{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:25:35Z","timestamp":1793917535299,"version":"4.8.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:00:00Z","timestamp":1793836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K23263"],"award-info":[{"award-number":["JP24K23263"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H02632"],"award-info":[{"award-number":["JP21H02632"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H04922 (AdAMS)"],"award-info":[{"award-number":["JP22H04922 (AdAMS)"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020051","name":"Tamura Science and Technology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.neuropharm.2026.111148","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T23:15:24Z","timestamp":1786576524000},"page":"111148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hippocampal teneurin-4 knockdown promotes depression-like behavioral phenotypes by disrupting oligodendrocyte differentiation in mice"],"prefix":"10.1016","volume":"300","author":[{"given":"Yuichiro","family":"Sugimori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1231-0649","authenticated-orcid":false,"given":"Yusuke","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiryu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Kaigawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1953-9378","authenticated-orcid":false,"given":"Jun","family":"Yokose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-5357","authenticated-orcid":false,"given":"Yuki","family":"Shigetsura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3185-7790","authenticated-orcid":false,"given":"Shin-ichi","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6916-9160","authenticated-orcid":false,"given":"Atsumi","family":"Nitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2026.111148_bib1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00406-002-0381-6","article-title":"Gender differences in depression. epidemiological findings from the european DEPRES I and II studies","volume":"252","author":"Angst","year":"2002","journal-title":"Eur. Arch. Psychiatr. Clin. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111148_bib2","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.stem.2018.09.017","article-title":"Notch-induced miR-708 antagonizes satellite cell migration and maintains quiescence","volume":"23","author":"Baghdadi","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neuropharm.2026.111148_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/jnr.490380402","article-title":"Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis","volume":"38","author":"Bauer","year":"1994","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neuropharm.2026.111148_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMra073096","article-title":"Major depressive disorder","volume":"358","author":"Belmaker","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neuropharm.2026.111148_bib5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jns.2016.11.067","article-title":"Prevalence of depression and anxiety in Multiple Sclerosis: a systematic review and meta-analysis","volume":"372","author":"Boeschoten","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuropharm.2026.111148_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1176\/ajp.157.1.115","article-title":"Hippocampal volume reduction in major depression","volume":"157","author":"Bremner","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2026.111148_bib7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00401-012-1009-1","article-title":"Reduced astrocytic NF-\u03baB activation by laquinimod protects from cuprizone-induced demyelination","volume":"124","author":"Br\u00fcck","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuropharm.2026.111148_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2026.153309","article-title":"Teneurin-4 in the nucleus accumbens modulates affective-like behaviors with potential effects on astrocytes in male mice","volume":"801","author":"Chen","year":"2026","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuropharm.2026.111148_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110817","article-title":"Teneurin-4 knockdown disrupts dopamine dynamics and attenuates methamphetamine-induced behaviors","volume":"286","author":"Chen","year":"2026","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2026.111148_bib10","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1007\/s11064-022-03649-2","article-title":"Shati\/Nat8l overexpression improves cognitive decline by upregulating neuronal trophic factor in alzheimer's disease model mice","volume":"47","author":"Chino","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuropharm.2026.111148_bib11","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1176\/appi.ajp.20220459","article-title":"Zuranolone for the treatment of adults with major depressive disorder: a randomized, placebo\u2010controlled phase 3 trial","volume":"180","author":"Clayton","year":"2023","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2026.111148_bib12","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.devcel.2013.05.013","article-title":"Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo","volume":"25","author":"Czopka","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuropharm.2026.111148_bib13","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S1044-7431(03)00210-0","article-title":"NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS","volume":"24","author":"Dawson","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.neuropharm.2026.111148_bib14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.neuroscience.2006.02.072","article-title":"Chronic restraint stress induces changes in synapse morphology in stratum lacunosum-moleculare CA1 rat