{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:09:07Z","timestamp":1789193347911,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.neuroscience.2007.07.033","type":"journal-article","created":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T11:27:28Z","timestamp":1185881248000},"page":"159-167","source":"Crossref","is-referenced-by-count":35,"title":["Upregulation of BNIP3 and translocation to mitochondria mediates cyanide-induced apoptosis in cortical cells"],"prefix":"10.1016","volume":"150","author":[{"given":"K.","family":"Prabhakaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Borowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.E.","family":"Isom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2007.07.033_bib1","doi-asserted-by":"crossref","first-page":"33939","DOI":"10.1074\/jbc.M605819200","article-title":"Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death","volume":"281","author":"An","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib2","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1084\/jem.186.12.1975","article-title":"The E1B 19K Bcl-2 binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis","volume":"186","author":"Chen","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1074\/jbc.274.1.7","article-title":"Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins","volume":"274","author":"Chen","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib4","doi-asserted-by":"crossref","first-page":"36027","DOI":"10.1074\/jbc.M304854200","article-title":"Production of reactive oxygen species by mitochondria: Central role of complex III","volume":"278","author":"Chen","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/01.RES.0000030195.38795.CF","article-title":"Hypoxia, BNip3 proteins, and the mitochondrial death pathway in cardiomyocytes","volume":"91","author":"Crow","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1083\/jcb.143.1.207","article-title":"Regulated targeting of BAX to mitochondria","volume":"143","author":"Goping","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib7","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1242\/jeb.01109","article-title":"A unique pathway of cardiac myocyte death caused by hypoxia-acidosis","volume":"207","author":"Graham","year":"2004","journal-title":"J Exp Biol"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.cdd.4400810","article-title":"Hypoxia induces the expression of the pro-apoptotic gene BNIP3","volume":"8","author":"Guo","year":"2001","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/exnr.1999.7160","article-title":"HIP-1\u03b1 and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia","volume":"159","author":"Halterman","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib10","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1046\/j.1471-4159.2003.01795.x","article-title":"Bcl-2 related protein family gene expression during oligodendroglial differentiation","volume":"85","author":"Itoh","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0161-813X(03)00042-1","article-title":"Cyanide enhancement of dopamine-induced apoptosis in mesencephalic cells involves mitochondrial dysfunction and oxidative stress","volume":"24","author":"Jones","year":"2003","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib12","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/sj.onc.1208095","article-title":"Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3","volume":"24","author":"Kanzawa","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0165-0270(02)00090-0","article-title":"Co-transfection with cDNA encoding the Bcl family of anti-apoptotic proteins improves the efficiency of transfection in primary fetal neural stem cells","volume":"117","author":"Kim","year":"2002","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib14","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/S0891-5849(01)00726-2","article-title":"Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptotic cell death in dopaminergic cells","volume":"31","author":"Kitazawa","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib15","doi-asserted-by":"crossref","first-page":"11926","DOI":"10.1073\/pnas.182272699","article-title":"RNAi functions in cultured mammalian neurons","volume":"99","author":"Krichevsky","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib16","doi-asserted-by":"crossref","first-page":"12825","DOI":"10.1073\/pnas.202474099","article-title":"Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNip3","volume":"99","author":"Kubasiak","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib17","first-page":"1","article-title":"Regulation of BNIP3 in normal and cancer cells","volume":"2","author":"Lee","year":"2006","journal-title":"Mol Cells"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib18","doi-asserted-by":"crossref","first-page":"30299","DOI":"10.1074\/jbc.272.48.30299","article-title":"Cell specific induction of apoptosis by microinjection of cytochrome c","volume":"272","author":"Li","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/taap.2002.9515","article-title":"Oxidative stress and cyclooxygenase-2 induction mediate cyanide-induced apoptosis of cortical cells","volume":"185","author":"Li","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/taap.1999.8630","article-title":"Differential susceptibility of brain areas to cyanide involves different modes of cell death","volume":"156","author":"Mills","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib21","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1124\/jpet.102.039453","article-title":"Cyanide