{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:30:07Z","timestamp":1786995007490,"version":"build-2736575974"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM154124"],"award-info":[{"award-number":["T32GM154124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["SCR_024461"],"award-info":[{"award-number":["SCR_024461"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK129321"],"award-info":[{"award-number":["R01DK129321"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.neuropharm.2025.110348","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T11:17:39Z","timestamp":1738754259000},"page":"110348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Sex-specific signatures of GLP-1 and amylin on resting state brain activity and functional connectivity in awake rats"],"prefix":"10.1016","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4876-7548","authenticated-orcid":false,"given":"Tanzil M.","family":"Arefin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stina","family":"B\u00f6rchers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Olekanma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0707-9193","authenticated-orcid":false,"given":"Samuel R.","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4303-3075","authenticated-orcid":false,"given":"Morgan R.","family":"Sotzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanyin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina P.","family":"Skibicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neuropharm.2025.110348_bib1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.bbr.2009.06.035","article-title":"Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: interaction between type 2 diabetes and Alzheimer's disease","volume":"205","author":"Abbas","year":"2009","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.neuropharm.2025.110348_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s12276-022-00758-4","article-title":"Brain circuits for promoting homeostatic and non-homeostatic appetites","volume":"54","author":"Ahn","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.neuropharm.2025.110348_bib3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.psyneuen.2015.11.021","article-title":"GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality","volume":"65","author":"Anderberg","year":"2016","journal-title":"Psychoneuroendocrinology"},{"issue":"8","key":"10.1016\/j.neuropharm.2025.110348_bib4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1089\/brain.2017.0486","article-title":"Remodeling of sensorimotor brain connectivity in gpr88-deficient mice","volume":"7","author":"Arefin","year":"2017","journal-title":"Brain Connect."},{"issue":"22","key":"10.1016\/j.neuropharm.2025.110348_bib5","doi-asserted-by":"crossref","first-page":"e4221","DOI":"10.21769\/BioProtoc.4221","article-title":"Macroscopic structural and connectome mapping of the mouse brain using diffusion magnetic resonance imaging","volume":"11","author":"Arefin","year":"2021","journal-title":"Bio Protoc"},{"key":"10.1016\/j.neuropharm.2025.110348_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2023.120111","article-title":"Towards reliable reconstruction of the mouse brain corticothalamic connectivity using diffusion MRI","volume":"273","author":"Arefin","year":"2023","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.neuropharm.2025.110348_bib7","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/dom.14937","article-title":"Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while CNS entry is required for locomotor and taste avoidance effects","volume":"25","author":"Asker","year":"2023","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.neuropharm.2025.110348_bib8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.09031","article-title":"A central role for the retrosplenial cortex in de novo environmental learning","volume":"4","author":"Auger","year":"2015","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.neuropharm.2025.110348_bib9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s13041-021-00880-w","article-title":"Retrosplenial cortex in spatial memory: focus on immediate early genes mapping","volume":"14","author":"Balcerek","year":"2021","journal-title":"Mol. Brain"},{"issue":"2","key":"10.1016\/j.neuropharm.2025.110348_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.brainres.2004.10.012","article-title":"Immunohistochemical mapping of calcitonin receptors in the adult rat brain","volume":"1030","author":"Becskei","year":"2004","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.neuropharm.2025.110348_bib11","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.conb.2011.09.004","article-title":"Metabolic and hedonic drives in the neural control of appetite: who is the boss?","volume":"21","author":"Berthoud","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"issue":"12","key":"10.1016\/j.neuropharm.2025.110348_bib12","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.2337\/db14-0849","article-title":"GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans","volume":"63","author":"van Bloemendaal","year":"2014","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.neuropharm.2025.110348_bib13","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/dom.12506","article-title":"Brain