{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:41:49Z","timestamp":1787312509008,"version":"build-2736575974"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["OPUS 2021\/41\/B\/NZ4\/03882"],"award-info":[{"award-number":["OPUS 2021\/41\/B\/NZ4\/03882"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.neuropharm.2026.111012","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:18:50Z","timestamp":1778084330000},"page":"111012","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Olfactory bulb circuits drive ketamine-enhanced high-frequency oscillations via kainate and GABAergic mechanisms"],"prefix":"10.1016","volume":"296","author":[{"given":"Taisiia","family":"Prosvirova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiktoria","family":"Podolecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Wrobel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7741-2191","authenticated-orcid":false,"given":"Mark Jeremy","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.neuropharm.2026.111012_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-017-0002-9","article-title":"Cortical high gamma network oscillations and connectivity: a translational index for antipsychotics to normalize aberrant neurophysiological activity","volume":"7","author":"Ahnaou","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"10.1016\/j.neuropharm.2026.111012_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2003.11.026","article-title":"Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro","volume":"46","author":"Alt","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2026.111012_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107745","article-title":"Modulation of thalamo-cortical activity by the NMDA receptor antagonists ketamine and phencyclidine in the awake freely-moving rat","volume":"158","author":"Amat-Foraster","year":"2019","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1152\/jn.1999.81.1.15","article-title":"Current-Source density analysis in the Rat Olfactory bulb: Laminar distribution of Kainate\/AMPA- and NMDA-Receptor-Mediated currents","volume":"81","author":"Aroniadou-Anderjaska","year":"1999","journal-title":"J. Neurophysiol."},{"issue":"4","key":"10.1016\/j.neuropharm.2026.111012_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0006-3223(99)00230-9","article-title":"Antidepressant effects of ketamine in depressed patients","volume":"47","author":"Berman","year":"2000","journal-title":"Biol. Psychiatry"},{"issue":"31","key":"10.1016\/j.neuropharm.2026.111012_bib6","doi-asserted-by":"crossref","first-page":"8358","DOI":"10.1523\/JNEUROSCI.1199-07.2007","article-title":"Olfactory bulb gamma oscillations are enhanced with task demands","volume":"27","author":"Beshel","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111012_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.737295","article-title":"Activity-State dependent reversal of ketamine-induced resting State EEG effects by clozapine and naltrexone in the freely moving rat","volume":"13","author":"Bowman","year":"2022","journal-title":"Front. Psychiatr."},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib8","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s42003-023-05093-6","article-title":"5-HT2AR and NMDAR psychedelics induce similar hyper-synchronous states in the rat cognitive-limbic cortex-basal ganglia system","volume":"6","author":"Brys","year":"2023","journal-title":"Commun. Biol."},{"issue":"4","key":"10.1016\/j.neuropharm.2026.111012_bib9","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1152\/jn.00109.2017","article-title":"Inhibitory circuits of the mammalian main olfactory bulb","volume":"118","author":"Burton","year":"2017","journal-title":"J. Neurophysiol."},{"issue":"8 August","key":"10.1016\/j.neuropharm.2026.111012_bib10","article-title":"Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb","volume":"22","author":"Burton","year":"2024","journal-title":"PLoS Biol."},{"issue":"6","key":"10.1016\/j.neuropharm.2026.111012_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nrn3241","article-title":"The origin of extracellular fields and currents \u2014 EEG, ECoG, LFP and spikes","volume":"13","author":"Buzs\u00e1ki","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"7","key":"10.1016\/j.neuropharm.2026.111012_bib12","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.neuron.2023.03.018","article-title":"Brain rhythms have come of age","volume":"111","author":"Buzs\u00e1ki","year":"2023","journal-title":"Neuron"},{"issue":"5793","key":"10.1016\/j.neuropharm.2026.111012_bib13","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.1128115","article-title":"High Gamma power is phase-locked to Theta oscillations in human neocortex","volume":"313","author":"Canolty","year":"2006","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.neuropharm.2026.111012_bib14","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.20-05-02011.2000","article-title":"Long-lasting depolarizations in mitral cells of the rat olfactory bulb","volume":"20","author":"Carlson","year":"2000","journal-title":"J. Neurosci."},{"issue":"33","key":"10.1016\/j.neuropharm.2026.111012_bib15","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1523\/JNEUROSCI.2944-15.2017","article-title":"Gamma oscillations in the Rat ventral striatum originate in the piriform cortex","volume":"37","author":"Carmichael","year":"2017","journal-title":"J. Neurosci."