{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:07:55Z","timestamp":1778659675552,"version":"3.51.4"},"reference-count":195,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.neuroscience.2006.10.045","type":"journal-article","created":{"date-parts":[[2006,12,16]],"date-time":"2006-12-16T12:14:37Z","timestamp":1166271277000},"page":"1280-1299","source":"Crossref","is-referenced-by-count":42,"title":["Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair"],"prefix":"10.1016","volume":"145","author":[{"given":"J.J.P.","family":"Perry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Tainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2006.10.045_bib1","doi-asserted-by":"crossref","first-page":"11167","DOI":"10.1021\/bi00035a023","article-title":"Subunit dissociation and unfolding of macrophage NO synthase: relationship between enzyme structure, prosthetic group binding, and catalytic function","volume":"34","author":"Abu-Soud","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib2","doi-asserted-by":"crossref","first-page":"22313","DOI":"10.1074\/jbc.274.32.22313","article-title":"Role of reductase domain cluster 1 acidic residues in neuronal nitric-oxide synthase","volume":"274","author":"Adak","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1432-1033.1974.tb03751.x","article-title":"Heterogeneity of erythrocyte catalase II","volume":"48","author":"Aebi","year":"1974","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib4","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/0264-6021:3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1179\/01610425017613","article-title":"Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer\u2019s disease?","volume":"26","author":"Aliyev","year":"2004","journal-title":"Neurol Res"},{"issue":"Suppl","key":"10.1016\/j.neuroscience.2006.10.045_bib6","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1038\/nrn1434","article-title":"Oxidative stress in neurodegeneration: cause or consequence?","volume":"10","author":"Andersen","year":"2004","journal-title":"Nat Med"},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2006.10.045_bib7","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1080\/14660820152415726","article-title":"Genetics of sporadic ALS","volume":"2","author":"Andersen","year":"2001","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib8","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/emboj\/cdg078","article-title":"Structural basis for endothelial nitric oxide synthase binding to calmodulin","volume":"22","author":"Aoyagi","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00412-004-0306-4","article-title":"MRE11\/RAD50\/NBS1: complex activities","volume":"113","author":"Assenmacher","year":"2004","journal-title":"Chromosoma"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib10","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1529\/biophysj.105.060616","article-title":"Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine","volume":"89","author":"Ayala","year":"2005","journal-title":"Biophys J"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib11","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1111\/j.1462-5822.2005.00586.x","article-title":"The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca(2+) transients in infected epithelial cells","volume":"7","author":"Ayala","year":"2005","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib12","doi-asserted-by":"crossref","first-page":"36476","DOI":"10.1074\/jbc.M303885200","article-title":"WRN interacts physically and functionally with the recombination mediator protein RAD52","volume":"278","author":"Baynton","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib13","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0306-4522(99)00380-2","article-title":"Distribution and kainate-mediated induction of the DNA mismatch repair protein MSH2 in rat brain","volume":"94","author":"Belloni","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib14","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1073\/pnas.90.12.5613","article-title":"Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid","volume":"90","author":"Bennett","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib15","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.str.2005.04.018","article-title":"Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain","volume":"13","author":"Bernstein","year":"2005","journal-title":"Structure (Camb)"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib16","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1093\/emboj\/cdg500","article-title":"High-resolution structure of the E.coli RecQ helicase catalytic core","volume":"22","author":"Bernstein","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib17","doi-asserted-by":"crossref","first-page":"29463","DOI":"10.1074\/jbc.274.41.29463","article-title":"Physical and functional interaction between p53 and the Werner\u2019s syndrome protein","volume":"274","author":"Blander","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib18","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.mrfmmm.2005.03.021","article-title":"Deficient DNA repair in the human progeroid disorder, Werner syndrome","volume":"577","author":"Bohr","year":"2005","journal-title":"Mutat Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0092-8674(92)90270-M","article-title":"The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles","volume":"71","author":"Borgstahl","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0921-8777(98)00018-4","article-title":"Detection of excision nuclease in cell-free extracts from the adult mammalian brain","volume":"408","author":"Brooks","year":"1998","journal-title":"Mutat Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib21","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1523\/JNEUROSCI.16-03-00939.1996","article-title":"DNA mismatch repair and DNA methylation in adult brain neurons","volume":"16","author":"Brooks","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib22","doi-asserted-by":"crossref","first-page":"35093","DOI":"10.1074\/jbc.M103332200","article-title":"p53 Modulates the exonuclease activity of Werner syndrome