{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:36:27Z","timestamp":1790498187310,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2003,1]]},"DOI":"10.1016\/j.neuroscience.2003.08.030","type":"journal-article","created":{"date-parts":[[2003,11,6]],"date-time":"2003-11-06T14:24:37Z","timestamp":1068128677000},"page":"707-715","source":"Crossref","is-referenced-by-count":32,"title":["Role and regulation of p53 in depolarization-induced neuronal death"],"prefix":"10.1016","volume":"122","author":[{"given":"J","family":"Jord\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F","family":"Galindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Ce\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2003.08.030_BIB1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1471-4159.1982.tb04711.x","article-title":"Sodium uptake and catecholamine secretion by primary cultures of adrenal medulla cells","volume":"39","author":"Amy","year":"1982","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0304-3940(02)00291-4","article-title":"Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu, Zn-superoxide dismutase transgenic mice","volume":"325","author":"Asanuma","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1113\/jphysiol.1992.sp019126","article-title":"Calcium requirements for secretion in bovine chromaffin cells","volume":"450","author":"Augustine","year":"1992","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB4","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1126\/science.282.5387.290","article-title":"Cell surface trafficking of Fas","volume":"282","author":"Bennett","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0968-0004(00)01745-X","article-title":"A mitochondrial perspective on cell death","volume":"26","author":"Bernardi","year":"2001","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB6","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1523\/JNEUROSCI.16-04-01324.1996","article-title":"Superoxide production in rat hippocampal neurons","volume":"16","author":"Bindokas","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/BF00502621","article-title":"Tetrodotoxin-sensitive and -resistant effects of veratridine on the noradrenergic neurone of the rat vas deferens","volume":"324","author":"B\u00f6nisch","year":"1983","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/370220a0","article-title":"p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes","volume":"370","author":"Caelles","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB9","first-page":"533","article-title":"Pharmacological properties of sodium channels in cultured rat heart cells","volume":"20","author":"Catterall","year":"1981","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB10","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/0306-4522(83)90126-4","article-title":"Pharmacological dissection of receptor-associated and voltage-sensitive ionic channels involved in catecholamine release","volume":"4","author":"Ce\u00f1a","year":"1983","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB11","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/0006-291X(92)91859-O","article-title":"p53 Expression in brain after middle cerebral artery occlusion in the rat","volume":"182","author":"Chopp","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB12","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1179\/016164102101199828","article-title":"Enhanced expression of p53 in reactive astrocytes following transient focal ischemia","volume":"24","author":"Chung","year":"2002","journal-title":"Neurol Res"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB13","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/jcbfm.1994.119","article-title":"Attenuation of p53 expression protects against focal ischemic damage in transgenic mice","volume":"14","author":"Crumrine","year":"1994","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0304-3940(94)90219-4","article-title":"Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins","volume":"182","author":"Davies","year":"1994","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB15","doi-asserted-by":"crossref","first-page":"28378","DOI":"10.1074\/jbc.273.43.28378","article-title":"Oncogene-dependent regulation of caspase activation by p53 protein in a cell-free system","volume":"273","author":"Ding","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1113\/jphysiol.1992.sp019115","article-title":"Relative mitochondrial membrane potential and [Ca2+]i in type I cells isolated from the rabbit carotid body","volume":"450","author":"Duchen","year":"1992","journal-title":"J Physiol Lond"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB17","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1128\/MCB.16.9.5178","article-title":"p53 Plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells","volume":"16","author":"Eizenberg","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB18","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/j.1460-9568.1996.tb01325.x","article-title":"Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons","volume":"8","author":"Enokido","year":"1996","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB19","doi-asserted-by":"crossref","unstructured":"Galindo MF, Jordan J, Gonz\u00e1lez-Garc\u00eda C, Ce\u00f1a V (2003) Reactive oxygen species induce swelling and cytochrome c release but not transmembrane depolarization in isolated rat brain mitochondria. Br J Pharmacol 139:797\u2013804","DOI":"10.1038\/sj.bjp.0705309"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/scbi.1998.0098","article-title":"p53 And apoptosis","volume":"8","author":"Gottlieb","year":"1998","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB21","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0896-6273(95)90287-2","article-title":"Superoxide dismutase delays neuronal apoptosis","volume":"14","author":"Greenlund","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB23","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0896-6273(00)80191-9","article-title":"Programmed cell death in the developing nervous system","volume":"17","author":"Henderson","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1085\/jgp.92.2.145","article-title":"Muscarinic activation of ionic currents measured by a new whole-cell recording method","volume":"92","author":"Horn","year":"1988","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB25","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1046\/j.1471-4159.1997.68041612.x","article-title":"Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture","volume":"68","author":"Jordan","year":"1997","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1523\/JNEUROSCI.17-04-01397.1997","article-title":"p53 Expression induces apoptosis in hippocampal pyramidal neuron cultures","volume":"17","author":"Jordan","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB27","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/sj.bjp.0704953","article-title":"Superoxide anions mediate veratridine-induced cytochrome c release and caspase activity in bovine chromaffin cells","volume":"137","author":"Jordan","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB28","first-page":"1095","article-title":"Expression of human copper\/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor","volume":"47","author":"Jordan","year":"1995","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB29","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0968-0004(92)90012-X","article-title":"Control