},{"issue":"6638","key":"10.1016\/j.neuropharm.2026.111012_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/40645","article-title":"Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons","volume":"388","author":"Castillo","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2026.111012_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.115231","article-title":"Cortical high-frequency oscillations (\u2248 110 Hz) in cats are state-dependent and enhanced by a subanesthetic dose of ketamine","volume":"476","author":"Castro-Zaballa","year":"2025","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.neuropharm.2026.111012_bib18","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0896-6273(00)81065-X","article-title":"Analysis of relations between NMDA receptors and GABA release at Olfactory Bulb reciprocal synapses","volume":"25","author":"Chen","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2026.111012_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.conb.2014.08.001","article-title":"Theta\u2013gamma coupling in the entorhinal\u2013hippocampal system","volume":"31","author":"Colgin","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"issue":"8","key":"10.1016\/j.neuropharm.2026.111012_bib20","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.euroneuro.2015.04.004","article-title":"Coupling in the cortico-basal ganglia circuit is aberrant in the ketamine model of schizophrenia","volume":"25","author":"Cordon","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"5","key":"10.1016\/j.neuropharm.2026.111012_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/syn.20376","article-title":"Expression and function of kainate receptors in the rat olfactory bulb","volume":"61","author":"Davila","year":"2007","journal-title":"Synapse"},{"issue":"Issue C","key":"10.1016\/j.neuropharm.2026.111012_bib22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0074-7742(08)60772-2","article-title":"Neurobiology of phencyclidine (Sernyl), A drug with an unusual spectrum of pharmacological activity","volume":"6","author":"Domino","year":"1964","journal-title":"Int. Rev. Neurobiol."},{"issue":"4","key":"10.1016\/j.neuropharm.2026.111012_bib23","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.semcdb.2006.04.006","article-title":"Dynamic connectivity in the mitral cell\u2013granule cell microcircuit","volume":"17","author":"Egger","year":"2006","journal-title":"Semin. Cell Dev. Biol."},{"issue":"47","key":"10.1016\/j.neuropharm.2026.111012_bib25","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.3685-11.2011","article-title":"Distinct functional roles of subunits within the heteromeric kainate receptor","volume":"31","author":"Fisher","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111012_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12738","article-title":"Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells","volume":"7","author":"Fi\u00e8vre","year":"2016","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.neuropharm.2026.111012_bib26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.tins.2007.05.005","article-title":"The gamma cycle","volume":"30","author":"Fries","year":"2007","journal-title":"Trends Neurosci."},{"issue":"9","key":"10.1016\/j.neuropharm.2026.111012_bib27","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/nn.3760","article-title":"Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb","volume":"17","author":"Fukunaga","year":"2014","journal-title":"Nat. Neurosci."},{"issue":"11","key":"10.1016\/j.neuropharm.2026.111012_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186732","article-title":"Neuronal correlates of ketamine and walking induced gamma oscillations in the medial prefrontal cortex and mediodorsal thalamus","volume":"12","author":"Furth","year":"2017","journal-title":"PLoS One"},{"issue":"5525","key":"10.1016\/j.neuropharm.2026.111012_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/science.1061395","article-title":"Spike transmission and synchrony detection in networks of GABAergic interneurons","volume":"292","author":"Galarreta","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2026.111012_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.172856","article-title":"Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: gamma power and long-term potentiation","volume":"189","author":"Gilbert","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"8","key":"10.1016\/j.neuropharm.2026.111012_bib31","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1093\/brain\/awy175","article-title":"Acute ketamine dysregulates task-related gamma-band oscillations in thalamo-cortical circuits in schizophrenia","volume":"141","author":"Grent-\u2018t-Jong","year":"2018","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.neuropharm.2026.111012_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006755","article-title":"NMDA receptor hypofunction leads to generalized and persistent aberrant \u03b3 oscillations independent of hyperlocomotion and the State of consciousness","volume":"4","author":"Hakami","year":"2009","journal-title":"PLoS