protein","volume":"276","author":"Brosh","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib23","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1093\/emboj\/20.20.5791","article-title":"Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity","volume":"20","author":"Brosh","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib24","doi-asserted-by":"crossref","first-page":"18341","DOI":"10.1074\/jbc.274.26.18341","article-title":"Functional and physical interaction between WRN helicase and human replication protein A","volume":"274","author":"Brosh","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib25","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1126\/science.281.5384.1851","article-title":"Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1","volume":"281","author":"Bruijn","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.phrs.2005.02.008","article-title":"Ageing and PARP","volume":"52","author":"Burkle","year":"2005","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib27","doi-asserted-by":"crossref","first-page":"11686","DOI":"10.1021\/bi9909142","article-title":"Role of tryptophan 161 in catalysis by human manganese superoxide dismutase","volume":"38","author":"Cabelli","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1097-2765(01)00153-8","article-title":"Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer","volume":"7","author":"Carrodeguas","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0092-8674(00)00083-0","article-title":"Electron crystal structure of the transcription factor and DNA repair complex, core TFIIH","volume":"102","author":"Chang","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0092-8674(03)01036-5","article-title":"Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair","volume":"116","author":"Chapados","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib31","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S1097-2765(01)00388-4","article-title":"Promotion of Dnl4-catalyzed DNA end-joining by the Rad50\/Mre11\/Xrs2 and Hdf1\/Hdf2 complexes","volume":"8","author":"Chen","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib32","doi-asserted-by":"crossref","first-page":"21169","DOI":"10.1074\/jbc.M312770200","article-title":"Linkage between Werner syndrome protein and the Mre11 complex via Nbs1","volume":"279","author":"Cheng","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0891-0618(96)00137-8","article-title":"Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study","volume":"10","author":"Chou","year":"1996","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib34","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35097565","article-title":"From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS","volume":"2","author":"Cleveland","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib35","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1038\/sj.emboj.7600480","article-title":"Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity","volume":"23","author":"Coin","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.molcel.2005.10.024","article-title":"p8\/TTD-A as a repair-specific TFIIH subunit","volume":"21","author":"Coin","year":"2006","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib37","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.mad.2004.06.004","article-title":"The Werner syndrome protein at the crossroads of DNA repair and apoptosis","volume":"125","author":"Comai","year":"2004","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib38","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1101\/gad.14.8.907","article-title":"Ku complex interacts with and stimulates the Werner protein","volume":"14","author":"Cooper","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib39","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrmicro885","article-title":"Type IV pilus structure and bacterial pathogenicity","volume":"2","author":"Craig","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib40","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.molcel.2006.07.004","article-title":"Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions","volume":"23","author":"Craig","year":"2006","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib41","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1126\/science.278.5337.425","article-title":"The structure of nitric oxide synthase oxygenase domain and inhibitor complexes","volume":"278","author":"Crane","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib42","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1126\/science.279.5359.2121","article-title":"Structure of nitric oxide synthase oxygenase dimer with pterin and substrate","volume":"279","author":"Crane","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib43","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1093\/emboj\/18.22.6271","article-title":"N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization","volume":"18","author":"Crane","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib44","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrm805","article-title":"The Mre11 complex: at the crossroads of dna repair and checkpoint signalling","volume":"3","author":"D\u2019Amours","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib45","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.1523\/JNEUROSCI.17-22-08711.1997","article-title":"DNA replication and postreplication mismatch repair in cell-free extracts from cultured human neuroblastoma and fibroblast cells","volume":"17","author":"David","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib46","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S1097-2765(01)00381-1","article-title":"Human Rad50\/Mre11 is a flexible complex that can tether DNA ends","volume":"8","author":"de Jager","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib47","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1101\/gad.13.7.768","article-title":"Molecular mechanism of nucleotide excision repair","volume":"13","author":"de Laat","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib48","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s00415-003-0167-4","article-title":"MR evidence of structural and metabolic changes in brains of patients with Werner\u2019s syndrome","volume":"250","author":"De Stefano","year":"2003","journal-title":"J Neurol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib49","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1152\/physrev.1970.50.3.319","article-title":"Catalase: Physical and chemical properties, mechanism of catalysis, and physiological