{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:42:24Z","timestamp":1791355344147,"version":"4.3.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.neuroscience.2007.04.035","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T12:49:58Z","timestamp":1180097398000},"page":"522-531","source":"Crossref","is-referenced-by-count":50,"title":["Decreased heat tolerance is associated with hypothalamo\u2013pituitary\u2013adrenocortical axis impairment"],"prefix":"10.1016","volume":"147","author":[{"given":"V.","family":"Michel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Peinnequin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Buguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cespuglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Canini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2007.04.035_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0361-9230(97)00303-1","article-title":"Stress-induced stimulation of pituitary POMC gene expression is associated with activation of transcription factor AP-1 in hypothalamus and pituitary","volume":"45","author":"Autelitano","year":"1998","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1042\/cs0940557","article-title":"Anti-inflammatory actions of glucocorticoids: molecular mechanisms","volume":"94","author":"Barnes","year":"1998","journal-title":"Clin Sci"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib3","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1056\/NEJMra011089","article-title":"Heat stroke","volume":"346","author":"Bouchama","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib4","first-page":"97","article-title":"Colonic temperature of rats during handling","volume":"20","author":"Briese","year":"1970","journal-title":"Acta Physiol Lat Am"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/bbrc.2000.2311","article-title":"HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state","volume":"269","author":"Calabrese","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1365-2826.1997.00593.x","article-title":"Neuroendocrine and behavioral responses and brain pattern of c-fos induction associated with audiogenic stress","volume":"9","author":"Campeau","year":"1997","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1152\/ajpregu.00675.2005","article-title":"Activation of spinally projecting and nitrergic neurons in the PVN following heat exposure","volume":"291","author":"Cham","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib8","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1523\/JNEUROSCI.13-12-05126.1993","article-title":"A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry","volume":"13","author":"Chan","year":"1993","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1042\/CS20030263","article-title":"Effect of hypervolaemic haemodilution on cerebral glutamate, glycerol, lactate and free radicals in heatstroke rats","volume":"106","author":"Chang","year":"2004","journal-title":"Clin Sci"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0361-9230(00)00231-8","article-title":"Induction and adaptation of Fos expression in the rat brain by two types of acute restraint stress","volume":"52","author":"Chowdhury","year":"2000","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0022-2275(20)41207-6","article-title":"In vivo regulation of lipolysis in humans","volume":"35","author":"Coppack","year":"1994","journal-title":"J Lipid Res"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/abbi.1997.0109","article-title":"Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress","volume":"342","author":"Crawford","year":"1997","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib13","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0031-9384(89)90097-8","article-title":"Plasma corticosterone response in continuous versus discontinuous chronic heat exposure in rat","volume":"45","author":"Cur\u00e9","year":"1988","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.33549\/physiolres.930273","article-title":"Different activation of ACTH and corticosterone release in response to various stressors in rats","volume":"52","author":"Djordjevic","year":"2003","journal-title":"Physiol Res"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib15","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/j.1365-2826.2004.01257.x","article-title":"Fos expression is selectively and differentially regulated by endogenous glucocorticoids in the paraventricular nucleus of the hypothalamus and the dentate gyrus","volume":"16","author":"Fevurly","year":"2004","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib16","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1046\/j.1365-2826.2003.01100.x","volume":"15","author":"Ginsberg","year":"2003","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib17","doi-asserted-by":"crossref","DOI":"10.1152\/jappl.1991.70.4.1821","article-title":"Splanchnic sympathetic nerve activity and circulating catecholamines in the hyperthermic rat","volume":"70","author":"Gisolfi","year":"1991","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.brainresbull.2003.07.001","article-title":"Differences in hypothalamic Fos expressions between two heat stress conditions in conscious mice","volume":"61","author":"Harikai","year":"2003","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib19","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1210\/me.6.7.1061","article-title":"Rapid regulation of corticotropin-releasing hormone gene transcription in vivo","volume":"6","author":"Herman","year":"1992","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/frne.1993.1006","article-title":"c-Fos and related immediate early gene products as markers of activity in neuroendocrine systems","volume":"14","author":"Hoffman","year":"1993","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1172\/JCI118026","article-title":"Stress-induced activation of neuronal activity and corticotropin-releasing factor gene expression in the paraventricular nucleus is modulated by glucocorticoids in rats","volume":"96","author":"Imaki","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib22","first-page":"367","article-title":"Regulation of the TNF-a gene","volume":"388","author":"Jongeneel","year":"1994","journal-title":"Prog Clin Biol Res"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1152\/jappl.1991.71.1.192","article-title":"Mechanism for pressor response to nonexertional heating in the conscious rat","volume":"71","author":"Kregel","year":"1991","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib24","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1152\/japplphysiol.01040.2005","article-title":"Time course of cytokine, corticosterone and tissue injury response in mice during heat strain recovery","volume":"100","author":"Leon","year":"2006","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.physbeh.2004.10.023","article-title":"Tyrosine prevents effects of hyperthermia on behavior and increases norepinephrine","volume":"84","author":"Lieberman","year":"2005","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib26","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0891-5849(03)00358-7","article-title":"Oxidative and calcium stress regulate DSR1 (Adapt78\/MCIP1) protein","volume":"35","author":"Lin","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib27","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1749-6632.1997.tb51748.x","article-title":"Heatstroke-induced cerebral ischemia and neuronal damage","volume":"813","author":"Lin","year":"1997","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib28","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0361-9230(95)00046-H","article-title":"Interleukin-1 receptor antagonist attenuates the heat stroke-induced neuronal damage by reducing the cerebral ischemia in rats","volume":"37","author":"Lin","year":"1995","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0306-4565(99)00069-8","article-title":"C-fos expression in rat brain during heat stress","volume":"24","author":"Lin","year":"1999","journal-title":"J Therm Biol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212DDCT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib31","first-page":"315","article-title":"Stressed or stressed out: what is the difference?","volume":"30","author":"McEwen","year":"2005","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib32","first-page":"1703","article-title":"Plasma hyperosmolality and arterial pressure regulation during heating in dehydrated and awake rats","volume":"275","author":"Nakajima","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0031-9384(87)90408-2","article-title":"Adrenal hormonal indices of stress in laboratory rats","volume":"39","author":"Natelson","year":"1986","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib34","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1152\/jappl.1975.38.4.724","article-title":"Prediction of survival time of rats in severe heat","volume":"38","author":"Ohara","year":"1975","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib35","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1111\/j.1460-9568.2005.04354.x","article-title":"Immediate-early gene induction in hippocampus and cortex as a result of novel experience is not directly related to the stressfulness of that experience","volume":"22","author":"Pace","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2172-5-3","article-title":"Rat pro-inflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green","volume":"5","author":"Peinnequin","year":"2004","journal-title":"BMC Immunol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib37","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1523\/JNEUROSCI.20-17-06473.2000","article-title":"Induction of IkBa mRNA expression in the brain by glucocorticoids: a negative feedback mechanism for immune-to-brain signaling","volume":"20","author":"Quan","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib38","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1053\/meta.2002.33353","article-title":"Immobilization stress alters intermediate metabolism and circulating lipoproteins in the rat","volume":"51","author":"Ricart-Jan\u00e9","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1050-1738(02)00188-3","article-title":"The role of modulatory calcineurin-interacting proteins in calcineurin signaling","volume":"13","author":"Rothermel","year":"2003","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1126\/science.270.5234.283","article-title":"Role of transcriptional activation of IkBa in mediation of immunosuppression by glucocorticoids","volume":"270","author":"Scheinman","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib41","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1136\/bmj.1.4667.1383","article-title":"Stress and the general adaptation syndrome","volume":"17","author":"Selye","year":"1950","journal-title":"BMJ"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0168-0102(97)00095-3","article-title":"Stress-induced expression of immediate early genes in the rat brain and peripheral organs of the rat","volume":"29","author":"Senba","year":"1997","journal-title":"Neurosci Res"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib43","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0896-6273(90)90106-P","article-title":"The regulation and function of c-fos and other immediate early genes in the nervous system","volume":"4","author":"Sheng","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib44","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.mad.2004.06.010","article-title":"Mechanisms of glucocorticoid receptor signaling during inflammation","volume":"125","author":"Smoak","year":"2004","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3940(99)00030-0","article-title":"Heatstroke induces c-fos expression in the rat hypothalamus","volume":"262","author":"Tsay","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib46","series-title":"Genome Biol 3:RESEARCH0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","author":"Vandesompele","year":"2002"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib47","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0024-3205(99)00095-8","article-title":"Dynamic regulation of the proinflammatory cytokine, interleukin-1\u03b2: molecular biology for non-molecular biologists","volume":"65","author":"Watkins","year":"1999","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib48","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1152\/physrev.1992.72.4.1063","article-title":"Mammalian stress response: cell physiology, structure\/function of stress proteins, and implications for medicine and disease","volume":"72","author":"Welch","year":"1992","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib49","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.physbeh.2004.02.030","article-title":"Reduced thirst in old, thermally dehydrated rats","volume":"81","author":"Whyte","year":"2004","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib50","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1172\/JCI119425","article-title":"Stress response decreases NF-kB nuclear translocation and increases I-kBa expression in A549 cells","volume":"99","author":"Wong","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib51","first-page":"1","article-title":"Heat shock activates the I-kBa promoter and increases I-kBa mRNA expression","volume":"4","author":"Wong","year":"1999","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1152\/jappl.1977.43.1.59","article-title":"Colonic heating patterns and the variation of thermal resistance among rats","volume":"43","author":"Wright","year":"1977","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neuroscience.2007.04.035_bib53","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1152\/jappl.1991.71.6.2434","article-title":"Heat stress and thermal dehydration: lactatemia and plasma volume regulation","volume":"71","author":"Zurovski","year":"1991","journal-title":"J Appl Physiol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452207005386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452207005386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T15:01:37Z","timestamp":1707922897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452207005386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0306452207005386"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2007.04.035","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}