{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:40:35Z","timestamp":1790937635358,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.neuroscience.2008.09.059","type":"journal-article","created":{"date-parts":[[2008,10,18]],"date-time":"2008-10-18T04:52:06Z","timestamp":1224305526000},"page":"642-653","source":"Crossref","is-referenced-by-count":49,"title":["Human olfactory epithelial cells generated in vitro express diverse neuronal characteristics"],"prefix":"10.1016","volume":"158","author":[{"given":"K.E.","family":"Borgmann-Winter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.E.","family":"Rawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.","family":"Ozdener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.K.","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Adamek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pribitkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-G.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2008.09.059_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J Mol Biol"},{"issue":"21","key":"10.1016\/j.neuroscience.2008.09.059_bib2","doi-asserted-by":"crossref","first-page":"9313","DOI":"10.1523\/JNEUROSCI.19-21-09313.1999","article-title":"Targeted deletion of a cyclic nucleotide-gated channel subunit (OCNC1): biochemical and morphological consequences in adult mice","volume":"19","author":"Baker","year":"1999","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.neuroscience.2008.09.059_bib3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neuron.2005.07.015","article-title":"The dopamine D2 receptor: new surprises from an old friend","volume":"47","author":"Bonci","year":"2005","journal-title":"Neuron"},{"issue":"65","key":"10.1016\/j.neuroscience.2008.09.059_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0092-8674(91)90418-X","article-title":"A novel multigene family may encode odorant receptors: a molecular basis for odor recognition","volume":"427","author":"Buck","year":"1991","journal-title":"Cell"},{"issue":"11 Pt 2","key":"10.1016\/j.neuroscience.2008.09.059_bib5","doi-asserted-by":"crossref","first-page":"S184","DOI":"10.1111\/j.1753-4887.2004.tb00097.x","article-title":"Olfactory receptors and odor coding in mammals","volume":"62","author":"Buck","year":"2004","journal-title":"Nutr Rev"},{"issue":"2","key":"10.1016\/j.neuroscience.2008.09.059_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0165-3806(91)90040-P","article-title":"Differentiation and survival of rat olfactory epithelial neurons in dissociated cell culture","volume":"60","author":"Chuah","year":"1991","journal-title":"Brain Res Dev Brain Res"},{"issue":"5","key":"10.1016\/j.neuroscience.2008.09.059_bib7","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/0896-6273(94)90047-7","article-title":"Genesis of olfactory receptor neurons in vitro: regulation of progenitor cell divisions by fibroblast growth factors","volume":"13","author":"DeHamer","year":"1994","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.neuroscience.2008.09.059_bib8","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0306-4522(98)00104-3","article-title":"Basic fibroblast growth factor supports human olfactory neurogenesis by autocrine\/paracrine mechanisms","volume":"86","author":"Ensoli","year":"1998","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.neuroscience.2008.09.059_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/ar.1091890206","article-title":"Differentiation of olfactory receptor cells in organ culture","volume":"189","author":"Farbman","year":"1977","journal-title":"Anat Rec"},{"issue":"3","key":"10.1016\/j.neuroscience.2008.09.059_bib10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0920-9964(99)00055-9","article-title":"Altered adhesion, proliferation and death in neural cultures from adults with schizophrenia","volume":"40","author":"Feron","year":"1999","journal-title":"Schizophr Res"},{"issue":"2","key":"10.1016\/j.neuroscience.2008.09.059_bib11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0006-8993(99)01959-9","article-title":"Dopamine promotes differentiation of olfactory neuron in vitro","volume":"845","author":"Feron","year":"1999","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.neuroscience.2008.09.059_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/jn.2000.84.1.39","article-title":"Functional role of NMDA autoreceptors in olfactory mitral cells","volume":"84","author":"Friedman","year":"2000","journal-title":"J Neurophysiol"},{"issue":"2","key":"10.1016\/j.neuroscience.2008.09.059_bib1a","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1085\/jgp.101.2.183","article-title":"Protein kinase C sensitizes olfactory adenylate cyclase","volume":"101","author":"Frings","year":"1993","journal-title":"J Gen Physiol"},{"issue":"1","key":"10.1016\/j.neuroscience.2008.09.059_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1474-9728.2004.00083.x","article-title":"Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients","volume":"3","author":"Ghanbari","year":"2004","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.neuroscience.2008.09.059_bib14","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/1097-4547(20001201)62:5<737::AID-JNR14>3.0.CO;2-A","article-title":"Characteristics of odorant elicited calcium changes in cultured human olfactory neurons","volume":"62","author":"Gomez","year":"2000","journal-title":"J Neurosci