{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:37:25Z","timestamp":1779385045289,"version":"3.53.1"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016981","name":"Pharmaceutical Society of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016981","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K06687"],"award-info":[{"award-number":["18K06687"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["S1511001L"],"award-info":[{"award-number":["S1511001L"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.neuropharm.2019.03.026","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T04:01:52Z","timestamp":1553313712000},"page":"121-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression"],"prefix":"10.1016","volume":"150","author":[{"given":"Takayo","family":"Odaira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-0802","authenticated-orcid":false,"given":"Osamu","family":"Nakagawasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Nemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakana","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Rong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6724-848X","authenticated-orcid":false,"given":"Koichi","family":"Tan-No","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2019.03.026_bib1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/374450a0","article-title":"A BDNF autocrine loop in adult sensory neurons prevents cell death","volume":"374","author":"Acheson","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.steroids.2015.05.010","article-title":"Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice","volume":"101","author":"Ali","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib3","first-page":"1159","article-title":"Cerium oxide nanoparticles promote neurogenesis and abrogate hypoxia-induced memory impairment through AMPK-PKC-CBP signaling cascade","volume":"11","author":"Arya","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib4","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.psyneuen.2011.09.007","article-title":"Social deprivation stress is a triggering factor for the emergence of anxiety-and depression-like behaviours and leads to reduced brain BDNF levels in C57BL\/6J mice","volume":"37","author":"Berry","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1017\/S1461145705005122","article-title":"The antidepressant effect of running is associated with increased hippocampal cell proliferation","volume":"8","author":"Bj\u00f8rnebekk","year":"2005","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib6","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1124\/mol.115.099457","article-title":"Protein kinase C (PKC)\u03b6 pseudosubstrate inhibitor peptide Promiscuously binds PKC family isoforms and Disrupts conventional PKC targeting and translocation","volume":"88","author":"Bogard","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0091-3057(75)90051-9","article-title":"Endogenous brain norepinephrine levels following bilateral olfactory bulb ablation","volume":"3","author":"Cairncross","year":"1975","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0006-3223(00)01114-8","article-title":"Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect","volume":"49","author":"Chen","year":"2001","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0006-3223(01)01083-6","article-title":"Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication","volume":"50","author":"Chen","year":"2001","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib10","doi-asserted-by":"crossref","first-page":"23554","DOI":"10.1074\/jbc.M201152200","article-title":"Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport","volume":"277","author":"Chen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/sj.mp.4001457","article-title":"In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice","volume":"9","author":"Cryan","year":"2004","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib12","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0960-9822(95)00144-8","article-title":"Neurotrophic factors. Neurotrophin autocrine loops","volume":"5","author":"Davies","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib13","article-title":"Direct intraventricular delivery of drugs to the rodent central nervous system","volume":"12","author":"DeVos","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib14","first-page":"1290","article-title":"Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes","volume":"13","author":"Dominguez","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib15","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib16","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1093\/emboj\/cdg370","article-title":"Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation","volume":"22","author":"Duran","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib17","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.stemcr.2016.08.007","article-title":"The aPKC-CBP pathway regulates AdultHippocampal neurogenesis in an age-dependent manner","volume":"7","author":"Gouveia","year":"2016","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib18","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/sj.mp.4002075","article-title":"Is it time to reassess the BDNF hypothesis of depression?","volume":"12","author":"Groves","year":"2007","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib19","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/1440-1681.12265","article-title":"Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus","volume":"41","author":"Guo","year":"2014","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib20","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1128\/MCB.00054-09","article-title":"Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta","volume":"29","author":"Gusarova","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib21","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1242\/dev.01702","article-title":"NF-kappaB signalling regulates thegrowth of neural processes in the developing PNS and CNS","volume":"132","author":"Gutierrez","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.brainres.2009.02.014","article-title":"Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice","volume":"1265","author":"Han","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physiol.00050.2013","article-title":"AMPK: regulating energy balance at the cellular and whole body levels","volume":"29","author":"Hardie","year":"2014","journal-title":"Physiology"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0166-4328(02)00183-3","article-title":"Characteristics of changes in cholinergic function and impairment of learning and memory-related behavior induced by olfactory bulbectomy","volume":"138","author":"Hozumi","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nn.2505","article-title":"Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons","volume":"13","author":"Ji","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib26","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1111\/j.1476-5381.2012.01902.x","article-title":"Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus","volume":"166","author":"Jiang","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib27","doi-asserted-by":"crossref","first-page":"a001271","DOI":"10.1101\/cshperspect.a001271","article-title":"NF-kappaB in the nervous system","volume":"1","author":"Kaltschmidt","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0165-1781(02)00005-7","article-title":"Decreased serum brain-derived neurotrophic factor levels in major depressed patients","volume":"109","author":"Karege","year":"2002","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib29","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/hipo.22109","article-title":"The effect of P2X7 receptor activation on nuclear factor-\u03baB