One"},{"issue":"43","key":"10.1016\/j.neuropharm.2026.111012_bib33","doi-asserted-by":"crossref","first-page":"11496","DOI":"10.1523\/JNEUROSCI.2213-07.2007","article-title":"NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons","volume":"27","author":"Homayoun","year":"2007","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.neuropharm.2026.111012_bib34","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/npp.2009.168","article-title":"Gamma and Delta neural oscillations and Association with clinical symptoms under subanesthetic ketamine","volume":"35","author":"Hong","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2026.111012_bib35","article-title":"Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA- and glutamatergic alterations","volume":"vol. 28","author":"Hu","year":"2023"},{"key":"10.1016\/j.neuropharm.2026.111012_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104625","article-title":"NMDA receptors on parvalbumin-positive interneurons and pyramidal neurons both contribute to MK-801 induced gamma oscillatory disturbances: complex relationships with behaviour","volume":"134","author":"Hudson","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.neuropharm.2026.111012_bib37","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41386-018-0173-y","article-title":"The olfactory bulb is a source of high-frequency oscillations (130\u2013180 Hz) associated with a subanesthetic dose of ketamine in rodents","volume":"44","author":"Hunt","year":"2019","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.neuropharm.2026.111012_bib38","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1177\/0269881110362126","article-title":"Differential effects produced by ketamine on oscillatory activity recorded in the rat hippocampus, dorsal striatum and nucleus accumbens","volume":"25","author":"Hunt","year":"2011","journal-title":"J. Psychopharmacol."},{"issue":"11","key":"10.1016\/j.neuropharm.2026.111012_bib39","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.biopsych.2006.01.020","article-title":"Ketamine dose-dependently induces high-frequency oscillations in the nucleus accumbens in freely moving rats","volume":"60","author":"Hunt","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.neuropharm.2026.111012_bib40","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0896-6273(00)81013-2","article-title":"Olfactory reciprocal synapses: dendritic signaling in the CNS","volume":"20","author":"Isaacson","year":"1998","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.neuropharm.2026.111012_bib41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/jnc.15602","article-title":"GABA B R activation partially normalizes acute NMDAR hypofunction oscillatory abnormalities but fails to rescue sensory processing deficits","volume":"161","author":"Janz","year":"2022","journal-title":"J. Neurochem."},{"issue":"7","key":"10.1016\/j.neuropharm.2026.111012_bib43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tins.2007.05.001","article-title":"Human gamma-frequency oscillations associated with attention and memory","volume":"30","author":"Jensen","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111012_bib42","article-title":"Cross-frequency coupling between neuronal oscillations","volume":"vol. 11","author":"Jensen","year":"2007"},{"issue":"2","key":"10.1016\/j.neuropharm.2026.111012_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/S0006-8993(96)01086-4","article-title":"The lateral and medial compartments of the olfactory tubercle and their relation to olfactory-related input as determined by artificial neural network analysis","volume":"744","author":"Josephson","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neuropharm.2026.111012_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2014.10.004","article-title":"Olfactory system oscillations across phyla","volume":"31","author":"Kay","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuropharm.2026.111012_bib46","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.neuropharm.2017.01.006","article-title":"The effect of NMDA-R antagonism on simultaneously acquired local field potentials and tissue oxygen levels in the brains of freely-moving rats","volume":"116","author":"Kealy","year":"2017","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.neuropharm.2026.111012_bib47","doi-asserted-by":"crossref","DOI":"10.1152\/jn.2001.86.3.1139","article-title":"Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: role of glutamate clearance","volume":"86","author":"Kidd","year":"2001","journal-title":"J. Neurophysiol."},{"issue":"11","key":"10.1016\/j.neuropharm.2026.111012_bib48","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.biopsych.2011.10.002","article-title":"Differential role of NR2A and NR2B subunits in N-Methyl-D-Aspartate receptor antagonist-induced aberrant cortical gamma oscillations","volume":"71","author":"Kocsis","year":"2012","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2011.05.035","article-title":"Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression","volume":"224","author":"Koike","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2026.111012_bib50","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2305772120","article-title":"Ketamine and the neurobiology of depression: toward next-generation rapid-acting antidepressant