{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:38:59Z","timestamp":1792791539983,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304464"],"award-info":[{"award-number":["82304464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["LCYSSQ20220823091405012"],"award-info":[{"award-number":["LCYSSQ20220823091405012"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M773565"],"award-info":[{"award-number":["2025M773565"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.neuropharm.2026.111177","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:49:10Z","timestamp":1788364150000},"page":"111177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["\u03b17 nicotinic acetylcholine receptor activation promotes anxiety- and depressive-like behaviors associated with CREB\/CRH signaling in the hypothalamic paraventricular nucleus"],"prefix":"10.1016","volume":"301","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-317X","authenticated-orcid":false,"given":"Canmao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongtian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yindan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waijiao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuropharm.2026.111177_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbr.2019.03.019","article-title":"Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice","volume":"366","author":"Alzarea","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2026.111177_bib3","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1177\/0269881110364271","article-title":"Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test","volume":"25","author":"Andreasen","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1177\/0269881108091587","article-title":"Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in the mouse forced swim and mouse tail suspension tests","volume":"23","author":"Andreasen","year":"2009","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib4","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.pbb.2011.11.004","article-title":"Combined alpha7 nicotinic acetylcholine receptor agonism and partial serotonin transporter inhibition produce antidepressant-like effects in the mouse forced swim and tail suspension tests: a comparison of SSR180711 and PNU-282987","volume":"100","author":"Andreasen","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuropharm.2026.111177_bib5","doi-asserted-by":"crossref","first-page":"11435","DOI":"10.1073\/pnas.172091899","article-title":"CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli","volume":"99","author":"Barrot","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuropharm.2026.111177_bib6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tins.2010.02.001","article-title":"CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models","volume":"33","author":"Benito","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111177_bib7","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1111\/ejn.13966","article-title":"Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamus","volume":"48","author":"Calarco","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111177_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135118","article-title":"PNU282987 alleviates A\u03b2-induced anxiety and depressive-like behaviors through upregulation of \u03b17nAChR by ERK-serotonin receptors pathway","volume":"731","author":"Chang","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuropharm.2026.111177_bib10","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1038\/s41380-025-03293-6","volume":"31","author":"Chen","year":"2026","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2026.111177_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0169-328X(01)00265-0","article-title":"Rapid phosphorylation of the CRE binding protein precedes stress-induced activation of the corticotropin releasing hormone gene in medial parvocellular hypothalamic neurons of the immature rat. Brain research","volume":"96","author":"Chen","year":"2001","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.neuropharm.2026.111177_bib11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bcp.2015.07.015","article-title":"The effect of \u03b17 nicotinic receptor activation on glutamatergic transmission in the hippocampus","volume":"97","author":"Cheng","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/10253890.2013.806907","article-title":"Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus","volume":"17","author":"Cope","year":"2014","journal-title":"Stress"},{"key":"10.1016\/j.neuropharm.2026.111177_bib13","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1037\/a0034733","article-title":"Comorbidity of anxiety and depression in children and adolescents: 20 years after","volume":"140","author":"Cummings","year":"2014","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.neuropharm.2026.111177_bib14","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41593-020-0591-0","article-title":"Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection","volume":"23","author":"Daviu","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111177_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.731831","article-title":"Naringin mediates adult hippocampal neurogenesis for antidepression via activating CREB signaling","volume":"10","author":"Gao","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3389\/fphar.2019.01245","article-title":"Cerebrolysin ameliorates focal cerebral ischemia injury through neuroinflammatory inhibition via CREB\/PGC-1\u03b1 Pathway","volume":"10","author":"Guan","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1749-6632.2009.05011.x","article-title":"Role of CRF receptor signaling in stress vulnerability, anxiety, and depression","volume":"1179","author":"Hauger","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuropharm.2026.111177_bib18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fendo.2016.00137","article-title":"Paraventricular hypothalamic mechanisms of chronic stress adaptation","volume":"7","author":"Herman","year":"2016","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib19","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1007\/s00018-016-2175-4","article-title":"Modulatory effects of \u03b17 nAChRs on the immune system and its relevance for CNS disorders","volume":"73","author":"Kalkman","year":"2016","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"key":"10.1016\/j.neuropharm.2026.111177_bib20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jad.2016.08.006","article-title":"Investigating the nature of co-occurring depression and anxiety: comparing diagnostic and dimensional research approaches","volume":"216","author":"Kircanski","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neuropharm.2026.111177_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/B978-0-444-64123-6.00004-7","article-title":"Hypothalamic-pituitary-adrenal axis and stress","volume":"175","author":"Leistner","year":"2020","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib22","article-title":"Systemic inhibition of CREB is well-tolerated in vivo","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuropharm.2026.111177_bib24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12974-023-02768-z","article-title":"\u03b17 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect","volume":"20","author":"Liu","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuropharm.2026.111177_bib23","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/s41596-018-0011-z","article-title":"Sucrose preference test for measurement of stress-induced anhedonia in mice","volume":"13","author":"Liu","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuropharm.2026.111177_bib25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods (San Diego, Calif.)"