{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:27:39Z","timestamp":1791160059648,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1016\/j.neuroscience.2006.04.013","type":"journal-article","created":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T20:50:00Z","timestamp":1148417400000},"page":"569-584","source":"Crossref","is-referenced-by-count":235,"title":["Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in huntington\u2019s disease transgenic mice"],"prefix":"10.1016","volume":"141","author":[{"given":"T.Y.C.","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.C.","family":"Stam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nithianantharajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"Hannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2006.04.013_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0169-328X(00)00095-4","article-title":"Transient increase of brain derived neurotrophic factor mRNA expression in substantia nigra reticulata after partial lesion of the nigrostriatal dopaminergic pathway","volume":"79","author":"Aliaga","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0166-2236(98)01273-9","article-title":"Neurotrophin trafficking by anterograde transport","volume":"21","author":"Altar","year":"1998","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib3","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1523\/JNEUROSCI.3920-03.2004","article-title":"Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor","volume":"24","author":"Baquet","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/jnr.10256","article-title":"Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum","volume":"68","author":"Berchtold","year":"2002","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainres.2004.01.021","article-title":"Early exploratory behavior abnormalities in R6\/1 Huntington\u2019s disease transgenic mice","volume":"1005","author":"Bolivar","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib6","doi-asserted-by":"crossref","first-page":"7727","DOI":"10.1523\/JNEUROSCI.1197-04.2004","article-title":"Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington\u2019s disease","volume":"24","author":"Canals","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.molbrainres.2004.11.012","article-title":"Endogenous brain-derived neurotrophic factor protects dopaminergic nigral neurons against transneuronal degeneration induced by striatal excitotoxic injury","volume":"134","author":"Canudas","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib8","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1073\/pnas.95.11.6480","article-title":"Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene","volume":"95","author":"Cha","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib9","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/hmg\/11.17.1939","article-title":"Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington\u2019s disease","volume":"11","author":"Chan","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib10","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.neuroscience.2004.04.020","article-title":"Identification of brain-derived neurotrophic factor in nestin-expressing astroglial cells in the neostriatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice","volume":"126","author":"Chen","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib11","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1111\/j.0953-816X.2004.03248.x","article-title":"Environmental enrichment reverses learning impairment in the Morris water maze after focal cerebral ischemia in rats","volume":"19","author":"Dahlqvist","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1101\/lm.36301","article-title":"Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memory","volume":"8","author":"Duffy","year":"2001","journal-title":"Learn Mem"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2003.09.029","article-title":"Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo","volume":"124","author":"Farmer","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0006-8993(00)02237-X","article-title":"Brain-derived neurotrophic factor in Huntington disease","volume":"866","author":"Ferrer","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib15","doi-asserted-by":"crossref","first-page":"7681","DOI":"10.1523\/JNEUROSCI.1958-04.2004","article-title":"Hippocampal plasticity across multiple days of exposure to novel environments","volume":"24","author":"Frank","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib16","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0197-4580(02)00138-0","article-title":"Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice","volume":"24","author":"Frick","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1101\/lm.50703","article-title":"Effects of environmental enrichment on spatial memory and neurochemistry in middle-aged mice","volume":"10","author":"Frick","year":"2003","journal-title":"Learn Mem"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0166-4328(01)00296-0","article-title":"Behavioral tests of hippocampal function","volume":"125","author":"Gerlai","year":"2001","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib20","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.nbd.2005.05.006","article-title":"Reduced hippocampal neurogenesis in R6\/2 transgenic Huntington\u2019s disease mice","volume":"20","author":"Gil","year":"2005","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0306-4522(93)90352-G","article-title":"Loss of cannabinoid receptors in the substantia nigra in Huntington\u2019s disease","volume":"56","author":"Glass","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0306-4522(00)00008-7","article-title":"The pattern of neurodegeneration in Huntington\u2019s disease","volume":"97","author":"Glass","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0306-4522(03)00595-5","article-title":"Delayed onset of Huntington\u2019s disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptors","volume":"123","author":"Glass","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0306-4522(03)00426-3","article-title":"Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice","volume":"121","author":"Gorski","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib25","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1111\/j.1460-9568.2005.04365.x","article-title":"Cognitive disorders and neurogenesis deficits in Huntington\u2019s disease mice are rescued by fluoxetine","volume":"22","author":"Grote","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib26","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1517\/14728222.9.4.639","article-title":"Novel therapeutic targets for Huntington\u2019s disease","volume":"9","author":"Hannan","year":"2005","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ana.10094","article-title":"Environmental enrichment slows disease progression in R6\/2 Huntington\u2019s disease mice","volume":"51","author":"Hockly","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib28","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(03)00422-6","article-title":"Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for increased voluntary wheel running","volume":"121","author":"Johnson","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib30","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/jnen\/63.6.598","article-title":"Gene expression profiling in the intact and injured brain following environmental enrichment","volume":"63","author":"Keyvani","year":"2004","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0168-0102(03)00171-8","article-title":"Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor epsilon 1 subunit","volume":"47","author":"Kitamura","year":"2003","journal-title":"Neurosci Res"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib32","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/00001756-200404090-00014","article-title":"Decreased hippocampal cell proliferation in R6\/1 Huntington\u2019s mice","volume":"15","author":"Lazic","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib33","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.0022-3042.2001.00747.x","article-title":"Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice","volume":"80","author":"Lee","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib34","doi-asserted-by":"crossref","first-page":"8473","DOI":"10.1523\/JNEUROSCI.21-21-08473.2001","article-title":"Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington\u2019s disease mice","volume":"21","author":"Li","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib35","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neulet.2005.06.009","article-title":"Increased