treatments","volume":"120","author":"Krystal","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"8","key":"10.1016\/j.neuropharm.2026.111012_bib51","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awu149","article-title":"High frequency oscillations are associated with cognitive processing in human recognition memory","volume":"137","author":"Kucewicz","year":"2014","journal-title":"Brain"},{"issue":"18","key":"10.1016\/j.neuropharm.2026.111012_bib52","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1523\/JNEUROSCI.5570-03.2004","article-title":"Interplay between local GABAergic interneurons and relay neurons generates \u03b3 oscillations in the Rat Olfactory bulb","volume":"24","author":"Lagier","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111012_bib54","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neuroscience.2017.06.039","article-title":"Local NMDA receptor hypofunction evokes generalized effects on gamma and high-frequency oscillations and behavior","volume":"358","author":"Lee","year":"2017","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib55","doi-asserted-by":"crossref","DOI":"10.2165\/00003495-200059010-00004","article-title":"Pharmacology of AMPA\/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders","volume":"59","author":"Lees","year":"2000","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.neuropharm.2026.111012_bib56","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.neuron.2013.07.025","article-title":"Odor discrimination requires proper olfactory fast oscillations in awake mice","volume":"80","author":"Lepousez","year":"2013","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib53","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0013-4694(85)90952-6","article-title":"Spectral analysis of hippocampal EEG in the freely moving rat: effects of centrally active drugs and relations to evoked potentials","volume":"60","author":"Leung","year":"1985","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"issue":"13","key":"10.1016\/j.neuropharm.2026.111012_bib57","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.neuron.2023.04.013","article-title":"Reinstating olfactory bulb-derived limbic gamma oscillations alleviates depression-like behavioral deficits in rodents","volume":"111","author":"Li","year":"2023","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.neuropharm.2026.111012_bib58","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.biopsych.2007.05.028","article-title":"Cellular mechanisms underlying the antidepressant effects of ketamine: role of \u03b1-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic acid receptors","volume":"63","author":"Maeng","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2026.111012_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2020.05.012","article-title":"Transient dose-dependent effects of ketamine on neural oscillatory activity in Wistar-Kyoto rats","volume":"441","author":"Manduca","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2026.111012_bib60","article-title":"Physiological features of parvalbumin-expressing GABAergic interneurons contributing to high-frequency oscillations in the cerebral cortex","volume":"vol. 6","author":"Milicevic","year":"2024"},{"issue":"8","key":"10.1016\/j.neuropharm.2026.111012_bib61","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1523\/JNEUROSCI.17-08-02921.1997","article-title":"Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex","volume":"17","author":"Moghaddam","year":"1997","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.neuropharm.2026.111012_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1096-9861(19990308)405:2<233::AID-CNE7>3.0.CO;2-A","article-title":"Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb","volume":"405","author":"Montague","year":"1999","journal-title":"J. Comp. Neurol."},{"issue":"6","key":"10.1016\/j.neuropharm.2026.111012_bib63","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1152\/jn.00475.2003","article-title":"Beta and gamma oscillations in the olfactory System of the urethane-anesthetized rat","volume":"90","author":"Neville","year":"2003","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib64","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1038\/s41598-020-66023-8","article-title":"Characteristic patterns of EEG oscillations in sheep (Ovis aries) induced by ketamine may explain the psychotropic effects seen in humans","volume":"10","author":"Nicol","year":"2020","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.neuropharm.2026.111012_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021814","article-title":"Ketamine-Induced oscillations in the motor circuit of the Rat basal ganglia","volume":"6","author":"Nicol\u00e1s","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib66","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00213-022-06272-9","article-title":"The effect of ketamine and D-cycloserine on the high frequency resting EEG spectrum in humans","volume":"240","author":"Nottage","year":"2023","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/j.neuropharm.2026.111012_bib67","doi-asserted-by":"crossref","DOI":"10.1152\/jn.2001.86.6.2823","article-title":"Disruption of GABAA receptors on GABAergic interneurons leads to increased oscillatory power in the olfactory bulb network","volume":"86","author":"Nusser","year":"2001","journal-title":"J. Neurophysiol."