role","volume":"50","author":"Deisseroth","year":"1970","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib50","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1126\/science.8351519","article-title":"Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase","volume":"261","author":"Deng","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib51","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0022-2836(03)00889-1","article-title":"ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization","volume":"332","author":"DiDonato","year":"2003","journal-title":"J Mol Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib52","first-page":"1","article-title":"Protein folding and its links with human disease","author":"Dobson","year":"2001","journal-title":"Biochem Soc Symp"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib53","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00005072-199705000-00008","article-title":"Aggregation of mutant Cu\/Zn superoxide dismutase proteins in a culture model of ALS","volume":"56","author":"Durham","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib54","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0092-8674(95)90105-1","article-title":"The Bloom\u2019s syndrome gene product is homologous to RecQ helicases","volume":"83","author":"Ellis","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib55","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.molcel.2006.02.017","article-title":"Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair","volume":"22","author":"Fan","year":"2006","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib56","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.jmb.2006.02.073","article-title":"A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase","volume":"358","author":"Fan","year":"2006","journal-title":"J Mol Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib57","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1021\/bi010102h","article-title":"Multiple regions of subunit interaction in Drosophila mitochondrial DNA polymerase: three functional domains in the accessory subunit","volume":"40","author":"Fan","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib58","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/6675","article-title":"Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation","volume":"6","author":"Fischmann","year":"1999","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib59","first-page":"61","article-title":"Superoxide dismutases","volume":"58","author":"Fridovich","year":"1986","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib60","doi-asserted-by":"crossref","first-page":"37918","DOI":"10.1074\/jbc.M406204200","article-title":"Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase","volume":"279","author":"Garcin","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib61","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/14660820050515377","article-title":"Current status of SOD1 mutations in familial amyotrophic lateral sclerosis","volume":"1","author":"Gaudette","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib62","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/306287a0","article-title":"Electrostatic recognition between superoxide and copper, zinc superoxide dismutase","volume":"306","author":"Getzoff","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib63","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1002\/elps.1150181110","article-title":"Further genetic heterogeneity in acatalasemia","volume":"18","author":"Goth","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib64","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0047-6374(97)00111-5","article-title":"Hierarchical deterioration of body systems in Werner\u2019s syndrome: implications for normal ageing","volume":"98","author":"Goto","year":"1997","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib65","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/ng0997-100","article-title":"The Werner syndrome protein is a DNA helicase","volume":"17","author":"Gray","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib66","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1021\/bi049888k","article-title":"Role of hydrogen bonding in the active site of human manganese superoxide dismutase","volume":"43","author":"Greenleaf","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib67","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0092-8674(03)00162-4","article-title":"Chromosomal cohesin forms a ring","volume":"112","author":"Gruber","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib68","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1021\/bi972394l","article-title":"Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34","volume":"37","author":"Guan","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib69","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pneurobio.2005.06.001","article-title":"The physiology and pathophysiology of nitric oxide in the brain","volume":"76","author":"Guix","year":"2005","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib70","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0006-291X(05)81443-3","article-title":"Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines","volume":"181","author":"Hallewell","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2190001","article-title":"Oxygen toxicity, oxygen radicals, transition metals and disease","volume":"219","author":"Halliwell","year":"1984","journal-title":"Biochem J"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib72","doi-asserted-by":"crossref","first-page":"22686","DOI":"10.1074\/jbc.M213103200","article-title":"The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity","volume":"278","author":"Harrigan","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib73","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1074\/jbc.M311310200","article-title":"Amino acid substitution at the dimeric interface of human manganese superoxide dismutase","volume":"279","author":"Hearn","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib74","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1021\/bi0266481","article-title":"Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel","volume":"42","author":"Hearn","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib75","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrc1012","article-title":"RecQ helicases: caretakers of the genome","volume":"3","author":"Hickson","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib76","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1006\/bcmd.1995.0026","article-title":"A novel human catalase mutation (358 T->del) causing Japanese-type acatalasemia","volume":"21","author":"Hirono","year":"1995","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib77","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib78","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nature00922","article-title":"The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair","volume":"418","author":"Hopfner","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib79","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0959-440X(02)00297-X","article-title":"DNA double-strand break repair from head to tail","volume":"12","author":"Hopfner","year":"2002","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib80","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0092-8674(01)00335-X","article-title":"Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase","volume":"105","author":"Hopfner","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib81","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0092-8674(00)81789-4","article-title":"Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity","volume":"95","author":"Hosfield","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib82","doi-asserted-by":"crossref","first-page":"18379","DOI":"10.1073\/pnas.0509380102","article-title":"Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein","volume":"102","author":"Hu","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib83","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1093\/nar\/28.12.2396","article-title":"Characterization of the human and mouse WRN 3\u2032->5\u2032 exonuclease","volume":"28","author":"Huang","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib84","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/2410","article-title":"The premature ageing syndrome protein, WRN, is a 3\u2032->5\u2032 exonuclease","volume":"20","author":"Huang","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib85","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00019052-200102000-00014","article-title":"Cerebral ischemia and inflammation","volume":"14","author":"Iadecola","year":"2001","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib86","doi-asserted-by":"crossref","first-page":"31761","DOI":"10.1074\/jbc.M203792200","article-title":"p52 Mediates XPB function within the transcription\/repair factor TFIIH","volume":"277","author":"Jawhari","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib87","doi-asserted-by":"crossref","first-page":"12571","DOI":"10.1073\/pnas.220417997","article-title":"Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis","volume":"97","author":"Johnston","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib88","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.biochem.72.121801.161455","article-title":"DNA polymerase gamma, the mitochondrial replicase","volume":"73","author":"Kaguni","year":"2004","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib89","doi-asserted-by":"crossref","first-page":"18291","DOI":"10.1074\/jbc.M111523200","article-title":"Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation","volume":"277","author":"Karmakar","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib90","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1093\/nar\/gkf482","article-title":"Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus","volume":"30","author":"Karmakar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib91","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0960-9822(99)80264-4","article-title":"Oligomeric ring structure of the Bloom\u2019s syndrome helicase","volume":"9","author":"Karow","year":"1999","journal-title":"Curr Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib92","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s004010000355","article-title":"Copper chaperone for superoxide dismutase co-aggregates with superoxide dismutase 1 (SOD1) in neuronal Lewy body-like hyaline inclusions: an immunohistochemical study on familial amyotrophic lateral sclerosis with SOD1 gene mutation","volume":"102","author":"Kato","year":"2001","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib93","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/85798","article-title":"DNA double-strand breaks: signaling, repair and the cancer connection","volume":"27","author":"Khanna","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib94","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1093\/nar\/gkl538","article-title":"Sit down, relax and unwind: structural insights into RecQ helicase mechanisms","volume":"34","author":"Killoran","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib95","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1126\/science.288.5470.1418","article-title":"Mechanism of ATP-dependent promoter melting by transcription factor IIH","volume":"288","author":"Kim","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib96","doi-asserted-by":"crossref","first-page":"31814","DOI":"10.1074\/jbc.M303267200","article-title":"Nitric-oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity","volume":"278","author":"Knudsen","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib97","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1750-3639.1999.tb00211.x","article-title":"Oxidative stress in bacterial meningitis","volume":"9","author":"Koedel","year":"1999","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib98","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1086\/426001","article-title":"Complex genetics of amyotrophic lateral sclerosis","volume":"75","author":"Kunst","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib99","doi-asserted-by":"crossref","first-page":"37795","DOI":"10.1074\/jbc.274.53.37795","article-title":"The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I","volume":"274","author":"Lebel","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mad.2004.09.011","article-title":"Pathways and functions of the Werner syndrome