astrocyte proliferation in rats after running exercise","volume":"386","author":"Li","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib36","doi-asserted-by":"crossref","first-page":"10428","DOI":"10.1523\/JNEUROSCI.19-23-10428.1999","article-title":"Selective discrimination learning impairments in mice expressing the human Huntington\u2019s disease mutation","volume":"19","author":"Lione","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib37","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","article-title":"Dysregulation of gene expression in the R6\/2 model of polyglutamine disease","volume":"11","author":"Luthi-Carter","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib38","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/hmg\/9.9.1259","article-title":"Decreased expression of striatal signaling genes in a mouse model of Huntington\u2019s disease","volume":"9","author":"Luthi-Carter","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib39","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/cne.10776","article-title":"Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington\u2019s disease with 140 CAG repeats","volume":"465","author":"Menalled","year":"2003","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib41","doi-asserted-by":"crossref","first-page":"8266","DOI":"10.1523\/JNEUROSCI.22-18-08266.2002","article-title":"Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington\u2019s disease knock-in mice","volume":"22","author":"Menalled","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib42","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1523\/JNEUROSCI.20-13-05115.2000","article-title":"Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington\u2019s disease mutation","volume":"20","author":"Murphy","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib43","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0166-4328(99)00019-4","article-title":"Effects of environmental enrichment on cognitive function and hippocampal NGF in the non-handled rats","volume":"103","author":"Pham","year":"1999","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib44","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0306-4522(99)00316-4","article-title":"Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year","volume":"94","author":"Pham","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib45","doi-asserted-by":"crossref","first-page":"11564","DOI":"10.1523\/JNEUROSCI.3796-05.2005","article-title":"Abnormalities of neurogenesis in the R6\/2 mouse model of Huntington\u2019s disease are attributable to the in vivo microenvironment","volume":"25","author":"Phillips","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib46","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.physbeh.2004.02.022","article-title":"Long-term effects of the periadolescent environment on exploratory activity and aggressive behaviour in mice","volume":"81","author":"Pietropaolo","year":"2004","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib47","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1471-4159.2005.03047.x","article-title":"Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington\u2019s disease","volume":"93","author":"Pineda","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib48","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1046\/j.1471-4159.1999.721773.x","article-title":"Brain neurotransmitter deficits in mice transgenic for the Huntington\u2019s disease mutation","volume":"72","author":"Reynolds","year":"1999","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib49","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1037\/0735-7044.117.5.1006","article-title":"Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running","volume":"117","author":"Rhodes","year":"2003","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib50","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1046\/j.1471-4159.2003.02041.x","article-title":"Expression of BDNF mRNA in substantia nigra is dependent on target integrity and independent of neuronal activation","volume":"87","author":"Rite","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib51","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0893-133X(99)00059-7","article-title":"Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression","volume":"21","author":"Russo-Neustadt","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib52","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.expneurol.2004.01.003","article-title":"Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice","volume":"187","author":"Schilling","year":"2004","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib53","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.neuroscience.2004.10.009","article-title":"A role for adult neurogenesis in spatial long-term memory","volume":"130","author":"Snyder","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib54","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1111\/j.1742-4658.2005.04677.x","article-title":"Nature, nurture and neurology","volume":"272","author":"Spires","year":"2005","journal-title":"FEBS J"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib55","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1523\/JNEUROSCI.1658-03.2004","article-title":"Environmental enrichment rescues protein deficits in a mouse model of Huntington\u2019s disease, indicating a possible disease mechanism","volume":"24","author":"Spires","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib56","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10048-003-0169-5","article-title":"Genetic and environmental factors in the pathogenesis of Huntington\u2019s disease","volume":"5","author":"van Dellen","year":"2004","journal-title":"Neurogenetics"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib57","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/j.1440-1681.2005.04313.x","article-title":"Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington\u2019s disease","volume":"32","author":"van Dellen","year":"2005","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib58","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/35008142","article-title":"Delaying the onset of Huntington\u2019s in mice","volume":"404","author":"van Dellen","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib59","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1097\/00001756-200011270-00032","article-title":"N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington\u2019s disease mice","volume":"11","author":"van Dellen","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib60","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/35044558","article-title":"Neural consequences of environmental enrichment","volume":"1","author":"van Praag","year":"2000","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib61","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","article-title":"Running enhances neurogenesis, learning, and long-term potentiation in mice","volume":"96","author":"van Praag","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib62","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1111\/j.1460-9568.2004.03720.x","article-title":"Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition","volume":"20","author":"Vaynman","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib63","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1073\/pnas.0308679101","article-title":"Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington\u2019s disease age of onset","volume":"101","author":"Wexler","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib64","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/7449","article-title":"Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective","volume":"5","author":"Young","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2006.04.013_bib65","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.1059581","article-title":"Loss of huntingtin-mediated BDNF gene transcription in Huntington\u2019s disease","volume":"293","author":"Zuccato","year":"2001","journal-title":"Science"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452206004933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452206004933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T07:11:06Z","timestamp":1575011466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452206004933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006]]}},"alternative-id":["S0306452206004933"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2006.04.013","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]}}}