reward-system activation in response to anticipation and consumption of palatable food is altered by glucagon-like peptide-1 receptor activation in humans","volume":"17","author":"van Bloemendaal","year":"2015","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.neuropharm.2025.110348_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2020.170366","article-title":"Amylin brain circuitry","volume":"132","author":"Boccia","year":"2020","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.neuropharm.2025.110348_bib98","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqae165","article-title":"GLP-1 and its analogs: does sex matter?","volume":"166","author":"B\u00f6rchers","year":"2025","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuropharm.2025.110348_bib15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.molmet.2017.11.009","article-title":"Amylin - its role in the homeostatic and hedonic control of eating and recent developments of amylin analogs to treat obesity","volume":"8","author":"Boyle","year":"2018","journal-title":"Mol. Metabol."},{"issue":"7","key":"10.1016\/j.neuropharm.2025.110348_bib16","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1111\/ejn.12672","article-title":"The role of the area postrema in the anorectic effects of amylin and salmon calcitonin: behavioral and neuronal phenotyping","volume":"40","author":"Braegger","year":"2014","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.neuropharm.2025.110348_bib17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s42255-021-00344-4","article-title":"Central and peripheral GLP-1 systems independently suppress eating","volume":"3","author":"Brierley","year":"2021","journal-title":"Nat. Metab."},{"issue":"7","key":"10.1016\/j.neuropharm.2025.110348_bib18","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1212\/WNL.0000000000002985","article-title":"Functional MRI of disease progression in Parkinson disease and atypical parkinsonian syndromes","volume":"87","author":"Burciu","year":"2016","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.neuropharm.2025.110348_bib19","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1002\/hbm.26201","article-title":"Functional connectome automatically differentiates multiple system atrophy (parkinsonian type) from idiopathic Parkinson's disease at early stages","volume":"44","author":"Chen","year":"2023","journal-title":"Hum. Brain Mapp."},{"issue":"10","key":"10.1016\/j.neuropharm.2025.110348_bib20","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.2174\/1570159X19666211201093147","article-title":"Amylin pharmacology in alzheimer's disease pathogenesis and treatment","volume":"20","author":"Corrigan","year":"2022","journal-title":"Curr. Neuropharmacol."},{"issue":"1","key":"10.1016\/j.neuropharm.2025.110348_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1017\/S0029665120006965","article-title":"Appetite, the enteroendocrine system, gastrointestinal disease and obesity","volume":"80","author":"Crooks","year":"2021","journal-title":"Proc. Nutr. Soc."},{"issue":"12","key":"10.1016\/j.neuropharm.2025.110348_bib22","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.biopsych.2022.02.013","article-title":"Translational structural and functional signatures of chronic alcohol effects in mice","volume":"91","author":"Degiorgis","year":"2022","journal-title":"Biol. Psychiatry"},{"issue":"14","key":"10.1016\/j.neuropharm.2025.110348_bib23","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1523\/JNEUROSCI.6326-11.2012","article-title":"The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors","volume":"32","author":"Dickson","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110348_bib24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ynstr.2018.06.002","article-title":"Mapping stress networks using functional magnetic resonance imaging in awake animals","volume":"9","author":"Dopfel","year":"2018","journal-title":"Neurobiol Stress"},{"issue":"1","key":"10.1016\/j.neuropharm.2025.110348_bib25","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1038\/s41467-019-09926-z","article-title":"Individual variability in behavior and functional networks predicts vulnerability using an animal model of PTSD","volume":"10","author":"Dopfel","year":"2019","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.neuropharm.2025.110348_bib26","doi-asserted-by":"crossref","first-page":"R355","DOI":"10.1152\/ajpregu.00462.2015","article-title":"Endogenous VMH amylin signaling is required for full leptin signaling and protection from diet-induced obesity","volume":"310","author":"Dunn-Meynell","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"5","key":"10.1016\/j.neuropharm.2025.110348_bib27","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/s00125-016-3874-y","volume":"59","author":"Farr","year":"2016","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.neuropharm.2025.110348_bib28","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2337\/db14-0645","article-title":"Amylin-induced central IL-6 production enhances ventromedial hypothalamic leptin signaling","volume":"64","author":"Le Foll","year":"2015","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.neuropharm.2025.110348_bib29","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.molmed.2017.06.003","article-title":"Amylin receptor: a potential therapeutic target for alzheimer's disease","volume":"23","author":"Fu","year":"2017","journal-title":"Trends Mol. Med."