{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:38:52Z","timestamp":1774867132505,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009873","name":"Regione Autonoma della Sardegna","doi-asserted-by":"publisher","award":["12023"],"award-info":[{"award-number":["12023"]}],"id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.neuroscience.2007.02.059","type":"journal-article","created":{"date-parts":[[2007,4,17]],"date-time":"2007-04-17T07:17:21Z","timestamp":1176794241000},"page":"1289-1301","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Proteinase-activated receptors 1 and 2 in rat olfactory system: Layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons"],"prefix":"10.1016","volume":"146","author":[{"given":"M.C.","family":"Olianas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dedoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Onali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2007.02.059_bib1","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1126\/science.2255909","article-title":"Identification of a specialized adenylyl cyclase that may mediate odorant detection","volume":"250","author":"Bakalyar","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1523\/JNEUROSCI.03-01-00069.1983","article-title":"Transneuronal regulation of tyrosine hydroxylase expression in olfactory bulb of mouse and rat","volume":"3","author":"Baker","year":"1983","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib3","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1152\/jn.1994.71.6.2557","article-title":"Evidence for glutamate as the olfactory receptor cell neurotransmitter","volume":"71","author":"Berkowicz","year":"1994","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1189\/jlb.0702351","article-title":"Expression and functional responses of protease-activated receptors on human eosinophils","volume":"74","author":"Bolton","year":"2003","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/0006-8993(95)00332-K","article-title":"Exogenous thrombin inhibits neuritogenesis in cultured neuroblastoma cells but not in rat hippocampal neurons","volume":"683","author":"Brewer","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib6","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1111\/j.1471-4159.1990.tb01228.x","article-title":"Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1","volume":"54","author":"Cavanaugh","year":"1990","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib7","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1111\/j.1471-4159.1992.tb10958.x","article-title":"Concerted CMP-dependent [3H]inositol labeling of phosphoinositides and agonist activation of phospholipase C in rat brain cortical membranes","volume":"58","author":"Claro","year":"1992","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib8","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/35025229","article-title":"Thrombin signalling and protease-activated receptors","volume":"407","author":"Coughlin","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib9","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0306-4522(97)00317-5","article-title":"Involvement of protease-activated receptor-1 in the in vitro development of mesencephalic dopaminergic neurons","volume":"82","author":"Debeir","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib10","doi-asserted-by":"crossref","first-page":"21699","DOI":"10.1016\/S0021-9258(17)31862-8","article-title":"A Chinese hamster fibroblast mutant defective in thrombin-induced signalling has a low level of phospholipase C-\u03b21","volume":"269","author":"Fee","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib11","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1097\/00001756-199705260-00031","article-title":"Glutamatergic deafferentation of olfactory bulb modulates the expression of mGluR1a mRNA","volume":"8","author":"Ferraris","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0006-8993(98)00344-8","article-title":"Thrombin induced inhibition of neurite outgrowth from dorsal root ganglion neurons","volume":"797","author":"Gill","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib13","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1523\/JNEUROSCI.20-12-04582.2000","article-title":"Potentiation of NMDA receptor function by the serine protease thrombin","volume":"20","author":"Gingrich","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib14","series-title":"Neuronal plasticity","first-page":"131","article-title":"The olfactory system: a model for the study of neurogenesis and axon regeneration in mammals","author":"Graziadei","year":"1978"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib15","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1073\/pnas.85.10.3440","article-title":"Thrombin modulates and reverses neuroblastoma neurite outgrowth","volume":"85","author":"Gurwitz","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib16","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/jnnp.62.5.436","article-title":"Olfactory dysfunction in Parkinson\u2019s disease","volume":"62","author":"Hawkes","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.lfs.2003.09.010","article-title":"Proteinase-mediated signalling: proteinase-activated receptors (PARs) and much more","volume":"74","author":"Hollenberg","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1083\/jcb.118.2.411","article-title":"Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers","volume":"118","author":"Jalink","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib19","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.126.3.801","article-title":"Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho","volume":"126","author":"Jalink","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrn753","article-title":"The molecular basis of CaMKII function in synaptic and behavioural memory","volume":"3","author":"Lisman","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nrn1867","article-title":"Adult neurogenesis and functional plasticity in neuronal circuits","volume":"7","author":"Lledo","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib22","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/0166-2236(85)90192-4","article-title":"Olfactory marker protein: from PAGE band to cDNA clone","volume":"8","author":"Margolis","year":"1985","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0006-8993(74)90844-0","article-title":"Denervation in the primary olfactory pathway of mice: biochemical and morphological effects","volume":"81","author":"Margolis","year":"1974","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0031-6997(24)01493-5","article-title":"Proteinase-activated receptors","volume":"53","author":"McFarlane","year":"2001","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib25","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1124\/jpet.103.064584","article-title":"2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist","volume":"309","author":"McGuire","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib26","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1161\/01.ATV.18.5.825","article-title":"Differential expression of functional protease-activated receptor-2 (PAR-2) in human vascular smooth muscle