phosphorylation induced by status epilepticus in the rat hippocampus","volume":"23","author":"Kim","year":"2013","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib30","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fphys.2015.00230","article-title":"Stress, glucocorticoid hormones, and hippocampal neural progenitor cells: implications to mood disorders","volume":"6","author":"Kino","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3892\/mmr.2013.1457","article-title":"Overexpression of mitofusin 2 improves translocation of glucose transporter 4 in skeletal muscle of high fat diet fed rats through AMP activated protein kinase signaling","volume":"8","author":"Kong","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib32","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jpsychires.2010.01.005","article-title":"Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment","volume":"44","author":"Larsen","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib33","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000149817","article-title":"Plasma brain-derived neurotrophic factor as a peripheral marker for the action mechanism of antidepressants","volume":"57","author":"Lee","year":"2008","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1046-2023(03)00162-2","article-title":"Voxelation and gene expression tomography for the acquisition of 3-D gene expression maps in the brain","volume":"31","author":"Liu","year":"2003","journal-title":"Methods"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib35","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.3892\/mmr.2017.7017","article-title":"Altered axon initial segment in hippocampal newborn neurons, associated with recurrence of temporal lobe epilepsy in rats","volume":"16","author":"Liu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jad.2013.11.025","article-title":"Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise","volume":"156","author":"Liu","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib37","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1007\/s10072-014-1837-y","article-title":"Dynamic study of the hippocampal volume by structural MRI in a rat model of depression","volume":"35","author":"Luo","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib38","doi-asserted-by":"crossref","first-page":"39209","DOI":"10.1038\/srep39209","article-title":"Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: role of BDNF-TrkB signaling","volume":"6","author":"Ma","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/(SICI)1097-4547(19990715)57:2<219::AID-JNR7>3.0.CO;2-C","article-title":"NGF-resistant PC12 cell death induced by arachidonic acid is accompanied by a decrease of active PKC zeta and nuclear factor kappa B","volume":"57","author":"Macdonald","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib40","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1073\/pnas.0337481100","article-title":"Course of illness, hippocampal function, and hippocampal volume in major depression","volume":"100","author":"MacQueen","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib41","doi-asserted-by":"crossref","first-page":"926","DOI":"10.2337\/diabetes.52.4.926","article-title":"Exercise increases nuclear AMPK alpha2 in human skeletal muscle","volume":"52","author":"McGee","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib42","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nn.2531","article-title":"PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking","volume":"13","author":"Migues","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib43","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuropharm.2008.04.012","article-title":"A role for nuclear beta-catenin in SNRI antidepressant-induced hippocampal cell proliferation","volume":"55","author":"Mostany","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib44","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1017\/S146114571100085X","article-title":"Mouse strain differences in phencyclidine-induced behavioural changes","volume":"15","author":"Mouri","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib45","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0306-4522(02)00788-1","article-title":"Enhancement of 5-hydroxytryptamine-induced head-twitch response after olfactory bulbectomy","volume":"117","author":"Nakagawasai","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib46","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jphs.2015.03.007","article-title":"Liver hydrolysate attenuates the sickness behavior induced by concanavalin A in mice","volume":"127","author":"Nakagawasai","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib47","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbr.2015.10.033","article-title":"BE360, a new selective estrogen receptor modulator, produces antidepressant and antidementia effects through the enhancement of hippocampal cell proliferation in olfactory bulbectomized mice","volume":"297","author":"Nakagawasai","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib48","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.neuroscience.2010.05.012","article-title":"Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression","volume":"169","author":"Negoias","year":"2010","journal-title":"Neurosci"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib49","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1523\/JNEUROSCI.16-07-02365.1996","article-title":"Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus","volume":"16","author":"Nibuya","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib50","doi-asserted-by":"crossref","first-page":"R1053","DOI":"10.1152\/ajpregu.00776.2010","article-title":"The lighter side of BDNF","volume":"300","author":"Noble","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib51","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0026-895X(24)12590-4","article-title":"Scabronine G-methylester enhances secretion of neurotrophic factors mediated by an activation of protein kinase C-zeta","volume":"59","author":"Obara","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib52","doi-asserted-by":"crossref","first-page":"9408","DOI":"10.1523\/JNEUROSCI.2700-12.2013","article-title":"Reduced adult hippocampal neurogenesis and working memory deficits in the Dgcr8-deficient mouse model of 22q11.2 deletion-associated schizophrenia can be rescued by IGF2","volume":"33","author":"Ouchi","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib53","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbi.2014.04.007","article-title":"Microglial NLRP3 inflammasome activation mediates IL-1\u03b2-related inflammation in prefrontal cortex of depressive rats","volume":"41","author":"Pan","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib54","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0140-6736(07)60368-7","article-title":"Mental health of young people: a global public-health challenge","volume":"369","author":"Patel","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainres.2013.09.033","article-title":"Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress","volume":"1539","author":"Patki","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib56","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0022-3956(01)00029-2","article-title":"Reduced olfactory performance in patients with major depression","volume":"35","author":"Pause","year":"2001","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib57","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuropharm.2011.09.003","article-title":"The neurogenesis hypothesis of affective and anxiety disorders: are we mistaking the scaffolding for the