{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:40:14Z","timestamp":1791250814741,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000368","name":"Brain Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2005]]},"DOI":"10.1016\/j.neuroscience.2004.09.069","type":"journal-article","created":{"date-parts":[[2004,12,29]],"date-time":"2004-12-29T00:13:36Z","timestamp":1104279216000},"page":"897-910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["The effect of peripheral nerve injury on disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis"],"prefix":"10.1016","volume":"130","author":[{"given":"P.S.","family":"Sharp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.T","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Greensmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2004.09.069_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/(SICI)1097-4598(199701)20:1<45::AID-MUS6>3.0.CO;2-H","article-title":"Progressive motor neuron impairment in an animal model of familial amyotrophic lateral sclerosis","volume":"20","author":"Azzouz","year":"1997","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib2","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1097\/00001756-199709080-00012","article-title":"Quantitative motor assessment in FALS mice","volume":"8","author":"Barneoud","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib3","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1111\/j.1471-4159.1993.tb07478.x","article-title":"Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis","volume":"61","author":"Bowling","year":"1993","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0896-6273(00)80272-X","article-title":"ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions","volume":"18","author":"Bruijn","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1113\/jphysiol.1960.sp006395","article-title":"Interactions between motoneurons and muscles in respect of the characteristic speeds of their responses","volume":"150","author":"Buller","year":"1960","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/mcne.1995.1027","article-title":"Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis","volume":"6","author":"Chiu","year":"1995","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib7","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35097565","article-title":"From Charcot to Lou Gehrig","volume":"2","author":"Cleveland","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib8","series-title":"Handbook of histopathological techniques","author":"Culling","year":"1963"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib9","first-page":"1271","article-title":"Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis","volume":"145","author":"Dal Canto","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib10","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1126\/science.8351519","article-title":"Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase","volume":"261","author":"Deng","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib11","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0969-9961(03)00041-X","article-title":"Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis","volume":"3","author":"Derave","year":"2003","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib12","doi-asserted-by":"crossref","first-page":"11159","DOI":"10.1073\/pnas.0402026101","article-title":"Evidence for defective energy homeostasis in amyotrophic lateral sclerosis","volume":"27","author":"Dupuis","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.bi.64.070195.000525","article-title":"Superoxide radical and superoxide dismutases","volume":"64","author":"Fridovich","year":"1995","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/14660820050515377","article-title":"Current status of SOD1 mutations in familial amyotrophic lateral sclerosis","volume":"1","author":"Gaudette","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib15","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib16","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1126\/science.1083129","article-title":"Mutations in dynein link motor neuron degeneration to defects in retrograde transport","volume":"300","author":"Hafezparast","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib17","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1046\/j.1460-9568.1999.00640.x","article-title":"Overexpression of GAP-43 induces prolonged sprouting and causes death of adult motoneurons","volume":"11","author":"Harding","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib18","doi-asserted-by":"crossref","first-page":"12571","DOI":"10.1073\/pnas.220417997","article-title":"Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis","volume":"97","author":"Johnston","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib19","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.1086137","article-title":"Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model","volume":"301","author":"Kaspar","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib20","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1097\/00001756-199605310-00021","article-title":"Neuromuscular function impairment is not caused by motor neurone loss in FALS mice","volume":"7","author":"Kennel","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nm1021","article-title":"Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice","volume":"10","author":"Kieran","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/6568","article-title":"Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis","volume":"5","author":"Klivenyi","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib23","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1523\/JNEUROSCI.18-09-03241.1998","article-title":"Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1","volume":"18","author":"Kong","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/(SICI)1096-9861(19990920)412:2<373::AID-CNE13>3.0.CO;2-N","article-title":"Peripheral axotomy slows motoneuron degeneration in a transgenic mouse line expressing mutant SOD1 G93A","volume":"412","author":"Kong","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/jn.00665.2003","article-title":"Hyperexcitability of cultured spinal motoneurons from presymptomatic ALS mice","volume":"91","author":"Kuo","year":"2004","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1113\/jphysiol.1982.sp014364","article-title":"Recovery of slow and fast muscles following nerve injury during early post-natal development in the rat","volume":"331","author":"Lowrie","year":"1982","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0165-3806(87)90086-1","article-title":"Permanent changes in muscle and motoneurones induced by nerve injury during a critical period of development of the rat","volume":"428","author":"Lowrie","year":"1987","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3940(00)01034-X","article-title":"Activation and response to axotomy of microglia in the facial motor nuclei of G93A superoxide dismutase transgenic mice","volume":"285","author":"Mariotti","year":"2000","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0306-4522(02)00448-7","article-title":"Altered reaction of facial motoneurons to axonal damage in the presymptomatic phase of a murine model of familial amyotrophic lateral sclerosis","volume":"115","author":"Mariotti","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1098\/rstb.1981.0082","article-title":"The localization of motoneurons supplying the hindlimb muscles of the mouse","volume":"293","author":"McHanwell","year":"1981","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib31","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.1073\/pnas.93.11.5472","article-title":"The golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease","volume":"93","author":"Mourelatos","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib32","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/5.4.420","article-title":"Cytochemical demonstration of succinate dehydrogenase by the use of a new P-nitrophenyl substituted ditetrazole","volume":"5","author":"Nachlas","year":"1957","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib33","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1113\/jphysiol.1984.sp015270","article-title":"Differential effect of nerve injury at birth on the activity pattern of reinnervated slow and fast muscles of the rat","volume":"351","author":"Navarrete","year":"1984","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00587391","article-title":"Effects of long-term electrical stimulation on some contractile and metabolic characteristics of fast rabbit muscles","volume":"338","author":"Pette","year":"1973","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib35","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1073\/pnas.92.3.689","article-title":"Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis","volume":"92","author":"Ripps","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib36","first-page":"11","article-title":"Motor localization and the effects of nerve injury on the ventral horn cells of the spinal cord","volume":"80","author":"Romanes","year":"1946","journal-title":"J Anat"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib38","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1113\/jphysiol.1969.sp008771","article-title":"The influence of activity on some contractile characteristics of mammalian fast and slow muscles","volume":"201","author":"Salmons","year":"1969","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib39","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1212\/WNL.53.6.1239","article-title":"Mice lacking cytosolic copper\/zinc superoxide dismutase display a distinctive motor axonopathy","volume":"53","author":"Shefner","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/aja.1001100203","article-title":"Histochemical classification of individual skeletal muscle fibres of the rat","volume":"110","author":"Stein","year":"1962","journal-title":"Am J Anat"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib41","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1073\/pnas.93.7.3155","article-title":"Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions","volume":"93","author":"Tu","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib42","first-page":"1051","article-title":"Assessing disease onset and progression in the SOD1 mouse model of ALS","volume":"14","author":"Weydt","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib43","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0306-4522(99)00512-6","article-title":"Repeated stimuli for axonal growth causes motoneuron death in adult rats","volume":"95","author":"White","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2004.09.069_bib44","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0896-6273(95)90259-7","article-title":"An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria","volume":"14","author":"Wong","year":"1995","journal-title":"Neuron"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452204009959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452204009959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:21:00Z","timestamp":1759677660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452204009959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005]]}},"alternative-id":["S0306452204009959"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2004.09.069","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2005]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of peripheral nerve injury on disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2004.09.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}