{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:09:38Z","timestamp":1793160578242,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1016\/j.neuroscience.2006.03.036","type":"journal-article","created":{"date-parts":[[2006,5,6]],"date-time":"2006-05-06T10:24:57Z","timestamp":1146911097000},"page":"245-257","source":"Crossref","is-referenced-by-count":34,"title":["Atp2b2, encoding plasma membrane Ca2+-ATPase type 2, (PMCA2) exhibits tissue-specific first exon usage in hair cells, neurons, and mammary glands of mice"],"prefix":"10.1016","volume":"141","author":[{"given":"R.S.","family":"Silverstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.L.","family":"Tempel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2006.03.036_bib1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/14734220310022289","article-title":"Distribution of calcium-binding proteins in the cerebellum","volume":"2","author":"Bastianelli","year":"2003","journal-title":"Cerebellum"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0888-7543(05)80246-0","article-title":"Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2","volume":"14","author":"Brandt","year":"1992","journal-title":"Genomics"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ceca.2005.01.003","article-title":"Presynaptic Ca2+ dynamics, Ca2+ buffers and synaptic efficacy","volume":"37","author":"Burnashev","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib4","doi-asserted-by":"crossref","first-page":"18464","DOI":"10.1074\/jbc.M301482200","article-title":"Alternative splicing of the first intracellular loop of plasma membrane Ca2+-ATPase isoform 2 alters its membrane targeting","volume":"278","author":"Chicka","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib5","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1074\/jbc.M111616200","article-title":"Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+\/H+ exchanger regulatory factor 2 in apical plasma membranes","volume":"277","author":"DeMarco","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib6","doi-asserted-by":"crossref","first-page":"21594","DOI":"10.1074\/jbc.M101448200","article-title":"Plasma membrane Ca2+-ATPase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95\/Dlg\/ZO-1) domain-containing proteins","volume":"276","author":"DeMarco","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib7","doi-asserted-by":"crossref","first-page":"11949","DOI":"10.1073\/pnas.90.24.11949","article-title":"Immunocytochemical localization of the plasma membrane calcium pump, calbindin-D28k, and parvalbumin in Purkinje cells of avian and mammalian cerebellum","volume":"90","author":"de Talamoni","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1006\/abbi.1995.1041","article-title":"The mouse plasma membrane Ca2+ pump isoform 1 promoter","volume":"316","author":"Du","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib9","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.1523\/JNEUROSCI.21-14-05066.2001","article-title":"Plasma membrane Ca2+-ATPase isoform 2a is the PMCA of hair bundles","volume":"21","author":"Dumont","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0021-9258(17)42307-6","article-title":"The Ca2+ affinity of the plasma membrane Ca2+ pump is controlled by alternative splicing","volume":"269","author":"Enyedi","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib11","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/25541","article-title":"Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites","volume":"396","author":"Finch","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0378-5955(98)00091-4","article-title":"Evidence for differential regulation of calcium by outer versus inner hair cells","volume":"123","author":"Furuta","year":"1998","journal-title":"Hear Res"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ceca.2005.06.032","article-title":"Exporting calcium from cells","volume":"38","author":"Guerini","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1054\/ceca.2000.0168","article-title":"Mitochondrial calcium transport","volume":"28","author":"Gunter","year":"2000","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib15","doi-asserted-by":"crossref","first-page":"7867","DOI":"10.1523\/JNEUROSCI.1196-05.2005","article-title":"The concentrations of calcium buffering proteins in mammalian cochlear hair cells","volume":"25","author":"Hackney","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib16","doi-asserted-by":"crossref","first-page":"19717","DOI":"10.1016\/S0021-9258(19)36574-3","article-title":"Structure of the gene encoding the human plasma membrane calcium pump isoform 1","volume":"268","author":"Hilfiker","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib17","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1242\/dev.119.4.1041","article-title":"The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture","volume":"119","author":"Kelley","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0378-5955(01)00420-8","article-title":"Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice","volume":"164","author":"Kozel","year":"2002","journal-title":"Hear Res"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib19","doi-asserted-by":"crossref","first-page":"18693","DOI":"10.1074\/jbc.273.30.18693","article-title":"Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2","volume":"273","author":"Kozel","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib20","first-page":"2486","article-title":"One-megabase yeast artificial chromosome and 400-kilobase cosmid-phage contigs containing the von Hippel-Lindau tumor suppressor and Ca(2+)-transporting adenosine triphosphatase isoform 2 genes","volume":"54","author":"Kuzmin","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib21","first-page":"129","article-title":"New mutants and linkages","volume":"77","author":"Lane","year":"1987","journal-title":"Mouse News Lett"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib22","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0898-6568(02)00049-9","article-title":"Expression of plasma membrane calcium pump isoform mRNAs in breast cancer cell lines","volume":"14","author":"Lee","year":"2002","journal-title":"Cell Signal"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib23","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1523\/JNEUROSCI.18-16-06300.1998","article-title":"Regulation of free Ca2+ concentration in hair-cell