{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:50:16Z","timestamp":1790988616896,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.neuroscience.2006.10.008","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T16:34:12Z","timestamp":1164818052000},"page":"1045-1056","source":"Crossref","is-referenced-by-count":86,"title":["Thiamine deficiency induces endoplasmic reticulum stress in neurons"],"prefix":"10.1016","volume":"144","author":[{"given":"X.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.-J.","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2006.10.008_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/cne.20375","article-title":"Developmental expression of matrix metalloproteinases 2 and 9 and their potential role in the histogenesis of the cerebellar cortex","volume":"481","author":"Ayoub","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0306-4522(98)90664-9","article-title":"Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke\u2019s encephalopathy","volume":"91","author":"Baker","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib3","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1046\/j.1471-4159.1995.64052013.x","article-title":"Thiamine deficiency in cultured neuroblastoma cells: effect on mitochondrial function and peripheral benzodiazepine receptors","volume":"64","author":"Bettendorff","year":"1995","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib4","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/00005072-199909000-00005","article-title":"Oxidative stress is associated with region-specific neuronal death during thiamine deficiency","volume":"58","author":"Calingasan","year":"1999","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1749-6632.2000.tb06386.x","article-title":"Vascular endothelium is a site of free radical production and inflammation in areas of neuronal loss in thiamine-deficient brain","volume":"903","author":"Calingasan","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1006\/nbdi.2002.0542","article-title":"Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12","volume":"11","author":"Chan","year":"2002","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib7","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1096\/fj.04-1551fje","article-title":"Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death","volume":"18","author":"Chen","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib8","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1023\/A:1020387414086","article-title":"Neuronal apoptosis induced by endoplasmic reticulum stress","volume":"27","author":"Chen","year":"2002","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib9","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0197-4580(02)00076-3","article-title":"Protein misfolding in Alzheimer\u2019s and Parkinson\u2019s disease: genetics and molecular mechanisms","volume":"23","author":"Forloni","year":"2002","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.nbd.2004.04.002","article-title":"GDNF regulates the A beta-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases","volume":"16","author":"Ghribi","year":"2004","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1385\/MN:31:1-3:043","article-title":"The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration","volume":"31","author":"Gibson","year":"2005","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3233\/JAD-2001-3308","article-title":"Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer\u2019s disease","volume":"3","author":"Gibson","year":"2001","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib13","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1471-4159.1966.tb09873.x","article-title":"Regional studies of catecholamines in the rat brain","volume":"13","author":"Glowinski","year":"1966","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1750-3639.1998.tb00136.x","article-title":"Glial-neuronal interactions in Alzheimer\u2019s disease: the potential role of a \u2018cytokine cycle\u2019 in disease progression","volume":"8","author":"Griffin","year":"1998","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ana.410130403","article-title":"Sequence of metabolic, clinical, and histological events in experimental thiamine deficiency","volume":"13","author":"Hakim","year":"1983","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.nbd.2003.10.005","article-title":"Oxidative injury to the endoplasmic reticulum in mouse brains after transient focal ischemia","volume":"15","author":"Hayashi","year":"2004","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib17","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1097\/01.WCB.0000089600.87125.AD","article-title":"Oxidative damage to the endoplasmic reticulum is implicated in ischemic neuronal cell death","volume":"23","author":"Hayashi","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib18","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.cdd.4400907","article-title":"VCP\/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration","volume":"8","author":"Hirabayashi","year":"2001","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib19","doi-asserted-by":"crossref","first-page":"19367","DOI":"10.1074\/jbc.M211821200","article-title":"Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons","volume":"278","author":"Holtz","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00401-005-1038-0","article-title":"The unfolded protein response is activated in Alzheimer\u2019s disease","volume":"110","author":"Hoozemans","year":"2005","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jchemneu.2003.12.004","article-title":"Induction of neuronal death by ER stress in Alzheimer\u2019s disease","volume":"28","author":"Katayama","year":"2004","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib22","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1101\/gad.13.10.1211","article-title":"Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls","volume":"13","author":"Kaufman","year":"1999","journal-title":"Gene Dev"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/jnen\/62.2.195","article-title":"Reversal of thiamine deficiency-induced neurodegeneration","volume":"62","author":"Ke","year":"2003","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib24","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.neuint.2003.09.008","article-title":"Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism","volume":"45","author":"Ke","year":"2004","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib25","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.neuint.2006.04.011","article-title":"Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism","volume":"49","author":"Ke","year":"2006","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neulet.2005.11.023","article-title":"Emergence of endoplasmic reticulum stress and activated microglia in Purkinje cell degeneration mice","volume":"396","author":"Kyuhou","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF02674735","article-title":"Increased cerebral free radical production during thiamine deficiency","volume":"12","author":"Langlais","year":"1997","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1021\/tx00026a012","article-title":"Evaluation