{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:38:11Z","timestamp":1791599891059,"version":"4.3.4"},"reference-count":159,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.neuropharm.2020.108013","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T23:34:51Z","timestamp":1581723291000},"page":"108013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Recent perspectives on orexin\/hypocretin promotion of addiction-related behaviors"],"prefix":"10.1016","volume":"168","author":[{"given":"Frederic W.","family":"Hopf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2020.108013_bib1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bbr.2005.02.017","article-title":"Compulsive-like behaviour according to the sex and the reproductive stage of female rats","volume":"161","author":"Agrati","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.282.5387.298","article-title":"Transition from moderate to excessive drug intake: change in hedonic set point","volume":"282","author":"Ahmed","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2020.108013_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pbb.2015.04.012","article-title":"Do Orexins contribute to impulsivity-driven binge consumption of rewarding stimulus and transition to drug\/food dependence?","volume":"134","author":"Alcaraz-Iborra","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2020.108013_bib4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fnbeh.2017.00186","article-title":"Different molecular\/behavioral endophenotypes in C57BL\/6J mice predict the impact of OX1 receptor blockade on binge-like ethanol intake","volume":"11","author":"Alcaraz-Iborra","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fnins.2014.00033","article-title":"Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models","volume":"8","author":"Anderson","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/164_2018_100","article-title":"Contribution of dynorphin and orexin neuropeptide systems to the motivational effects of alcohol","volume":"248","author":"Anderson","year":"2018","journal-title":"Handb. Exp. Pharmacol."},{"issue":"Suppl. 2","key":"10.1016\/j.neuropharm.2020.108013_bib8","doi-asserted-by":"crossref","first-page":"S211","DOI":"10.1046\/j.1360-0443.95.8s2.9.x","article-title":"Obsessive-compulsive aspects of craving: development of the obsessive compulsive drinking scale","volume":"95","author":"Anton","year":"2000","journal-title":"Addiction"},{"key":"10.1016\/j.neuropharm.2020.108013_bib9","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2009.09.106","article-title":"Lateral hypothalamic orexin\/hypocretin neurons: a role in reward-seeking and addiction","volume":"1314","author":"Aston-Jones","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neulet.2010.07.050","article-title":"Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats","volume":"482","author":"Azizi","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2020.108013_bib11","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrn3104","article-title":"Opiate versus psychostimulant addiction: the differences do matter","volume":"12","author":"Badiani","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pbb.2013.01.023","article-title":"Individual differences in elevated plus-maze exploration predicted higher ethanol consumption and preference in outbred mice","volume":"105","author":"Bahi","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2020.108013_bib13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/adb.12139","article-title":"Anterior thalamic paraventricular nucleus is involved in intermittent access ethanol drinking: role of orexin receptor 2","volume":"20","author":"Barson","year":"2015","journal-title":"Addiction Biol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.pnpbp.2015.02.006","article-title":"Hypothalamic neuropeptide signaling in alcohol addiction","volume":"65","author":"Barson","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2020.108013_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/adb.12288","article-title":"Substance P in the anterior thalamic paraventricular nucleus: promotion of ethanol drinking in response to orexin from the hypothalamus","volume":"22","author":"Barson","year":"2017","journal-title":"Addiction Biol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib16","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1124\/pr.115.011163","article-title":"Sex differences in animal models: focus on addiction","volume":"68","author":"Becker","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuropharm.2020.108013_bib17","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1523\/JNEUROSCI.2254-15.2016","article-title":"The first alcohol drink triggers mTORC1-dependent synaptic plasticity in nucleus accumbens dopamine D1 receptor neurons","volume":"36","author":"Beckley","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib159","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011940","article-title":"Responses to novelty and vulnerability to cocaine addiction: contribution of a multi-symptomatic animal model","volume":"2","author":"Belin","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neuropharm.2020.108013_bib18","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/ejn.12866","article-title":"Orexin-1 receptor signaling increases motivation for cocaine-associated cues","volume":"41","author":"Bentzley","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib19","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/adb.12553","article-title":"Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine","volume":"23","author":"Bernstein","year":"2018","journal-title":"Addiction Biol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41593-017-0023-y","article-title":"Accumbal D2 cells orchestrate innate risk-avoidance according to orexin signals","volume":"21","author":"Blomeley","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroscience.2018.04.005","article-title":"Sex- and age-dependent effects of orexin 1 receptor blockade on open-field behavior and neuronal activity","volume":"381","author":"Blume","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2020.108013_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3389\/fphar.2017.00357","article-title":"Evaluation of JNJ-54717793 a novel brain penetrant