{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:26:30Z","timestamp":1767979590854,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.neuroscience.2007.07.037","type":"journal-article","created":{"date-parts":[[2007,8,2]],"date-time":"2007-08-02T11:27:04Z","timestamp":1186054024000},"page":"915-924","source":"Crossref","is-referenced-by-count":30,"title":["Analysis of the action of euxanthone, a plant-derived compound that stimulates neurite outgrowth"],"prefix":"10.1016","volume":"148","author":[{"given":"M.","family":"Naidu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-Y.K.","family":"Kuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.-L.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Raza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tolkovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.-K.","family":"Mak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.N.-S.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Keynes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2007.07.037_bib1","doi-asserted-by":"crossref","first-page":"27489","DOI":"10.1074\/jbc.270.46.27489","article-title":"PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo","volume":"270","author":"Alessi","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib2","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1128\/MCB.19.6.4209","article-title":"Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells","volume":"19","author":"Corbit","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib3","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1242\/jcs.113.14.2567","article-title":"The role of retinoic acid receptors in neurite outgrowth from different populations of embryonic mouse dorsal root ganglia","volume":"113","author":"Corcoran","year":"2000","journal-title":"J Cell Sci"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(94)90133-3","article-title":"Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells","volume":"77","author":"Cowley","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib5","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1073\/pnas.73.7.2424","article-title":"Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor","volume":"73","author":"Greene","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib6","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1523\/JNEUROSCI.01-10-01085.1981","article-title":"The action of nerve growth factor and dibutyryl adenosine cyclic 3\u2032:5\u2032-monophosphate on rat pheochromocytoma reveals distinct stages in the mechanisms underlying neurite outgrowth","volume":"1","author":"Gunning","year":"1981","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A series of normal stages in the development of the chick embryo","volume":"88","author":"Hamburger","year":"1951","journal-title":"J Morphol"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib8","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1146\/annurev.biochem.72.121801.161629","article-title":"Trk receptors: roles in neuronal signal transduction","volume":"72","author":"Huang","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1242\/jcs.109.2.289","article-title":"Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase","volume":"109","author":"Jackson","year":"1996","journal-title":"J Cell Sci"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib10","series-title":"Protocols for neural cell culture","first-page":"95","article-title":"Primary cultures for myelination study","author":"Johnson","year":"2001"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nn840","article-title":"A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth","volume":"5","author":"Kao","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib12","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0959-4388(00)00092-1","article-title":"Neurotrophin signal transduction in the nervous system","volume":"10","author":"Kaplan","year":"2000","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib13","doi-asserted-by":"crossref","first-page":"18961","DOI":"10.1016\/S0021-9258(17)32260-3","article-title":"Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase","volume":"269","author":"Kimura","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib14","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/(SICI)1097-4547(19961215)46:6<720::AID-JNR8>3.0.CO;2-H","article-title":"Nerve growth factor-stimulated mitogen-activated protein kinase activity is not necessary for neurite outgrowth of chick dorsal root ganglion sensory and sympathetic neurons","volume":"46","author":"Klinz","year":"1996","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib15","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1523\/JNEUROSCI.21-13-04572.2001","article-title":"Kainate receptors expressed by a subpopulation of developing nociceptors rapidly switch from high to low Ca2+ permeability","volume":"21","author":"Lee","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0024-3205(99)00596-2","article-title":"Effects of euxanthone on neuronal differentiation","volume":"66","author":"Mak","year":"2000","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1055\/s-2001-15809","article-title":"Expression of protein kinase C isoforms in euxanthone-induced differentiation of neuroblastoma cells","volume":"67","author":"Mak","year":"2001","journal-title":"Planta Med"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0896-6273(02)00752-3","article-title":"Raf and akt mediate distinct aspects of sensory axon growth","volume":"35","author":"Markus","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","article-title":"Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation","volume":"80","author":"Marshall","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib19a","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.ne.19.030196.002335","article-title":"Intracellular signaling pathways activated by neurotrophic factors","volume":"19","author":"Segal","year":"1996","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0959-4388(99)80052-X","article-title":"Signal transduction underlying growth cone guidance by diffusible factors","volume":"9","author":"Song","year":"1999","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib21","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuroscience.2005.01.028","article-title":"Sargachromenol, a novel nerve growth factor-potentiating substance isolated from Sargassum macrocarpum, promotes neurite outgrowth and survival via distinct signaling pathways in PC12D cells","volume":"132","author":"Tsang","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/jnr.10073","article-title":"Mitogen-activated protein kinase inhibition reveals differences in signalling pathways activated by neurotrophin-3 and other growth-stimulating conditions of adult mouse dorsal root ganglia neurons","volume":"67","author":"Wiklund","year":"2002","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2007.07.037_bib23","doi-asserted-by":"crossref","first-page":"17406","DOI":"10.1074\/jbc.M111902200","article-title":"c-SRC mediates neurite outgrowth through recruitment of Crk to the scaffolding protein Sin\/Efs without altering the kinetics of ERK activation","volume":"277","author":"Yang","year":"2002","journal-title":"J Biol Chem"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452207009517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452207009517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T02:00:48Z","timestamp":1629511248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452207009517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0306452207009517"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2007.07.037","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}