{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:19:49Z","timestamp":1790785189845,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["03134298"],"award-info":[{"award-number":["03134298"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroscience.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.neuroscience.2007.12.042","type":"journal-article","created":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T12:36:48Z","timestamp":1200400608000},"page":"495-501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Mechanical allodynia and spinal up-regulation of P2X4 receptor in experimental autoimmune neuritis rats"],"prefix":"10.1016","volume":"152","author":[{"given":"Z.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.-Y.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Fauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.J.","family":"Schluesener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2007.12.042_bib1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jneuroim.2004.10.027","article-title":"Experimental autoimmune neuritis induces differential microglia activation in the rat spinal cord","volume":"160","author":"Beiter","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0014-5793(95)01203-Q","article-title":"A P2X purinoceptor cDNA conferring a novel pharmacological profile","volume":"375","author":"Bo","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib3","first-page":"140","article-title":"Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1","volume":"83","author":"Damoiseaux","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib4","doi-asserted-by":"crossref","unstructured":"Echeverry S, Shi XQ, Zhang J (2007) Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain. Pain [Epub ahead of print]. doi:10.1016\/j.pain.2007.05.002.","DOI":"10.1016\/j.pain.2007.05.002"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib5","first-page":"100","article-title":"Spinal cord microglia in experimental allergic neuritis","volume":"67","author":"Gehrmann","year":"1992","journal-title":"Lab Invest"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/glia.440070110","article-title":"Microglial involvement in experimental autoimmune inflammation of the central and peripheral nervous system","volume":"7","author":"Gehrmann","year":"1993","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1750-3639.1995.tb00570.x","article-title":"Astrocytes upregulate glial fibrillary acidic protein (GFAP), but not insulin-like growth factor-I (IGF-I) during experimental autoimmune neuritis (EAN)","volume":"5","author":"Gehrmann","year":"1995","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neuroscience.2005.04.026","article-title":"Lesional accumulation of P2X(4) receptor(+) macrophages in rat CNS during experimental autoimmune encephalomyelitis","volume":"134","author":"Guo","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jneuroim.2005.03.007","article-title":"Expression of P2X4 receptor by lesional activated microglia during formalin-induced inflammatory pain","volume":"163","author":"Guo","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib10","first-page":"115","article-title":"Demyelination and axonal degeneration in Lewis rat experimental allergic neuritis depend on the myelin dosage","volume":"59","author":"Hahn","year":"1988","journal-title":"Lab Invest"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib11","first-page":"328","article-title":"Experimental allergic neuritis (EAN) as a model for the immune-mediated demyelinating neuropathies","volume":"152","author":"Hahn","year":"1996","journal-title":"Rev Neurol (Paris)"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib12","first-page":"824","article-title":"Pain management for multiple sclerosis patients","volume":"16","author":"Howarth","year":"2000","journal-title":"Prof Nurse"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib13","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0140-6736(05)67665-9","article-title":"Guillain-Barre syndrome","volume":"366","author":"Hughes","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib14","first-page":"209","article-title":"Morphologic study on experimental allergic neuritis mediated by T cell line specific for bovine P2 protein in Lewis rats","volume":"53","author":"Izumo","year":"1985","journal-title":"Lab Invest"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib15","first-page":"reE14","article-title":"Cell signaling and the genesis of neuropathic pain","volume":"252","author":"Ji","year":"2004","journal-title":"Sci STKE"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.expneurol.2004.11.001","article-title":"Immune and glial cell factors as pain mediators and modulators","volume":"192","author":"McMahon","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.bbi.2006.07.007","article-title":"Pain hypersensitivity in rats with experimental autoimmune neuritis: an animal model of human inflammatory demyelinating neuropathy","volume":"21","author":"Moalem-Taylor","year":"2007","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/cne.902300112","article-title":"The cytoarchitectonic organization of the spinal cord in the rat","volume":"230","author":"Molander","year":"1984","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib19","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1212\/WNL.48.2.328","article-title":"Pain in Guillain-Barre syndrome","volume":"48","author":"Moulin","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib20","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/glia.20339","article-title":"Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X4, a key molecule for mechanical allodynia","volume":"53","author":"Nasu-Tada","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib21","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","article-title":"Molecular physiology of P2X receptors","volume":"82","author":"North","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/glia.20489","article-title":"Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis","volume":"55","author":"Ohsawa","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0304-3959(94)90068-X","article-title":"Pain in the Guillain-Barre syndrome: a clinical review","volume":"59","author":"Pentland","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jneuroim.2005.02.016","article-title":"Spinal cord injury induces early and persistent lesional P2X4 receptor expression","volume":"163","author":"Schwab","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib25","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nature01786","article-title":"P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury","volume":"424","author":"Tsuda","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/glia.20591","article-title":"Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury","volume":"56","author":"Tsuda","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tins.2004.12.002","article-title":"Neuropathic pain and spinal microglia: a big problem from molecules in \u201csmall\u201d glia","volume":"28","author":"Tsuda","year":"2005","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib28","series-title":"Neuroinflammation, mechanism and management","first-page":"61","article-title":"Inflammatory markers in chronic neurodegenerative disorders with emphasis on Alzheimer\u2019 disease","author":"Walker","year":"1998"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2172-5-16","article-title":"P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells","volume":"5","author":"Wang","year":"2004","journal-title":"BMC Immunol"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib30","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0165-5728(97)00238-5","article-title":"Cytokine production and the pathogenesis of experimental autoimmune neuritis and Guillain-Barre syndrome","volume":"84","author":"Zhu","year":"1998","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2007.12.042_bib32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1046\/j.1365-2249.1999.00768.x","article-title":"Linomide suppresses experimental autoimmune neuritis in Lewis rats by inhibiting myelin antigen-reactive T and B cell responses","volume":"115","author":"Zhu","year":"1999","journal-title":"Clin Exp Immunol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452207016685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452207016685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T16:41:49Z","timestamp":1719420109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452207016685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0306452207016685"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2007.12.042","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanical allodynia and spinal up-regulation of P2X4 receptor in experimental autoimmune neuritis rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2007.12.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 IBRO. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}