},{"issue":"10","key":"10.1016\/j.neuropharm.2025.110348_bib30","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.biopsych.2023.07.011","article-title":"Amylin modulates a ventral tegmental area-to-medial prefrontal cortex circuit to suppress food intake and impulsive food-directed behavior","volume":"95","author":"Geisler","year":"2024","journal-title":"Biol. Psychiatry"},{"issue":"14","key":"10.1016\/j.neuropharm.2025.110348_bib31","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1002\/cne.24905","article-title":"A novel mouse model of glucagon-like peptide-1 receptor expression: a look at the brain","volume":"528","author":"Graham","year":"2020","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuropharm.2025.110348_bib32","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.neuroimage.2014.08.043","article-title":"Optimization of anesthesia protocol for resting-state fMRI in mice based on differential effects of anesthetics on functional connectivity patterns","volume":"2","author":"Grandjean","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuropharm.2025.110348_bib33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.appet.2015.10.003","article-title":"Cognitive processing of food rewards","volume":"104","author":"Higgs","year":"2016","journal-title":"Appetite"},{"issue":"1","key":"10.1016\/j.neuropharm.2025.110348_bib34","doi-asserted-by":"crossref","DOI":"10.1080\/23312025.2016.1229086","article-title":"The physiological role of the brain GLP-1 system in stress","volume":"2","author":"Holt","year":"2016","journal-title":"Cogent Biol"},{"issue":"2","key":"10.1016\/j.neuropharm.2025.110348_bib35","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/npp.2014.175","article-title":"Hippocampal GLP-1 receptors influence food intake, meal size, and effort-based responding for food through volume transmission","volume":"40","author":"Hsu","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.neuropharm.2025.110348_bib36","first-page":"G920","article-title":"Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms","volume":"273","author":"Imeryuz","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.neuropharm.2025.110348_bib95","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1063033","article-title":"The therapeutic potential of glucagon-like peptide-1 for persons with addictions based on findings from preclinical and clinical studies","volume":"14","author":"Jerlhag","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.neuropharm.2025.110348_bib37","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2337\/diab.39.5.634","article-title":"Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells","volume":"39","author":"Kahn","year":"1990","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.neuropharm.2025.110348_bib38","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/adb.12603","article-title":"Activation of amylin receptors attenuates alcohol-mediated behaviours in rodents","volume":"24","author":"Kalafateli","year":"2019","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuropharm.2025.110348_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2020.104885","article-title":"Activation of the amylin pathway modulates cocaine-induced activation of the mesolimbic dopamine system in male mice","volume":"127","author":"Kalafateli","year":"2021","journal-title":"Horm. Behav."},{"issue":"2","key":"10.1016\/j.neuropharm.2025.110348_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12910","article-title":"Effects of a selective long-acting amylin receptor agonist on alcohol consumption, food intake and body weight in male and female rats","volume":"26","author":"Kalafateli","year":"2021","journal-title":"Addict. Biol."},{"issue":"10","key":"10.1016\/j.neuropharm.2025.110348_bib41","doi-asserted-by":"crossref","first-page":"R885","DOI":"10.1152\/ajpregu.00520.2015","article-title":"GLP-1 and weight loss: unraveling the diverse neural circuitry","volume":"310","author":"Kanoski","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neuropharm.2025.110348_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106550","article-title":"Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: implications for neurodegenerative disease treatment","volume":"186","author":"Kopp","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"12","key":"10.1016\/j.neuropharm.2025.110348_bib43","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1007\/s00125-015-3754-x","article-title":"Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes","volume":"58","author":"ten Kulve","year":"2015","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.neuropharm.2025.110348_bib44","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0306-4522(96)00434-4","article-title":"Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem","volume":"77","author":"Larsen","year":"1997","journal-title":"Neuroscience"},{"issue":"30","key":"10.1016\/j.neuropharm.2025.110348_bib45","doi-asserted-by":"crossref","first-page":"10183","DOI":"10.1523\/JNEUROSCI.1020-12.2012","article-title":"Intrinsic