},{"issue":"Issue 12","key":"10.1016\/j.neuropharm.2026.111012_bib68","article-title":"Glutamate receptor dysfunction and schizophrenia","volume":"52","author":"Olney","year":"1995","journal-title":"Arch. Gen. Psychiatry"},{"issue":"12","key":"10.1016\/j.neuropharm.2026.111012_bib69","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.euroneuro.2013.01.012","article-title":"NMDA receptor antagonist-enhanced high frequency oscillations: are they generated broadly or regionally specific?","volume":"23","author":"Olszewski","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"3","key":"10.1016\/j.neuropharm.2026.111012_bib70","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1152\/jn.00090.2018","article-title":"Pharmacological manipulation of the olfactory bulb modulates beta oscillations: testing model predictions","volume":"120","author":"Osinski","year":"2018","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib71","doi-asserted-by":"crossref","DOI":"10.1002\/cne.903490107","article-title":"Histological and ultrastructural localization of the kainate receptor subunits, KA2 and GluR6\/7, in the rat nervous system using selective antipeptide antibodies","volume":"349","author":"Petralia","year":"1994","journal-title":"J. Comp. Neurol."},{"issue":"3","key":"10.1016\/j.neuropharm.2026.111012_bib72","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.neuropharm.2011.04.006","article-title":"Differential effects of NMDA antagonists on high frequency and gamma EEG oscillations in a neurodevelopmental model of schizophrenia","volume":"62","author":"Phillips","year":"2012","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/j.neuropharm.2026.111012_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-018-0341-9","article-title":"NMDA 2A receptors in parvalbumin cells mediate sex-specific rapid ketamine response on cortical activity","volume":"24","author":"Picard","year":"2019","journal-title":"Mol. Psychiatr."},{"issue":"8","key":"10.1016\/j.neuropharm.2026.111012_bib74","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.biopsych.2007.10.006","article-title":"N-Methyl d-Aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant \u03b3 oscillations in the Rat neocortex","volume":"63","author":"Pinault","year":"2008","journal-title":"Biol. Psychiatry"},{"issue":"6 June","key":"10.1016\/j.neuropharm.2026.111012_bib75","article-title":"Computational modeling of ketamine-induced changes in gamma-band oscillations: the contribution of parvalbumin and somatostatin interneurons","volume":"21","author":"Rademacher","year":"2025","journal-title":"PLoS Comput. Biol."},{"issue":"6","key":"10.1016\/j.neuropharm.2026.111012_bib76","doi-asserted-by":"crossref","DOI":"10.1152\/jn.1968.31.6.884","article-title":"Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb","volume":"31","author":"Rall","year":"1968","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib84","doi-asserted-by":"crossref","first-page":"6390","DOI":"10.1038\/s41598-021-85705-5","article-title":"Network and synaptic mechanisms underlying high frequency oscillations in the rat and cat olfactory bulb under ketamine-xylazine anesthesia","volume":"11","author":"\u015aredniawa","year":"2021","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.neuropharm.2026.111012_bib77","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/schbul\/sbv051","article-title":"Ketamine dysregulates the amplitude and connectivity of high-frequency oscillations in cortical\u2013subcortical networks in humans: evidence from resting-state magnetoencephalography-recordings","volume":"41","author":"Rivolta","year":"2015","journal-title":"Schizophr. Bull."},{"issue":"50","key":"10.1016\/j.neuropharm.2026.111012_bib78","doi-asserted-by":"crossref","first-page":"12996","DOI":"10.1523\/JNEUROSCI.3503-06.2006","article-title":"AMPA\/Kainate receptors drive rapid output and precise synchrony in Olfactory Bulb Granule cells","volume":"26","author":"Schoppa","year":"2006","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.neuropharm.2026.111012_bib79","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.euroneuro.2015.04.012","article-title":"Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex","volume":"25","author":"Shaw","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"Issue 4","key":"10.1016\/j.neuropharm.2026.111012_bib80","article-title":"Synaptic organization of the mammalian olfactory bulb","volume":"52","author":"Shepherd","year":"1972","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuropharm.2026.111012_bib81","doi-asserted-by":"crossref","DOI":"10.1111\/j.1749-6632.2009.03937.x","article-title":"Symposium overview and historical perspective: dendrodendritic synapses: past, present, and future","volume":"1170","author":"Shepherd","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.neuropharm.2026.111012_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000685","article-title":"Genuine cross-frequency coupling networks in human resting-state electrophysiological recordings","volume":"18","author":"Siebenh\u00fchner","year":"2020","journal-title":"PLoS Biol."