protein","volume":"126","author":"Lee","year":"2005","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib101","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.biochi.2003.09.010","article-title":"DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy","volume":"85","author":"Lehmann","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib102","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.289.5482.1190","article-title":"Twists in catalysis: alternating conformations of Escherichia coli thioredoxin reductase","volume":"289","author":"Lennon","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib103","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.1021\/bi9929958","article-title":"Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis","volume":"39","author":"Leveque","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib104","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nsb894","article-title":"Extensive conformational sampling in a ternary electron transfer complex","volume":"10","author":"Leys","year":"2003","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib105","doi-asserted-by":"crossref","first-page":"39800","DOI":"10.1074\/jbc.C000289200","article-title":"Functional interaction between Ku and the Werner syndrome protein in DNA end processing","volume":"275","author":"Li","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib106","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1074\/jbc.M008575200","article-title":"Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70\/80 complex","volume":"276","author":"Li","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib107","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1093\/nar\/gkf488","article-title":"Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein","volume":"30","author":"Li","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib108","doi-asserted-by":"crossref","first-page":"13659","DOI":"10.1074\/jbc.M311606200","article-title":"Identification and biochemical characterization of a Werner\u2019s syndrome protein complex with Ku70\/80 and poly(ADP-ribose) polymerase-1","volume":"279","author":"Li","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib109","doi-asserted-by":"crossref","first-page":"13868","DOI":"10.1021\/bi020417c","article-title":"The novel binding mode of N-alkyl-N\u2032-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis","volume":"41","author":"Li","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib110","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng1295-376","article-title":"Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase","volume":"11","author":"Li","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib111","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0969-2126(00)88346-X","article-title":"The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins","volume":"7","author":"Liu","year":"1999","journal-title":"Structure"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib112","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.1073\/pnas.96.13.7376","article-title":"Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation","volume":"96","author":"Luo","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib113","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0169-328X(97)00311-2","article-title":"Expression of long-patch and short-patch DNA mismatch repair proteins in the embryonic and adult mammalian brain","volume":"53","author":"Marietta","year":"1998","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib114","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ng0897-335","article-title":"Impaired nuclear localization of defective DNA helicases in Werner\u2019s syndrome","volume":"16","author":"Matsumoto","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib115","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0968-0004(97)01147-X","article-title":"Biosynthesis and action of nitric oxide in mammalian cells","volume":"22","author":"Mayer","year":"1997","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib116","doi-asserted-by":"crossref","first-page":"14234","DOI":"10.1016\/S0021-9258(18)77291-8","article-title":"Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine","volume":"265","author":"McRee","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib117","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.280.5361.301","article-title":"Rejoining of DNA by the RAG1 and RAG2 proteins","volume":"280","author":"Melek","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib118","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ng0298-159","article-title":"A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase","volume":"18","author":"Melov","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib119","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/bbrc.1999.1643","article-title":"Rapid kinetic studies of electron transfer in the three isoforms of nitric oxide synthase","volume":"265","author":"Miller","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib120","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/oxfordjournals.jbchem.a021471","article-title":"Identification of a novel growth-promoting factor with a wide target cell spectrum from various tumor cells as catalase","volume":"120","author":"Miyamoto","year":"1996","journal-title":"J Biochem (Tokyo)"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib121","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0092-8674(95)90467-0","article-title":"Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA","volume":"82","author":"Mol","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib122","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1093\/nar\/25.24.5110","article-title":"The proofreading domain of Escherichia coli DNA polymerase I and other DNA and\/or RNA exonuclease domains","volume":"25","author":"Moser","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib123","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/nar\/28.2.648","article-title":"WRN helicase expression in Werner syndrome cell lines","volume":"28","author":"Moser","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuroscience.2006.10.045_bib124","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1073\/pnas.94.11.5831","article-title":"Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs","volume":"94","author":"Mushegian","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib125","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/BF00341449","article-title":"Isolation and genetic characterization of a