building?","volume":"62","author":"Petrik","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib59","doi-asserted-by":"crossref","first-page":"8342","DOI":"10.1073\/pnas.90.18.8342","article-title":"Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation","volume":"90","author":"Sacktor","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib60","doi-asserted-by":"crossref","first-page":"E179","DOI":"10.1152\/ajpendo.00392.2009","article-title":"AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC","volume":"298","author":"Sajan","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib61","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/bj3340177","article-title":"AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform","volume":"334","author":"Salt","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib62","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/nn.4116","article-title":"5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response","volume":"18","author":"Samuels","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib63","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib64","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bbr.2010.02.042","article-title":"Effect of non-selective dopaminergic receptor agonist on disrupted maternal behavior in olfactory bulbectomized mice","volume":"210","author":"Sato","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib65","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.expneurol.2004.11.016","article-title":"Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats","volume":"192","author":"Scharfman","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib66","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1073\/pnas.0308061100","article-title":"The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress","volume":"101","author":"Shaw","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib67","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1523\/JNEUROSCI.22-08-03251.2002","article-title":"Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression","volume":"22","author":"Shirayama","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib68","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/(SICI)1097-4547(19990701)57:1<33::AID-JNR4>3.0.CO;2-6","article-title":"Expression and translocation of protein kinase C isoforms in rat microglial and astroglial cultures","volume":"57","author":"Slepko","year":"1999","journal-title":"J. Neurosci. Res."},{"issue":"Suppl. 4","key":"10.1016\/j.neuropharm.2019.03.026_bib69","first-page":"17","article-title":"Evidence of early onset of antidepressant effect in randomized controlled trials","volume":"62","author":"Stahl","year":"2001","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib70","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1017\/S003329170700089X","article-title":"Physical activity and prevalence and incidence of mental disorders in adolescents and young adults","volume":"37","author":"Str\u00f6hle","year":"2007","journal-title":"Psychol. Med."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib71","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejphar.2011.10.002","article-title":"Differences between mice strains in response to paroxetine in the forced swimming test: involvement of serotonergic or noradrenergic systems","volume":"672","author":"Sugimoto","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib72","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s00213-016-4224-y","article-title":"Alterations in behavioral responses to dopamine agonists in olfactory bulbectomized mice: relationship to changes in the striatal dopaminergic system","volume":"233","author":"Takahashi","year":"2016","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib73","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.euroneuro.2017.08.071","article-title":"Time-dependent role of prefrontal cortex and hippocampus on cognitive improvement by aripiprazole in olfactory bulbectomized mice","volume":"27","author":"Takahashi","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib74","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuropharm.2018.04.013","article-title":"Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice","volume":"137","author":"Takahashi","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib75","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1523\/JNEUROSCI.20-11-04030.2000","article-title":"cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment","volume":"20","author":"Thome","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib76","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.stem.2012.03.016","article-title":"Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation","volume":"11","author":"Wang","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib77","doi-asserted-by":"crossref","first-page":"8384","DOI":"10.1523\/JNEUROSCI.4682-14.2015","article-title":"Autocrine action of BDNF on dendrite development of adult-born hippocampal neurons","volume":"35","author":"Wang","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib78","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1017\/S1461145714000364","article-title":"Protein kinase M\u03b6 is involved in the modulatory effect of fluoxetine on hippocampal neurogenesis in vitro","volume":"17","author":"Wang","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib79","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0168-0102(99)00051-6","article-title":"Deprived of habitual running, rats downregulate BDNF and TrkB messages in the brain","volume":"34","author":"Widenfalk","year":"1999","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib80","first-page":"E299","article-title":"Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise","volume":"270","author":"Winder","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib81","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbi.2015.07.015","article-title":"Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKK\u03b2-dependent AMPK activation","volume":"50","author":"Xu","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib82","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.psychres.2016.06.037","article-title":"Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF\/TrkB\/CREB signaling pathway","volume":"243","author":"Yan","year":"2016","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024263","article-title":"Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats","volume":"6","author":"Yau","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2019.03.026_bib84","doi-asserted-by":"crossref","first-page":"15810","DOI":"10.1073\/pnas.1415219111","article-title":"Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin","volume":"111","author":"Yau","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib85","doi-asserted-by":"crossref","first-page":"7903918","DOI":"10.1155\/2017\/7903918","article-title":"Huanglian-jie-du-tang Extract ameliorates depression-like behaviors through BDNF-TrkB-CREB pathway in rats with chronic unpredictable stress","volume":"2017","author":"Ye","year":"2017","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib86","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.3892\/mmr.2017.6851","article-title":"Resveratrol reversed chronic restraint stress-induced impaired cognitive function in rats","volume":"16","author":"Zhang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neuropharm.2019.03.026_bib87","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390819301054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390819301054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:53:46Z","timestamp":1758437626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390819301054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":87,"alternative-id":["S0028390819301054"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2019.03.026","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2019.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}