Res"},{"issue":"3","key":"10.1016\/j.neuroscience.2008.09.059_bib15","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1176\/appi.ajp.162.3.616","article-title":"Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorder","volume":"162","author":"Hahn","year":"2005","journal-title":"Am J Psychiatry"},{"issue":"2","key":"10.1016\/j.neuroscience.2008.09.059_bib16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/cne.20424","article-title":"In vivo and in vitro neurogenesis in human olfactory epithelium","volume":"483","author":"Hahn","year":"2005","journal-title":"J Comp Neurol"},{"issue":"13","key":"10.1016\/j.neuroscience.2008.09.059_bib18","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1523\/JNEUROSCI.20-13-05124.2000","article-title":"Calcium influx through NMDA receptors directly evokes GABA release in olfactory bulb granule cells","volume":"20","author":"Halabisky","year":"2000","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.neuroscience.2008.09.059_bib19","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/(SICI)1096-9861(19990906)411:4<666::AID-CNE10>3.0.CO;2-S","article-title":"Olfactory receptor neurons express D2 dopamine receptors","volume":"411","author":"Koster","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2008.09.059_bib20","series-title":"Experimental cell biology of taste and olfaction","first-page":"47","article-title":"Collection of human olfactory tissue","author":"Lowry","year":"1995"},{"issue":"3","key":"10.1016\/j.neuroscience.2008.09.059_bib21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2174\/1389450013348434","article-title":"NMDA receptor pharmacology: perspectives from molecular biology","volume":"2","author":"Lynch","year":"2001","journal-title":"Curr Drug Targets"},{"issue":"1","key":"10.1016\/j.neuroscience.2008.09.059_bib1b","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/(SICI)1097-4547(19960401)44:1<27::AID-JNR4>3.0.CO;2-K","article-title":"FGF2 promotes neuronal differentiation in explant cultures of adult and embryonic mouse olfactory epithelium","volume":"44","author":"MacDonald","year":"1996","journal-title":"J Neurosci Res"},{"issue":"3","key":"10.1016\/j.neuroscience.2008.09.059_bib22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1399-5618.2006.00302.x","article-title":"Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder","volume":"8","author":"MacDonald","year":"2006","journal-title":"Bipolar Disord"},{"issue":"1","key":"10.1016\/j.neuroscience.2008.09.059_bib23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0306-4522(93)90119-Z","article-title":"Bromocriptine, a dopamine D2 receptor agonist, inhibits adenylyl cyclase activity in rat olfactory epithelium","volume":"57","author":"Mania-Farnell","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2008.09.059_bib24","series-title":"Proteins of the nervous system","first-page":"59","article-title":"A marker protein for the olfactory chemoreceptor neuron","author":"Margolis","year":"1980"},{"issue":"1","key":"10.1016\/j.neuroscience.2008.09.059_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.conb.2004.01.014","article-title":"Odorant receptor gene choice in olfactory sensory neurons: the one receptor-one neuron hypothesis revisited","volume":"14","author":"Mombaerts","year":"2004","journal-title":"Curr Opin Neurobiol"},{"issue":"3","key":"10.1016\/j.neuroscience.2008.09.059_bib26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s004410050063","article-title":"Olfactory neuron-specific expression of NeuroD in mouse and human nasal mucosa","volume":"298","author":"Nibu","year":"1999","journal-title":"Cell Tissue Res"},{"issue":"20","key":"10.1016\/j.neuroscience.2008.09.059_bib27","doi-asserted-by":"crossref","first-page":"13019","DOI":"10.1074\/jbc.272.20.13019","article-title":"TrkB variants with deletions in the leucine-rich motifs of the extracellular domain","volume":"272","author":"Ninkina","year":"1997","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.neuroscience.2008.09.059_bib28","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0006-8993(03)02267-4","article-title":"Dopamine modulates a voltage-gated calcium channel in rat olfactory receptor neurons","volume":"968","author":"Okada","year":"2003","journal-title":"Brain Res"},{"issue":"5\u20136","key":"10.1016\/j.neuroscience.2008.09.059_bib1c","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/10520290500469777","article-title":"Clonal analysis of adult human olfactory neurosphere forming cells","volume":"80","author":"Othman","year":"2005","journal-title":"Biotech Histochem"},{"issue":"1","key":"10.1016\/j.neuroscience.2008.09.059_bib1d","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0742-8413(83)90165-2","article-title":"Different distribution of serotonin in an elasmobranch (Scyliorhinus stellaris) and in a teleost (Conger conger) fish","volume":"74","author":"Piomelli","year":"1983","journal-title":"Comp Biochem Physiol C"},{"issue":"7\u20138","key":"10.1016\/j.neuroscience.2008.09.059_bib29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0736-5748(96)00057-3","article-title":"Characterization of olfactory receptor neurons and other cell types in dissociated rat olfactory cell cultures","volume":"14","author":"Pixley","year":"1996","journal-title":"Int J Dev Neurosci"},{"issue":"1\u20132","key":"10.1016\/j.neuroscience.2008.09.059_bib30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0006-8993(95)00283-V","article-title":"Functionally mature olfactory neurons from two anosmic patients with Kallmann syndrome","volume":"681","author":"Rawson","year":"1995","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.neuroscience.2008.09.059_bib31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1471-4159.2000.0750185.x","article-title":"Expression