thymineless death-resistant mutant of Escherichia coli K12: identification of a new mutation (recQ1) that blocks the RecF recombination pathway","volume":"195","author":"Nakayama","year":"1984","journal-title":"Mol Gen Genet"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib126","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/35037509","article-title":"Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA","volume":"407","author":"Obmolova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib127","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1097\/00005537-200309000-00034","article-title":"Molecular disruption of the MRN(95) complex induces radiation sensitivity in head and neck cancer","volume":"113","author":"O\u2019Malley","year":"2003","journal-title":"Laryngoscope"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib128","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/carcin\/bgg034","article-title":"Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process","volume":"24","author":"Opresko","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib129","doi-asserted-by":"crossref","first-page":"44677","DOI":"10.1074\/jbc.M107548200","article-title":"Coordinate action of the helicase and 3\u2032 to 5\u2032 exonuclease of Werner syndrome protein","volume":"276","author":"Opresko","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib130","doi-asserted-by":"crossref","first-page":"41110","DOI":"10.1074\/jbc.M205396200","article-title":"Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases","volume":"277","author":"Opresko","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib131","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1093\/nar\/29.9.1926","article-title":"A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA","volume":"29","author":"Orren","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib132","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.mrfmmm.2005.03.020","article-title":"Current advances in unraveling the function of the Werner syndrome protein","volume":"577","author":"Ozgenc","year":"2005","journal-title":"Mutat Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib133","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/46972","article-title":"Natural engineering principles of electron tunnelling in biological oxidation-reduction","volume":"402","author":"Page","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib134","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1073\/pnas.89.13.6109","article-title":"Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase","volume":"89","author":"Parge","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib135","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0960-9822(00)00610-2","article-title":"A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage","volume":"10","author":"Paull","year":"2000","journal-title":"Curr Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib136","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nature01230","article-title":"Insights into DNA recombination from the structure of a RAD51-BRCA2 complex","volume":"420","author":"Pellegrini","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib137","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nsmb1088","article-title":"WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing","volume":"13","author":"Perry","year":"2006","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib138","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1006\/jmbi.1999.3458","article-title":"Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism","volume":"296","author":"Putnam","year":"2000","journal-title":"J Mol Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib139","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1006\/jmbi.1999.2605","article-title":"Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase","volume":"287","author":"Putnam","year":"1999","journal-title":"J Mol Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib140","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.dnarep.2005.08.007","article-title":"Protein mimicry of DNA and pathway regulation","volume":"4","author":"Putnam","year":"2005","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib141","doi-asserted-by":"crossref","first-page":"47551","DOI":"10.1074\/jbc.M207356200","article-title":"Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis","volume":"277","author":"Rakhit","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib142","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.pharmthera.2005.04.010","article-title":"New and future migraine therapy","volume":"112","author":"Ramadan","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib143","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0092-8674(00)81718-3","article-title":"Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center","volume":"95","author":"Raman","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib144","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.molstruc.2005.10.054","article-title":"Kinetic and structural characterization of human manganese superoxide dismutase containing 3-fluorotyrosines","volume":"3","author":"Ren","year":"2006","journal-title":"J Mol Struct 1\u2013"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib145","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1021\/cr000661e","article-title":"Intrinsic and extrinsic modulation of nitric oxide synthase activity","volume":"102","author":"Roman","year":"2002","journal-title":"Chem Rev"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib146","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib147","doi-asserted-by":"crossref","first-page":"13915","DOI":"10.1021\/bi026313j","article-title":"Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency","volume":"41","author":"Rosenfeld","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib148","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-2443.2001.00433.x","article-title":"Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51","volume":"6","author":"Sakamoto","year":"2001","journal-title":"Genes