{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:35:51Z","timestamp":1791048951143,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.neuroscience.2004.07.027","type":"journal-article","created":{"date-parts":[[2004,9,17]],"date-time":"2004-09-17T15:08:02Z","timestamp":1095433682000},"page":"831-841","source":"Crossref","is-referenced-by-count":33,"title":["R-type voltage-gated ca2+ channel interacts with synaptic proteins and recruits synaptotagmin to the plasma membrane of xenopus oocytes"],"prefix":"10.1016","volume":"128","author":[{"given":"R.","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Atlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2004.07.027_bib1","doi-asserted-by":"crossref","first-page":"8323","DOI":"10.1523\/JNEUROSCI.20-22-08323.2000","article-title":"R-type Ca2+ channels are coupled to the rapid component of secretion in mouse adrenal slice chromaffin cells","volume":"20","author":"Albillos","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib49","doi-asserted-by":"crossref","first-page":"29231","DOI":"10.1074\/jbc.M301401200","article-title":"Syntaxin 1A modulates the voltage-gated l-type calcium channel (Cav1.2) in a cooperative manner","volume":"278","author":"Arien","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib2","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1046\/j.1471-4159.2001.00347.x","article-title":"Functional and physical coupling of voltage-sensitive calcium channels with exocytotic proteins: ramifications for the secretion mechanism","volume":"77","author":"Atlas","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib3","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1023\/A:1015104105262","article-title":"The voltage-gated Ca2+ channel is the Ca2+ sensor of fast neurotransmitter release","volume":"21","author":"Atlas","year":"2001","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib4","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1016\/S0006-3495(01)75964-4","article-title":"Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells","volume":"81","author":"Barg","year":"2001","journal-title":"Biophys J"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib5","doi-asserted-by":"crossref","first-page":"13943","DOI":"10.1073\/pnas.220389697","article-title":"Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating","volume":"97","author":"Bezprozvanny","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib6","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1523\/JNEUROSCI.16-16-04983.1996","article-title":"The alpha 1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels","volume":"16","author":"Bourinet","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0143-4160(98)90055-0","article-title":"Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release","volume":"24","author":"Catterall","year":"1998","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib8","doi-asserted-by":"crossref","first-page":"9258","DOI":"10.1074\/jbc.M210270200","article-title":"The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Cav1.2 (Lc-type) and Cav2.3 (R-type)","volume":"278","author":"Cohen","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib9","doi-asserted-by":"crossref","unstructured":"Fasshauer D, Margittai M (2003) A transient interaction of SNAP-25 and syntaxin nucleates SNARE assembly. J Biol Chem.","DOI":"10.1074\/jbc.M312064200"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib10","doi-asserted-by":"crossref","first-page":"28036","DOI":"10.1074\/jbc.272.44.28036","article-title":"Structural changes are associated with soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor complex formation","volume":"272","author":"Fasshauer","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib11","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0079-6107(01)00017-7","article-title":"The function of Ca(2+) channel subtypes in exocytotic secretion: new perspectives from synaptic and non-synaptic release","volume":"77","author":"Fisher","year":"2001","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib12","doi-asserted-by":"crossref","first-page":"8715","DOI":"10.1523\/JNEUROSCI.21-22-08715.2001","article-title":"Presynaptic R-type calcium channels contribute to fast excitatory synaptic transmission in the rat hippocampus","volume":"21","author":"Gasparini","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1083\/jcb.57.2.315","article-title":"Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction","volume":"57","author":"Heuser","year":"1973","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0896-6273(02)00667-0","article-title":"RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels","volume":"34","author":"Hibino","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib15","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.2337\/diabetes.51.5.1425","article-title":"Modulation of L-type Ca(2+) channels by distinct domains within SNAP-25","volume":"51","author":"Ji","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1085\/jgp.112.2.125","article-title":"Mechanism of auxiliary subunit modulation of neuronal alpha1E calcium channels","volume":"112","author":"Jones","year":"1998","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib17","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1523\/JNEUROSCI.23-11-04533.2003","article-title":"Spontaneous oscillation by hair bundles of the bullfrog's sacculus","volume":"23","author":"Martin","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib18","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1523\/JNEUROSCI.22-05-01648.2002","article-title":"Calcium secretion coupling at calyx of held governed by nonuniform channel-vesicle topography","volume":"22","author":"Meinrenken","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib19","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0896-6273(00)80254-8","article-title":"Ultrafast exocytosis elicited by calcium current in synaptic terminals of retinal bipolar neurons","volume":"17","author":"Mennerick","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib20","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nature01755","article-title":"Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis","volume":"424","author":"Missler","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib21","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0896-6273(00)80209-3","article-title":"Inhibition of neurotransmission by peptides containing the synaptic protein interaction site of N-type Ca2+ channels","volume":"17","author":"Mochida","year":"1996","journal-title":"Neuron"},{"issue":"Pt 3","key":"10.1016\/j.neuroscience.2004.07.027_bib22","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1113\/jphysiol.1996.sp021799","article-title":"Coupling between charge movement and pore opening in vertebrate neuronal alpha 1E calcium channels","volume":"497","author":"Olcese","year":"1996","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib23","doi-asserted-by":"crossref","first-page":"C1324","DOI":"10.1152\/ajpcell.1998.274.5.C1324","article-title":"Modulation of human neuronal alpha 1E-type calcium channel by alpha 2 