stereocilia","volume":"18","author":"Lumpkin","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.heares.2004.05.003","article-title":"Haplo-insufficiency revealed in deafwaddler mice when tested for hearing loss and ataxia","volume":"195","author":"McCullough","year":"2004","journal-title":"Hear Res"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/(SICI)1096-9861(19990405)406:2<183::AID-CNE4>3.0.CO;2-K","article-title":"Class III beta-tubulin expression in sensory and nonsensory regions of the developing avian inner ear","volume":"406","author":"Molea","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10911-005-5395-z","article-title":"Calcium secretion into milk","volume":"10","author":"Neville","year":"2005","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1226","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"35","author":"Noben-Trauth","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-5955(01)00356-2","article-title":"Characterization of the deafwaddler mutant of the rat plasma membrane calcium-ATPase 2","volume":"162","author":"Penheiter","year":"2001","journal-title":"Hear Res"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib29","doi-asserted-by":"crossref","first-page":"C1595","DOI":"10.1152\/ajpcell.2000.279.5.C1595","article-title":"Ca(2+)-ATPase protein expression in mammary tissue","volume":"279","author":"Reinhardt","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib30","doi-asserted-by":"crossref","first-page":"C796","DOI":"10.1152\/ajpcell.1999.276.4.C796","article-title":"Ca2+-ATPases and their expression in the mammary gland of pregnant and lactating rats","volume":"276","author":"Reinhardt","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib31","doi-asserted-by":"crossref","first-page":"42369","DOI":"10.1074\/jbc.M407788200","article-title":"Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk","volume":"279","author":"Reinhardt","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib32","series-title":"Molecular cloning","author":"Sambrook","year":"2001"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib33","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJMoa043899","article-title":"Modification of human hearing loss by plasma-membrane calcium pump PMCA2","volume":"352","author":"Schultz","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib34","doi-asserted-by":"crossref","first-page":"8646","DOI":"10.1016\/S0021-9258(18)68354-1","article-title":"Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases","volume":"263","author":"Shull","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib35","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1210\/endo-126-6-2882","article-title":"Developmental regulation of murine mammary progesterone receptor gene expression","volume":"126","author":"Shyamala","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0169-328X(92)90229-5","article-title":"Plasma membrane Ca(2+)-ATPase isoforms","volume":"16","author":"Stahl","year":"1992","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib37","doi-asserted-by":"crossref","first-page":"12184","DOI":"10.1074\/jbc.270.20.12184","article-title":"Tissue distribution of the four gene products of the plasma membrane Ca2+ pump. A study using specific antibodies","volume":"270","author":"Stauffer","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0006-8993(96)01282-6","article-title":"Immunolocalization of the plasma membrane Ca2+ pump isoforms in the rat brain","volume":"748","author":"Stauffer","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib39","doi-asserted-by":"crossref","first-page":"16899","DOI":"10.1073\/pnas.242603899","article-title":"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences","volume":"99","author":"Strausberg","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib40","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/1284","article-title":"Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice","volume":"19","author":"Street","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib41","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2174\/1566524043360735","article-title":"Calcium pumps of plasma membrane and cell interior","volume":"4","author":"Strehler","year":"2004","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.2001.81.1.21","article-title":"Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps","volume":"81","author":"Strehler","year":"2001","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib43","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1006\/bbrc.1999.1102","article-title":"A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse Sagami","volume":"261","author":"Takahashi","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib44","doi-asserted-by":"crossref","unstructured":"Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:RESEARCH0034. http:\/\/genomebiology.com.","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib45","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10162-003-4022-1","article-title":"Low endolymph calcium concentrations in deafwaddler2J mice suggest that PMCA2 contributes to endolymph calcium maintenance","volume":"5","author":"Wood","year":"2004","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib46","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s00424-003-1011-5","article-title":"PMR1\/SPCA Ca2+ pumps and the role of the Golgi apparatus as a Ca2+ store","volume":"446","author":"Wuytack","year":"2003","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib47","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1523\/JNEUROSCI.18-02-00610.1998","article-title":"Plasma membrane Ca2+-ATPase extrudes Ca2+ from hair cell stereocilia","volume":"18","author":"Yamoah","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.03.036_bib48","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/35012009","article-title":"Prestin is the motor protein of cochlear outer hair cells","volume":"405","author":"Zheng","year":"2000","journal-title":"Nature"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452206004052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452206004052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T19:40:44Z","timestamp":1627328444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452206004052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006]]}},"alternative-id":["S0306452206004052"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2006.03.036","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]}}}