{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T08:59:02Z","timestamp":1780822742651,"version":"3.54.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271510"],"award-info":[{"award-number":["82271510"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.neuropharm.2025.110752","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:02:52Z","timestamp":1761696172000},"page":"110752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["\u03b2-Caryophyllene prevents cognitive impairment in mice following acute sleep deprivation by alleviating hippocampal structural and functional alterations"],"prefix":"10.1016","volume":"283","author":[{"given":"Lingli","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9842-0438","authenticated-orcid":false,"given":"Xianxia","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-715X","authenticated-orcid":false,"given":"Lei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2025.110752_bib1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3390\/cells11050764","article-title":"Adult neurogenesis under control of the circadian system","volume":"11","author":"Ali","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.neuropharm.2025.110752_bib2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/bdi.12838","article-title":"Lithium acts to modulate abnormalities at behavioral, cellular, and molecular levels in sleep deprivation-induced mania-like behavior","volume":"22","author":"Andrabi","year":"2020","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neuropharm.2025.110752_bib3","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1476-5381.2010.00729.x","article-title":"CB2: a cannabinoid receptor with an identity crisis","volume":"160","author":"Atwood","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/ACO.0000000000000616","article-title":"An overview of the cannabinoid type 2 (CB2) receptor system and its therapeutic potential","volume":"31","author":"Bie","year":"2018","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.neuro.31.060407.125646","article-title":"Balancing structure and function at hippocampal dendritic spines","volume":"31","author":"Bourne","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110752_bib6","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1196\/annals.1432.037","article-title":"Ultrastructural localization of neuronal brain CB2 cannabinoid receptors","volume":"1139","author":"Brusco","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2025.110752_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/cercor\/bhx324","article-title":"Synaptic potentiation at basal and apical dendrites of hippocampal pyramidal neurons involves activation of a distinct set of extracellular and intracellular molecular cues","volume":"29","author":"Brzdak","year":"2019","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.neuropharm.2025.110752_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsw032","article-title":"Sleep, cognitive impairment, and Alzheimer's disease: a Systematic review and meta-analysis","volume":"40","author":"Bubu","year":"2017","journal-title":"Sleep"},{"key":"10.1016\/j.neuropharm.2025.110752_bib9","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1152\/jn.2002.88.2.1073","article-title":"Sleep deprivation impairs long-term potentiation in rat hippocampal slices","volume":"88","author":"Campbell","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib10","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1101\/lm.030775.113","article-title":"The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice","volume":"20","author":"Chang","year":"2013","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuropharm.2025.110752_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148425","article-title":"Effects of oral \u03b2-caryophyllene (BCP) treatment on perioperative neurocognitive disorders: attenuation of neuroinflammation associated with microglial activation and reinforcement of autophagy activity in aged mice","volume":"1815","author":"Chen","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2025.110752_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000362689","article-title":"\u03b2-Caryophyllene ameliorates the alzheimer-like phenotype in APP\/PS1 mice through CB2 receptor activation and the PPAR\u03b3 pathway","volume":"94","author":"Cheng","year":"2014","journal-title":"Pharmacology"},{"key":"10.1016\/j.neuropharm.2025.110752_bib13","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1038\/s41467-021-23133-9","article-title":"NMDAR-Dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95","volume":"12","author":"Compans","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuropharm.2025.110752_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12574","article-title":"Role of melatonin in sleep deprivation-induced intestinal barrier dysfunction in mice","volume":"67","author":"Gao","year":"2019","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.neuropharm.2025.110752_bib15","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0803601105","article-title":"Beta-caryophyllene is a dietary cannabinoid","volume":"105","author":"Gertsch","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2025.110752_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.416","article-title":"Fatherhood contributes to increased hippocampal spine density and anxiety regulation in California mice","volume":"6","author":"Glasper","year":"2016","journal-title":"Brain Behav."