selective orexin 1 receptor antagonist in two rat models of panic attack provocation","volume":"8","author":"Bonaventure","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib23","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1124\/jpet.114.220392","article-title":"A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects","volume":"352","author":"Bonaventure","year":"2015","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2020.108013_bib24","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1523\/JNEUROSCI.6096-08.2009","article-title":"Orexin A\/hypocretin-1 selectively promotes motivation for positive reinforcers","volume":"29","author":"Borgland","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnbeh.2013.00059","article-title":"The hypocretins and the reward function: what have we learned so far?","volume":"7","author":"Boutrel","year":"2013","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib27","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1017\/S1461145713000333","article-title":"Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats","volume":"16","author":"Brown","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/adb.12251","article-title":"Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in iP rats","volume":"21","author":"Brown","year":"2015","journal-title":"Addiction Biol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fnsys.2015.00009","article-title":"To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance","volume":"9","author":"Brown","year":"2015","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib29","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1073\/pnas.1521238113","article-title":"In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward","volume":"113","author":"Calipari","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2020.108013_bib30","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbr.2015.03.046","article-title":"Orexin receptor 1 signaling contributes to ethanol binge-like drinking: pharmacological and molecular evidence","volume":"287","author":"Carvajal","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib31","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00213-013-3051-7","article-title":"Attenuation of saccharin-seeking in rats by orexin\/hypocretin receptor 1 antagonist","volume":"228","author":"Cason","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neuropharm.2014.07.007","article-title":"Role of orexin\/hypocretin in conditioned sucrose-seeking in female rats","volume":"86","author":"Cason","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib33","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1038\/npp.2016.10","article-title":"Orexin in rostral hotspot of nucleus accumbens enhances sucrose 'liking' and intake but scopolamine in caudal shell shifts 'liking' toward 'disgust' and 'fear","volume":"41","author":"Castro","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib34","series-title":"Excessive Drinking Costs U.S. $223.5 Billion","author":"CDC","year":"2014"},{"key":"10.1016\/j.neuropharm.2020.108013_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3940(98)00977-X","article-title":"Orexin A-like immunoreactivity in the rat brain","volume":"260","author":"Chen","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2020.108013_bib36","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuroscience.2012.02.036","article-title":"Orexin signaling in the paraventricular thalamic nucleus modulates mesolimbic dopamine and hedonic feeding in the rat","volume":"210","author":"Choi","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2020.108013_bib37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.15288\/jsad.2013.74.141","article-title":"Behavioral control in alcohol use disorders: relationships with severity","volume":"74","author":"Claus","year":"2013","journal-title":"J. Stud. Alcohol Drugs"},{"key":"10.1016\/j.neuropharm.2020.108013_bib38","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1803-19.2020","article-title":"Medial prefrontal cortex neural plasticity, orexin receptor 1 signaling, and connectivity with the lateral hypothalamus are necessary in cue-potentiated feeding","author":"Cole","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.molbrainres.2005.02.002","article-title":"Opposite effects of sleep rebound on orexin OX1 and OX2 receptor expression in rat brain","volume":"136","author":"D'Almeida","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuropharm.2020.108013_bib40","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.biopsych.2007.02.002","article-title":"Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse","volume":"63","author":"Dayas","year":"2008","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2020.108013_bib41","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2020.108013_bib42","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/ADM.0b013e3181bd893f","article-title":"The orexin-1 receptor antagonist SB-334867 reduces alcohol relapse drinking, but not alcohol-seeking, in alcohol-preferring (P) rats","volume":"4","author":"Dhaher","year":"2010","journal-title":"J. Addiction Med."},{"key":"10.1016\/j.neuropharm.2020.108013_bib44","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fnbeh.2015.00161","article-title":"Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats","volume":"9","author":"Dong","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib43","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"DSM\u20135","year":"2013"},{"key":"10.1016\/j.neuropharm.2020.108013_bib45","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3389\/fnins.2018.00934","article-title":"Orexin depolarizes central amygdala neurons via orexin receptor 1, phospholipase C and sodium-calcium exchanger and modulates conditioned fear","volume":"12","author":"Dustrude","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-psych-122414-033457","article-title":"Drug addiction: updating actions to habits to compulsions ten years on","volume":"67","author":"Everitt","year":"2016","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib47","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1038\/s41386-019-0420-x","article-title":"The role of orexin-1 receptor signaling in demand for the opioid