organization of the anesthetized brain","volume":"32","author":"Liang","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110348_bib46","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neuroimage.2013.06.029","article-title":"Mapping thalamocortical networks in rat brain using resting-state functional connectivity","volume":"83","author":"Liang","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuropharm.2025.110348_bib47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroimage.2014.10.013","article-title":"Dynamic resting state functional connectivity in awake and anesthetized rodents","volume":"104","author":"Liang","year":"2015","journal-title":"Neuroimage"},{"issue":"Pt B","key":"10.1016\/j.neuropharm.2025.110348_bib48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.physbeh.2018.02.011","article-title":"Homeostatic and non-homeostatic controls of feeding behavior: distinct vs. common neural systems","volume":"193","author":"Liu","year":"2018","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2025.110348_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117094","article-title":"An open database of resting-state fMRI in awake rats","volume":"220","author":"Liu","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuropharm.2025.110348_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.109946","article-title":"GLP-1 modulated the firing activity of nigral dopaminergic neurons in both normal and parkinsonian mice","volume":"252","author":"Liu","year":"2024","journal-title":"Neuropharmacology"},{"issue":"7197","key":"10.1016\/j.neuropharm.2025.110348_bib51","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nature06976","article-title":"What we can do and what we cannot do with fMRI","volume":"453","author":"Logothetis","year":"2008","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.neuropharm.2025.110348_bib52","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/mp.2017.187","article-title":"Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight","volume":"23","author":"Lopez-Ferreras","year":"2018","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2025.110348_bib53","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.molmet.2018.11.005","article-title":"GLP-1 modulates the supramammillary nucleus-lateral hypothalamic neurocircuit to control ingestive and motivated behavior in a sex divergent manner","volume":"20","author":"Lopez-Ferreras","year":"2019","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.neuropharm.2025.110348_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.104720","article-title":"The supramammillary nucleus controls anxiety-like behavior; key role of GLP-1R","volume":"119","author":"L\u00f3pez-Ferreras","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuropharm.2025.110348_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.101960","article-title":"Dorsolateral septum GLP-1R neurons regulate feeding via lateral hypothalamic projections","volume":"85","author":"Lu","year":"2024","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.neuropharm.2025.110348_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.101960","article-title":"Dorsolateral septum GLP-1R neurons regulate feeding via lateral hypothalamic projections","volume":"85","author":"Lu","year":"2024","journal-title":"Mol. Metabol."},{"issue":"6","key":"10.1016\/j.neuropharm.2025.110348_bib56","doi-asserted-by":"crossref","first-page":"R1475","DOI":"10.1152\/ajpregu.00703.2009","article-title":"The role of amylin in the control of energy homeostasis","volume":"298","author":"Lutz","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"12","key":"10.1016\/j.neuropharm.2025.110348_bib57","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1007\/s00018-011-0905-1","article-title":"Control of energy homeostasis by amylin","volume":"69","author":"Lutz","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"issue":"7","key":"10.1016\/j.neuropharm.2025.110348_bib58","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/sj.ijo.0801664","article-title":"The anorectic effect of a chronic peripheral infusion of amylin is abolished in area postrema\/nucleus of the solitary tract (AP\/NTS) lesioned rats","volume":"25","author":"Lutz","year":"2001","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.neuropharm.2025.110348_bib59","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fnins.2015.00216","article-title":"Amylin at the interface between metabolic and neurodegenerative disorders","volume":"9","author":"Lutz","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110348_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.118960","article-title":"Gaining insight into the neural basis of resting-state fMRI signal","volume":"250","author":"Ma","year":"2022","journal-title":"Neuroimage"},{"issue":"41","key":"10.1016\/j.neuropharm.2025.110348_bib61","doi-asserted-by":"crossref","first-page":"11603","DOI":"10.1073\/pnas.1601640113","article-title":"Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome","volume":"113","author":"Mechling","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.neuropharm.2025.110348_bib62","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1096-9861(19990111)403:2<261::AID-CNE8>3.0.CO;2-5","article-title":"Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system","volume":"403","author":"Merchenthaler","year":"1999","journal-title":"J. Comp. Neurol."