of mRNAs encoding for two different olfactory receptors in a subset of olfactory receptor neurons","volume":"75","author":"Rawson","year":"2000","journal-title":"J Neurochem"},{"issue":"3","key":"10.1016\/j.neuroscience.2008.09.059_bib32","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1152\/jn.1997.77.3.1606","article-title":"Selectivity and response characteristics of human olfactory neurons","volume":"77","author":"Rawson","year":"1997","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2008.09.059_bib33","series-title":"Bioinformatics methods and protocols: methods in molecular biology","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","author":"Rozen","year":"2000"},{"issue":"4","key":"10.1016\/j.neuroscience.2008.09.059_bib35","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1523\/JNEUROSCI.16-04-01294.1996","article-title":"Sequential expression of Trks A, B, and C in the regenerating olfactory neuroepithelium","volume":"16","author":"Roskams","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.09.059_bib36","series-title":"Molecular cloning: a laboratory manual","author":"Sambrook","year":"1989"},{"issue":"5594","key":"10.1016\/j.neuroscience.2008.09.059_bib37","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1126\/science.1075333","article-title":"Postsynaptic signaling and plasticity mechanisms","volume":"298","author":"Sheng","year":"2002","journal-title":"Science"},{"issue":"Pt 2","key":"10.1016\/j.neuroscience.2008.09.059_bib38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1113\/jphysiol.2002.017376","article-title":"Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent","volume":"542","author":"Tucker","year":"2002","journal-title":"J Physiol"},{"issue":"6","key":"10.1016\/j.neuroscience.2008.09.059_bib39","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1523\/JNEUROSCI.15-06-04382.1995","article-title":"Neuroblast long-term cell cultures from human fetal olfactory epithelium respond to odors","volume":"15","author":"Vannelli","year":"1995","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.neuroscience.2008.09.059_bib40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1152\/jn.1999.81.1.149","article-title":"Dopamine modulates inwardly rectifying hyperpolarization-activated current (Ih) in cultured rat olfactory receptor neurons","volume":"81","author":"Vargas","year":"1999","journal-title":"J Neurophysiol"},{"issue":"1","key":"10.1016\/j.neuroscience.2008.09.059_bib1e","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/exnr.1996.0189","article-title":"Human olfactory neuroepithelial cells: tyrosine phosphorylation and process extension are increased by the combination of IL-1beta, IL-6, NGF, and bFGF","volume":"142","author":"Vawter","year":"1996","journal-title":"Exp Neurol"},{"issue":"2\u20134","key":"10.1016\/j.neuroscience.2008.09.059_bib1f","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000072272","article-title":"The role of serotonin in early cortical development","volume":"25","author":"Vitalis","year":"2003","journal-title":"Dev Neurosci"},{"issue":"17","key":"10.1016\/j.neuroscience.2008.09.059_bib41","doi-asserted-by":"crossref","first-page":"7426","DOI":"10.1523\/JNEUROSCI.19-17-07426.1999","article-title":"Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus laevis oocytes","volume":"19","author":"Wetzel","year":"1999","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.neuroscience.2008.09.059_bib42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF02919405","article-title":"Continuous culture of neuronal cells from adult human olfactory epithelium","volume":"3","author":"Wolozin","year":"1992","journal-title":"J Mol Neurosci"},{"issue":"3","key":"10.1016\/j.neuroscience.2008.09.059_bib43","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0896-6273(00)00060-X","article-title":"Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice","volume":"27","author":"Wong","year":"2000","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.neuroscience.2008.09.059_bib44","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.expneurol.2003.10.022","article-title":"Adult human olfactory neural progenitors cultured in defined medium","volume":"186","author":"Zhang","year":"2004","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2008.09.059_bib1g","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.brainres.2005.12.059","article-title":"Induction of neuronal differentiation of adult human olfactory neuroepithelial-derived progenitors","volume":"1073\u20131074","author":"Zhang","year":"2006","journal-title":"Brain Res"},{"issue":"3","key":"10.1016\/j.neuroscience.2008.09.059_bib45","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/(SICI)1096-9861(20000508)420:3<324::AID-CNE4>3.0.CO;2-6","article-title":"Serotonergic nerve fibers in the primary olfactory pathway of the larval sea lamprey, Petromyzon marinus","volume":"420","author":"Zielinski","year":"2000","journal-title":"J Comp Neurol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452208014437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452208014437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T15:36:39Z","timestamp":1557848199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452208014437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0306452208014437"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2008.09.059","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}