hippocampus: a stereological and three-dimensional ultrastructural study","volume":"140","author":"Donohue","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2026.111148_bib15","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.neuroscience.2004.04.044","article-title":"Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats","volume":"126","author":"Drossopoulou","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuropharm.2026.111148_bib16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pnpbp.2003.11.018","article-title":"Central monoamines and their role in major depression","volume":"28","author":"Elhwuegi","year":"2004","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2026.111148_bib17","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1126\/science.1190927","article-title":"Regulation of oligodendrocyte differentiation and myelination","volume":"330","author":"Emery","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2026.111148_bib18","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1101\/gad.1806309","article-title":"Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS","volume":"23","author":"Fancy","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.neuropharm.2026.111148_bib19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/glia.24284","article-title":"A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning","volume":"71","author":"Fang","year":"2023","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.neuropharm.2026.111148_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.neuropharm.2026.111148_bib21","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"2008"},{"key":"10.1016\/j.neuropharm.2026.111148_bib22","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1176\/appi.ajp.159.7.1112","article-title":"Hippocampal changes in patients with a first episode of major depression","volume":"159","author":"Frodl","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuropharm.2026.111148_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.nbd.2012.03.012","article-title":"How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans","volume":"52","author":"Frodl","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2026.111148_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbr.2011.02.003","article-title":"The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF","volume":"220","author":"Furukawa-Hibi","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2026.111148_bib25","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/S0140-6736(17)32346-2","article-title":"Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial","volume":"390","author":"Green","year":"2017","journal-title":"Lancet"},{"issue":"5369","key":"10.1016\/j.neuropharm.2026.111148_bib26","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1126\/science.280.5369.1610","article-title":"Axonal swellings and degeneration in mice lacking the major proteolipid of myelin","volume":"280","author":"Griffiths","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuropharm.2026.111148_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbr.2007.03.018","article-title":"Extracellular levels of serotonin and GABA in the hippocampus after chronic mild stress in rats. A microdialysis study in an animal model of depression","volume":"181","author":"Gr\u00f8nli","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2026.111148_bib28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pnpbp.2012.03.012","article-title":"Altered white matter integrity of forebrain in treatment-resistant depression: a diffusion tensor imaging study with tract-based spatial statistics","volume":"38","author":"Guo","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.neuropharm.2026.111148_bib29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3390\/bioengineering13010078","article-title":"Macromolecular proton fraction reveals divergent white matter myelination in bipolar disorder and unipolar recurrent depression","volume":"13","author":"Gusakova","year":"2026","journal-title":"Bioengineering (Basel)."},{"key":"10.1016\/j.neuropharm.2026.111148_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-65485-0","article-title":"Development of type I\/II oligodendrocytes regulated by teneurin-4 in the murine spinal cord","volume":"10","author":"Hayashi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2026.111148_bib31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jpsychires.2022.09.025","article-title":"Stress-induced myelin damage in the hippocampal formation in a rat model of depression","volume":"155","author":"Huang","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neuropharm.2026.111148_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111481","article-title":"The preferential effect of clemastine on F3\/Contactin-1\/Notch-1 compared to Jagged-1\/Notch-1 justifies its remyelinating effect in an experimental model of multiple sclerosis in rats","volume":"128","author":"Ibrahim","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.neuropharm.2026.111148_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/974819","article-title":"Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice","volume":"2013","author":"Iida","year":"2013","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.neuropharm.2026.111148_bib34","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/mp.2016.259","article-title":"A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder","volume":"23","author":"Ikeda","year":"2018","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2026.111148_bib35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.schres.2014.07.004","article-title":"Replication of previous genome-wide association studies of psychiatric diseases in a large schizophrenia case-control sample from Spain","volume":"159","author":"Ivorra","year":"2014","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.neuropharm.2026.111148_bib36","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/jamapsychiatry.2025.1317","article-title":"Esketamine monotherapy in adults with treatment-resistant depression: a randomized clinical trial","volume":"82","author":"Janik","year":"2025","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neuropharm.2026.111148_bib37","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1017\/S104161020999007X","article-title":"Morphometric changes in early- and late-life major depressive disorder: evidence from postmortem studies","volume":"21","author":"Khundakar","year":"2009","journal-title":"Int. Psychogeriatr."