of transcription factors by signal transduction pathways","volume":"17","author":"Karin","year":"1992","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB30","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1096\/fasebj.9.13.7557017","article-title":"The biochemistry of programmed cell death","volume":"9","author":"Kroemer","year":"1995","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB31","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/74994","article-title":"Mitochondrial control of cell death","volume":"6","author":"Kroemer","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB32","doi-asserted-by":"crossref","first-page":"32000","DOI":"10.1074\/jbc.M100138200","article-title":"Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes","volume":"276","author":"Lakkaraju","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB33","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/01.STR.25.4.849","article-title":"p53-Immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats","volume":"25","author":"Li","year":"1994","journal-title":"Stroke"},{"issue":"Suppl","key":"10.1016\/j.neuroscience.2003.08.030_BIB34","first-page":"S67","article-title":"Antioxidant intervention studies related to DNA damage, DNA repair and gene expression","volume":"33","author":"Lof","year":"2000","journal-title":"Free Radic Res"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB35","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1091\/mbc.11.8.2543","article-title":"The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis","volume":"11","author":"McKay","year":"2000","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB36","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.cdd.4400736","article-title":"Neuronal life and death","volume":"7","author":"Miller","year":"2000","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1021687810103","article-title":"p53-Dependent cell death signaling in neurons","volume":"28","author":"Morrison","year":"2003","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB38","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1523\/JNEUROSCI.16-04-01337.1996","article-title":"Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death","volume":"16","author":"Morrison","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB39","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1080\/1071576021000016409","article-title":"Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells","volume":"36","author":"Niwa","year":"2002","journal-title":"Free Radic Res"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB40","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0166-2236(96)01035-1","article-title":"NF-kappaB","volume":"20","author":"O'Neill","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB41","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/0024-3205(91)90220-6","article-title":"Calcium and sodium channels involved in neuronal cell death","volume":"48","author":"Pauwels","year":"1991","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB42","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0952-7915(98)80222-7","article-title":"Mechanisms of CD95 (APO-1\/Fas)-mediated apoptosis","volume":"10","author":"Peter","year":"1998","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB43","first-page":"319","article-title":"Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons","volume":"49","author":"Prehn","year":"1996","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB44","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1046\/j.1471-4159.1997.68041679.x","article-title":"Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis","volume":"68","author":"Prehn","year":"1997","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB45","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1523\/JNEUROSCI.15-05-03318.1995","article-title":"Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation","volume":"15","author":"Reynolds","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB46","doi-asserted-by":"crossref","first-page":"7525","DOI":"10.1073\/pnas.91.16.7525","article-title":"p53 Induction is associated with neuronal damage in the central nervous system","volume":"91","author":"Sakhi","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB47","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1523\/JNEUROSCI.16-19-06125.1996","article-title":"Mitochondrial dysfunction is a primary event in glutamate neurotoxicity","volume":"16","author":"Schinder","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB48","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1523\/JNEUROSCI.05-10-02685.1985","article-title":"Evidence for a presynaptic adenylate cyclase system facilitating (3H)norepinephrine releases from rat brain neocortex slices and synaptosomes","volume":"5","author":"Schoffelmeer","year":"1985","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB49","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1006\/exnr.1994.1216","article-title":"Tumor suppressor p53 induction and DNA damage in hippocampal granule cells after adrenalectomy","volume":"130","author":"Schreiber","year":"1994","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB50","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0092-8674(02)00818-8","article-title":"p53","volume":"110","author":"Sharpless","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB51","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0092-8674(94)90201-1","article-title":"DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2","volume":"79","author":"Strasser","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB52","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1046\/j.1460-9568.1998.00042.x","article-title":"Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids","volume":"10","author":"Uberti","year":"1998","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB53","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1523\/JNEUROSCI.15-08-05851.1995","article-title":"The role of free radicals and p53 in neuron apoptosis in vivo","volume":"15","author":"Wood","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB54","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1523\/JNEUROSCI.18-04-01363.1998","article-title":"Bax involvement in p53-mediated neuronal cell death","volume":"18","author":"Xiang","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB55","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/35010529","article-title":"Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents","volume":"2","author":"Xu","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.neuroscience.2003.08.030_BIB56","doi-asserted-by":"crossref","first-page":"15220","DOI":"10.1074\/jbc.272.24.15220","article-title":"Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation","volume":"272","author":"Yan","year":"1997","journal-title":"J Biol Chem"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645220300664X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645220300664X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T16:17:19Z","timestamp":1585239439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645220300664X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["S030645220300664X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2003.08.030","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}