},{"issue":"2","key":"10.1016\/j.neuropharm.2026.111012_bib83","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1152\/jn.00765.2016","article-title":"Ketamine induced converged synchronous gamma oscillations in the cortico-basal ganglia network of nonhuman primates","volume":"118","author":"Slovik","year":"2017","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuropharm.2026.111012_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.147996","article-title":"The effect of ketamine on delta-range coupling between prefrontal cortex and hippocampus supported by respiratory rhythmic input from the olfactory bulb","volume":"1791","author":"Staszelis","year":"2022","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-52727-2","article-title":"Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states","volume":"15","author":"Tao","year":"2024","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.neuropharm.2026.111012_bib87","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tins.2018.01.007","article-title":"Respiration-Entrained brain rhythms are global but often overlooked","volume":"41","author":"Tort","year":"2018","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.neuropharm.2026.111012_bib88","doi-asserted-by":"crossref","DOI":"10.1152\/jn.00106.2010","article-title":"Measuring phase-amplitude coupling between neuronal oscillations of different frequencies","volume":"104","author":"Tort","year":"2010","journal-title":"J. Neurophysiol."},{"issue":"51","key":"10.1016\/j.neuropharm.2026.111012_bib89","doi-asserted-by":"crossref","first-page":"20517","DOI":"10.1073\/pnas.0810524105","article-title":"Dynamic cross-frequency couplings of local field potential oscillations in rat striatum and hippocampus during performance of a T-maze task","volume":"105","author":"Tort","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.neuropharm.2026.111012_bib90","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/pr.109.002451","article-title":"Glutamate receptor ion channels: structure, regulation, and function","volume":"62","author":"Traynelis","year":"2010","journal-title":"Pharmacol. Rev."},{"issue":"3","key":"10.1016\/j.neuropharm.2026.111012_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2007.02.035","article-title":"Differential contribution of kainate receptors to excitatory postsynaptic currents in superficial layer neurons of the rat medial entorhinal cortex","volume":"146","author":"West","year":"2007","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib92","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-71749-w","article-title":"NMDA receptor antagonist high-frequency oscillations are transmitted via bottom-up feedforward processing","volume":"14","author":"Wr\u00f3bel","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib93","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75641-1","article-title":"Nasal respiration is necessary for ketamine-dependent high frequency network oscillations and behavioral hyperactivity in rats","volume":"10","author":"Wr\u00f3bel","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.neuropharm.2026.111012_bib94","doi-asserted-by":"crossref","DOI":"10.1152\/jn.00091.2005","article-title":"Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex","volume":"94","author":"Wu","year":"2005","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib95","article-title":"Synaptic kainate currents reset interneuron firing phase","volume":"578","author":"Yang","year":"2007","journal-title":"J. Physiol. (Paris)"},{"key":"10.1016\/j.neuropharm.2026.111012_bib96","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fncir.2018.00061","article-title":"Ten-Hour exposure to low-dose ketamine enhances corticostriatal cross-frequency coupling and hippocampal broad-band gamma oscillations","volume":"12","author":"Ye","year":"2018","journal-title":"Front. Neural Circ."},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111012_bib97","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1523\/JNEUROSCI.15-01-00030.1995","article-title":"Sharp wave-associated high-frequency oscillation (200 Hz) in the intact hippocampus: network and intracellular mechanisms","volume":"15","author":"Ylinen","year":"1995","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.neuropharm.2026.111012_bib98","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"issue":"17","key":"10.1016\/j.neuropharm.2026.111012_bib99","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1073\/pnas.1617249114","article-title":"Selective entrainment of gamma subbands by different slow network oscillations","volume":"114","author":"Zhong","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2026.111012_bib100","article-title":"Ionotropic glutamate receptors contribute to pain transmission and chronic pain","volume":"vol 112","author":"Zhuo","year":"2017"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390826001851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390826001851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:11:12Z","timestamp":1783113072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390826001851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":100,"alternative-id":["S0028390826001851"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2026.111012","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Olfactory bulb circuits drive ketamine-enhanced high-frequency oscillations via kainate and GABAergic mechanisms","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2026.111012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111012"}}