delta-subunit","volume":"274","author":"Qin","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0896-6273(94)90216-X","article-title":"Participation of multiple calcium channel types in transmission at single climbing fiber to Purkinje cell synapses","volume":"12","author":"Regehr","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib25","doi-asserted-by":"crossref","first-page":"7662","DOI":"10.1523\/JNEUROSCI.18-19-07662.1998","article-title":"Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila","volume":"18","author":"Reist","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib26","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.1523\/JNEUROSCI.17-17-06647.1997","article-title":"Alteration of Ca2+ dependence of neurotransmitter release by disruption of Ca2+ channel\/syntaxin interaction","volume":"17","author":"Rettig","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib27","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1074\/jbc.C200692200","article-title":"Mechanism of calcium-independent synaptotagmin binding to target SNAREs","volume":"278","author":"Rickman","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib28","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1074\/jbc.M310879200","article-title":"High affinity interaction of syntaxin and SNAP-25 on the plasma membrane is abolished by botulinum toxin E","volume":"279","author":"Rickman","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib29","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1073\/pnas.94.3.997","article-title":"Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses","volume":"94","author":"Schiavo","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib30","first-page":"255","article-title":"Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit","volume":"2","author":"Schneider","year":"1994","journal-title":"Receptors Channels"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib31","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/0896-6273(94)90417-0","article-title":"Identification of a syntaxin-binding site on N-type calcium channels","volume":"13","author":"Sheng","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib32","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1152\/jn.00482.2002","article-title":"Functional interaction of auxiliary subunits and synaptic proteins with Ca(v)1.3 may impart hair cell Ca2+ current properties","volume":"89","author":"Song","year":"2003","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib33","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1749-6632.1993.tb22915.x","article-title":"Presynaptic calcium channels and the transmitter release mechanism","volume":"681","author":"Stanley","year":"1993","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib34","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0166-2236(97)01091-6","article-title":"The calcium channel and the organization of the presynaptic transmitter release face","volume":"20","author":"Stanley","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib35","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/366156a0","article-title":"Different types of calcium channels mediate central synaptic transmission","volume":"366","author":"Takahashi","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib36","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1073\/pnas.94.5.1703","article-title":"A Xenopus oocyte beta subunit: evidence for a role in the assembly\/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit","volume":"94","author":"Tareilus","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib37","first-page":"89","article-title":"N-type voltage-sensitive calcium channel interacts with syntaxin, synaptotagmin and SNAP-25 in a multiprotein complex","volume":"6","author":"Tobi","year":"1998","journal-title":"Receptors Channels"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib38","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0306-4522(01)00083-5","article-title":"The transmembrane domain of syntaxin 1A negatively regulates voltage-sensitive Ca(2+) channels","volume":"104","author":"Trus","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib39","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1046\/j.1432-1327.2001.01969.x","article-title":"Functional coupling between \u2018R-type\u2019 Ca2+ channels and insulin secretion in the insulinoma cell line INS-1","volume":"268","author":"Vajna","year":"2001","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib40","doi-asserted-by":"crossref","first-page":"9235","DOI":"10.1523\/JNEUROSCI.19-21-09235.1999","article-title":"An R-type Ca(2+) current in neurohypophysial terminals preferentially regulates oxytocin secretion","volume":"19","author":"Wang","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib41","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1002\/j.1460-2075.1996.tb00785.x","article-title":"Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels","volume":"15","author":"Wiser","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib42","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1073\/pnas.052017299","article-title":"Ionic dependence of Ca2+ channel modulation by syntaxin 1A","volume":"99","author":"Wiser","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0014-5793(97)00130-0","article-title":"Synaptotagmin restores kinetic properties of a syntaxin-associated N-type voltage sensitive calcium channel","volume":"404","author":"Wiser","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib44","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1073\/pnas.96.1.248","article-title":"The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery","volume":"96","author":"Wiser","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib45","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/0896-6273(94)90321-2","article-title":"Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus","volume":"12","author":"Wu","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib46","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1073\/pnas.95.8.4720","article-title":"R-type Ca2+ currents evoke transmitter release at a rat central synapse","volume":"95","author":"Wu","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib47","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1523\/JNEUROSCI.19-02-00726.1999","article-title":"Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses","volume":"19","author":"Wu","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2004.07.027_bib48","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0896-6273(02)00671-2","article-title":"Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis","volume":"34","author":"Zhang","year":"2002","journal-title":"Neuron"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452204005925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452204005925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T05:00:03Z","timestamp":1585890003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452204005925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0306452204005925"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2004.07.027","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}