Cells"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib149","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1073\/pnas.90.13.6335","article-title":"DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions","volume":"90","author":"Satoh","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib150","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nsb0995-752","article-title":"Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex","volume":"2","author":"Savva","year":"1995","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib151","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.8465201","article-title":"DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor","volume":"260","author":"Schaeffer","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib152","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0092-8674(00)00082-9","article-title":"Molecular structure of human TFIIH","volume":"102","author":"Schultz","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib153","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1073\/pnas.96.5.1863","article-title":"Structure of a cytochrome P450-redox partner electron-transfer complex","volume":"96","author":"Sevrioukova","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib154","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2174\/1568011053765985","article-title":"DNA helicases as targets for anti-cancer drugs","volume":"5","author":"Sharma","year":"2005","journal-title":"Curr Med Chem Anticancer Agents"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib155","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1042\/BJ20060450","article-title":"Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability","volume":"398","author":"Sharma","year":"2006","journal-title":"Biochem J"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib156","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1093\/nar\/26.12.2879","article-title":"Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A","volume":"26","author":"Shen","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib157","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00005072-199604000-00011","article-title":"Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement","volume":"55","author":"Shibata","year":"1996","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib158","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1093\/emboj\/cdg429","article-title":"Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2","volume":"22","author":"Shin","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib159","doi-asserted-by":"crossref","first-page":"7309","DOI":"10.1074\/jbc.271.13.7309","article-title":"Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains","volume":"271","author":"Siddhanta","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib160","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0076-6879(02)49321-4","article-title":"Catalytic pathway of manganese superoxide dismutase by direct observation of superoxide","volume":"349","author":"Silverman","year":"2002","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib161","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0014-5793(01)02486-3","article-title":"Protein misfolding and disease: protein refolding and therapy","volume":"498","author":"Soto","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib162","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0959-440X(99)00059-7","article-title":"DNA helicases: \u2018inching forward.\u2019","volume":"10","author":"Soultanas","year":"2000","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib163","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0968-0004(00)01734-5","article-title":"Unwinding the \u2018Gordian knot\u2019 of helicase action","volume":"26","author":"Soultanas","year":"2001","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib164","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.dnarep.2004.03.014","article-title":"The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together","volume":"3","author":"Stracker","year":"2004","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib165","doi-asserted-by":"crossref","first-page":"11365","DOI":"10.1073\/pnas.97.21.11365","article-title":"Werner protein recruits DNA polymerase delta to the nucleolus","volume":"97","author":"Szekely","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib166","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2174\/1568026054679281","article-title":"An introduction to NO-related therapeutic agents","volume":"5","author":"Thatcher","year":"2005","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib167","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/156720506777632925","article-title":"NO chimeras as therapeutic agents in Alzheimer\u2019s disease","volume":"3","author":"Thatcher","year":"2006","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib168","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1097-2765(00)80177-X","article-title":"Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7","volume":"3","author":"Tirode","year":"1999","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib169","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1179\/016164104225016236","article-title":"Nitric oxide pathways in Alzheimer\u2019s disease and other neurodegenerative dementias","volume":"26","author":"Togo","year":"2004","journal-title":"Neurol Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib170","doi-asserted-by":"crossref","unstructured":"Tsutakawa SE. H, GL, Frankel KA, Cooper PK, Tainer JA (2006) Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography. J Struct Biol [Epub ahead of print], doi: 10.1016\/j.jsb.2006.09.008.","DOI":"10.1016\/j.jsb.2006.09.008"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib171","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/sj.embor.embor925","article-title":"The MRN complex: coordinating and mediating the response to broken chromosomes","volume":"4","author":"van den Bosch","year":"2003","journal-title":"EMBO Rep"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib172","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/1521-4141(200203)32:3<701::AID-IMMU701>3.0.CO;2-T","article-title":"Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells","volume":"32","author":"Verkaik","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib173","doi-asserted-by":"crossref","unstructured":"Vignini A, Nanetti L, Moroni C, Tanase L, Bartolini M, Luzzi S, Provinciali L, Mazzanti L (2006) Modifications of platelet from Alzheimer disease patients: A possible relation between membrane properties and NO metabolites. Neurobiol