},{"key":"10.1016\/j.neuropharm.2025.110752_bib17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/jnc.14543","article-title":"The combination of ribose and adenine promotes adenosine release and attenuates the intensity and frequency of epileptiform activity in hippocampal slices: evidence for the rapid depletion of cellular ATP during electrographic seizures","volume":"147","author":"Hall","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuropharm.2025.110752_bib18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.pneurobio.2007.10.011","article-title":"Synaptic adhesion molecules and PSD-95","volume":"84","author":"Han","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.conb.2017.02.005","article-title":"The tired hippocampus: the molecular impact of sleep deprivation on hippocampal function","volume":"44","author":"Havekes","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13424","article-title":"Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1","volume":"5","author":"Havekes","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.neuropharm.2025.110752_bib21","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1111\/bph.14969","article-title":"\u03b2-Caryophyllene, a dietary terpenoid, inhibits nicotine taking and nicotine seeking in rodents","volume":"177","author":"He","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib22","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.brainres.2016.11.013","article-title":"The effects of NBM- lesion on synaptic plasticity in rats","volume":"1655","author":"Hosseini","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2025.110752_bib23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbr.2019.01.038","article-title":"REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation","volume":"364","author":"Hou","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2025.110752_bib24","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2119\/molmed.2015.00201","article-title":"Preclinical models of overwhelming sepsis implicate the neural system that encodes contextual fear memory","volume":"22","author":"Huerta","year":"2016","journal-title":"Mol. Med."},{"key":"10.1016\/j.neuropharm.2025.110752_bib25","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3389\/fnins.2016.00321","article-title":"Cannabinoid type 2 (CB2) receptors activation protects against oxidative stress and neuroinflammation associated dopaminergic neurodegeneration in rotenone model of parkinson's disease","volume":"10","author":"Javed","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110752_bib26","doi-asserted-by":"crossref","first-page":"9488","DOI":"10.1038\/srep09488","article-title":"Spatial training preserves associative memory capacity with augmentation of dendrite ramification and spine generation in Tg2576 mice","volume":"5","author":"Jiang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2025.110752_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113621","article-title":"Effects of sleep deprivation of various durations on novelty-related object recognition memory and object location memory in mice","volume":"418","author":"Jiao","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2025.110752_bib28","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1113\/jphysiol.2014.286633","article-title":"Chronic activation of CB2 cannabinoid receptors in the hippocampus increases excitatory synaptic transmission","volume":"593","author":"Kim","year":"2015","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/ijms22010019","article-title":"CB2 receptor in microglia: the guardian of self-control","volume":"22","author":"Komorowska-M\u00fcller","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuropharm.2025.110752_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-96285-9","article-title":"Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus","volume":"11","author":"Komorowska-M\u00fcller","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2025.110752_bib31","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrn.2017.55","article-title":"The sleep-deprived human brain","volume":"18","author":"Krause","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110752_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9815092","article-title":"Correlations between the memory-related behavior and the level of oxidative stress biomarkers in the mice brain, provoked by an acute administration of CB receptor ligands","volume":"2016","author":"Kruk-Slomka","year":"2016","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuropharm.2025.110752_bib33","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1523\/JNEUROSCI.23-02-00659.2003","article-title":"Associative memory formation increases the observation of dendritic spines in the hippocampus","volume":"23","author":"Leuner","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110752_bib34","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neuroscience.2015.10.041","article-title":"Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus","volume":"311","author":"Li","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2025.110752_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9817089","article-title":"CB2 cannabinoid receptor knockout in mice impairs contextual long-term memory and enhances spatial working memory","volume":"2016","author":"Li","year":"2016","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuropharm.2025.110752_bib36","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1089\/can.2023.0186","article-title":"Electrophysiological phenotypes of hippocampal synaptic and network functions in cannabinoid receptor 2 knockout mice","volume":"9","author":"Li","year":"2024","journal-title":"Cannabis Cannabinoid Res."},{"key":"10.1016\/j.neuropharm.2025.110752_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112012","article-title":"The cannabinoid receptor 2 agonist, \u03b2-caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged Male mice","volume":"372","author":"Lindsey","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2025.110752_bib38","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/jsr.12436","article-title":"Sleep deprivation increases formation of false memory","volume":"25","author":"Lo","year":"2016","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.neuropharm.2025.110752_bib39","doi-asserted-by":"crossref","first-page":"9026","DOI":"10.1523\/JNEUROSCI.1215-09.2009","article-title":"NR2A at CA1 synapses is obligatory for the susceptibility of hippocampal plasticity to sleep loss","volume":"29","author":"Longordo","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110752_bib40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neuropharm.2012.08.014","article-title":"Maternal deprivation effects on brain plasticity and recognition memory in adolescent male and female