fentanyl","volume":"44","author":"Fragale","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib48","article-title":"Activation of medial hypothalamic orexin neurons during a Go\/No-Go task","author":"Freeman","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib49","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/alcalc\/agz022","article-title":"Sex differences in aversion-resistant ethanol intake in mice","volume":"54","author":"Fulenwider","year":"2019","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.neuropharm.2020.108013_bib50","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S2215-0366(18)30337-7","article-title":"The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"5","author":"GBD 2016 Alcohol and Drug Use Collaborators","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.neuropharm.2020.108013_bib51","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/npp.2017.158","article-title":"Effects of suvorexant, a dual orexin\/hypocretin receptor antagonist, on impulsive behavior associated with cocaine","volume":"43","author":"Gentile","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41398-019-0415-8","article-title":"Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder\/agoraphobia, CBT treatment response and fear-related intermediate phenotypes","volume":"9","author":"Gottschalk","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuropharm.2020.108013_bib53","series-title":"The Contribution of Orexins to Sex Differences in the Stress Response","author":"Grafe","year":"2018"},{"key":"10.1016\/j.neuropharm.2020.108013_bib54","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.biopsych.2016.10.013","article-title":"Orexins mediate sex differences in the stress response and in cognitive flexibility","volume":"81","author":"Grafe","year":"2017","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2020.108013_bib55","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0273-17.2018","article-title":"Reduced orexin system function contributes to resilience to repeated social stress","volume":"5","author":"Grafe","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.neuropharm.2020.108013_bib56","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.neuroscience.2019.08.026","article-title":"Sex- and stress-dependent effects on dendritic morphology and spine densities in putative orexin neurons","volume":"418","author":"Grafe","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2020.108013_bib57","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1001\/jamapsychiatry.2017.2161","article-title":"Prevalence of 12-month alcohol use, high-risk drinking, and DSM-IV alcohol use disorder in the United States, 2001-2002 to 2012-2013: results from the national epidemiologic survey on alcohol and related conditions","volume":"74","author":"Grant","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neuropharm.2020.108013_bib58","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1001\/jamapsychiatry.2015.0584","article-title":"Epidemiology of DSM-5 alcohol use disorder: results from the national epidemiologic survey on alcohol and related conditions III","volume":"72","author":"Grant","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neuropharm.2020.108013_bib59","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.neuron.2019.04.036","article-title":"Central amygdala prepronociceptin-expressing neurons mediate palatable food consumption and reward","volume":"102","author":"Hardaway","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2020.108013_bib60","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature04071","article-title":"A role for lateral hypothalamic orexin neurons in reward seeking","volume":"437","author":"Harris","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2020.108013_bib61","doi-asserted-by":"crossref","first-page":"107527","DOI":"10.1016\/j.neuropharm.2019.02.009","article-title":"Orexin\/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour","volume":"156","author":"Harro","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib62","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.physbeh.2013.10.005","article-title":"Optogenetic examination identifies a context-specific role for orexins\/hypocretins in anxiety-related behavior","volume":"130","author":"Heydendael","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2020.108013_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-020-0600-8","article-title":"Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory","author":"Hogarth","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib64","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1007\/s00213-018-4922-8","article-title":"Alcohol use disorder symptoms are associated with greater relative value ascribed to alcohol, but not greater discounting of costs imposed on alcohol","volume":"235","author":"Hogarth","year":"2018","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib65","doi-asserted-by":"crossref","first-page":"19480","DOI":"10.1073\/pnas.0808023105","article-title":"Insular hypocretin transmission regulates nicotine reward","volume":"105","author":"Hollander","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2020.108013_bib66","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/gbb.12348","article-title":"Do specific NMDA receptor subunits act as gateways for addictive behaviors?","volume":"16","author":"Hopf","year":"2017","journal-title":"Gene Brain Behav."},{"key":"10.1016\/j.neuropharm.2020.108013_bib67","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.alcohol.2014.03.001","article-title":"Rodent models for compulsive alcohol intake","volume":"48","author":"Hopf","year":"2014","journal-title":"Alcohol"},{"key":"10.1016\/j.neuropharm.2020.108013_bib68","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/ilar.52.3.239","article-title":"Translational models of interactions between stress and alcohol consumption: strengths and limitations","volume":"52","author":"Hopf","year":"2011","journal-title":"ILAR J."