},{"issue":"9","key":"10.1016\/j.neuropharm.2025.110348_bib63","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1038\/npp.2013.66","article-title":"Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake","volume":"38","author":"Mietlicki-Baase","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1016\/j.neuropharm.2025.110348_bib64","doi-asserted-by":"crossref","first-page":"E1116","DOI":"10.1152\/ajpendo.00087.2015","article-title":"Cooperative interaction between leptin and amylin signaling in the ventral tegmental area for the control of food intake","volume":"308","author":"Mietlicki-Baase","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.neuropharm.2025.110348_bib65","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/npp.2014.180","article-title":"Amylin modulates the mesolimbic dopamine system to control energy balance","volume":"40","author":"Mietlicki-Baase","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"S13","key":"10.1016\/j.neuropharm.2025.110348_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/alz.077376","article-title":"AMYLOID-\u0392 and phosphorylated-tau accumulation in retrosplenial cortex of young ALZHEIMER\u2019S model","volume":"19","author":"Mondrag\u00f3n-Rodr\u00edguez","year":"2023","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.neuropharm.2025.110348_bib67","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","article-title":"Glucagon-like peptide 1 (GLP-1)","volume":"30","author":"Muller","year":"2019","journal-title":"Mol. Metabol."},{"issue":"1","key":"10.1016\/j.neuropharm.2025.110348_bib68","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0169-328X(99)00335-6","article-title":"Localization of calcitonin receptor mRNA in the mouse brain: coexistence with serotonin transporter mRNA","volume":"76","author":"Nakamoto","year":"2000","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.neuropharm.2025.110348_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101979","article-title":"Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease","volume":"89","author":"Nowell","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neuropharm.2025.110348_bib70","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuroimage.2018.01.014","article-title":"Functional connectivity under six anesthesia protocols and the awake condition in rat brain","volume":"172","author":"Paasonen","year":"2018","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.neuropharm.2025.110348_bib71","doi-asserted-by":"crossref","first-page":"R623","DOI":"10.1152\/ajpregu.00791.2009","article-title":"Noradrenergic neurons of the area postrema mediate amylin's hypophagic action","volume":"299","author":"Potes","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"3","key":"10.1016\/j.neuropharm.2025.110348_bib72","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion","volume":"59","author":"Power","year":"2012","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.neuropharm.2025.110348_bib73","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s10194-024-01744-z","article-title":"Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1\/2 dorsal root ganglia","volume":"25","author":"Rees","year":"2024","journal-title":"J. Headache Pain"},{"issue":"6","key":"10.1016\/j.neuropharm.2025.110348_bib74","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.cmet.2008.11.002","article-title":"Glucose sensing in L cells: a primary cell study","volume":"8","author":"Reimann","year":"2008","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.neuropharm.2025.110348_bib75","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1210\/en.2014-1248","article-title":"GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence","volume":"155","author":"Richard","year":"2014","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.neuropharm.2025.110348_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119034","article-title":"Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system","volume":"10","author":"Richard","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2025.110348_bib77","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13293-016-0059-9","article-title":"Sex and estrogens alter the action of glucagon-like peptide-1 on reward","volume":"7","author":"Richard","year":"2016","journal-title":"Biol. Sex Differ."