rats","volume":"68","author":"Marco","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2025.110752_bib41","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pbb.2016.11.005","article-title":"Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences","volume":"152","author":"Marco","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2025.110752_bib42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-2094-9-8","article-title":"Prolonged oral cannabinoid administration prevents neuroinflammation, lowers \u03b2-amyloid levels and improves cognitive performance in Tg APP 2576 mice","volume":"9","author":"Mart\u00edn-Moreno","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuropharm.2025.110752_bib43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neuroimage.2013.03.001","article-title":"The role of sleep and sleep deprivation in consolidating fear memories","volume":"75","author":"Menz","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuropharm.2025.110752_bib44","doi-asserted-by":"crossref","first-page":"12673","DOI":"10.1073\/pnas.91.26.12673","article-title":"An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses","volume":"91","author":"Moser","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2025.110752_bib45","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1469-7793.2000.00513.x","article-title":"Release probability modulates short-term plasticity at a rat giant terminal","volume":"524","author":"Oleskevich","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib46","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00421-020-04468-5","article-title":"Acute partial sleep deprivation and high-intensity interval exercise effects on postprandial endothelial function","volume":"120","author":"Papadakis","year":"2020","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib47","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1523\/JNEUROSCI.6142-10.2011","article-title":"Reduced spine density in specific regions of CA1 pyramidal neurons in two transgenic mouse models of Alzheimer's disease","volume":"31","author":"Perez-Cruz","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110752_bib48","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.nlm.2013.11.021","article-title":"Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory","volume":"109","author":"Prince","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neuropharm.2025.110752_bib49","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbr.2009.10.014","article-title":"Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behavior","volume":"207","author":"Ramanathan","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2025.110752_bib50","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/npp.2009.6","article-title":"Impaired off-line consolidation of motor memories after combined blockade of cholinergic receptors during REM sleep-rich sleep","volume":"34","author":"Rasch","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2025.110752_bib51","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1164\/rccm.201904-0819OC","article-title":"Impact of sleep deprivation on respiratory motor output and endurance. A physiological study","volume":"201","author":"Rault","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.neuropharm.2025.110752_bib52","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13195-021-00920-6","article-title":"N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors","volume":"13","author":"Rivas-Santisteban","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neuropharm.2025.110752_bib53","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13195-021-00920-6","article-title":"N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors","volume":"13","author":"Rivas-Santisteban","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neuropharm.2025.110752_bib54","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13195-021-00920-6","article-title":"N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors","volume":"13","author":"Rivas-Santisteban","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neuropharm.2025.110752_bib55","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1016\/j.cell.2023.10.025","article-title":"Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals","volume":"186","author":"Sang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.neuropharm.2025.110752_bib56","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/biom14030333","article-title":"Activation of cannabinoid type 2 receptor in microglia reduces neuroinflammation through inhibiting aerobic glycolysis to relieve hypertension","volume":"14","author":"Shan","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.neuropharm.2025.110752_bib57","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.neuron.2016.03.034","article-title":"Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus","volume":"90","author":"Stempel","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2025.110752_bib58","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.neuron.2016.03.034","article-title":"Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus","volume":"90","author":"Stempel","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2025.110752_bib59","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.neuron.2016.03.034","article-title":"Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus","volume":"90","author":"Stempel","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2025.110752_bib60","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.expneurol.2008.11.012","article-title":"Long-term depression of excitatory synaptic transmission in rat hippocampal CA1 neurons following sleep-deprivation","volume":"216","author":"Tadavarty","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib61","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.euroneuro.2017.08.431","article-title":"Neuropeptide S overcomes short term memory deficit induced by sleep restriction by increasing prefrontal cortex activity","volume":"27","author":"Thomasson","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib62","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3390\/antiox10040546","article-title":"Improvement of oxidative stress and mitochondrial dysfunction by \u03b2-Caryophyllene: a focus on the nervous