},{"key":"10.1016\/j.neuropharm.2020.108013_bib69","series-title":"Introduction to the Special Issue: \"Orexin\/hypocretin Receptor Antagonists for the Treatment of Addiction and Related Psychiatric Disease: what Are the Steps from Here?","author":"James","year":"2020"},{"key":"10.1016\/j.neuropharm.2020.108013_bib70","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1111\/ejn.14166","article-title":"Demand elasticity predicts addiction endophenotypes and the therapeutic efficacy of an orexin\/hypocretin-1 receptor antagonist in rats","volume":"50","author":"James","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib71","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/7854_2016_56","article-title":"Role of the orexin\/hypocretin system in stress-related psychiatric disorders","volume":"33","author":"James","year":"2017","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.neuropharm.2020.108013_bib72","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1017\/S1461145711000423","article-title":"Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking","volume":"14","author":"James","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib73","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/7854_2016_57","article-title":"A decade of orexin\/hypocretin and addiction: where are we now?","volume":"33","author":"James","year":"2017","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.neuropharm.2020.108013_bib74","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.biopsych.2018.07.022","article-title":"Increased number and activity of a lateral subpopulation of hypothalamic orexin\/hypocretin neurons underlies the expression of an addicted state in rats","volume":"85","author":"James","year":"2019","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2020.108013_bib75","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.physbeh.2012.04.016","article-title":"Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network","volume":"107","author":"Johnson","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2020.108013_bib76","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.brainres.2011.03.045","article-title":"The orexin(1) receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats","volume":"1391","author":"Jupp","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib77","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbr.2014.07.011","article-title":"Intra-nucleus accumbens shell injections of R(+)- and S(-)-baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl\/6J mice","volume":"272","author":"Kasten","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib78","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s40263-014-0179-x","article-title":"Orexin\/hypocretin based pharmacotherapies for the treatment of addiction: DORA or SORA?","volume":"28","author":"Khoo","year":"2014","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neuropharm.2020.108013_bib79","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.conb.2013.03.011","article-title":"Negative reinforcement in drug addiction: the darkness within","volume":"23","author":"Koob","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib80","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/npp.2009.110","article-title":"Neurocircuitry of addiction","volume":"35","author":"Koob","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib81","first-page":"151","article-title":"Relapse prevention. An overview of Marlatt's cognitive-behavioral model","volume":"23","author":"Larimer","year":"1999","journal-title":"Alcohol Res. Health"},{"key":"10.1016\/j.neuropharm.2020.108013_bib82","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/sj.bjp.0706789","article-title":"The orexin system regulates alcohol-seeking in rats","volume":"148","author":"Lawrence","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib83","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainres.2014.12.029","article-title":"Hypothalamic, feeding\/arousal-related peptidergic projections to the paraventricular thalamic nucleus in the rat","volume":"1598","author":"Lee","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib84","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fnins.2019.00088","article-title":"Nucleus accumbens shell orexin-1 receptors are critical mediators of binge intake in excessive-drinking individuals","volume":"13","author":"Lei","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib85","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neuropharm.2016.08.008","article-title":"Orexin-1 receptor blockade suppresses compulsive-like alcohol drinking in mice","volume":"110","author":"Lei","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2016.00400","article-title":"Nucleus accumbens shell and mPFC but not insula orexin-1 receptors promote excessive alcohol drinking","volume":"10","author":"Lei","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib87","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11920-015-0639-0","article-title":"Hypocretins, neural systems, physiology, and psychiatric disorders","volume":"18","author":"Li","year":"2016","journal-title":"Curr. Psychiatr. Rep."},{"key":"10.1016\/j.neuropharm.2020.108013_bib88","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsy141","article-title":"Optical probing of orexin\/hypocretin receptor antagonists","volume":"41","author":"Li","year":"2018","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2020.108013_bib89","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00213-010-1948-y","article-title":"Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats","volume":"212","author":"Li","year":"2010","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib90","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.physbeh.2010.10.006","article-title":"Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal","volume":"102","author":"Li","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2020.108013_bib91","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2016.01.049","article-title":"The highly selective orexin\/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice","volume":"1636","author":"Lopez","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib92","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ebiom.2017.03.043","article-title":"Sexually dimorphic changes of hypocretin (orexin) in depression","volume":"18","author":"Lu","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neuropharm.2020.108013_bib93","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.neuropharm.2014.01.024","article-title":"mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions","volume":"79","author":"Lum","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib94","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/nn.3810","article-title":"Motivational