},{"key":"10.1016\/j.neuropharm.2026.111177_bib26","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.neuropharm.2026.111177_bib27","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1038\/s41380-022-01618-3","article-title":"Association between vascular endothelial growth factor-mediated blood-brain barrier dysfunction and stress-induced depression","volume":"27","author":"Matsuno","year":"2022","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2026.111177_bib28","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/npp.2015.316","article-title":"Multiple nicotinic acetylcholine receptor subtypes in the mouse Amygdala regulate affective behaviors and response to social stress","volume":"41","author":"Mineur","year":"2016","journal-title":"Neuropsychopharmacology : Off. Publ. Am. College Neuropsychopharmacol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib29","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1111\/bph.13769","article-title":"Hippocampal \u03b17 nicotinic ACh receptors contribute to modulation of depression-like behaviour in C57BL\/6J mice","volume":"175","author":"Mineur","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41398-023-02710-0","article-title":"Optogenetic recruitment of hypothalamic corticotrophin-releasing-hormone (CRH) neurons reduces motivational drive","volume":"14","author":"Mitchell","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuropharm.2026.111177_bib31","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1007\/s12035-020-02077-z","article-title":"Nicotine rescues depressive-like behaviors via \u03b17-type nicotinic acetylcholine receptor activation in CaMKIV null mice","volume":"57","author":"Moriguchi","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.109836","article-title":"BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents","volume":"246","author":"O'Connor","year":"2024","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2026.111177_bib33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuropharm.2013.01.004","article-title":"Activation of the \u03b17 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT1a receptor antagonist","volume":"70","author":"Pandya","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuropharm.2026.111177_bib34","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1124\/jpet.108.150151","article-title":"Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine","volume":"329","author":"Papke","year":"2009","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuropharm.2026.111177_bib35","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA axis in major depression: classical theories and new developments","volume":"31","author":"Pariante","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111177_bib36","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0140-6736(21)00359-7","article-title":"Anxiety disorders","volume":"397","author":"Penninx","year":"2021","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.neuropharm.2026.111177_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/neu.10109","article-title":"Desensitization of neuronal nicotinic receptors","volume":"53","author":"Quick","year":"2002","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib39","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00213-006-0568-z","article-title":"The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice","volume":"189","author":"Rabenstein","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2026.111177_bib40","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0149-7634(96)00058-9","article-title":"Anxiety, defence and the elevated plus-maze","volume":"21","author":"Rodgers","year":"1997","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuropharm.2026.111177_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2023.101117","article-title":"The role of stress in perinatal depression and anxiety - a systematic review","volume":"72","author":"Schalla","year":"2024","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neuropharm.2026.111177_bib42","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1523\/JNEUROSCI.13-02-00596.1993","article-title":"Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium","volume":"13","author":"S\u00e9gu\u00e9la","year":"1993","journal-title":"J. Neurosci. : Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111177_bib43","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.1646483","article-title":"CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases","volume":"252","author":"Sheng","year":"1991","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.neuropharm.2026.111177_bib44","doi-asserted-by":"crossref","first-page":"383","DOI":"10.31887\/DCNS.2006.8.4\/ssmith","article-title":"The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress","volume":"8","author":"Smith","year":"2006","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.neuropharm.2026.111177_bib45","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuropharm.2026.111177_bib46","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.bbr.2010.08.015","article-title":"Behavioral effects of PNU-282987, an alpha7 nicotinic receptor agonist, in mice","volume":"216","author":"Vicens","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuropharm.2026.111177_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.107122","article-title":"\u03b17 nicotinic acetylcholine receptor and depression: mechanistic insights and therapeutic prospects","volume":"216","author":"Wang","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuropharm.2026.111177_bib47","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1038\/s41380-022-01881-4","article-title":"Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis","volume":"29","author":"Wang","year":"2024","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuropharm.2026.111177_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.113236","article-title":"Exogenous IGF-1 alleviates depression-like behavior and hippocampal mitochondrial dysfunction in high-fat diet mice","volume":"229","author":"Yang","year":"2021","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuropharm.2026.111177_bib50","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12974-017-1007-2","article-title":"Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress","volume":"14","author":"Zhao","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuropharm.2026.111177_bib51","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyad064","article-title":"MiR-182-5p: a novel biomarker in the treatment of depression in CSDS-induced mice","volume":"27","author":"Zheng","year":"2024","journal-title":"Int. J. Neuropsychopharmacol."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390826003527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390826003527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:53:19Z","timestamp":1792788799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390826003527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":51,"alternative-id":["S0028390826003527"],"URL":"https:\/\/doi.org\/10.1016\/j.neuropharm.2026.111177","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b17 nicotinic acetylcholine receptor activation promotes anxiety- and depressive-like behaviors associated with CREB\/CRH signaling in the hypothalamic paraventricular nucleus","name":"articletitle","label":"Article Title"},{"value":"Neuropharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuropharm.2026.111177","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111177"}}