system","volume":"10","author":"Ullah","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.neuropharm.2025.110752_bib63","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nature08488","article-title":"Sleep deprivation impairs cAMP signaling in the hippocampus","volume":"461","author":"Vecsey","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2025.110752_bib64","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nature08488","article-title":"Sleep deprivation impairs cAMP signalling in the hippocampus","volume":"461","author":"Vecsey","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2025.110752_bib65","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jnr.20759","article-title":"Age-related alterations in hippocampal spines and deficiencies in spatial memory in mice","volume":"83","author":"von Bohlen und Halbach","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2025.110752_bib66","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuropharm.2025.110752_bib67","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0380-22.2022","article-title":"Chemogenetic enhancement of cAMP signaling renders hippocampal synaptic plasticity resilient to the impact of acute sleep deprivation","volume":"10","author":"Walsh","year":"2023","journal-title":"eNeuro"},{"key":"10.1016\/j.neuropharm.2025.110752_bib68","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3233\/JAD-160763","article-title":"Role of glutamate and NMDA receptors in alzheimer's disease","volume":"57","author":"Wang","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neuropharm.2025.110752_bib69","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1007\/s12035-017-0676-2","article-title":"Deletion of Type-2 cannabinoid receptor induces alzheimer's disease-like tau pathology and memory impairment through AMPK\/GSK3\u03b2 pathway","volume":"55","author":"Wang","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib70","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1111\/bph.15089","article-title":"Inflammation induces developmentally regulated sumatriptan inhibition of spinal synaptic transmission","volume":"177","author":"Winters","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2025.110752_bib71","article-title":"Faecalibacterium prausnitzii supplementation prevents intestinal barrier injury and gut microflora dysbiosis induced by sleep deprivation","volume":"16","author":"X","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.neuropharm.2025.110752_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/srep37251","article-title":"Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation","volume":"6","author":"Xiao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2025.110752_bib73","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bbrc.2020.11.029","article-title":"Caffeine-related effects on cognitive performance: roles of apoptosis in rat hippocampus following sleep deprivation","volume":"534","author":"Xie","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuropharm.2025.110752_bib74","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.apsb.2019.07.001","article-title":"Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice","volume":"10","author":"Yang","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.neuropharm.2025.110752_bib75","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/jdn.10307","article-title":"Sex-specific dendritic morphology of hippocampal pyramidal neurons in the adolescent and young adult rats","volume":"84","author":"Yarmohammadi-Samani","year":"2024","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110752_bib76","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biopha.2018.11.039","article-title":"Beta-caryophyllene alleviates diet-induced neurobehavioral changes in rats: the role of CB2 and PPAR-\u03b3 receptors","volume":"110","author":"Youssef","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.neuropharm.2025.110752_bib77","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1146\/annurev.neuro.24.1.1071","article-title":"Morphological changes in dendritic spines associated with long-term synaptic plasticity","volume":"24","author":"Yuste","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110752_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1059730","article-title":"Dendritic spinule-mediated structural synaptic plasticity: implications for development, aging, and psychiatric disease","volume":"16","author":"Zaccard","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuropharm.2025.110752_bib79","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.nbd.2011.12.039","article-title":"The beneficial effects of regular exercise on cognition in REM sleep deprivation: behavioral, electrophysiological and molecular evidence","volume":"45","author":"Zagaar","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2025.110752_bib80","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s41105-023-00450-8","article-title":"Dexmedetomidine prevents spatial learning and memory impairment induced by chronic REM sleep deprivation in rats","volume":"21","author":"Zhang","year":"2023","journal-title":"Sleep Biol. Rhythm"},{"key":"10.1016\/j.neuropharm.2025.110752_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114704","article-title":"rTMS reduces spatial learning and memory deficits induced by sleep deprivation possibly via suppressing the expression of kynurenine 3-monooxygenase in rats","volume":"456","author":"Zheng","year":"2024","journal-title":"Behav. Brain Res."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390825004605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390825004605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T08:20:00Z","timestamp":1780820400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390825004605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":81,"alternative-id":["S0028390825004605"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2025.110752","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b2-Caryophyllene prevents cognitive impairment in mice following acute sleep deprivation by alleviating hippocampal structural and functional alterations","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2025.110752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110752"}}