{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:30:55Z","timestamp":1793147455817,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81773702, 81130023"],"award-info":[{"award-number":["81773702, 81130023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Priority Academic Program Development of the Jiangsu Higher Education Institutes"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.neuropharm.2019.107675","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T08:16:35Z","timestamp":1561104995000},"page":"107675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice"],"prefix":"10.1016","volume":"157","author":[{"given":"Panpan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiguo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Waddington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechu","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2019.107675_bib1","doi-asserted-by":"crossref","first-page":"35642","DOI":"10.1038\/srep35642","article-title":"Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse","volume":"6","author":"Bai","year":"2016","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.neuropharm.2019.107675_bib2","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/mp.2009.84","article-title":"Schizophrenia is associated with an increase in cortical microRNA biogenesis","volume":"15","author":"Beveridge","year":"2010","journal-title":"Mol. Psychiatry"},{"issue":"8","key":"10.1016\/j.neuropharm.2019.107675_bib3","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1093\/hmg\/ddn005","article-title":"Dysregulation of miRNA 181b in the temporal cortex in schizophrenia","volume":"17","author":"Beveridge","year":"2008","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.neuropharm.2019.107675_bib4","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1176\/appi.ajp.2015.15081060","article-title":"Circulating miRNA biomarkers for schizophrenia?","volume":"172","author":"Cairns","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2019.107675_bib5","series-title":"Dysregulation of miRNA and its Potential Therapeutic Application in Schizophrenia. CNS Neuroscience & Therapeutics","author":"Cao","year":"2018"},{"issue":"4","key":"10.1016\/j.neuropharm.2019.107675_bib6","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.bbi.2012.02.010","article-title":"Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene x environment interaction","volume":"26","author":"Desbonnet","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuropharm.2019.107675_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.toxlet.2018.10.020","article-title":"Involvement of NLRP3 Inflammasome in Methamphetamine-Induced Microglial Activation through miR-143\/PUMA axis","volume":"301","author":"Du","year":"2019","journal-title":"Toxicology Letters"},{"issue":"5","key":"10.1016\/j.neuropharm.2019.107675_bib51","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.euroneuro.2011.09.002","article-title":"Perinatal phencyclidine treatment alters neuregulin 1\/erbB4 expression and activation in later life","volume":"22","author":"du Bois","year":"2012","journal-title":"Eur Neuropsychopharmacol"},{"issue":"7","key":"10.1016\/j.neuropharm.2019.107675_bib52","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyu114","article-title":"Neuregulin 1 Prevents Phencyclidine-Induced Behavioral Impairments and Disruptions to GABAergic Signaling in Mice","volume":"18","author":"Engel","year":"2015","journal-title":"Int J Neuropsychopharmacol"},{"issue":"3","key":"10.1016\/j.neuropharm.2019.107675_bib8","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s12031-015-0503-z","article-title":"Altered microRNA expression in peripheral blood mononuclear cells from young patients with schizophrenia","volume":"56","author":"Fan","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neuropharm.2019.107675_bib53","doi-asserted-by":"crossref","first-page":"859516","DOI":"10.1155\/2010\/859516","article-title":"Expressions of neuregulin 1beta and ErbB4 in prefrontal cortex and hippocampus of a rat schizophrenia model induced by chronic MK-801 administration","volume":"2010","author":"Feng","year":"2010","journal-title":"J Biomed Biotechnol"},{"issue":"11","key":"10.1016\/j.neuropharm.2019.107675_bib9","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1073\/pnas.1101219108","article-title":"Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex","volume":"108","author":"F\u00e9nelon","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"8","key":"10.1016\/j.neuropharm.2019.107675_bib10","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/mp.2011.78","article-title":"Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells","volume":"17","author":"Gardiner","year":"2012","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.neuropharm.2019.107675_bib54","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1001\/jamapsychiatry.2014.2206","article-title":"Identification of a common neurobiological substrate for mental illness","volume":"72","author":"Goodkind","year":"2014","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"10.1016\/j.neuropharm.2019.107675_bib11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.biopsych.2005.11.002","article-title":"Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology","volume":"60","author":"Harrison","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"1\u20133","key":"10.1016\/j.neuropharm.2019.107675_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.schres.2014.01.034","article-title":"Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells","volume":"153","author":"Hill","year":"2014","journal-title":"Schizophr. Res."},{"issue":"2","key":"10.1016\/j.neuropharm.2019.107675_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/0269881114563634","article-title":"Glutamate and dopamine in schizophrenia: an update for the 21st century","volume":"29","author":"Howes","year":"2015","journal-title":"J. Psychopharmacol."},{"issue":"4","key":"10.1016\/j.neuropharm.2019.107675_bib14","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1476-5381.2011.01386.x","article-title":"Animal models of schizophrenia","volume":"164","author":"Jones","year":"2011","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.neuropharm.2019.107675_bib15","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.pnpbp.2007.09.008","article-title":"Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague-Dawley rats: a locomotor activity and gene induction study","volume":"32","author":"Kalinichev","year":"2008","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"1\u20133","key":"10.1016\/j.neuropharm.2019.107675_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.schres.2010.07.002","article-title":"MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders","volume":"124","author":"Kim","year":"2010","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.neuropharm.2019.107675_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.213","article-title":"Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue","volume":"6","author":"Lai","year":"2016","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"10.1016\/j.neuropharm.2019.107675_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021635","article-title":"MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia","volume":"6","author":"Lai","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.neuropharm.2019.107675_bib19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/mp.2016.150","article-title":"MiR-137: an important player in neural development and neoplastic transformation","volume":"22","author":"Mahmoudi","year":"2017","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.neuropharm.2019.107675_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuron.2014.06.007","article-title":"Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases","volume":"83","author":"Mei","year":"2014","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/j.neuropharm.2019.107675_bib21","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1073\/pnas.1113793109","article-title":"MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function","volume":"109","author":"Miller","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.neuropharm.2019.107675_bib22","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.biopsych.2010.09.039","article-title":"Altered MicroRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder","volume":"69","author":"Moreau","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"12","key":"10.1016\/j.neuropharm.2019.107675_bib23","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/s41398-017-0041-2","article-title":"Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients","volume":"7","author":"Mostaid","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuropharm.2019.107675_bib24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neubiorev.2016.06.001","article-title":"Neuregulin-1 and schizophrenia in the genome-wide association study era","volume":"68","author":"Mostaid","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuropharm.2019.107675_bib25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbi.2015.04.014","article-title":"MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation","volume":"49","author":"Ni","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.neuropharm.2019.107675_bib26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/schbul\/sbw120","article-title":"Epistatic and independent effects on schizophrenia-related phenotypes following Co-disruption of the risk factors neuregulin-1 x DISC1","volume":"43","author":"O'Tuathaigh","year":"2017","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.neuropharm.2019.107675_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neubiorev.2015.01.016","article-title":"Closing the translational gap between mutant mouse models and the clinical reality of psychotic illness","volume":"58","author":"O'Tuathaigh","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"7","key":"10.1016\/j.neuropharm.2019.107675_bib28","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1007\/s00429-017-1389-z","article-title":"MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex","volume":"222","author":"Olsen","year":"2017","journal-title":"Brain Struct. Funct."},{"issue":"2","key":"10.1016\/j.neuropharm.2019.107675_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2007-8-2-r27","article-title":"microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder","volume":"8","author":"Perkins","year":"2007","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.neuropharm.2019.107675_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156325","article-title":"Identification of beta-dystrobrevin as a direct target of mir-143: involvement in early stages of neural differentiation","volume":"11","author":"Quaranta","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.neuropharm.2019.107675_bib55","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00213-013-2999-7","article-title":"Perinatal phencyclidine administration decreases the density of cortical interneurons and increases the expression of neuregulin-1","volume":"227","author":"Radonji\u0107","year":"2013","journal-title":"Psychopharmacology"},{"issue":"13","key":"10.1016\/j.neuropharm.2019.107675_bib31","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1242\/dev.144337","article-title":"MicroRNAs in neural development: from master regulators to fine-tuners","volume":"144","author":"Rajman","year":"2017","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.neuropharm.2019.107675_bib32","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1128\/MCB.05896-11","article-title":"Dopamine-regulated microRNA MiR-181a controls GluA2 surface expression in hippocampal neurons","volume":"32","author":"Saba","year":"2012","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.neuropharm.2019.107675_bib33","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.biopsych.2010.09.030","article-title":"Upregulation of dicer and MicroRNA expression in the dorsolateral prefrontal cortex brodmann area 46 in schizophrenia","volume":"69","author":"Santarelli","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.neuropharm.2019.107675_bib56","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/jamapsychiatry.2017.0669","article-title":"Transdiagnostic Associations Between Functional Brain Network Integrity and Cognition","volume":"74","author":"Sheffield","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"10.1016\/j.neuropharm.2019.107675_bib34","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/ng.138","article-title":"Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model","volume":"40","author":"Stark","year":"2008","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.neuropharm.2019.107675_bib35","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/CIRCRESAHA.117.311572","article-title":"RNA-seq identifies circulating mir-125a-5p, mir-125b-5p, and mir-143-3p as potential biomarkers for acute ischemic stroke","volume":"121","author":"Tiedt","year":"2017","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.neuropharm.2019.107675_bib36","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/schbul\/sbp132","article-title":"Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects","volume":"36","author":"van den Buuse","year":"2010","journal-title":"Schizophr. Bull."},{"issue":"6","key":"10.1016\/j.neuropharm.2019.107675_bib37","first-page":"2716","article-title":"MiR-143 targets CTGF and exerts tumor-suppressing functions in epithelial ovarian cancer","volume":"8","author":"Wang","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"11","key":"10.1016\/j.neuropharm.2019.107675_bib38","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1176\/appi.ajp.2015.14030273","article-title":"Detection of circulating miRNA levels in schizophrenia","volume":"172","author":"Wei","year":"2015","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.neuropharm.2019.107675_bib39","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ncb0309-228","article-title":"Many roads to maturity: microRNA biogenesis pathways and their regulation","volume":"11","author":"Winter","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.neuropharm.2019.107675_bib40","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.biopsych.2017.10.021","article-title":"Small RNAs may answer big questions in mental illness","volume":"83","author":"Wright","year":"2018","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.neuropharm.2019.107675_bib41","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/adb.12417","article-title":"Morphine-induced inhibition of Ca2+ -dependent d-serine release from astrocytes suppresses excitability of GABAergic neurons in the nucleus accumbens","volume":"22","author":"Wu","year":"2017","journal-title":"Addict. Biol."},{"issue":"1\u20132","key":"10.1016\/j.neuropharm.2019.107675_bib42","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cell.2012.11.052","article-title":"Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion","volume":"152","author":"Xu","year":"2013","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.neuropharm.2019.107675_bib43","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.pnpbp.2012.03.007","article-title":"Neural basis of the potentiated inhibition of repeated haloperidol and clozapine treatment on the phencyclidine-induced hyperlocomotion","volume":"38","author":"Zhao","year":"2012","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390819302357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390819302357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T15:42:21Z","timestamp":1569080541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390819302357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":49,"alternative-id":["S0028390819302357"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2019.107675","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2019.107675","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107675"}}