activation: a unifying hypothesis of orexin\/hypocretin function","volume":"17","author":"Mahler","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib95","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00213-012-2681-5","article-title":"Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats","volume":"226","author":"Mahler","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib96","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/B978-0-444-59489-1.00007-0","article-title":"Multiple roles for orexin\/hypocretin in addiction","volume":"198","author":"Mahler","year":"2012","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib97","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.1190","article-title":"Differential expression of orexin receptors 1 and 2 in the rat brain","volume":"435","author":"Marcus","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib98","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/npp.2017.250","article-title":"Dynorphin counteracts orexin in the paraventricular nucleus of the thalamus: cellular and behavioral evidence","volume":"43","author":"Matzeu","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib99","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1124\/jpet.116.235945","article-title":"Orexin-A\/Hypocretin-1 mediates cocaine-seeking behavior in the posterior paraventricular nucleus of the thalamus via orexin\/hypocretin receptor-2","volume":"359","author":"Matzeu","year":"2016","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2020.108013_bib100","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3389\/fneur.2018.00720","article-title":"Drug seeking and relapse: new evidence of a role for orexin and dynorphin Co-transmission in the paraventricular nucleus of the thalamus","volume":"9","author":"Matzeu","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib101","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1016\/j.cub.2019.07.069","article-title":"Orexin in the posterior paraventricular thalamus mediates hunger-related signals in the nucleus accumbens core","volume":"29","author":"Meffre","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib102","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.physbeh.2016.11.002","article-title":"Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice","volume":"168","author":"Mitra","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2020.108013_bib103","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1523\/JNEUROSCI.0255-19.2019","article-title":"Orexin-1 receptor signaling in ventral pallidum regulates motivation for the opioid remifentanil","volume":"39","author":"Mohammadkhani","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib104","first-page":"146461","article-title":"Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil","author":"Mohammadkhani","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib105","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s00213-018-4871-2","article-title":"The hypocretin\/orexin system as a target for excessive motivation in alcohol use disorders","volume":"235","author":"Moorman","year":"2018","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib106","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.alcohol.2009.07.002","article-title":"Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol--preferring Sprague--Dawley rats","volume":"43","author":"Moorman","year":"2009","journal-title":"Alcohol"},{"key":"10.1016\/j.neuropharm.2020.108013_bib107","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/ejn.13170","article-title":"Orexin\/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner","volume":"43","author":"Moorman","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib108","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainres.2016.10.018","article-title":"Orexin\/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats","volume":"1654","author":"Moorman","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib109","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neulet.2014.06.038","article-title":"Blockade of orexin type-1 receptors in locus coeruleus nucleus attenuates the development of morphine dependency in rats","volume":"578","author":"Mousavi","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2020.108013_bib110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00429-010-0268-7","article-title":"The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making","volume":"214","author":"Naqvi","year":"2010","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neuropharm.2020.108013_bib111","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1523\/JNEUROSCI.2761-05.2006","article-title":"Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine","volume":"26","author":"Narita","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib112","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/acer.12591","article-title":"Binge-like consumption of ethanol and other salient reinforcers is blocked by orexin-1 receptor inhibition and leads to a reduction of hypothalamic orexin immunoreactivity","volume":"39","author":"Olney","year":"2015","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib113","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/acer.13336","article-title":"The role of orexin signaling in the ventral tegmental area and central amygdala in modulating binge-like ethanol drinking behavior","volume":"41","author":"Olney","year":"2017","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib114","first-page":"e12795","article-title":"The number of lateral hypothalamus orexin\/hypocretin neurons contributes to individual differences in cocaine demand","author":"Pantazis","year":"2019","journal-title":"Addiction Biol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib115","article-title":"Therapeutics development for addiction: orexin-1 receptor antagonists","author":"Perrey","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib116","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079465","article-title":"The development of a preference for cocaine over food identifies individual rats with addiction-like