induces different modes of death in cortical and mesencephalic cells","volume":"303","author":"Prabhakaran","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib22","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1124\/jpet.105.088625","article-title":"Upregulation of uncoupling protein 2 by cyanide is linked with cytotoxicity in mesencephalic cells","volume":"314","author":"Prabhakaran","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib23","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1074\/jbc.275.2.1439","article-title":"BNIP3 heterodimerizes with Bcl-2\/BclXL and induces cell death independent of a Bcl-2 homology3 (BH3) domain at both mitochondrial and nonmitochondrial sites","volume":"275","author":"Ray","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/01.RES.0000029232.42227.16","article-title":"Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia mediated cell death of ventricular myocytes","volume":"91","author":"Regula","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2006.05.006","article-title":"Localization and developmental ontogeny of the pro-apoptotic Bnip3 mRNA in the postnatal rat cortex and hippocampus","volume":"1100","author":"Sandau","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainres.2003.11.065","article-title":"Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus","volume":"1001","author":"Schmidt-Kastner","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib27","doi-asserted-by":"crossref","first-page":"35049","DOI":"10.1074\/jbc.M104988200","article-title":"Oxidative stress induces neuronal death by recruiting a protease and phosphatase-gated mechanism","volume":"276","author":"See","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib28","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1073\/pnas.97.7.3100","article-title":"BH4 domain of anti-apoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death","volume":"97","author":"Shimizu","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib29","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1006\/taap.2000.8900","article-title":"Cyanide-induced apoptosis involves oxidative-stress-activated NF-kappaB in cortical neurons","volume":"164","author":"Shou","year":"2000","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib30","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1046\/j.1471-4159.2002.00880.x","article-title":"NF-kappaB-mediated up-regulation of Bcl-X(S) and Bax contributes to cytochrome c release in cyanide-induced apoptosis","volume":"81","author":"Shou","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/toxsci\/kfg157","article-title":"p38 Mitogen-activated protein kinase regulates Bax translocation in cyanide-induced apoptosis","volume":"75","author":"Shou","year":"2003","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib32","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0022-3565(24)36517-6","article-title":"Modulation of the NMDA receptor by cyanide: Enhancement of receptor mediated responses","volume":"280","author":"Sun","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib33","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1161\/01.RES.75.3.426","article-title":"Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes","volume":"75","author":"Tanaka","year":"1994","journal-title":"Circ Res"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib34","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1128\/MCB.20.15.5454-5468.2000","article-title":"BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore","volume":"20","author":"Vande Velde","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib35","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.pa.24.040184.002315","article-title":"Cyanide intoxication and its mechanism of antagonism","volume":"24","author":"Way","year":"1984","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.yjmcc.2004.11.007","article-title":"BNip3 and signal-specific programmed death in the heart","volume":"38","author":"Webster","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib37","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.bbrc.2006.05.160","article-title":"Upregulation of BNIP3 promotes apoptosis of lung cancer cells that were induced by p53","volume":"346","author":"Yan","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib38","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbrc.2004.06.144","article-title":"Nitric oxide induces BNIP3 expression that causes cell death in macrophages","volume":"321","author":"Yook","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1023\/A:1023616620970","article-title":"BNips: A group of pro-apoptotic proteins in the Bcl-2 family","volume":"8","author":"Zhang","year":"2003","journal-title":"Apoptosis"},{"key":"10.1016\/j.neuroscience.2007.07.033_bib40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.freeradbiomed.2007.04.005","article-title":"HIF-1alpha activation by a redox-sensitive pathway mediates cyanide-induced BNIP3 upregulation and mitochondrial-dependent cell death","volume":"43","author":"Zhang","year":"2007","journal-title":"Free Radic Biol Med"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452207008883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452207008883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T01:06:58Z","timestamp":1737335218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452207008883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0306452207008883"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2007.07.033","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}