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A ketogenic diet diminishes behavioral responses to cocaine in young adult male and female rats","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2019.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}