},{"issue":"6","key":"10.1016\/j.neuropharm.2026.111148_bib38","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1038\/s41380-022-01512-y","article-title":"Chronic stress disrupts the homeostasis and progeny progression of oligodendroglial lineage cells, associating immune oligodendrocytes with prefrontal cortex hypomyelination","volume":"27","author":"Kokkosis","year":"2022","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2026.111148_bib39","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1002\/hbm.20801","article-title":"Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studies","volume":"30","author":"Koolschijn","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuropharm.2026.111148_bib40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neulet.2008.11.058","article-title":"Demyelination of the hippocampus is prominent in the cuprizone model","volume":"451","author":"Koutsoudaki","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2026.111148_bib41","first-page":"24","article-title":"Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment","volume":"2","author":"Krugers","year":"2010","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111148_bib42","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.neuron.2010.05.004","article-title":"Retinoid x receptor gamma control of affective behaviors involves dopaminergic signaling in mice","volume":"66","author":"Krzyzosiak","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuropharm.2026.111148_bib43","first-page":"7","article-title":"Treatment-resistant depression: approaches to treatment","volume":"59","author":"Kverno","year":"2021","journal-title":"J. Psychosoc. Nurs. Ment. Health Serv."},{"key":"10.1016\/j.neuropharm.2026.111148_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.00580","article-title":"Teneurins: mediators of complex neural circuit assembly in mammals","volume":"13","author":"Leamey","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111148_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0166-2236(00)01691-X","article-title":"The oligodendrocyte precursor cell in health and disease","volume":"24","author":"Levine","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111148_bib46","doi-asserted-by":"crossref","DOI":"10.1172\/JCI161559","article-title":"The Eph receptor A4 plays a role in demyelination and depression-related behavior","volume":"132","author":"Li","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.neuropharm.2026.111148_bib47","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1523\/JNEUROSCI.3608-15.2016","article-title":"Clemastine enhances myelination in the prefrontal cortex and rescues behavioral changes in socially isolated mice","volume":"36","author":"Liu","year":"2016","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.neuropharm.2026.111148_bib48","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/glia.24661","article-title":"Oligodendroglia are primed for antigen presentation in response to chronic stress-induced microglial-derived inflammation","volume":"73","author":"Madeira","year":"2025","journal-title":"Glia"},{"key":"10.1016\/j.neuropharm.2026.111148_bib49","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/JCP.0000000000001967","article-title":"Navacaprant, a novel and highly selective kappa opioid receptor antagonist, in adults with major depressive disorder: a randomized, double-blind phase 2 clinical Trial","volume":"45","author":"Mathew","year":"2025","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2026.111148_bib50","doi-asserted-by":"crossref","first-page":"8454","DOI":"10.1523\/JNEUROSCI.2453-12.2013","article-title":"Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes","volume":"33","author":"Mei","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111148_bib51","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jneumeth.2011.12.017","article-title":"Estimation of the total number of hippocampal CA1 pyramidal neurons: new methodology applied to helpless rats","volume":"205","author":"Miettinen","year":"2012","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neuropharm.2026.111148_bib52","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/ijnp\/pyx078","article-title":"Striatal n-acetylaspartate synthetase Shati\/Nat8l regulates depression-like behaviors via mGluR3-mediated serotonergic suppression in mice","volume":"20","author":"Miyamoto","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2026.111148_bib53","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/s41386-021-01033-2","article-title":"Striatal Shati\/Nat8l\u2013BDNF pathways determine the sensitivity to social defeat stress in mice through epigenetic regulation","volume":"46","author":"Miyanishi","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuropharm.2026.111148_bib54","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1038\/s41598-017-04625-5","article-title":"CRISPR\/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice","volume":"7","author":"Ohmori","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2026.111148_bib55","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/s41593-024-01642-2","article-title":"Dynamics of mature myelin","volume":"27","author":"Osso","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111148_bib56","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41593-019-0582-1","article-title":"Preservation of a remote fear memory requires new myelin formation","volume":"23","author":"Pan","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111148_bib57","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2026.111148_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2021.102781","article-title":"Amygdala substructure volumes in Major Depressive Disorder","volume":"31","author":"Roddy","year":"2021","journal-title":"Neuroimage, Clin."