Aging, in press.","DOI":"10.1016\/j.neurobiolaging.2006.05.010"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib174","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1242\/jcs.00076","article-title":"A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949\u20131092","volume":"115","author":"von Kobbe","year":"2002","journal-title":"J Cell Sci"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib175","doi-asserted-by":"crossref","first-page":"8601","DOI":"10.1128\/MCB.23.23.8601-8613.2003","article-title":"Central role for the Werner syndrome protein\/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage","volume":"23","author":"von Kobbe","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib176","doi-asserted-by":"crossref","first-page":"52997","DOI":"10.1074\/jbc.M308338200","article-title":"Werner syndrome protein contains three structure-specific DNA binding domains","volume":"278","author":"von Kobbe","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib177","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1093\/nar\/gkh721","article-title":"Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein","volume":"32","author":"von Kobbe","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib178","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/genetics\/154.1.357","article-title":"Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene","volume":"154","author":"Wang","year":"2000","journal-title":"Genetics"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib179","doi-asserted-by":"crossref","first-page":"8411","DOI":"10.1073\/pnas.94.16.8411","article-title":"Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes","volume":"94","author":"Wang","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib180","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1357-4310(00)01761-5","article-title":"Protein aggregation in Huntington\u2019s and Parkinson\u2019s disease: implications for therapy","volume":"6","author":"Wanker","year":"2000","journal-title":"Mol Med Today"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib181","first-page":"320","article-title":"A mutation in the XPB\/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy","volume":"60","author":"Weeda","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib182","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.molcel.2005.07.006","article-title":"A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks","volume":"19","author":"Williams","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib183","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nsmb928","article-title":"The Rad50 hook domain is a critical determinant of Mre11 complex functions","volume":"12","author":"Wiltzius","year":"2005","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib184","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1126\/science.1056154","article-title":"Human DNA repair genes","volume":"291","author":"Wood","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib185","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1093\/nar\/25.15.2985","article-title":"Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells","volume":"25","author":"Xiao","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib186","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1021\/bi0157161","article-title":"A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3\u2032- 5\u2032 exonuclease and 5\u2032-protruding strand endonuclease activities","volume":"41","author":"Xue","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib187","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0891-5849(98)00203-2","article-title":"Resistance to nitric oxide-mediated apoptosis in HL-60 variant cells is associated with increased activities of Cu,Zn-superoxide dismutase and catalase","volume":"26","author":"Yabuki","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib188","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1074\/jbc.M509730200","article-title":"Functional human mitochondrial DNA polymerase gamma forms a heterotrimer","volume":"281","author":"Yakubovskaya","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib189","doi-asserted-by":"crossref","first-page":"38242","DOI":"10.1074\/jbc.M101913200","article-title":"Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase","volume":"276","author":"Yannone","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib190","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1126\/science.272.5259.258","article-title":"Positional cloning of the Werner\u2019s syndrome gene","volume":"272","author":"Yu","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib191","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s11910-003-0026-9","article-title":"Mitochondrial disorders","volume":"3","author":"Zeviani","year":"2003","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib192","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.cr.7310007","article-title":"The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control","volume":"16","author":"Zhang","year":"2006","journal-title":"Cell Res"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib193","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/33612","article-title":"Electron transfer by domain movement in cytochrome bc1","volume":"392","author":"Zhang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib194","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0960-9822(01)00019-7","article-title":"Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice","volume":"11","author":"Zhu","year":"2001","journal-title":"Curr Biol"},{"key":"10.1016\/j.neuroscience.2006.10.045_bib195","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1111\/j.1530-0277.1998.tb03958.x","article-title":"Distribution and kinetics of ethanol metabolism in rat brain","volume":"22","author":"Zimatkin","year":"1998","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452206013893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452206013893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T01:50:45Z","timestamp":1683683445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452206013893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":195,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0306452206013893"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2006.10.045","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}