{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:06:10Z","timestamp":1791032770990,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1016\/j.neuroscience.2006.03.032","type":"journal-article","created":{"date-parts":[[2006,5,6]],"date-time":"2006-05-06T06:24:57Z","timestamp":1146896697000},"page":"299-310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Localization and ontogeny of damage-induced neuronal endopeptidase mRNA-expressing neurons in the rat nervous system"],"prefix":"10.1016","volume":"141","author":[{"given":"K.","family":"Nagata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kiryu-Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2006.03.032_bib1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1042\/bj20040215","article-title":"Endothelin-converting enzyme-like 1 (ECEL1) is present both in the plasma membrane and in the endoplasmic reticulum","volume":"380","author":"Benoit","year":"2004","journal-title":"Biochem J"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/104454901316976127","article-title":"Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family","volume":"20","author":"Bonvouloir","year":"2001","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib3","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1096\/fj.05-4192fje","article-title":"Sodium\/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves","volume":"19","author":"Chau","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib5","doi-asserted-by":"crossref","first-page":"15262","DOI":"10.1074\/jbc.270.25.15262","article-title":"Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum","volume":"270","author":"Emoto","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib6","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1073\/pnas.0401667101","article-title":"Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice","volume":"101","author":"Ferguson","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1042\/bj3470419","article-title":"Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family","volume":"347","author":"Ghaddar","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib8","doi-asserted-by":"crossref","first-page":"11563","DOI":"10.1073\/pnas.210221897","article-title":"Targeted disruption of the galanin gene reduces the number of sensory neurons and their regenerative capacity","volume":"97","author":"Holmes","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib9","doi-asserted-by":"crossref","first-page":"32469","DOI":"10.1074\/jbc.274.45.32469","article-title":"Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides","volume":"274","author":"Ikeda","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib10","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1126\/science.1059946","article-title":"Metabolic regulation of brain Abeta by neprilysin","volume":"292","author":"Iwata","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/72237","article-title":"Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma","volume":"6","author":"Iwata","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib12","doi-asserted-by":"crossref","first-page":"9410","DOI":"10.1523\/JNEUROSCI.22-21-09410.2002","article-title":"Damage-induced neuronal endopeptidase (DINE\/ECEL) expression is regulated by leukemia inhibitory factor and deprivation of nerve growth factor in rat sensory ganglia after nerve injury","volume":"22","author":"Kato","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib13","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1073\/pnas.070509897","article-title":"Damage-induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers","volume":"97","author":"Kiryu-Seo","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib14","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1073\/pnas.88.14.6353","article-title":"Molecular cloning and primary structure of Kell blood group protein","volume":"88","author":"Lee","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2174\/0929866043406481","article-title":"The zinc metallopeptidase family","volume":"11","author":"Lew","year":"2004","journal-title":"Protein Pept Lett"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0006-291X(87)80475-8","article-title":"Molecular cloning and amino acid sequence of rat enkephalinase","volume":"144","author":"Malfroy","year":"1987","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib17","doi-asserted-by":"crossref","first-page":"16075","DOI":"10.1074\/jbc.M110106200","article-title":"Pituitary adenylyl cyclase-activating polypeptide prevents induced cell death in retinal tissue through activation of cyclic AMP-dependent protein kinase","volume":"277","author":"Mariana","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0896-6273(02)01020-6","article-title":"Roles of neurotransmitter in synapse formation","volume":"36","author":"Misgeld","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.mcn.2003.12.004","article-title":"PACAP promotes sensory neuron differentiation","volume":"25","author":"Nielsen","year":"2004","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib20","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/j.1471-4159.2004.02784.x","article-title":"Expression of damage-induced neuronal endopeptidase (DINE) mRNA in peri-infarct cortical and thalamic neurons following middle cerebral artery occlusion","volume":"91","author":"Ohba","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib21","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1006\/bbrc.2000.2664","article-title":"Neprilysin II","volume":"271","author":"Ouimet","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib22","doi-asserted-by":"crossref","first-page":"20450","DOI":"10.1074\/jbc.274.29.20450","article-title":"Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family","volume":"274","author":"Schweizer","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib23","doi-asserted-by":"crossref","first-page":"21394","DOI":"10.1016\/S0021-9258(19)36936-4","article-title":"Purification and characterization of endothelin-converting enzyme from rat lung","volume":"268","author":"Takahashi","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib24","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ng1095-130","article-title":"A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets","volume":"11","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0169-328X(98)00321-0","article-title":"XCE, a new member of the endothelin-converting enzyme and neutral endopeptidase family, is preferentially expressed in the CNS","volume":"64","author":"Valdenaire","year":"1999","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2006.03.032_bib26","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1242\/dev.125.5.825","article-title":"Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene","volume":"125","author":"Yanagisawa","year":"1998","journal-title":"Development"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452206003940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452206003940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:26:03Z","timestamp":1759677963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452206003940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006]]}},"alternative-id":["S0306452206003940"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2006.03.032","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Localization and ontogeny of damage-induced neuronal endopeptidase mRNA-expressing neurons in the rat nervous system","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2006.03.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}