cells","volume":"18","author":"Molino","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib27","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1046\/j.1460-9568.1998.00183.x","article-title":"Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion","volume":"10","author":"Niclou","year":"1998","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib28","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nrn1255","article-title":"Proteinase-activated receptors in the nervous system","volume":"4","author":"Noorbakhsh","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib29","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.bjp.0702349","article-title":"GABAB receptor-mediated stimulation of adenylyl cyclase activity in membranes of rat olfactory bulb","volume":"126","author":"Olianas","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib30","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/sj.bjp.0705951","article-title":"G protein activation and cyclic AMP potentiation by naloxone benzohylhydrazone in distinct layers of rat olfactory bulb","volume":"143","author":"Onali","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib31","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1046\/j.1471-4159.2001.00371.x","article-title":"Dual coupling of opioid receptor-like (ORL1) receptors to adenylyl cyclase in the different layers of the rat main olfactory bulb","volume":"77","author":"Onali","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib32","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1152\/physrev.00028.2003","article-title":"Protease-activated receptors: contribution to physiology and disease","volume":"84","author":"Ossovskaya","year":"2004","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neures.2005.09.007","article-title":"Evidence that protease-activated receptor-2 mediates trypsin-induced reversal of stellation in cultured rat astrocytes","volume":"54","author":"Park","year":"2006","journal-title":"Neurosci Res"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib34","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0896-6273(88)90188-2","article-title":"Detection of glia-derived nexin in the olfactory system of the rat","volume":"1","author":"Reinhard","year":"1988","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib35","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/emboj\/18.3.578","article-title":"Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton","volume":"18","author":"Ren","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tips.2005.01.007","article-title":"Receptors coupled to heterotrimeric G proteins of the G12 family","volume":"26","author":"Riobo","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib37","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/1073858404269955","article-title":"Protease-activated receptors in neuronal development, neurodegeneration, and neuroprotection: thrombin as signaling molecule in the brain","volume":"10","author":"Rohatgi","year":"2004","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib38","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1523\/JNEUROSCI.11-05-01243.1991","article-title":"Primary culture of neonatal rat olfactory neurons","volume":"11","author":"Ronnett","year":"1991","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000147301","article-title":"Differential localization of G proteins, Gi and Go, in the olfactory epithelium and the main olfactory bulb of the rat","volume":"144","author":"Shinohara","year":"1992","journal-title":"Acta Anat"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib40","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.1523\/JNEUROSCI.15-08-05840.1995","article-title":"Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury","volume":"15","author":"Smith-Swintosky","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib41","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1046\/j.1471-4159.1997.69051890.x","article-title":"Protease-activated receptor-2 (PAR-2) is present in the rat hippocampus and is associated with neurodegeneration","volume":"69","author":"Smith-Swintosky","year":"1997","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2003-0025","article-title":"Proteinase-activated receptors: transducers of proteinase-mediated signalling in inflammation and immune response","volume":"26","author":"Steinhoff","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib43","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.0953-816x.2001.01676.x","article-title":"Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia","volume":"14","author":"Striggow","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib44","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0896-6273(92)90302-T","article-title":"Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors","volume":"8","author":"Suidan","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib45","doi-asserted-by":"crossref","first-page":"47438","DOI":"10.1074\/jbc.M408846200","article-title":"A novel G\u03b1q\/11-selective inhibitor","volume":"279","author":"Takasaki","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib46","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/337736a0","article-title":"Pathological changes in olfactory neurons in patients with Alzheimer\u2019s disease","volume":"337","author":"Talamo","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib47","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1523\/JNEUROSCI.15-07-05389.1995","article-title":"Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults","volume":"15","author":"Vaughan","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib48","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0165-6147(00)01634-5","article-title":"Protease-activated receptors in inflammation, neuronal signalling and pain","volume":"22","author":"Vergnolle","year":"2001","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib49","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0896-6273(00)80561-9","article-title":"Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in neurons: a mechanism for attenuation of olfactory signals","volume":"21","author":"Wei","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib50","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1523\/JNEUROSCI.15-04-02906.1995","article-title":"Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA","volume":"15","author":"Weinstein","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.02.059_bib51","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0896-6273(00)00060-X","article-title":"Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice","volume":"27","author":"Wong","year":"2000","journal-title":"Neuron"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452207002412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452207002412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T07:37:15Z","timestamp":1754465835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452207002412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0306452207002412"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2007.02.059","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteinase-activated receptors 1 and 2 in rat olfactory system: Layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2007.02.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 IBRO. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}