of the probe 2\u2032,7\u2032-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress","volume":"5","author":"LeBel","year":"1992","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0165-3806(02)00573-4","article-title":"Effects of prenatal exposure to ethanol on the cyclin-dependent kinase system in the developing rat cerebellum","volume":"139","author":"Li","year":"2002","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib30","first-page":"134","article-title":"The role of thiamine deficiency in alcoholic brain disease","volume":"27","author":"Martin","year":"2003","journal-title":"Alcohol Res Health"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib31","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s00415-005-0722-2","article-title":"Vermal atrophy of alcoholics correlate with serum thiamine levels but not with dentate iron concentrations as estimated by MRI","volume":"252","author":"Maschke","year":"2005","journal-title":"J Neurol"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/14734220600551707","article-title":"Susceptibility of the cerebellum to thiamine deficiency","volume":"5","author":"Mulholland","year":"2006","journal-title":"Cerebellum"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib33","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.neuroscience.2005.06.077","article-title":"Thiamine deficiency in the pathogenesis of chronic ethanol-associated cerebellar damage in vitro","volume":"135","author":"Mulholland","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/47513","article-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta","volume":"403","author":"Nakagawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib35","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","article-title":"Roles of CHOP\/GADD153 in endoplasmic reticulum stress","volume":"11","author":"Oyadomari","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib36","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/1097-4547(20001015)62:2<286::AID-JNR13>3.0.CO;2-0","article-title":"Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: an in vitro model for the study of cell death mechanisms in Wernicke\u2019s encephalopathy","volume":"62","author":"Pannunzio","year":"2000","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib37","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/jnr.10062","article-title":"Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy","volume":"66","author":"Park","year":"2001","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib38","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1046\/j.1471-4159.2000.0740114.x","article-title":"Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture","volume":"74","author":"Park","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib39","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1172\/JCI0216784","article-title":"Translational control in the endoplasmic reticulum stress response","volume":"110","author":"Ron","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tcb.2003.11.001","article-title":"A trip to the ER: coping with stress","volume":"14","author":"Rutkowski","year":"2004","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib41","doi-asserted-by":"crossref","first-page":"10690","DOI":"10.1523\/JNEUROSCI.22-24-10690.2002","article-title":"Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson\u2019s disease","volume":"22","author":"Ryu","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib42","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0006-8993(95)01257-5","article-title":"Neurofibrillary tangles of Guam Parkinson-dementia are associated with reactive microglia and complement proteins","volume":"707","author":"Schwab","year":"1996","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0197-0186(02)00196-1","article-title":"Neurodegenerative disorders of protein aggregation","volume":"43","author":"Shastry","year":"2003","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jchemneu.2004.02.006","article-title":"The unfolded protein response: a stress signaling pathway of the endoplasmic reticulum","volume":"28","author":"Shen","year":"2004","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib45","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1158\/0008-5472.CAN-05-0312","article-title":"Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells","volume":"65","author":"Shiraishi","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib46","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1471-4159.2005.03428.x","article-title":"CHOP\/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism","volume":"95","author":"Silva","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib47","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2174\/1566524013363870","article-title":"Molecular mechanisms of thiamine utilization","volume":"1","author":"Singleton","year":"2001","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib48","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1093\/hmg\/ddi396","article-title":"Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity","volume":"14","author":"Smith","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib49","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1196\/annals.1299.032","article-title":"Caspase-12 and ER-stress-mediated apoptosis: the story so far","volume":"1010","author":"Szegezdi","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib50","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/sj.cdd.4401365","article-title":"Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP","volume":"11","author":"Tajiri","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib51","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1749-6632.1999.tb07866.x","article-title":"Mechanisms of selective neuronal cell death due to thiamine deficiency","volume":"893","author":"Todd","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/156652406775574550","article-title":"ER stress and UPR in familial amyotrophic lateral sclerosis","volume":"6","author":"Turner","year":"2006","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib53","series-title":"The Wernicke-Korsakoff syndrome and related neurological disorders due to alcoholism and malnutrition","author":"Victor","year":"1989"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib54","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2006.10.008_bib55","doi-asserted-by":"crossref","first-page":"33917","DOI":"10.1074\/jbc.M505818200","article-title":"Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha","volume":"280","author":"Xue","year":"2005","journal-title":"J Biol Chem"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452206013637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452206013637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T12:38:42Z","timestamp":1555936722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452206013637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0306452206013637"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2006.10.008","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}