},{"key":"10.1016\/j.neuropharm.2026.111148_bib59","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuropharm.2026.111148_bib60","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1073\/pnas.93.9.3908","article-title":"Hippocampal atrophy in recurrent major depression","volume":"93","author":"Sheline","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuropharm.2026.111148_bib61","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ng.943","article-title":"Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4","volume":"43","author":"Sklar","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuropharm.2026.111148_bib62","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/515180a","article-title":"Mental health: a world of depression","volume":"515","author":"Smith","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuropharm.2026.111148_bib63","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/WNR.0000000000000416","article-title":"Induction of neuronal axon outgrowth by Shati\/Nat8l by energy metabolism in mice cultured neurons","volume":"26","author":"Sumi","year":"2015","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuropharm.2026.111148_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17151-1","article-title":"Behavioral impairment in SHATI\/NAT8L knockout mice via dysfunction of myelination development","volume":"7","author":"Sumi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2026.111148_bib65","doi-asserted-by":"crossref","first-page":"11586","DOI":"10.1523\/JNEUROSCI.2045-11.2012","article-title":"Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS","volume":"32","author":"Suzuki","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111148_bib66","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1096\/fj.13-241034","article-title":"Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling","volume":"28","author":"Suzuki","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.neuropharm.2026.111148_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040124","article-title":"TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis","volume":"4","author":"Takahashi","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.neuropharm.2026.111148_bib68","article-title":"A role of GABAA receptor \u03b11 subunit in the hippocampus for rapid-acting antidepressant-like effects of ketamine","volume":"225","author":"Tang","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2026.111148_bib69","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3389\/fnins.2018.00938","article-title":"Teneurins: domain architecture, evolutionary origins, and patterns of expression","volume":"12","author":"Tucker","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111148_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810816","article-title":"Investigation of Anxiety- and depressive-like symptoms in 4- and 8-Month-Old Male triple transgenic mouse models of alzheimer's disease","volume":"23","author":"V\u00e1rkonyi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuropharm.2026.111148_bib71","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pnpbp.2017.04.008","article-title":"The recent progress in animal models of depression","volume":"77","author":"Wang","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuropharm.2026.111148_bib72","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0896-6273(00)80515-2","article-title":"Notch receptor activation inhibits oligodendrocyte differentiation","volume":"21","author":"Wang","year":"1998","journal-title":"Neuron"},{"issue":"16","key":"10.1016\/j.neuropharm.2026.111148_bib73","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2412995122","article-title":"Peripheral CD4+ T cells mediate the destructive effects of maternal separation on prefrontal myelination and cognitive functions","volume":"122","author":"Xiong","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2026.111148_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2018.00725","article-title":"Exome sequencing identifies TENM4 as a novel candidate gene for schizophrenia in the SCZD2 locus at 11q14-21","volume":"9","author":"Xue","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.neuropharm.2026.111148_bib75","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1038\/s41467-022-29751-1","article-title":"Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390826003230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390826003230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:51:42Z","timestamp":1793915502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390826003230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":75,"alternative-id":["S0028390826003230"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2026.111148","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hippocampal teneurin-4 knockdown promotes depression-like behavioral phenotypes by disrupting oligodendrocyte differentiation in mice","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2026.111148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111148"}}