behaviors","volume":"8","author":"Perry","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.neuropharm.2020.108013_bib117","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.biopsych.2011.06.025","article-title":"Hypocretin\/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal","volume":"71","author":"Plaza-Zabala","year":"2012","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2020.108013_bib118","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/adb.12323","article-title":"Individual differences in orexin-I receptor modulation of motivation for the opioid remifentanil","volume":"22","author":"Porter-Stransky","year":"2017","journal-title":"Addiction Biol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib119","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fnbeh.2013.00144","article-title":"Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference","volume":"7","author":"Qi","year":"2013","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib120","first-page":"e12829","article-title":"Additive influences of acute early life stress and sex on vulnerability for aversion-resistant alcohol drinking","author":"Radke","year":"2019","journal-title":"Addiction Biol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib158","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1369-1600.2011.00394.x","article-title":"Characterization of an alcohol addiction-prone phenotype in mice","volume":"17","author":"Radwanska","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib121","doi-asserted-by":"crossref","first-page":"10935","DOI":"10.1523\/JNEUROSCI.4322-15.2016","article-title":"Behavioral and neural signatures of reduced updating of alternative options in alcohol-dependent patients during flexible decision-making","volume":"36","author":"Reiter","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib122","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1126\/science.aat2512","article-title":"The paraventricular thalamus is a critical thalamic area for wakefulness","volume":"362","author":"Ren","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2020.108013_bib160","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1369-1600.2011.00333.x","article-title":"Alpha4 subunit-containing GABAA receptors in the accumbens shell contribute to the reinforcing effects of alcohol","volume":"17","author":"Rewal","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib123","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-pharmtox-010510-100528","article-title":"Orexin receptors: pharmacology and therapeutic opportunities","volume":"51","author":"Scammell","year":"2011","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib124","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/npp.2014.293","article-title":"Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats","volume":"40","author":"Schmeichel","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib125","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.biopsych.2016.06.010","article-title":"Hypocretin neurotransmission within the central amygdala mediates escalated cocaine self-administration and stress-induced reinstatement in rats","volume":"81","author":"Schmeichel","year":"2017","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2020.108013_bib126","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1038\/s41386-018-0054-4","article-title":"Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats","volume":"43","author":"Schmeichel","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib127","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.biopsych.2017.04.019","article-title":"When habits are dangerous: alcohol expectancies and habitual decision making predict relapse in alcohol dependence","volume":"82","author":"Sebold","year":"2017","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2020.108013_bib128","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/nn.3445","article-title":"Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake","volume":"16","author":"Seif","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib129","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1038\/npp.2015.84","article-title":"D-serine and D-cycloserine reduce compulsive alcohol intake in rats","volume":"40","author":"Seif","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib130","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00213-010-2127-x","article-title":"Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement","volume":"215","author":"Shoblock","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib131","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1748-1716.2009.02049.x","article-title":"Role of orexins in the hypothalamic\u2010pituitary\u2010ovarian relationships","volume":"198","author":"Silveyra","year":"2010","journal-title":"Acta Physiol."},{"key":"10.1016\/j.neuropharm.2020.108013_bib132","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/acer.13923","article-title":"Sex differences in binge-like and aversion-resistant alcohol drinking in C57BL\/6J mice","volume":"43","author":"Sneddon","year":"2019","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib133","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/s41467-017-01782-z","article-title":"Orexin modulates behavioral fear expression through the locus coeruleus","volume":"8","author":"Soya","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuropharm.2020.108013_bib134","doi-asserted-by":"crossref","first-page":"e44726","DOI":"10.1371\/journal.pone.0044726","article-title":"The dual orexin\/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration","volume":"7","author":"Srinivasan","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.neuropharm.2020.108013_bib135","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.yhbeh.2013.12.014","article-title":"The orexin-1 receptor antagonist SB-334867 attenuates anxiety in rats exposed to cat odor but not the elevated plus maze: an investigation of Trial 1 and Trial 2 effects","volume":"65","author":"Staples","year":"2014","journal-title":"Horm. Behav."