},{"issue":"2","key":"10.1016\/j.neuropharm.2025.110348_bib78","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0022-3565(25)22436-3","article-title":"Autoradiographic distribution and receptor binding profile of [125I]Bolton Hunter-rat amylin binding sites in the rat brain","volume":"270","author":"van Rossum","year":"1994","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"22","key":"10.1016\/j.neuropharm.2025.110348_bib79","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1001\/jama.2023.16620","article-title":"As semaglutide's popularity soars, rare but serious adverse effects are emerging","volume":"330","author":"Ruder","year":"2023","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.neuropharm.2025.110348_bib80","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084241","article-title":"Resting state FMRI reveals diminished functional connectivity in a mouse model of amyloidosis","volume":"8","author":"Shah","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.neuropharm.2025.110348_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061965","article-title":"Gut peptide GLP-1 and its analogue, Exendin-4, decrease alcohol intake and reward","volume":"8","author":"Shirazi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuropharm.2025.110348_bib82","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fnins.2013.00181","article-title":"The central GLP-1: implications for food and drug reward","volume":"7","author":"Skibicka","year":"2013","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110348_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.113085","article-title":"Neural correlates of top-down guidance of attention to food: an fMRI study","volume":"225","author":"Spetter","year":"2020","journal-title":"Physiol. Behav."},{"issue":"5","key":"10.1016\/j.neuropharm.2025.110348_bib84","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/joim.13699","article-title":"Neurobiology of eating behavior, nutrition, and health","volume":"294","author":"Stover","year":"2023","journal-title":"J. Intern. Med."},{"issue":"6","key":"10.1016\/j.neuropharm.2025.110348_bib85","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/cne.24381","article-title":"Brain maps 4.0-Structure of the rat brain: an open access atlas with global nervous system nomenclature ontology and flatmaps","volume":"526","author":"Swanson","year":"2018","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.neuropharm.2025.110348_bib86","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1152\/ajpregu.00460.2015","article-title":"Role of lateral septum glucagon-like peptide 1 receptors in food intake","volume":"311","author":"Terrill","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"12","key":"10.1016\/j.neuropharm.2025.110348_bib87","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1007\/s00213-013-3409-x","article-title":"Effects of the 5-HT2C receptor agonist meta-chlorophenylpiperazine on appetite, food intake and emotional processing in healthy volunteers","volume":"231","author":"Thomas","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2025.110348_bib88","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neubiorev.2019.04.016","article-title":"Retrosplenial cortex and its role in cue-specific learning and memory","volume":"107","author":"Todd","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6560","key":"10.1016\/j.neuropharm.2025.110348_bib89","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/379069a0","article-title":"A role for glucagon-like peptide-1 in the central regulation of feeding","volume":"379","author":"Turton","year":"1996","journal-title":"Nature"},{"issue":"Pt A","key":"10.1016\/j.neuropharm.2025.110348_bib90","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.neuropharm.2016.07.039","article-title":"GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight","volume":"110","author":"Vogel","year":"2016","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.neuropharm.2025.110348_bib91","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1210\/en.2008-1045","article-title":"Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety","volume":"150","author":"Williams","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuropharm.2025.110348_bib92","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.3389\/fnins.2019.01401","article-title":"Brain distribution and sexually dimorphic expression of amylin in different reproductive stages of the zebra finch (Taeniopygia guttata) suggest roles of the neuropeptide in song learning and social behaviour","volume":"13","author":"Zachar","year":"2019","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.neuropharm.2025.110348_bib93","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.braindev.2006.07.002","article-title":"Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI","volume":"29","author":"Zang","year":"2007","journal-title":"Brain Dev."},{"issue":"2","key":"10.1016\/j.neuropharm.2025.110348_bib94","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jneumeth.2010.04.001","article-title":"Mapping resting-state brain networks in conscious animals","volume":"189","author":"Zhang","year":"2010","journal-title":"J. Neurosci. Methods"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390825000541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390825000541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:24:50Z","timestamp":1777350290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390825000541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":97,"alternative-id":["S0028390825000541"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2025.110348","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-specific signatures of GLP-1 and amylin on resting state brain activity and functional connectivity in awake rats","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2025.110348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110348"}}