},{"key":"10.1016\/j.neuropharm.2020.108013_bib136","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.bbr.2010.08.032","article-title":"Opposite effects on the ingestion of ethanol and sucrose solutions after injections of muscimol into the nucleus accumbens shell","volume":"216","author":"Stratford","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib137","series-title":"Preliminary Examination of the Orexin System on Relapse-Related Factors in Cocaine Use Disorder","author":"Suchting","year":"2019"},{"key":"10.1016\/j.neuropharm.2020.108013_bib138","article-title":"Orexin\/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: potential for therapy","author":"Summers","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib139","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bbr.2008.01.001","article-title":"Procedural learning and cognitive flexibility in a mouse model of restricted, repetitive behaviour","volume":"189","author":"Tanimura","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib140","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao4953","article-title":"Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy","volume":"10","author":"Thannickal","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuropharm.2020.108013_bib141","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.brainres.2005.05.045","article-title":"Orexin A in the nucleus accumbens stimulates feeding and locomotor activity","volume":"1050","author":"Thorpe","year":"2005","journal-title":"Brain Res."},{"issue":"Suppl. 2","key":"10.1016\/j.neuropharm.2020.108013_bib142","first-page":"S145eS153","article-title":"A cognitive processing model of alcohol craving and compulsive alcohol use","volume":"95","author":"Tiffany","year":"2000","journal-title":"Addiction"},{"key":"10.1016\/j.neuropharm.2020.108013_bib143","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbr.2014.04.012","article-title":"Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement","volume":"269","author":"Uslaner","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib144","doi-asserted-by":"crossref","first-page":"385","DOI":"10.31887\/DCNS.2016.18.4\/rvalentino","article-title":"Sex-biased cellular signaling: molecular basis for sex differences in neuropsychiatric diseases","volume":"18","author":"Valentino","year":"2016","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib145","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.yhbeh.2011.08.017","article-title":"Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence","volume":"60","author":"von der Goltz","year":"2011","journal-title":"Horm. Behav."},{"key":"10.1016\/j.neuropharm.2020.108013_bib146","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/mp.2014.44","article-title":"Disorders of compulsivity: a common bias towards learning habits","volume":"20","author":"Voon","year":"2015","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2020.108013_bib147","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00213-010-2082-6","article-title":"Involvement of the orexin\/hypocretin system in ethanol conditioned place preference","volume":"214","author":"Voorhees","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib148","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/7854_2016_55","article-title":"The role of orexins\/hypocretins in alcohol use and abuse","volume":"33","author":"Walker","year":"2017","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.neuropharm.2020.108013_bib149","doi-asserted-by":"crossref","first-page":"7215","DOI":"10.1523\/JNEUROSCI.4823-14.2015","article-title":"Drug predictive cues activate aversion-sensitive striatal neurons that encode drug seeking","volume":"35","author":"Wheeler","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib150","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/acer.12815","article-title":"Converging patterns of alcohol use and related outcomes among females and males in the United States, 2002 to 2012","volume":"39","author":"White","year":"2015","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib151","article-title":"The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task","author":"Wiskerke","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2020.108013_bib152","doi-asserted-by":"crossref","first-page":"e21100","DOI":"10.1371\/journal.pone.0021100","article-title":"Genomic analysis of individual differences in ethanol drinking: evidence for non-genetic factors in C57BL\/6 mice","volume":"6","author":"Wolstenholme","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.neuropharm.2020.108013_bib153","first-page":"36","article-title":"Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls","volume":"25","author":"Yeoh","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib154","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuropharm.2018.09.033","article-title":"Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin\/hypocretin cells","volume":"154","author":"Yeoh","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2020.108013_bib155","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1460-9568.2004.03476.x","article-title":"Contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue-evoked goal-directed behavior","volume":"20","author":"Yun","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2020.108013_bib156","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1124\/jpet.111.187567","article-title":"Orexin-1 receptor mediation of cocaine seeking in male and female rats","volume":"340","author":"Zhou","year":"2012","journal-title":"J. Pharmacol.Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2020.108013_bib157","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.neuropharm.2012.07.044","article-title":"Repeated orexin 1 receptor antagonism effects on cocaine seeking in rats","volume":"63","author":"Zhou","year":"2012","journal-title":"Neuropharmacology"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390820300794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390820300794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:59:46Z","timestamp":1758437986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390820300794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":159,"alternative-id":["S0028390820300794"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2020.108013","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent perspectives on orexin\/hypocretin promotion of addiction-related behaviors","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2020.108013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108013"}}